Article
Oncology
Fan Yang, Zhanwen Sun, Dengyun Wang, Tian Du
Summary: The study reveals that miR-106b-5p enhances proliferation, colony formation, adhesion, migration, and invasion, and induces cell cycle progression, while repressing apoptosis in esophageal squamous cell carcinoma (ESCC) by targeting HPGD. This finding suggests that the miR-106b-5p/HPGD axis may serve as a promising target for the diagnosis and treatment of ESCC.
Article
Biochemistry & Molecular Biology
Mingyan Xu, Junling Zhang, Xuemei Lu, Fan Liu, Songlin Shi, Xiaoling Deng
Summary: SMARCA4 is highly upregulated in oral squamous cell carcinoma (OSCC) tissues, promoting cell invasion and tumor growth. Mechanistic studies reveal that miR-199a-5p-regulated SMARCA4 promotes tumor cell invasion and metastasis through epithelial-mesenchymal transition (EMT). These findings provide insights into the role of SMARCA4 in OSCC and have important implications for therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Xincheng Su, Cong Xue, Chengke Xie, Xianzhe Si, Jie Xu, Wenbo Huang, Zhijun Huang, Jianqing Lin, Zhiyao Chen
Summary: This study revealed that the downregulation of lncRNA-LET is associated with poor prognosis in ESCC patients, and the upregulation of lncRNA-LET can reduce cell viability. In vivo experiments demonstrated that increased lncRNA-LET has significant inhibitory effects on tumor growth. Additionally, the effects of miR-106b-5p or miR-93-5p and SOCS4 on ESCC are related to the feedback of lncRNA-LET.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Meng Ding, Xiaozhi Zhao, Xiaoqing Chen, Wenli Diao, Yansheng Kan, Wenmin Cao, Wei Chen, Bo Jiang, Haixiang Qin, Jie Gao, Junlong Zhuang, Qing Zhang, Hongqian Guo
Summary: This study reveals that the enrichment of cancer-associated fibroblasts (CAFs) is positively correlated with tumor progression and cancer stemness in renal cell carcinoma (RCC). The study further demonstrates that CAFs enhance cancer stemness by delivering exosomes containing miR-181d-5p to RCC cells, which activates the Wnt/beta-catenin signaling pathway and promotes tumor progression.
CELL DEATH DISCOVERY
(2022)
Article
Obstetrics & Gynecology
Huier Sun, Xuejun Chen
Summary: This study revealed that miR-106b-5p modulates cervical squamous cell carcinoma cells by targeting TIMP2, promoting malignant behaviors and showing an inverse correlation with TIMP2 levels.
REPRODUCTIVE SCIENCES
(2022)
Article
Cell Biology
Min Lu, Xinglei Qin, Yajun Zhou, Gang Li, Zhaoyang Liu, Xiwen Geng, Haodi Yue
Summary: The study showed that LINC00665 plays a crucial role in gemcitabine resistance of CCA cells by regulating BCL9L expression, leading to modulation of EMT, stemness, and Wnt/β-Catenin activation.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Siyuan Wang, Xiaorong Yang, Wenjie Xie, Shengqiang Fu, Qiang Chen, Zhilong Li, Zhicheng Zhang, Ting Sun, Binbin Gong, Ming Ma
Summary: Our study identified that GAPLINC is significantly upregulated in RCC tissues and cell lines, and is associated with a poor prognosis in RCC patients. Knockdown of GAPLINC inhibited RCC growth in vitro and in vivo, while overexpression of GAPLINC had the opposite effect. Mechanistically, GAPLINC upregulates the oncogene CSF1 expression by acting as a sponge for miR-135b-5p.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Qi Lv, Gangmin Wang, Yinan Zhang, Aijun Shen, Junjun Tang, Yi Sun, Chunhui Ma, Peijun Wang
Summary: This study reveals that circAGAP1 is significantly upregulated in ccRCC tissues and is closely associated with tumor size, nuclear grade, and clinical stage. Mechanistic studies demonstrate that cytoplasmic circAGAP1 functions as a ceRNA by sponging miR-15-5p, thereby promoting E2F3 expression. Targeting circAGAP1 may offer a new therapeutic strategy for ccRCC.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Bo Huang, YiChao Zhang, Peng Sun, YuanYuan Yuan, CunChuan Wang
Summary: miR-138-5p inhibits the growth and stemness of thyroid cancer cells through the regulation of TRPC5/Wnt/beta-catenin pathway, providing guidance for studying the potential function of miR-138-5p in thyroid cancer progression.
MOLECULAR BIOTECHNOLOGY
(2023)
Article
Medicine, Research & Experimental
Shenshuo Gao, Zhikai Zhang, Xubin Wang, Yan Ma, Chensheng Li, Hongjun Liu, Changqing Jing, Leping Li, Xiaobo Guo
Summary: In this study, it was found that miR-875-5p can inhibit the proliferation, migration, and invasion of gastric cancer cells by directly targeting USF2. Overexpression of miR-875-5p was also shown to suppress the TGF-beta signaling pathway. MiR-875-5p has the potential to be a target for the diagnosis and treatment of gastric cancer in the future.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Wenyan Liao, Jun He, Cyrollah Disoma, Yi Hu, Junhua Li, Guodong Chen, Ying Sheng, Xinyu Cai, Chuanfu Li, Kai Cheng, Chunfen Yang, Yongxi Qin, Dong Han, Wu Wen, Chengming Ding, Mujun Li
Summary: This study demonstrated that hsa_circ_0107593 has low expression in cervical cancer tissues and cell lines, negatively correlated with tumor characteristics, and inhibits cell proliferation, migration, and invasion. It may serve as a diagnostic biomarker due to its tumor-suppressing activity by sponging hsa-miR-20a-5p, hsa-miR-93-5p, and hsa-miR-106b-5p in cervical cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Environmental Sciences
Bin Meng, Pengfei Wang, Chaofei Zhao, Guangwei Yin, Xin Meng, Lin Li, Shengyong Cai, Chengquan Yan
Summary: This study reveals the stimulatory role of miR-21-5p in renal cell carcinoma and its contribution to the progression of the disease through the modulation of its downstream target gene ARHGAP24 expression.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Oncology
Wenkang Luan, Yuting Ding, Haolan Xi, Hongru Ruan, Feng Lu, Shaojun Ma, Jinlong Wang
Summary: This study revealed that miR-106b-5p levels are elevated in melanoma tissues, and high expression of miR-106b-5p is an independent risk factor for overall survival in melanoma patients. Exosomal miR-106b-5p promotes melanocyte migration, invasion and metastasis by targeting EphA4 to activate the ERK pathway.Overall, melanoma cell-secreted exosomal miR-106b-5p could potentially serve as a diagnostic indicator and therapeutic target for melanoma patients.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Bin Gao, Lijuan Wang, Na Zhang, Miaomiao Han, Yubo Zhang, Huancai Liu, Dongli Sun, Xiaolong Xiao, Yifei Liu
Summary: Our study reveals that miR-129-5p is down-regulated and SPN is up-regulated in ccRCC. Overexpressed miR-129-5p inhibits cell proliferation, migration, and invasion, induces cell cycle arrest, and promotes apoptosis. Dual-luciferase assay confirms the binding relationship between miR-129-5p and SPN, suggesting a potential target for precise treatment of ccRCC.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Lin Li, Kai Lei, Yingcheng Lyu, Binghua Tan, Ruihao Liang, Duoguang Wu, Kefeng Wang, Wenjian Wang, Huayue Lin, Minghui Wang
Summary: This study discovers that hsa_circ_0001741 is upregulated in ESCC and is associated with poor prognosis and tumor progression. Mechanistically, hsa_circ_0001741 acts as a sponge for miR-491-5p to upregulate NOTCH3 expression, promoting ESCC stemness, invasion, and migration.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Cell Biology
Ji-Ming Bao, Qiang Dang, Chun-Jung Lin, U-Ging Lo, Boris Feldkoren, Andrew Dang, Elizabeth Hernandez, Fei Li, Vandana Panwar, Cheng-Fan Lee, Jun-Jie Cen, Bing Guan, Vitaly Margulis, Payal Kapur, Rolf A. Brekken, Jun-Hang Luo, Jer-Tsong Hsieh, Wan-Long Tan
Summary: The aberrant expression of TGF-beta 1 is associated with RCC progression, with SPARC identified as a critical effector in the TGF-beta signaling pathway. Elevated SPARC expression in RCC is positively correlated with disease stage and grade, while inversely correlated with patient survival. Targeting SPARC may be a potential therapeutic strategy for RCC metastasis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Dermatology
Deng Zhang, Junjie Cen, Pengju Li, Li Shao, Jinhuan Wei, Zhenhua Chen, Junhang Luo, Wei Chen, Yong Huang
WOUND MANAGEMENT & PREVENTION
(2020)
Article
Biochemistry & Molecular Biology
Junjie Cen, Yanping Liang, Yong Huang, Yihui Pan, Guannan Shu, Zhousan Zheng, Xiaozhong Liao, Mi Zhou, Danlei Chen, Yong Fang, Wei Chen, Junhang Luo, Jiaxing Zhang
Summary: CircSDHC expression is correlated with advanced TNM stage and poor survival in RCC patients, and it promotes RCC progression by competitively binding to miR-127-3p, thereby preventing its suppression of CDKN3 and the E2F1 pathway. This suggests that circSDHC could be a potential therapeutic target in RCC treatment.
Article
Biotechnology & Applied Microbiology
Cheng-Peng Gui, Jia-Zheng Cao, Lei Tan, Yong Huang, Yi-Ming Tang, Peng-Ju Li, Yu-Hang Chen, Jun Lu, Hao-Hua Yao, Zhen-Hua Chen, Yi-Hui Pan, Yun-Lin Ye, Zi-Ke Qin, Wei Chen, Jin-Huan Wei, Jun-Hang Luo
Summary: The study identified an autophagy-related lncRNA signature to improve postoperative risk stratification for clear-cell renal cell carcinoma patients, confirming its significance as an independent prognostic signature, and could potentially serve as a promising tool for predicting patient survival.
Article
Cell Biology
Pengju Li, Shihui Hao, Yongkang Ye, Jinhuan Wei, Yiming Tang, Lei Tan, Zhuangyao Liao, Mingxiao Zhang, Jiaying Li, Chengpeng Gui, Jiefei Xiao, Yong Huang, Xu Chen, Jiazheng Cao, Junhang Luo, Wei Chen
Summary: The study identified an immune-related risk signature consisting of eight mRNAs, including ANXA1, IL22, IL9R, and others, through analysis of bladder urothelial cancer cases from the TCGA dataset. This risk signature successfully categorizes patients into high-risk and low-risk groups and may predict survival and treatment benefit in ICI therapy for urothelial cancer patients, potentially playing a role in precision immunotherapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Jinhuan Wei, Jun Lu, Yun Cao, Gaosheng Yao, Yong Huang, Hongwei Zhao, Yihui Pan, Zihao Feng, Zhenhua Chen, Wei Chen, Junhang Luo, Jiazheng Cao
Summary: High expression of DDX39B predicts poor overall survival in ccRCC patients and is positively correlated with the expression of PD-L1 and other immunomodulators. In ccRCC, DDX39B expression is negatively correlated with cytotoxic T-lymphocyte and HDAC10 exon 3 inclusion. DDX39B may increase PD-L1 expression by enhancing HDAC10 exon 3 skipping, thereby promoting the response to ICI therapy.
CURRENT CANCER DRUG TARGETS
(2021)
Article
Oncology
Lei Tan, Yiming Tang, Hongbo Li, Pengju Li, Yunlin Ye, Junjie Cen, Chengpeng Gui, Junhang Luo, Jiazheng Cao, Jinhuan Wei
Summary: This study characterized a lncRNA DUXAP9 in localized ccRCC and found that high expression of DUXAP9 is associated with poor prognosis. Knockdown of DUXAP9 inhibited renal cancer cell proliferation and motility, while overexpression promoted these capacities. DUXAP9 may serve as a prognostic marker and therapeutic target in localized ccRCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Urology & Nephrology
Jun Lu, Junjie Cen, Wenwei Wang, Hongwei Zhao, Pengju Li, Jiacong Mo, Zhenhua Chen, Yiming Tang, Jinhuan Wei, Junhang Luo, Shiying Huang, Yong Fang
Summary: Positioning the external urethral orifice in the coronary sulcus may help reduce the occurrence of epididymitis for patients with hypospadias complicating with a PUC connecting to the vas deferens.
Article
Oncology
Yiming Tang, Fei Liu, Xiaopeng Mao, Pengju Li, Mukhtar A. Mumin, Jiaying Li, Yi Hou, Hongde Song, Haishan Lin, Lei Tan, Chengpeng Gui, Mingxiao Zhang, Liangmin Fu, Wei Chen, Yong Huang, Junhang Luo
Summary: This study aimed to investigate whether tumor growth in patients with small renal masses (SRMs) leads to tumor progression. The results showed a significant correlation between tumor size and all-cause mortality and cancer-specific mortality, with 2 cm being considered as a prognostically relevant size threshold for patients with T1a RCC. Due to the lack of accurate predictors of tumor growth rate, active surveillance for patients with SRMs incurs a risk of tumor progression.
Article
Genetics & Heredity
Jiaying Li, Chengpeng Gui, Haohua Yao, Chenggong Luo, Hongde Song, Haishan Lin, Quanhui Xu, Xu Chen, Yong Huang, Junhang Luo, Wei Chen
Summary: A new mRNA model based on aging and senescence-related genes (ASRGs) was established for risk assessment and prognosis prediction in ccRCC patients. The model showed significant value in survival prediction and risk assessment, providing new insights into the roles of aging and senescence in ccRCC.
FRONTIERS IN GENETICS
(2022)
Article
Chemistry, Multidisciplinary
Mi Zhou, Jiaqi Dong, Junqing Huang, Wen Ye, Zhousan Zheng, Kangbo Huang, Yihui Pan, Junjie Cen, Yanping Liang, Guannan Shu, Sheng Ye, Xuanxuan Lu, Jiaxing Zhang
Summary: Chemoresistance is a major challenge in gastric cancer treatment. This study identifies a novel lncRNA TMEM44-AS1 related to 5-FU resistance and develops a new nanocarrier CGE for efficient delivery of si-TMEM44-AS1, leading to the reversal of 5-FU resistance and enhanced therapeutic effect in a mouse model.
Article
Oncology
U-Ging Lo, Yu-An Chen, Junjie Cen, Su Deng, Junghang Luo, Haiyen Zhau, Lin Ho, Chih-Ho Lai, Ping Mu, Leland W. K. Chung, Jer-Tsong Hsieh
Summary: This study identifies the role of interferon-related signaling pathway and IFIT5 in promoting prostate cancer stemness and highlights the potential of JAK or STAT1 inhibitors in preventing therapy-resistant prostate cancer. Inhibition of JAK-STAT1 signaling suppresses the capabilities of cancer stem cells and knocking down IFIT5 reduces cancer stemness and tumor initiating capability.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Letter
Urology & Nephrology
Wanmei Zhong, Junjie Cen, Yu Chen, Wei Chen, Junhang Luo, Xu Chen
ASIAN JOURNAL OF UROLOGY
(2021)