Article
Oncology
Shuting Liu, Liang Chen, Hua Chen, Kangkang Xu, Xi Peng, Mingchang Zhang
Summary: The study revealed that circ_0119872 is upregulated in UM cell lines and tissues, promoting the malignancy of UM cells. Additionally, circ_0119872 can directly interact with miR-622, acting as a miRNA sponge to regulate the expression of the miR-622 target gene G3BP1 and downstream Wnt/beta-catenin and mTOR signaling pathways.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Yanqiu Bao, Jingshu Cui, Yuyang Yue, Shuxia Cao, Xiangdan Li, Lan Liu
Summary: Ebp1 is highly expressed in malignant melanoma and is associated with clinical stage and lymph node metastases. Knockdown of Ebp1 inhibits cell proliferation, migration, and invasion in melanoma. Ebp1 may promote the proliferation and metastasis of melanoma cells through activation of the Wnt/β-catenin pathway.
CANCER CELL INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Mingliang He, Xiaoyang Lv, Xiukai Cao, Zehu Yuan, Tesfaye Getachew, Yutao Li, Shanhe Wang, Wei Sun
Summary: SRY-box transcription factor 18 (SOX18) is expressed in dermal papilla cells (DPCs) of sheep hair follicles and plays a crucial role in promoting DPC proliferation through activating the Wnt/β-Catenin signaling pathway. Inhibition of the Wnt/β-Catenin signaling pathway can be rescued by SOX18, suggesting the essential role of SOX18 in governing DPC proliferation and hair growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Ruiyao Xu, Xianxian Wang, Sadia Safi, Nico Braunegger, Agnes Hipgrave Ederveen, Michelle Rottmann, Joachim Wittbrodt, Manfred Wuhrer, Janine Wesslowski, Gary Davidson
Summary: Reception of Wnt signals is mediated by Frizzled receptors and a co-receptor LRP6 or LRP5. Precise control of receptor activation is crucial to regulate Wnt/beta-catenin signaling for proper cellular function. A glycosyltransferase B3GnT2-like has been identified to modify LRP6 and enhance Wnt/beta-catenin signaling. This study highlights the importance of LRP6 as a regulatory hub in Wnt signaling and provides insight into the selective targeting of a signaling pathway component by a specific glycosyltransferase.
Article
Multidisciplinary Sciences
Ahmet Acar, Ana Hidalgo-Sastre, Michael K. Leverentz, Christopher G. Mills, Simon Woodcock, Martin Baron, Giovanna M. Collu, Keith Brennan
Summary: Notch and Wnt are two essential signaling pathways in animals, with typically opposing effects on cell fate decisions. Notch can limit Wnt signaling through mechanisms at the cell membrane and in the cell nucleus, contributing to the robustness of cell fate decisions by sharpening the distinction between opposing Notch/Wnt responses.
SCIENTIFIC REPORTS
(2021)
Article
Agriculture, Dairy & Animal Science
Mingliang He, Xiaoyang Lv, Xiukai Cao, Zehu Yuan, Kai Quan, Tesfaye Getachew, Joram M. M. Mwacharo, Aynalem Haile, Yutao Li, Shanhe Wang, Wei Sun
Summary: In our study, we found that CRABP2 was highly expressed in Hu sheep hair follicles, indicating its potential influence on dermal papilla cells (DPCs). Our experiments demonstrated that overexpression of CRABP2 promoted DPC proliferation and activated the Wnt/beta-catenin pathway. These findings highlight the crucial role of CRABP2 in Hu sheep DPC proliferation and shed light on its function in hair follicles.
Article
Biotechnology & Applied Microbiology
Jingrong Li, Ruihua Fang, Jiang Wu, Yuan Si, Jingzhu Bai, Qi Wang
Summary: NOP14 overexpression inhibits the stemness and function of melanoma stem-like cells (SLCs) by inactivating Wnt/beta-catenin signaling. NOP14 may serve as a novel target for CSC treatment in melanoma.
Article
Biotechnology & Applied Microbiology
Zhi Fang, Min Zhong, Ling Zhou, Yi Le, Heng Wang, Ziling Fang
Summary: LRP8 is markedly overexpressed in NSCLC tissues and cell lines, correlating with poor clinicopathological characteristics and prognosis. Depletion of LRP8 suppresses proliferation, migration, invasion, and epithelial-mesenchymal transition of NSCLC cells, partly by inhibiting the Wnt/beta-catenin pathway.
Article
Pharmacology & Pharmacy
Xiujuan Zhu, Huanyao Gao, Sisi Qin, Duan Liu, Junmei Cairns, Yayun Gu, Jia Yu, Richard M. M. Weinshilboum, Liewei Wang
Summary: This study has revealed a novel mechanism for regulation of the expression of cholesterol-metabolizing CYPs, particularly CYP1B1, by TSPYL1 via Wnt/beta-catenin signaling.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell & Tissue Engineering
Kai Hang, Li Ying, Jinwu Bai, Yibo Wang, Zhihui Kuang, Deting Xue, Zhijun Pan
Summary: The study showed that the silencing of SERPINB2 can promote osteogenic differentiation of BMSCs through the Wnt/β-catenin signaling pathway. In vivo experiments demonstrated that silencing SERPINB2 effectively improves bone fracture healing, suggesting that SERPINB2 may be a novel target for bone fracture healing.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Dermatology
Kyung-Il Kim, Kyung Eun Jung, Young-Bin Shin, Chang-Deok Kim, Tae-Jin Yoon
Summary: In this study, we conducted a large-scale screening test on drugs approved for other diseases to find pigmentation-modulating agents. Among the potential drugs, sorafenib was selected for further investigation on its effect on pigmentation in melanoma cells. The results showed that sorafenib promoted pigmentation by increasing the melanin content and tyrosinase activity. Mechanistic studies revealed that this effect was mediated by the activation of beta-catenin signaling through the regulation of GSK3 beta phosphorylation.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Peng Li, Lihua Ma, Weiqiang Zhan, Dong Xie, Guanhao Hong, Mingzhu Deng, Zijie Wu, Peichun Lin, Linhong Yan, Zifan Lu, Chengyong Li, Hao Lin
Summary: In this study, Pinctada martensii mucilage exosome-like nanovesicles (PMMENs) were successfully isolated. It was found that PMMENs inhibited the viability and proliferation of 143B cells by suppressing the activation of the ERK1/2 and Wnt signaling pathways. PMMENs also inhibited cell migration and invasion by downregulating specific proteins. Transcriptomic and metabolomic analyses revealed the co-enrichment of differential genes and metabolites in cancer signaling pathways. Moreover, tumor xenograft model experiments showed that PMMENs can inhibit the growth of osteosarcoma in mice, suggesting their potential as an anti-osteosarcoma drug.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Agriculture, Multidisciplinary
Duoduo Zhang, Xingtao Zhou, Linyuan Liu, Mi Guo, Tongwen Huang, Wengan Zhou, Fang Geng, Steve W. Cui, Shaoping Nie
Summary: The study revealed that glucomannan from Aloe vera gel promoted proliferation and differentiation of intestinal stem cells through the Wnt/β-catenin signaling pathway, facilitating epithelial cell regeneration and alleviating colitis in mice.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Pin Lv, Yuan Xue
Summary: The study identified the expression level of LINC01638 in papillary thyroid carcinoma (PTC) and its role in PTC progression. It was found that LINC01638 regulates PTC progression by inhibiting the Wnt/beta-catenin pathway and activating Axin2.
Article
Biochemistry & Molecular Biology
Roland Kotolloshi, Mieczyslaw Gajda, Marc-Oliver Grimm, Daniel Steinbach
Summary: The study revealed that BCL9L and Wnt/beta-catenin signaling play an oncogenic role in bladder cancer cells, and may be associated with the progression of bladder cancer. Mutations in UTRs of BCL9L can affect its activity, thereby influencing cell proliferation, migration, and invasion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)