Journal
ONCOTARGET
Volume 8, Issue 28, Pages 45242-45248Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.16891
Keywords
VDAC; male infertility; semen
Categories
Funding
- National Natural Science Foundation of China [81501239, 81501672, 81370679, 81671410]
- Medical Science and technology development Foundation Nanjing Department of Health [YKK14129, YKK15154]
- Nanjing science and technology [201402024, 201503047]
- Science and Technology Development Fund of Nanjing Medical University [2014NJMUZD052]
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Voltage-dependent anion channel (VDAC) is a multifunctional channel protein across the outer mitochondrial membrane of somatic cells and participates in many physiological and pathophysiological processes. Up to now, only a few studies, including our previous studies, showed that VDAC exists in mammalian spermatozoa and is involved in spermatogenesis and sperm functions. There is no report about VDAC genetic variants in germinal tissues or cells. To investigate the possible association between VDAC genetic variants and human sperm quality, we performed semen analysis and variant Genotyping of VDAC3 subtype (rs7004637, rs16891278 and rs6773) of 523 Han-Chinese males with idiopathic infertility respectively by computer assisted semen analysis (CASA) and single nucleotide polymorphism (SNP) Genotyping assay. No significant association was found between rs7004637 and rs6773 genotypes and semen quality. However, the AG genotype of rs16891278 showed a significantly lower sperm concentration compared with the AA genotype (P = 0.044). Our findings suggest that VDAC3 genetic variants may be associated with human sperm count.
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