Article
Oncology
Durgesh Wankhede
Summary: The study found that the survival discrimination of the 8th edition is better than the 7th edition in all stages except IIA and IIB. The prognostic value of the two staging systems is similar, with no added advantage of the new edition.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
R. Mallet, P. Decazes, R. Modzelewski, J. Lequesne, P. Vera, B. Dubray, S. Thureau
Summary: Low skeletal muscle mass is a strong prognostic factor in non-small-cell lung cancer patients treated with radiochemotherapy. The automatic software Anthropometer3D can identify high-risk patients who may benefit from tailored therapy.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Weijie Yu, Ruixue Liu, Zhoulin Miao, Liwei Zhang, Ilyar Sheyhidin, Julaiti Ainiwaer
Summary: This meta-analysis indicates that circRNAs are highly useful diagnostic biomarkers for NSCLC in China. Further prospective studies on the diagnostic value of circRNAs should be conducted in multiple countries.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Viola W. Zhu, Joseph J. Zhao, Yanfei Gao, Nicholas L. Syn, Shannon S. Zhang, Sai-Hong Ignatius Ou, Kenneth A. Bauer, Misako Nagasaka
Summary: Patients with ALK+ and ROS1+ NSCLC have an increased risk of thromboembolism (TE), with ROS1+ NSCLC patients having a higher risk than ALK+ NSCLC patients.
Review
Oncology
Viviane Teixeira Loiola de Alencar, Marcos Pedro Guedes Camandaroba, Rafaela Pirolli, Camilla A. Z. Fogassa, Vladmir C. Cordeiro de Lima
Summary: The study demonstrates that ICIs appear to be effective in patients with NSCLC with untreated BM, showing activity particularly in patients with brain metastases, suggesting that ICIs may be used as a single treatment approach for active BM in selected patients with advanced NSCLC.
JOURNAL OF THORACIC ONCOLOGY
(2021)
Review
Oncology
Verena Waller, Martin Pruschy
Summary: Metalloproteinases play a crucial role in the irradiated tumor microenvironment, regulating processes such as intercellular communication, matrix remodeling, and tumor growth. Despite challenges faced in pharmaceutical research targeting metalloproteinases, there is still potential for combining specific metalloproteinase inhibitors with radiotherapy for cancer treatment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Anthony M. Magliocco, Jennifer Moughan, David T. Miyamoto, Jeff Simko, William U. Shipley, Phillip J. Gray, Michael P. Hagan, Matthew Parliament, William J. Tester, Anthony L. Zietman, Susan McCarthy, Daryoush Saeed-Vafa, Yin Xiong, Taylor Ayral, Alan C. Hartford, Ashish Patel, Seth A. Rosenthal, Susan Chafe, Richard Greenberg, Michael A. Schwartz, Mark E. Augspurger, John A. Keech, Kathryn A. Winter, Felix Y. Feng, Jason A. Efstathiou
Summary: This study evaluated MRE11 expression as a prognostic biomarker in MIBC patients receiving trimodality therapy, using automated quantitative image analysis. The results demonstrated that higher MRE11 signal ratios were associated with better disease-specific mortality, while lower MRE11 signal ratios identified a poor prognosis subgroup that may benefit from intensification of therapy.
Article
Biochemistry & Molecular Biology
Chengyuan Yu, Yitong Han, Mu Wang, Peiyan Hua, Yan Zhang, Bin Wang
Summary: This study systematically evaluated the consistency of mutations in circulating tumor DNA (ctDNA) in plasma and tumor tissue samples in non-small cell lung cancer (NSCLC) patients. The results showed that there was higher consistency in small-sample studies compared to large-sample studies, and there was higher heterogeneity in studies with EGFR gene mutations alone. The type of mutation gene and sample size measured by the patient significantly influenced the consistency of using plasma ctDNA to detect mutations in NSCLC patients.
CELLULAR AND MOLECULAR BIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Xiaoyu Qian, Xiaodan Guo, Ting Li, Wei Hu, Lin Zhang, Caisheng Wu, Feng Ye
Summary: ICI monotherapy did not improve the overall survival (OS) or progression-free survival (PFS) of patients with EGFR-TKI-resistant NSCLC. However, ICI-based combination therapy showed better PFS and objective response rate (ORR) compared to conventional chemotherapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Maja Guberina, Kaid Darwiche, Hubertus Hautzel, Till Ploenes, Christoph Poettgen, Nika Guberina, Ken Herrmann, Lale Umutlu, Axel Wetter, Dirk Theegarten, Clemens Aigner, Wilfried Ernst Erich Eberhardt, Martin Schuler, Ruediger Karpf-Wissel, Martin Stuschke
Summary: Incorporating systematic mediastinal LN mapping through EBUS-TBNA in addition to PET/CT can improve the accuracy of target volume definition, especially in echelon-3 LNs. EBUS-TBNA is recommended as an integral part of staging for radiochemotherapy in stage III NSCLC.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Review
Oncology
Lihui Liu, Hua Bai, Chao Wang, Samuel Seery, Zhijie Wang, Jianchun Duan, Sini Li, Pei Xue, Guoqiang Wang, Yiting Sun, Xinyang Du, Xue Zhang, Zixiao Ma, Jie Wang
Summary: This study found that anti-PD-1 combinations may be associated with higher survival outcomes than anti-PD-L1 combinations in patients with advanced NSCLC. Pembrolizumab plus chemotherapy and nivolumab plus ipilimumab plus chemotherapy appear to be superior first-line immunotherapy combinations. (Word count: 104)
JOURNAL OF THORACIC ONCOLOGY
(2021)
Review
Medicine, General & Internal
Wenjie Li, Yanjun Zhao, Hongjun Zhang, Wenying Zheng, Ruixuan Wang, Xing Gu
Summary: This study investigated the association between tumor mutational burden (TMB) and the therapeutic effect of Programmed Death 1/Programmed Death Ligand 1 inhibitors in non-small cell lung cancer. The results suggest that high TMB can serve as a potential predictive biomarker for improved progression-free survival and reduced overall response rate, but further investigation is needed to assess its predictive value in overall survival.
Review
Pharmacology & Pharmacy
Long Ma, Gang Jin, Keying Yao, Yi Yang, Ruitong Chang, Wenhao Wang, Jiawei Liu, Zijiang Zhu
Summary: The meta-analysis revealed that anti-PD-1/PD-L1 Inhibitors had better overall survival and progression-free survival compared to docetaxel in treating non-small cell lung cancer, with a lower incidence of adverse events.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Nika Guberina, Christoph Poettgen, Martin Schuler, Maja Guberina, Georgios Stamatis, Till Ploenes, Martin Metzenmacher, Dirk Theegarten, Thomas Gauler, Kaid Darwiche, Clemens Aigner, Wilfried E. E. Eberhardt, Martin Stuschke
Summary: This study compared the long-term survival rates of cT4 N0/1 M0 non-small-cell lung carcinoma (NSCLC) patients receiving ccRTx/CTx with those receiving trimodality treatment. The results showed that both treatment approaches had comparable overall survival rates, but ccRTx/CTx resulted in higher rates of loco-regional relapse and lower rates of non-cancer deaths.
RADIATION ONCOLOGY
(2022)
Review
Oncology
Conor S. Gillespie, Mohammad A. Mustafa, George E. Richardson, Ali M. Alam, Keng Siang Lee, David M. Hughes, Carles Escriu, Rasheed Zakaria
Summary: A comprehensive meta-analysis reveals a higher prevalence and incidence of brain metastases in patients with specific targetable genomic alterations. This supports the need for brain imaging during staging and follow-up, as well as the use of targeted therapies with brain penetrance.
JOURNAL OF THORACIC ONCOLOGY
(2023)
Article
Oncology
Nika Guberina, Christoph Poettgen, Martin Schuler, Maja Guberina, Georgios Stamatis, Till Ploenes, Bettina Krebs, Martin Metzenmacher, Dirk Theegarten, Thomas Gauler, Karl-Heinz Joeckel, Kaid Darwiche, Clemens Aigner, Martin Stuschke, Wilfried E. Eberhardt
EUROPEAN JOURNAL OF CANCER
(2020)
Article
Oncology
Martin Metzenmacher, Moritz Goetz, Thomas Herold, Martin Stuschke, Clemens Aigner, Kaid Darwiche, Wilfried E. Eberhardt, Martin Schuler, Marcel Wiesweg
Summary: Therapy with BRAF plus MEK-inhibitor is an approved principle for treating BRAF V600-mutated NSCLC. Understanding mechanisms of resistance against this therapy is crucial, particularly in the context of MAPK reactivation leading to increased ERK signaling. Rebiopsy for detecting BRAF V600 mutation is emphasized for monitoring disease progression.
CLINICAL LUNG CANCER
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Maja Guberina, Kaid Darwiche, Hubertus Hautzel, Till Ploenes, Christoph Poettgen, Nika Guberina, Ken Herrmann, Lale Umutlu, Axel Wetter, Dirk Theegarten, Clemens Aigner, Wilfried Ernst Erich Eberhardt, Martin Schuler, Ruediger Karpf-Wissel, Martin Stuschke
Summary: Incorporating systematic mediastinal LN mapping through EBUS-TBNA in addition to PET/CT can improve the accuracy of target volume definition, especially in echelon-3 LNs. EBUS-TBNA is recommended as an integral part of staging for radiochemotherapy in stage III NSCLC.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Oncology
Frank Griesinger, Wilfried Eberhardt, Arnd Nusch, Marcel Reiser, Mark-Oliver Zahn, Christoph Maintz, Christiane Bernhardt, Christoph Losem, Albrecht Stenzinger, Lukas C. Heukamp, Reinhard Buettner, Norbert Marschner, Martina Jaenicke, Annette Fleitz, Lisa Spring, Joerg Sahlmann, Aysun Karatas, Annette Hipper, Wilko Weichert, Monika Heilmann, Parvis Sadjadian, Wolfgang Gleiber, Christian Grah, Cornelius F. Waller, Martin Reck, Achim Rittmeyer, Petros Christopoulos, Martin Sebastian, Michael Thomas
Summary: The testing rates for biomarkers in advanced NSCLC patients in Germany are high but still leave out a significant portion of patients who could potentially benefit, highlighting the need for specific measures to increase implementation.
Review
Oncology
Nadia Harbeck, Andreas Schneeweiss, Peter Thuss-Patience, Kurt Miller, Claus Garbe, Frank Griesinger, Wilfried E. E. Eberhardt, Jens P. Klussmann, Barbara Wollenberg, Marc-Oliver Grimm, Thomas Zander, Diana Lueftner
Summary: HTA plays an essential role in evaluating the clinical and economic value of new interventions for cancer patients. While overall survival is a preferred criterion, incorporating end-points like pathological complete response and disease-free survival is crucial for patients with early cancer, as they provide important psychological benefits.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Oncology
Lea M. Schotten, Kaid Darwiche, Michal Seweryn, Vedat Yildiz, Peter J. Kneuertz, Wilfried E. E. Eberhardt, Stephan Eisenmann, Stefan Welter, Brianna E. Sisson, Maciej Pietrzak, Marcel Wiesweg, Till Ploenes, Thomas Hager, Kai He, Lutz Freitag, Clemens Aigner, Christian Taube, Filiz Oezkan
Summary: This study aimed to evaluate the predictive ability of DNA hypermethylation of SHOX2 and PTGER4 in plasma to discriminate between lung cancer, benign lesions, and COPD patients. The results showed that PTGER4 DNA hypermethylation was significantly more frequent in lung cancer patients compared to controls, which may serve as a biomarker to support clinical decision-making. Further exploration in prospective studies is needed.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Oncology
Marcel Wiesweg, Cedric Preuss, Julia Roeper, Martin Metzenmacher, Wilfried Eberhardt, Ursula Stropiep, Katrin Wedeken, Henning Reis, Thomas Herold, Kaid Darwiche, Clemens Aigner, Martin Stuschke, Hans-Ulrich Schildhaus, Kurt W. Schmid, Markus Falk, Lukas Heukamp, Markus Tiemann, Frank Griesinger, Martin Schuler
Summary: BRAF mutations in NSCLC patients have different subtypes, with V600E being the most common, but a majority of patients harbor other BRAF mutations of functional classes II/III. Despite the poor prognosis of BRAF-mutated NSCLC, they exhibit high susceptibility to immune checkpoint inhibitors compared to other tractable driver mutations in NSCLC.
EUROPEAN JOURNAL OF CANCER
(2021)
Editorial Material
Oncology
Martin Sebastian, Jan Alexander Stratmann, Wilfried E. E. Eberhardt
JOURNAL OF THORACIC ONCOLOGY
(2021)
Article
Oncology
Martin Sebastian, Wilfried E. E. Eberhardt, Petra Hoffknecht, Martin Metzenmacher, Thomas Wehler, Konrad Kokowski, Juergen Alt, Wolfgang Schuette, Reinhard Buettner, Lukas C. Heukamp, Albrecht Stenzinger, Martina Jaenicke, Annette Fleitz, Stefan Zacharias, Stephanie Dille, Annette Hipper, Marlen Sandberg, Wilko Weichert, Matthias Groschek, Eyck von der Heyde, Jacqueline Rauh, Tobias Dechow, Michael Thomas, Frank Griesinger
Summary: The study analyzed treatment outcomes of 1039 patients with advanced KRAS-mutant or wildtype NSCLC in Germany and found higher proportion of patients with G12C and non-G12C mutations receiving first-line treatment combined with immune checkpoint inhibitors. It was also observed that high PD-L1 expression (TPS>50%) was associated with a significantly decreased risk of mortality.
Article
Oncology
Justin Ferdinandus, Martin Metzenmacher, Lukas Kessler, Lale Umutlu, Clemens Aigner, Kambartel Otto Karl, Viktor Gruenwald, Wilfried Eberhardt, Wolfgang Peter Fendler, Ken Herrmann, Martin Faehling, Daniel Christian Christoph
Summary: After a minimum of 24 months of palliative immunotherapy for NSCLC, CMR occurred in almost two thirds of patients. Potentially, achievement of CMR might identify patients, for whom palliative immunotherapy may be safely discontinued.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Cardiac & Cardiovascular Systems
Georgios Stamatis, Stefanie Mueller, Gerhard Weinreich, Birte Schwarz, Wilfried Eberhardt, Christoph Pottgen, Clemens Aigner
Summary: This study aimed to identify subgroups with persistent N2 disease in NSCLC after neoadjuvant treatment, and determine if these subgroups could benefit from surgery. The results showed that lobectomy or bilobectomy could be a potentially curative option with promising long-term results for patients with persistent single-station N2 involvement, either skip or additionally with N1 status, after induction treatment.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Correction
Oncology
Frank Griesinger, Wilfried Eberhardt, Arnd Nusch, Marcel Reiser, Mark-Oliver Zahn, Christoph Maintz, Christiane Bernhardt, Christoph Losem, Albrecht Stenzinger, Lukas C. Heukamp, Reinhard Buettner, Norbert Marschner, Martina Jaenicke, Annette Fleitz, Lisa Spring, Joerg Sahlmann, Aysun Karatas, Annette Hipper, Wilko Weichert, Monika Heilmann, Parvis Sadjadian, Wolfgang Gleiber, Christian Grah, Cornelius F. Waller, Martin Reck, Achim Rittmeyer, Petros Christopoulos, Martin Sebastian, Michael Thomas
Article
Respiratory System
C. Aigner, T. Bruening, W. E. E. Eberhardt, M. Haerter, H-P Kaelberlah, M. Metzenmacher, R. Shah, C. Taube, M. Thomas
Summary: Asbestos-related mesotheliomas are among the most frequent occupational diseases in Germany, with a poor prognosis. Efforts to advance early diagnosis and individualized therapy have been made, with standard treatments including surgery, chemotherapy, and radiotherapy while new therapeutic avenues are being explored.
Article
Oncology
Martin Metzenmacher, Hans-Georg Kopp, Frank Griesinger, Niels Reinmuth, Martin Sebastian, Monika Serke, Cornelius Florian Waller, Michael Thomas, Jochen Eggert, Gerald Schmid-Bindert, Mathias Hoiczyk, Daniel Christian Christoph, Martin Kimmich, Burkhard Deuss, Stephanie Seifert, Swantje Held, Martin Schuler, Thomas Herold, Frank Breitenbuecher, Wilfried Ernst Erich Eberhardt
Summary: The study compared the efficacy and safety of split-dose cisplatin with the standard schedule in non-squamous non-small-cell lung cancer treatment, finding no significant differences in objective response rate and overall survival, but a slightly better progression-free survival in the split-dose cisplatin group. The advantages of split-dose cisplatin in specific toxicities allow for personalized chemotherapy treatment.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2021)
Article
Oncology
Hossein Borghaei, Scott Gettinger, Everett E. Vokes, Laura Q. M. Chow, Marco Angelo Burgio, Javier de Castro Carpeno, Adam Pluzanski, Oscar Arrieta, Osvaldo Aren Frontera, Rita Chiari, Charles Butts, Joanna Wojcik-Tomaszewska, Bruno Coudert, Marina Chiara Garassino, Neal Ready, Enriqueta Felip, Miriam Alonso Garcia, David Waterhouse, Manuel Domine, Fabrice Barlesi, Scott Antonia, Markus Wohlleber, David E. Gerber, Grzegorz Czyzewicz, David R. Spigel, Lucio Crino, Wilfried Enst Erich Eberhardt, Ang Li, Sathiya Marimuthu, Julie Brahmer
Summary: Immunotherapy with nivolumab has shown improved overall survival and safety compared to docetaxel in patients with advanced NSCLC in two phase III trials. Pooled 5-year data demonstrated a significant survival benefit with nivolumab and no new safety concerns.
JOURNAL OF CLINICAL ONCOLOGY
(2021)