Article
Oncology
Julieta Afonso, Celine Goncalves, Marta Costa, Debora Ferreira, Lucio Santos, Adhemar Longatto-Filho, Fatima Baltazar
Summary: Glycolysis-related proteins are associated with bladder cancer aggressiveness and poor prognosis. The HK2 inhibitor 2-deoxy-D-glucose can inhibit glycolysis, reduce bladder cancer cell invasion, and increase sensitivity to cisplatin.
Review
Oncology
Marek Samec, Alena Liskova, Lenka Koklesova, Sandra Mersakova, Jan Strnadel, Karol Kajo, Martin Pec, Kevin Zhai, Karel Smejkal, Sepideh Mirzaei, Kiavash Hushmandi, Milad Ashrafizadeh, Luciano Saso, Aranka Brockmueller, Mehdi Shakibaei, Dietrich Busselberg, Peter Kubatka
Summary: This comprehensive review discusses the anticancer effects of plant phenolic compounds, known as flavonoids, through the targeting of HIF-1 and critical enzymes contributing to the Warburg effect. Flavonoids represent a promising avenue in cancer-related research by regulating glucose metabolism through HIF-1 activity. Further investigations are needed to elucidate the mechanistic and clinical connections between HIF-1 and cancer metabolism.
Review
Oncology
Carlo Ganini, Ivano Amelio, Riccardo Bertolo, Pierluigi Bove, Oreste Claudio Buonomo, Eleonora Candi, Chiara Cipriani, Nicola Di Daniele, Hartmut Juhl, Alessandro Mauriello, Carla Marani, John Marshall, Sonia Melino, Paolo Marchetti, Manuela Montanaro, Maria Emanuela Natale, Flavia Novelli, Giampiero Palmieri, Mauro Piacentini, Erino Angelo Rendina, Mario Roselli, Giuseppe Sica, Manfredi Tesauro, Valentina Rovella, Giuseppe Tisone, Yufang Shi, Ying Wang, Gerry Melino
Summary: Advancements in sequencing technologies have enabled more accurate and comprehensive cancer sequencing projects, such as deep sequencing of entire genomes, bypassing the high costs of whole-genome sequencing. Large-scale WGS applications on databases have allowed scientists to analyze molecular features, large structural variations, and noncoding regions of the genome globally for the first time. Thorough deciphering of the vast amount of data is needed, with the emergence of machine-learning approaches expected to lead to the development of personalized approaches for cancer medicine.
MOLECULAR ONCOLOGY
(2021)
Article
Oncology
Yin Yuan, Shuo Ni, Aoxiang Zhuge, Bo Li, Lanjuan Li
Summary: Iron plays a dual role in cancer development, promoting cell proliferation while inducing cell death. Research has shown that iron can enhance the Warburg effect of colorectal cancer cells, suppress sensitivity to ferroptosis, and promote tumorigenesis by inducing reactive oxygen species and activating NRF2. Therefore, iron elimination or a low-iron diet may be valid therapeutic approaches for colorectal cancer.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Quan Zhao, Lina Wang, Zongwei Lv, Xia Wang, Zhenqun Xu, Kefeng Wang
Summary: This study analyzed the global research status of the Warburg effect in cancer using bibliometrics. The findings showed an overall increase in annual publications over the past decade, with China being the most productive country and the United States receiving the most citations. Lactate metabolism, citrate production, and non-coding RNAs related to the Warburg effect received increasing attention in cancer research.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Zhen Li, Jin Su, Mingming Sun, Jiaqi Song, Huanran Sun, Jun Fan, Guo Chen, Changliang Shan, Qi Qi, Shuai Zhang
Summary: The up-regulation of OCT1 in non-small cell lung cancer promotes glycolysis flux and cell proliferation by up-regulating HK2, ultimately contributing to the Warburg effect. This study suggests that targeting the OCT1/HK2 axis may offer a potential therapeutic strategy for NSCLC treatment.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Health Care Sciences & Services
Dong Hyeok Kim, Kyung Eun Lee
Summary: This study analyzed breast cancer datasets from TCGA to identify potential biomarkers for breast cancer. Several differentially expressed mRNAs, both downregulated and upregulated, were selected and demonstrated excellent diagnostic performance. The results provide foundational data for further research on identifying new tumor biomarkers.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, Research & Experimental
Kateryna Tarhonska, Beata Janasik, Joanna Roszak, Kornelia Kowalczyk, Monika Lesicka, Edyta Reszka, Edyta Wieczorek, Marcin Braun, Agnieszka Kolacinska-Wow, Jaroslaw Skokowski, Leszek Kalinowski, Ewa Jablonska
Summary: The association between cadmium and the Warburg effect in breast cancer was suggested by an observational study, although not confirmed in vitro. However, cadmium seems to interfere with tamoxifen treatment, which deserves further investigation in terms of its possible implication in intrinsic resistance to hormone therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Andrology
Zhenan Zhang, Qinhan Li, Aolin Li, Feng Wang, Zhicun Li, Yisen Meng, Qian Zhang
Summary: The study established a novel 29-gene hypoxia-related signature model to predict the prognosis of bladder cancer cases. This model and identified hypoxia-related genes may be used as biomarkers to assist in evaluating prognosis and clinical decision-making.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ana Silva, Monica Costa Cerqueira, Beatriz Rosa, Catarina Sobral, Filipa Pinto-Ribeiro, Marta Freitas Costa, Fatima Baltazar, Julieta Afonso
Summary: Cancer produces energy through accelerated glycolysis, resulting in increased lactate production. The lactate is transported to and from cancer cells by monocarboxylate transporters (MCTs). MCT1 acts as both an importer and an extruder of lactate and has been studied extensively in recent years, being generally associated with aggressive cancer. This systematic review aimed to evaluate the prognostic value of MCT1 immunoexpression in various malignancies. The results showed that MCT1 is a poor prognostic indicator and is associated with decreased survival in sixteen types of cancer. However, MCT1 overexpression was also linked to better outcomes in colorectal cancer, pancreatic ductal adenocarcinoma, and non-small cell lung cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Xinyang Zhong, Xuefeng He, Yaxian Wang, Zijuan Hu, Huixia Huang, Senlin Zhao, Ping Wei, Dawei Li
Summary: Colorectal cancer is a common and deadly cancer, and the Warburg effect plays a significant role in promoting cancer metastasis and altering the tumor microenvironment. Understanding the mechanisms of the Warburg effect in colorectal cancer and identifying new therapeutic targets is a promising approach.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Oncology
Zhaopei Liu, Han Zeng, Kaifeng Jin, Yanze Yu, Runze You, Hongyi Zhang, Chunnan Liu, Xiaohe Su, Sen Yan, Yuan Chang, Li Liu, Le Xu, Jiejie Xu, Yu Zhu, Zewei Wang
Summary: In muscle-invasive bladder cancer, immune classification based on TIGIT and PD-1 can serve as a predictor for the response to systemic therapy, including adjuvant chemotherapy and immunotherapy.
BRITISH JOURNAL OF CANCER
(2022)
Article
Gastroenterology & Hepatology
Qiaozhu Zuo, Jia He, Shu Zhang, Hui Wang, Guangzhi Jin, Haojie Jin, Zhuoan Cheng, Xuemei Tao, Chengtao Yu, Botai Li, Chen Yang, Siying Wang, Yuanyuan Lv, Fangyu Zhao, Ming Yao, Wenming Cong, Cun Wang, Wenxin Qin
Summary: The study revealed that PGC1 alpha is down-regulated in HCC, and its low expression is associated with poor prognosis, vascular invasion, and larger tumor size. PGC1 alpha inhibits HCC metastasis by regulating the WNT/beta-catenin/PDK1 axis.
Article
Biochemistry & Molecular Biology
Xuelian Ma, Shumin Cheng, Ruofan Ding, Zhaozhao Zhao, XuDong Zou, Shouhong Guang, Qixuan Wang, Huan Jing, Chen Yu, Ting Ni, Lei Li
Summary: Functional interpretation of disease-associated non-coding variants is challenging. The development of ipaQTL-atlas as a comprehensive portal for intronic polyadenylation provides a valuable resource for studying the role of intronic polyadenylation in human diseases.
NUCLEIC ACIDS RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Martyna Jaworska, Julia Szczudlo, Adrian Pietrzyk, Jay Shah, Sonia E. Trojan, Barbara Ostrowska, Kinga A. Kocemba-Pilarczyk
Summary: Although Warburg's discovery of intensive glucose uptake and lactate fermentation in tumors is a century old, it remains an area of active research. This metabolic reprogramming of cancer cells has implications for various processes such as cell signaling, proliferation, energy supply, and immunosuppression. The Warburg effect is regulated by signaling pathways like PI3K/Akt/mTOR and transcription factors like HIF-1, p53, and c-Myc, and it plays a role in meeting the metabolic demands of rapidly proliferating tumor cells. Lactate, the end-product of aerobic glycolysis, acts as an oncometabolite that can provide fuel for neighboring cancer cells and promote metastasis and immunosuppression.
PHARMACOLOGICAL REPORTS
(2023)
Article
Computer Science, Software Engineering
Chunxue Wang, Linlin Xu, Ligang Liu
Summary: This paper proposes a novel image decomposition model for various image processing applications such as compression, enhancement, and texture removal. The model utilizes non-convex regularization and convolutional sparse coding to accurately decompose images into structure and texture components. It also incorporates structure-aware and texture-aware measures to effectively distinguish between these components.
Review
Chemistry, Multidisciplinary
Lijian Zuo, Zexin Li, Hongzheng Chen
Summary: This review summarizes and discusses the recent progresses and fundamental understandings of ion migration and accumulation behaviors in halide perovskite semiconductors-based solar cells (PVSCs). The ionic feature of perovskite semiconductors induces freely-moving ions to migrate and accumulate in the perovskite films and devices under different external stresses, which strongly couples with the electronic process and dramatically affects the performance and stability of PVSCs.
CHINESE JOURNAL OF CHEMISTRY
(2023)
Article
Nursing
Yuying Chu, Yuqiang Zhang, Dan Yang, Suyan Wang, Chunguang Liang, Xue Wang, Hongliang Dai
Summary: This study aims to explore the relationship between family function, alexithymia, and social anxiety among Chinese nursing students and determine if alexithymia acts as a mediator between family function and social anxiety. The results showed that alexithymia partially mediated the impact of family function on social anxiety, suggesting that improving alexithymia could be an effective strategy to alleviate social anxiety in Chinese nursing students.
Article
Optics
Yong Zhang, Lei LI, Han Xie, Zhi Jiang, Yang LI, Tongtong Wang, Danyang Yao, Yan Liu, Genquan Han, Yue Hao
Summary: This paper proposes a compact, low-energy, and non-volatile optical readout memory based on ferroelectric electrostatic doping and the epsilon-near-zero (ENZ) effect. The device utilizes compatible CMOS processes and residual polarization charges of the ferroelectric film to achieve the ENZ state and control the writing/erasing state through electrical pulses. Simulation results demonstrate a significant modulation depth of 10.4 dB for a device length of 60 μm with an energy consumption below 1 pJ.
Article
Thermodynamics
Ying Yu, Yuqi Dai, Linyu Xu, Hanzhong Zheng, Wenhao Wu, Lei Chen
Summary: This paper explored the energy-related carbon emission characteristics of the Pearl River Delta, a typical urban agglomeration in China, by decomposing carbon emissions by sector and cities. The study found that most cities experienced a rebound in carbon emissions around 2017, but overall carbon emissions sharply decreased. There were differences in key reduction industries among different cities, and the production and supply of electric power and transport sector had a negative impact on reduction processes in most cities. The decrease in energy intensity played a significant role in reducing carbon emissions in main industries reduction cities.
Article
Immunology
Yongsheng Wang, Ningbo Li, Xuejian Wu
Summary: This study aims to explore the role and mechanism of circ_0003800 in osteoarthritis (OA). The results show that circ_0003800 exacerbates IL-18-induced chondrocyte injury through the miR-197-3p/SOX5 axis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Zixu Sa, Fengjing Liu, Xinming Zhuang, Yanxue Yin, Zengtao Lv, Mingxu Wang, Jie Zhang, Kepeng Song, Feng Chen, Zai-xing Yang
Summary: In this study, a high-kappa oxide dielectric shell was uniformly configured onto the surface of GaSb NWs to improve the bias-stress stability of p-type NWFETs. The optimized oxide dielectric shell showed insignificant attenuation of on-state current (within 10%) and negligible negative shift of threshold voltage under continuous gate bias. This enhanced stability allowed for gate-controlled photodetection behaviors when used in a near-infrared photodetector.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Clinical Neurology
Jinli Zhang, Xiaohui Zheng, Zhenying Zhao
Summary: This study assessed the effects of selective serotonin reuptake inhibitors (SSRIs) on the alleviation of depressive symptoms in patients with Alzheimer's disease (AD). The results showed that SSRIs can attenuate depressive symptoms in AD patients, especially escitalopram, paroxetine, and sertraline have significant effects. However, larger randomized clinical trials are recommended to compare the efficacy of different SSRIs in AD patients with depression.
Article
Environmental Sciences
Zhi-Ming Ding, Shang-Ke Wang, Shou-Xin Zhang, Yang-Wu Chen, Yong-Sheng Wang, Sheng-Ji Yang, Yun-Xia Cao, Yi-Liang Miao, Li-Jun Huo
Summary: Triclocarban (TCC) is a harmful chemical that is used globally as a broad-spectrum antibacterial agent and is present in high concentrations in the environment. The exposure to TCC can occur through skin contact, diet, and inhalation, leading to its accumulation in the human body. The impact of TCC on human health, specifically its reproductive toxicity, needs to be evaluated due to the lack of clear understanding about its safety profile. This study examined the effect of TCC on the early embryonic development of mice and identified the mechanisms involved.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Chemistry, Applied
Jinxia Dai, Hui Lin, Yuning Pan, Yanmin Sun, Ye Wang, Jun-qin Qiao, Hong- zhen Lian, Chun-xiang Xu
Summary: A method was developed for the identification and determination of chlorpromazine (CPZ) and its metabolites in animal-derived foods. The method showed satisfactory results in actual commercial samples and is important for monitoring potential risk compounds.
Article
Chemistry, Organic
Linlin Xu, Yuchen Rong, Hailin Liao, Mei Pan, Yuliang Qian, Liangce Rong, Jinpeng Zhang
Summary: An efficient three-component reaction has been developed for the synthesis of spiro[benzo[a]acridine-12,4'-imidazolidine]-2',5'-dione derivatives through the ring-opening and recyclization process of isatins and dehydroxylation of 2-naphthol, which differs from their conventional reaction modes. Experimental observations indicate that p-toluenesulfonic acid is the crucial factor in promoting the success of this synthetic approach. This research provides a novel method for the construction of spiro compounds from isatins and 2-naphthol in organic synthesis.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Geosciences, Multidisciplinary
Jimei Li, Yunhui Wang, An Chen, Guanghui Wang, Xiaohui Yao, Tongtong Wang
Summary: Global climate change, economic development, and urbanization have increased the frequency and complexity of incidents. This study proposes a multi-dimensional risk matrix and four comprehensive risk assessment methods for dealing with different crises and incidents. Empirical research on three types of natural disasters in 30 regions in China shows that the multi-dimensional risk matrix can effectively characterize and compare the all-round risk situation of different regions and dimensions. The Euclidean distance method has the highest accuracy in terms of fitting coefficient when comparing the results of the evaluation methods.
Article
Multidisciplinary Sciences
Martin Klapper, Alexander Huebner, Anan Ibrahim, Ina Wasmuth, Maxime Borry, Veit G. Haensch, Shuaibing Zhang, Walid K. Al-Jammal, Harikumar Suma, James A. Fellows Yates, Jasmin Frangenberg, Irina M. Velsko, Somak Chowdhury, Rosa Herbst, Evgeni Bratovanov, Hans-Martin Dahse, Therese Horch, Christian Hertweck, Manuel Ramon Gonzalez Morales, Lawrence Guy Straus, Ivan Vilotijevic, Christina Warinner, Pierre Stallforth
Summary: Major advances in ancient DNA research have allowed access to paleogenomic diversity, however, the functions and capabilities of this genetic material remain largely unknown. In this study, dental calculus samples from ancient humans were examined, leading to the discovery of a biosynthetic gene cluster that produces previously unknown metabolites called paleofurans. This demonstrates the possibility of obtaining natural products from ancient organisms and opens up new opportunities for exploration in this field.
Article
Chemistry, Analytical
Lei Yang, Yanhui Zhang, Yinchuan Li, Lei Qin, Jingtao Dong, Feng Ji, Yongqing Wei, Songtao Chang, Rongsheng Lu
Summary: In this study, an open smooth triangular cavity was designed to enhance the laser-induced breakdown spectroscopy (LIBS) by plasma confinement and light collection. The results show that the designed cavity has the best enhancement factor and sensitivity compared to other two cavities.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2023)
Article
Materials Science, Multidisciplinary
Salman Ullah, Ling Li, Yixiu Wang, Xiaoyu Yang, Mingwei Tang, Yuan Xiang, Qing Yang
Summary: In this study, a controllable p-type doping strategy was reported by sodium intercalation during the chemical vapor deposition (CVD) process. X-Ray techniques confirmed the incorporation of sodium into the host MoS2 lattice and p-type carrier conduction was demonstrated through a constructed field-effect transistor. The doping method improved the photo response of the MoS2 photodetector by approximately 2 times compared to a pristine MoS2 photodetector. This doping route has the potential for a wide range of nanoelectronics and can be extended to other transition metal dichalcogenides (TMDCs) to counteract their native unipolar propensity.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)