Review
Biochemistry & Molecular Biology
Agnieszka Gajewska-Naryniecka, Urszula Szwedowicz, Zofia Lapinska, Julia Rudno-Rudzinska, Wojciech Kielan, Julita Kulbacka
Summary: Pancreatic cancer is a silent and aggressive disease that only shows symptoms in advanced stages. The only curative treatment is surgical resection, but irreversible electroporation (IRE) offers hope for patients with unresectable tumors. IRE is an ablation therapy that uses high-voltage electrical pulses to destroy cancer cells. This review summarizes the applications and potential of IRE in treating pancreatic cancer, including its combination with drugs or standard treatments. However, further research is needed to assess its effectiveness in humans and understand its full potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Jian Shen, Penglin Pan, Xiaoli Hu, Jun Zhao, Heshui Wu
Summary: This study evaluated the safety and efficacy of irreversible electroporation (IRE) against locally advanced pancreatic cancer (LAPC) and its impact on anti-tumor immunity. The IRE group had a similar rate of major complications to the vascular resection group, but higher than the palliative surgery group. The overall survival of IRE-treated patients was shorter than the vascular resection group, but longer than the palliative surgery group. IRE demonstrated tumor ablation and immune modulation effects, making it a feasible treatment for patients with LAPC.
Review
Cell & Tissue Engineering
Philippa R. Kennedy, Martin Felices, Jeffrey S. Miller
Summary: NK cells are innate immune cells that can recognize and kill malignant cells. Their activation leads to cytotoxicity and immune system activation. NK cell therapy has shown promising results in treating advanced hematologic malignancies and can serve as a bridge to stem cell transplantation.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Oncology
Bathiya Ratnayake, Dhya Al-Leswas, Ghazaleh Mohammadi-Zaniani, Peter Littler, Gourab Sen, Derek Manas, Sanjay Pandanaboyana
Summary: Preliminary evidence suggests that electroporation may improve survival rates and complete resection rates following pancreatic surgery for higher stage pancreatic cancer, but with a high rate of complications. Early non-randomized data indicate that MA IRE during pancreatic surgery for stage III pancreatic cancer may lead to increased R0 resection rates and improved overall survival. Further larger studies are needed to confirm these findings.
Article
Radiology, Nuclear Medicine & Medical Imaging
Tze Min Wah, James Lenton, Jonathan Smith, Paul Bassett, Satinder Jagdev, Christy Ralph, Naveen Vasudev, Selina Bhattarai, Michael Kimuli, Jon Cartledge
Summary: The study evaluated the safety and efficacy of CT-guided IRE for cT1a renal tumors close to vital structures. The primary technical success rate was 73.3% and all patients preserved renal function without the need for dialysis. The 2- and 3-year cancer-specific survival rates were 89% and 87%.
EUROPEAN RADIOLOGY
(2021)
Review
Medicine, General & Internal
Zainab L. Rai, Roger Feakins, Laura J. Pallett, Derek Manas, Brian R. Davidson
Summary: IRE treatment may improve the survival of patients with locally advanced pancreatic cancer, but it comes with a high rate of complications. The mechanism of action of IRE remains unknown, but emerging data suggests that it can be augmented with synergistic therapies such as immunotherapy to enhance efficacy.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Jia Yang, Aydin Eresen, Junjie Shangguan, Quanhong Ma, Vahid Yaghmai, Zhuoli Zhang
Summary: The study showed that the combination of IRE ablation and DC vaccination was more effective in treating PDAC compared to using IRE or DC vaccination alone. The combined treatment significantly improved survival rates, reduced tumor growth, and increased infiltration of CD8(+) T cells and Granzyme B+ cells.
Review
Oncology
Guo Tian, Jiajia Guan, Yanhua Chu, Qiyu Zhao, Tian'an Jiang
Summary: Emerging studies have focused on irreversible electroporation (IRE) in pancreatic cancer (PC), but the effects of IRE treatment on the immune response and the combination of IRE with immunotherapy in treating PC remain unclear and require further exploration.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Chaobin He, Shuxin Sun, Yu Zhang, Shengping Li
Summary: Combining IRE with toripalimab for LAPC showed better overall survival and progression-free survival compared to IRE alone, with acceptable toxic effects. Although some adverse events were more common in the IRE plus toripalimab group, there were no significant differences between the two groups.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Review
Oncology
Argyrios Gyftopoulos, Ioannis A. Ziogas, Andrew S. Barbas, Dimitrios Moris
Summary: IRE, as a local ablative technique used in conjunction with chemotherapy, has shown increased overall survival in patients with locally advanced pancreatic cancer by possibly enhancing the action and delivery of chemotherapeutic drugs. Investigating the potentiating mechanism of IRE on immunotherapy, oncolytic virus, and dendritic cell treatments is of great importance for improving current treatment algorithms for pancreatic cancer in the future.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Nicky A. Beelen, Merel R. Aberle, Virginia Bruno, Steven W. M. Olde Damink, Gerard M. J. Bos, Sander S. Rensen, Lotte Wieten
Summary: This study evaluated the cytotoxic potential of adoptive NK cells against pancreatic cancer organoids and found that ADCC-inducing antibodies can enhance NK cell anti-tumor responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Kaushal Kundalia, Abdul Hakeem, Michail Papoulas, Mark Mcphail, Shruthi Reddy, Praveen Peddu, Nabil Kibriya, Simon Atkinson, Andreas Prachalias, Parthi Srinivasan, Nigel Heaton, Debashis Sarker, Paul Ross, Yoh Zen, Krishna Menon
Summary: IRE for MA during PD in resectable pancreatic head tumors can reduce margin positivity and potentially offer advantages in terms of complications, DFS, and OS.
Article
Oncology
Virender Kumar, Ram I. Mahato
Summary: This article discusses various approaches to enhance NK cell functions for the treatment of pancreatic cancer, as well as new advances in boosting NK cell therapeutic efficacy using nanoparticle mediation.
Article
Immunology
Yangyang Ma, Yanli Xing, Hongmei Li, Ting Yuan, Bing Liang, Rongrong Li, Jianyu Li, Zhonghai Li, Shuying Li, Lizhi Niu
Summary: This study compared the potential of combining irreversible electroporation (IRE) with chemotherapy and PD-1/PD-L1 blockade versus combining IRE with chemotherapy alone to enhance the antitumor immune response in locally advanced pancreatic cancer (LAPC) patients. The results showed that combining IRE with chemotherapy and PD-1/PD-L1 blockade improved survival and induced a robust immune response, which was identified as an independent prognostic factor. The addition of PD-1/PD-L1 blockade to the regimen of IRE combined with chemotherapy enhanced antitumor immunity and extended survival in LAPC patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Erica L. Heipertz, Evan R. Zynda, Tor Espen Stav-Noraas, Andrew D. Hungler, Shayne E. Boucher, Navjot Kaur, Mohan C. Vemuri
Summary: Natural killer (NK) cells are a crucial part of the immune system, with the ability to kill virally infected and malignant cells. Current research is focused on testing the efficacy of NK cell therapy for cancer and exploring the use of CAR-NK for treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yang Liu, Yabin Zhang, Hongyu Chen, Jiahui Zhao, Qiang Ma, Guang Yang, Xiaohua Wang, Zhen Wu, Jiebin Hou, Qingli Cheng, Qiangguo Ao
Summary: This study investigated the efficacy of adding tolvaptan (TLV) in improving the prognosis of elderly patients with acute heart failure (AHF) and oliguria. The results showed that adding TLV significantly increased urine output, reduced NT-proBNP levels, alleviated the progression of AHF, and may reduce the risk of all-cause mortality at 7 and 90-day in elderly patients with AHF with oliguria.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Surgery
Junfeng Wang, Xiaohua Wang, Bin Sun, Liang Yuan, Ke Zhang, Bin Yang
Summary: The variability of patellar height was reduced with the use of 3D printed patient-specific instrumentation in total knee arthroplasty (TKA). However, even with 3D-printed PSI, there were still significant reductions in patellar height and other radiographic parameters after TKA, which could lead to more patellofemoral complications.
FRONTIERS IN SURGERY
(2023)
Article
Psychology, Multidisciplinary
Qing Yang, Kunqiang Zhao, Lanjuan Cao, Xiaohua Wang, Qizhe Guo, Xingxing Liu
Summary: The combination of technology and finance has a significant impact on regional social and economic development. Strategic emerging industries, as the convergence of technological innovation and financial support, are of great significance for industrial structure adjustment and improvement of industrial quality. However, the geographical distribution of emerging strategic industries in China is uneven. Thus, this study investigates the input-output efficiency of science and technology finance integration and examines the path of integrated development of science and technology innovation and financial support. The findings reveal the large demand for financial support and obvious regional differences in the development of strategic emerging industries, with the government playing a strong guiding role. Measures and suggestions for the development of strategic emerging industries are proposed accordingly.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jing-yu Weng, Xin-xing Chen, Xiao-hua Wang, Hui-er Ye, Yan-ping Wu, Wan-yang Sun, Lei Liang, Wen-jun Duan, Hiroshi Kurihara, Feng Huang, Xin-xin Sun, Shu-hua Ou-Yang, Rong-rong He, Yi-fang Li
Summary: Psychological stress increases susceptibility to HSV-1 infection, and the underlying molecular mechanisms are unknown. This study explored the antiviral effect of rosmarinic acid (RA) and demonstrated that RA could decrease stress-augmented mortality and reduce symptoms in HSV-1-infected mice. In vitro, RA increased cell viability and inhibited stress-induced elevation of viral proteins and genes. The study revealed the critical role of lipid peroxidation in stress-induced HSV-1 susceptibility and suggested the potential of RA as an effective intervention in anti-HSV-1 therapy.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Chemistry, Medicinal
Manman Ma, Xiaohua Wang, Xiaohui Liu, Yang Han, Yanhui Chu, Yanzhong Guan, Haifeng Liu
Summary: A novel tT beta RII variant, Z-tT beta RII, was designed by fusing the PDGF beta receptor-specific affibody Z(PDGF beta R) to the N-terminus of tT beta RII. Z-tT beta RII exhibited superior specific fibrotic liver-targeting potential and stronger anti-fibrotic effects in vitro and in vivo. It also showed no significant sign of potential side effects in other vital organs in liver fibrotic mice, making it a potential candidate for targeted therapy for liver fibrosis.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Article
Chemistry, Applied
Xiaohua Wang, Ying Liang, Qi Wang, Xinlan Wang, Hanyan Li, Jinshui Wang
Summary: In this study, the correlations between dough rheology and gluten aggregation were investigated by analyzing the rheological properties of low-sodium salt dough and the molecular properties of dough gluten. The results showed that low-sodium salt improved the hardness, extensibility, and compression resistance of the dough, and induced the formation of larger protein clusters. The analysis also revealed that low-sodium salt increased the content of certain glutenin subunits and reduced the content of certain gliadin fractions, resulting in the aggregation of gluten. This study provides new insights and a more comprehensive theoretical basis for sodium reduction.
FOOD HYDROCOLLOIDS
(2023)
Article
Engineering, Electrical & Electronic
Xi Ran, Xiao-Hua Wang, Teng-Fei Wei, Shi-Wei Qu, Bing-Zhong Wang
Summary: In this article, an inverse design for a dielectric-type superstrate of antenna is proposed using the inverse scattering method to achieve arbitrary shaped-beam radiation pattern. The permittivity distribution of the superstrate is reconstructed based on the known desired radiation patterns, and the scattering fields can be assumed in the far-zone. The reconstructed superstrate parameters are validated through 2-D and 3-D simulations, showing good agreement and efficient performance compared to traditional forward design methods.
IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
(2023)
Article
Immunology
Hui Guan, Ming Zhong, Kongyang Ma, Chun Tang, Xiaohua Wang, Muzi Ouyang, Rencai Qin, Jiasi Chen, Enyi Zhu, Ting Zhu, Yongping Lu, Yu Liu, Chengzi Tian, Zhihua Zheng
Summary: This study comprehensively investigated the roles and mechanisms of HMGB1 in different tumors. HMGB1 was found to be differentially expressed in many tumors and normal tissues, and was closely related to tumor burden, drug resistance, and various pathways of tumors. HMGB1 may serve as a novel biomarker for predicting tumor prognosis and efficacy of immune checkpoint inhibitors, and a potential target for anti-tumor therapy.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Dou Ye, Suqing Qu, Yinxiang Yang, Zhaoyan Wang, Qian Wang, Weipeng Liu, Fan Zhang, Qian Guan, Xiaohua Wang, Jing Zang, Xin Li, Hengtao Liu, Ruiqin Yao, Zhichun Feng, Zuo Luan
Summary: Immunosuppressants are not suitable for premature infants, but desensitization can induce immune tolerance. In this study, Wistar rat fetuses were injected with hOPCs-1 and returned to the mother. After desensitization, brain and muscle transplantation was performed with hOPCs-1, hNSCs-1, and hOPCs-2. The desensitized group showed higher levels of hOPCs-1 and hNSCs-1 compared to the control group, while hOPCs-2 were rejected. There were significant differences in Treg, CD4CD28, CD8CD28, and CD45RC between the desensitization and control group. Inflammatory cells were lower in the desensitized group with hOPCs-1 and hNSCs-1. hOPCs-1 could differentiate into myelin in the desensitized group. Wistar rats with desensitization developed immune tolerance.
Article
Cardiac & Cardiovascular Systems
Jiebin Hou, Xin Zhang, Zhen Wu, Yang Liu, Yabin Zhang, Jiahui Zhao, Xiaohua Wang, Hongyu Chen, Guang Yang, Qiang Ma, Qingli Cheng, Qiangguo Ao
Summary: Elderly patients with chronic heart failure (CHF) have a higher incidence of acute kidney injury (AKI), which can lead to poor prognosis. The relationship between kidney dysfunction and levels of N-terminal pro-brain natriuretic peptides (NT-proBNP) in elderly CHF patients has been analyzed in a retrospective cohort study. The results suggest that a decreased change in NT-proBNP during AKI can reduce the risk of more severe AKI and improve survival outcomes. However, an excessive decrease in NT-proBNP is a risk factor for non-recovery of renal function following AKI, especially in elderly survivors with low baseline NT-proBNP levels.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Endocrinology & Metabolism
Jiasi Chen, Keping Wu, Yan Lei, Mingcheng Huang, Lokyu Cheng, Hui Guan, Jiawen Lin, Ming Zhong, Xiaohua Wang, Zhihua Zheng
Summary: The role of FABP4 in regulating ferroptosis in diabetic kidney disease was explored. The expression of FABP4 was found to be increased in kidney biopsies of DKD patients. Inhibition of FABP4 in HG-HK2 cells altered the redox state, suppressed the production of reactive oxygen species and iron, and reversed ferroptosis-associated mitochondrial damage.
ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Orthopedics
Xiaohua Wang, Lin Xie, Shuo Yang
Summary: This research investigates the correlation between the weight-adjusted-waist Index (WWI) and the incidence of Rheumatoid Arthritis (RA) and Osteoarthritis (OA). The findings reveal a linear positive correlation between WWI and OA prevalence, and a complex non-linear relationship with RA prevalence.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Chemistry, Applied
Xiaohua Wang, Yangyang Chen, Jingjing Zhang, Zewen Wang, Kaijie Qi, Hongxiang Li, Ruiping Tian, Xiao Wu, Xin Qiao, Shaoling Zhang, Hao Yin
Summary: The aroma composition of 202 pear cultivars' mature fruits was analyzed using GC-MS. A total of 221 major volatile components were detected, with aldehydes, esters, and alcohols being the dominant aroma components. Variations in aroma composition and content were observed among different pear varieties, and geographical flavor characteristics were also identified. These findings provide important insights for understanding aroma variations in pear varieties and promoting pear breeding programs.
Article
Environmental Sciences
Xiaohua Wang, Yimeng Wang, Nannan Liu
Summary: The economic differentiation between the north and the south of China is aggravating, and environmental regulation plays a significant role in widening the economic gap. Based on panel data of 285 cities in China from 2004 to 2019, the study finds that environmental regulation has a significant positive impact on narrowing the economic gap between the North and the South, but its effect shows a non-linear relationship.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Medicine, Research & Experimental
Xiaohua Wang, Xiang Shi, Dahua Sun, Meiping Wan
Summary: This case report analyzed the clinical symptoms, fine-needle aspiration cytology, histopathological and immunohistochemical results of a patient with angiolymphoid hyperplasia with eosinophilia (ALHE), and summarized the clinicopathological diagnostic features of the disease. As far as we know, this is the first comprehensive report on the cytological, histopathological and immunophenotypic characteristics of ALHE, which could contribute to a better understanding of this rare proliferative tumor for clinicians.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
