Article
Medical Laboratory Technology
Xiaokaiti Abuduhadeer, Xincai Xu, Kamali Aihesan, Maimaiti Yilihamu, Yanjun Zhao, Wenbin Zhang
Summary: The study revealed that elevated expression of Kallikrein 5 (KLK5) in gastric cancer tissues was associated with tumor invasion depth and lymph node metastasis, leading to poorer overall survival in patients. KLK5 was identified as an independent risk factor in gastric cancer, and can promote tumor cell migration and invasion.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Biotechnology & Applied Microbiology
Diqun Chen, Rouxin Zhang, Aosi Xie, Jinpeng Yuan, Jinhai Zhang, Yongjian Huang, Hongxia Zhang, Feiran Zhang
Summary: Gastric cancer is among the most common and deadly cancers globally. This study reveals that NUDT10 expression is significantly reduced in GC tissues compared to normal tissues, and high expression is associated with worse prognosis in terms of tumor malignancy and survival outcomes. NUDT10 shows potential as an independent biomarker for GC prognosis.
Article
Biochemistry & Molecular Biology
Fei Long, Shuo Li, Yaqi Xu, Min Liu, Xuan Zhang, Junting Zhou, Yiyi Chen, Yuan Rong, Xiangyu Meng, Fubing Wang
Summary: Early diagnosis and progression assessment are crucial for gastric cancer (GC) patients. A 10-gene panel was identified as a diagnostic biomarker for early detection of GC, showing good diagnostic performance in different cohorts. This panel not only aids in early detection, but also provides information on GC subtypes and their progression characteristics.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Review
Medicine, General & Internal
Yasushi Sato, Koichi Okamoto, Yoshifumi Kida, Yasuhiro Mitsui, Yutaka Kawano, Masahiro Sogabe, Hiroshi Miyamoto, Tetsuji Takayama
Summary: Gastric cancer (GC) is a challenging cancer, but recent advances in molecular-targeted agents and immunotherapy have improved prognosis. HER2 expression is important in first-line chemotherapy for advanced GC, and the addition of trastuzumab has extended overall survival. For HER2-negative GC, the combination of nivolumab and a cytotoxic agent has shown promise. New treatments for advanced GC include ramucirumab, trifluridine/tipiracil, and trastuzumab deruxtecan. Combining immunotherapy and molecular-targeted agents is an exciting prospect. Understanding biomarkers and selecting optimal therapies is crucial. In resectable disease, differences in lymphadenectomy between Eastern and Western countries lead to different standard treatments: neoadjuvant and adjuvant therapy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
S. Bach, I Paulis, N. R. Sluiter, M. Tibbesma, I Martin, M. A. van de Wiel, J. B. Tuynman, I Bahce, G. Kazemier, R. D. M. Steenbergen
Summary: This study assessed the feasibility of detecting colorectal cancer through analysis of tumor-derived DNA fragments in urine. It found that a marker panel consisting of SEPT9 and SDC2 in urine supernatant could detect up to 70% of CRC cases.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Nayra Felipez, Sheyla Montori, Naroa Mendizuri, Joan Llach, Pedro G. G. Delgado, Leticia Moreira, Enrique Santamaria, Joaquin Fernandez-Irigoyen, Eduardo Albeniz
Summary: Gastric cancer is a global public health problem with high mortality rates. Biomarker research is crucial for early detection of gastric cancer. Technological advances have identified several potential biomarkers, but their low specificity in biofluids limits their clinical use. Recent research focuses on exploring gastric juice as an alternative source for biomarker identification, as it contains disease-specific biomarkers generated at the site of damage. This narrative review describes potential biomarkers for gastric cancer screening in gastric juice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jen-Tai Lin, Kuo-Wang Tsai
Summary: The study showed that certain miRNAs in urine could potentially serve as noninvasive biomarkers for diagnosing bladder cancer, with implications for early detection and patient survival. Further validation in larger cohorts is necessary to confirm the clinical utility of urinary miRNAs in bladder cancer diagnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Jinyao Shi, Zhouqiao Wu, Xiaolong Wu, Longtao Huangfu, Ting Guo, Xiaojing Cheng, Jing Han, Ziyu Li, Xiaofang Xing, Jiafu Ji
Summary: This study used multi-omics data of 2471 gastric cancer samples to identify glycometabolic subtypes and immune clustering subgroups of gastric cancer, and established a scoring system to predict the survival and response of chemotherapy and immunotherapy. The assessment of tumor glucose metabolism and immune microenvironment in gastric cancer has application value for predicting curative effects and formulating combined treatment strategies.
Article
Oncology
Jae-Yong Park, Chil-Sung Kang, Ho-Chan Seo, Jin-Chul Shin, Sung-Min Kym, Young-Soo Park, Tae-Seop Shin, Jae-Gyu Kim, Yoon-Keun Kim
Summary: Gastric cancer patients have distinct microbial changes compared to normal subjects, and the microbial composition from bacteria-derived EVs can be used to build diagnostic prediction models. Further validation is required, but integrating liquid biopsy and metagenome analysis shows potential for non-invasive diagnosis of gastric cancer.
Article
Biochemistry & Molecular Biology
Sangjoon Choi, Sujin Park, Hyunjin Kim, So Young Kang, Soomin Ahn, Kyoung-Mee Kim
Summary: This article reviews established and promising new biomarkers in gastric cancer (GC), including their clinical implications, diagnostic methods, and the efficacy of targeted agents. Comprehensive characterization of the molecular profile and tumor immune microenvironment in GC has enabled researchers to explore promising biomarkers for GC treatment and has introduced a new paradigm in precision-targeted immunotherapy.
Article
Oncology
Xinyue Qin, Yinhao Chen, Shuo Ma, Lei Shen, Shaoqing Ju
Summary: TM4SF18 is a promising biomarker for gastric cancer, promoting proliferation, migration, and invasion abilities of GC cells, and being associated with immune response.
MOLECULAR ONCOLOGY
(2022)
Article
Pediatrics
Liat Ashkenazi-Hoffnung, Gilat Livni, Oded Scheuerman, Itay Berger, Eran Eden, Kfir Oved, Liran Shani, Gali Kronenfeld, Einav Simon, Olga Boico, Roy Navon, Tanya M. Gottlieb, Eran Barash, Meital Paz, Yael Yuhas, Eva Berent, Shai Ashkenazi
Summary: This study evaluated the potential of CRP, IP-10, and TRAIL as biomarkers to aid in diagnosis and management of UTI. The results showed that these biomarkers could differentiate between UTI, nephronia, and response to antibiotic treatment, indicating their potential clinical utility.
FRONTIERS IN PEDIATRICS
(2021)
Article
Oncology
Peter Ka-Fung Chiu, Yan-Ho Fung, Jeremy Yuen-Chun Teoh, Chun-Hong Chan, Ka-Lun Lo, Kai-Man Li, Ryan Tsz-Hei Tse, Chi-Ho Leung, Yim-Ping Wong, Monique J. Roobol, Ka-Leung Wong, Chi-Fai Ng
Summary: The study showed that urine spermine levels and Spermine Risk Score can help predict high-grade prostate cancer, reducing unnecessary biopsies.
PROSTATE CANCER AND PROSTATIC DISEASES
(2021)
Article
Oncology
Tingna Chen, Chaogang Yang, Rongzhang Dou, Bin Xiong
Summary: This study developed a prognostic signature using 10 immune-related genes, which can effectively predict the prognosis of gastric cancer patients with high accuracy. The signature is correlated with multiple immune infiltrating cells and important signaling pathways.
Article
Medicine, Research & Experimental
Zong-Chao Liu, Wen-Hui Wu, Sha Huang, Zhong-Wu Li, Xue Li, Guang-Hou Shui, Sin Man Lam, Bo-Wen Li, Zhe-Xuan Li, Yang Zhang, Tong Zhou, Wei-Cheng You, Kai-Feng Pan, Wen-Qing Li
Summary: This study identified lipidomic signatures associated with the risk of gastric lesion progression and gastric cancer occurrence, with translational implications for gastric cancer prevention.