Review
Behavioral Sciences
Nafiseh Shokri-Mashhadi, Mina Darand, Mohammad Hossein Rouhani, Maryam Yahay, Bradley A. Feltham, Sahar Saraf-Bank
Summary: This comprehensive systematic review and meta-analysis aimed to evaluate the effects of melatonin supplementation on brain-derived neurotrophic factor (BDNF) concentration and clinical depressive disorder. The results showed that melatonin supplementation had no significant effect on BDNF concentration but improved depression. Subgroup analysis indicated that melatonin supplementation significantly decreased BDNF levels in doses <= 10 mg/day, with more than 4 weeks of duration, and in men.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Review
Clinical Neurology
Sarah K. Ashcroft, Daniel D. Ironside, Liam Johnson, Suzanne S. Kuys, Angelica G. Thompson-Butel
Summary: This systematic review and meta-analysis of 17 studies found that high intensity aerobic exercise can increase circulating BDNF concentrations, which may contribute to increased neuroplasticity in individuals poststroke.
Review
Clinical Neurology
Andrea Ballesio, Andrea Zagaria, Davide Gusmeo Curti, Rosalyn Moran, Peter J. Goadsby, Ivana Rosenzweig, Caterina Lombardo
Summary: The brain-derived neurotrophic factor (BDNF) is considered a transdiagnostic biomarker for mental disorders and is associated with emotional and cognitive functioning. A systematic review and meta-analysis of case-control studies were conducted to examine the levels of peripheral BDNF in individuals with insomnia. The results showed that subjects with insomnia had lower BDNF levels compared to healthy controls. However, the interpretation of the results should be cautious due to the small sample size, cross-sectional nature of the measurement, and high heterogeneity of the included data.
SLEEP MEDICINE REVIEWS
(2023)
Article
Behavioral Sciences
Sagun Tiwari, Lili Qi, John Wong, Zhenxiang Han
Summary: According to a meta-analysis, peripheral levels of brain-derived neurotrophic factor (BDNF) significantly decrease in depression compared to nondepressed healthy controls. However, the study reveals significant heterogeneity among the included studies. Factors such as history of depression and alcohol consumption affect the level of BDNF, while age and gender do not impact the heterogeneity. Although decreased BDNF expression is a risk factor for depression, it cannot be used as a reliable biomarker to assess depression in clinical practice.
BRAIN AND BEHAVIOR
(2022)
Review
Behavioral Sciences
Ya-Hai Wang, Huan-Huan Zhou, Qiang Luo, Sidong Cui
Summary: This study investigated the effects of physical exercise on brain-derived neurotrophic factor (BDNF) in healthy individuals. The findings showed that both acute and long-term exercise had significant positive effects on circulating BDNF levels. Subgroup analysis revealed that long-term aerobic exercise, female participants, participants older than 60 years, and aerobic exercise contributed to a more pronounced improvement in BDNF levels.
BRAIN AND BEHAVIOR
(2022)
Review
Behavioral Sciences
Ryoki Sasaki, Shota Miyaguchi, Hideaki Onishi
Summary: Studies suggest that BDNF genotype may have a minor impact on individual motor performance and motor learning abilities.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Psychiatry
Lin-Shuai Hao, Yang Du, Lei Chen, Yu-Guo Jiao, Yong Cheng
Summary: The present study conducted a systematic review with meta-analysis to compare peripheral blood BDNF levels between patients with OCD and healthy controls. The results showed that patients with OCD had significantly decreased peripheral blood levels of BDNF compared to the healthy controls.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Review
Psychiatry
Kyana Jafarabady, Arman Shafiee, Razman Arabzadeh Bahri, Shahryar Rajai Firouzabadi, Ida Mohammadi, Mohammad Javad Amini
Summary: This systematic review and meta-analysis provide evidence of lower BDNF protein levels in individuals diagnosed with perinatal depression (PND), indicating that BDNF dysregulation may play a part in the development of PND.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Review
Medicine, Research & Experimental
Helia Mojtabavi, Zoha Shaka, Sara Momtazmanesh, Atra Ajdari, Nima Rezaei
Summary: The study confirms that stroke significantly decreases BDNF levels, affecting cognition, affect, and motor function. Patients with depression have lower BDNF levels. Physical training has a short-term positive effect on BDNF levels, while the long-term effects are unclear. Repeated transcranial magnetic stimulation has no effect on BDNF levels.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Psychiatry
Chunhui Zhang, Xuefang Wang, Qinghua Zhu, Yongxia Mei, Zhenxiang Zhang, Hui Xu
Summary: This study found that serum BDNF levels are lower in poststroke depression (PSD) patients compared to stroke patients without PSD, suggesting that BDNF may serve as a potential biomarker for predicting the risk of PSD among stroke survivors.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Clinical Neurology
Francieli Cristina Krey, Bruna Alvim Stocchero, Kerstin Camile Creutzberg, Bernardo Aguzzoli Heberle, Saulo Gantes Tractenberg, Li Xiang, Wei Wei, Bruno Kluwe-Schiavon, Thiago Wendt Viola
Summary: The study conducted a meta-analysis of 16 studies and found significantly lower BDNF and NT-3 levels in preterm infants compared to term infants, with no significant difference in NGF and NT-4 levels. Sample type was identified as a significant moderator of heterogeneity in BDNF meta-analysis.
FRONTIERS IN NEUROLOGY
(2021)
Review
Psychiatry
Zuxing Wang, Zhili Zou, Jun Xiao, Wenjiao Min, Li-Ping Nan, Cui Yuan, Lu Yuan, Chenghui Yang, Rui Huang, Ying He
Summary: Multiple studies have shown that electroconvulsive therapy (ECT) can increase brain-derived neurotrophic factor (BDNF) concentrations in patients with different mental disorders. The aim of this synthesis was to evaluate post-ECT BDNF concentrations in patients with various mental disorders. The standardized mean difference (SMD) was calculated to quantify BDNF concentration differences.
GENERAL HOSPITAL PSYCHIATRY
(2023)
Review
Clinical Neurology
Xuan Liu, Jun-Chao Fang, Xin-Yue Zhi, Qiu-Yu Yan, Hong Zhu, Juan Xie
Summary: Carrier of Val66Met AA genotype may have worse rehabilitation outcomes compared to GA+GG carriers. In general, Asian patients may have a higher proportion of the A allele. Further research is needed to determine the impact of Val66Met polymorphism on stroke recovery.
NEUROREHABILITATION AND NEURAL REPAIR
(2021)
Review
Behavioral Sciences
Xi-Yi Hu, Yu-Long Wu, Chao-Hui Cheng, Xiao-Xi Liu, Lan Zhou
Summary: The meta-analysis suggests that the BDNF rs6265 G > A polymorphism is associated with PTSD susceptibility, with an increased risk of A allele mutations. Subgroup analysis showed similar situations in Asian populations and other groups.
BRAIN AND BEHAVIOR
(2021)
Review
Medicine, General & Internal
Anna Maria Szota, Beata Kowalewska, Malgorzata Cwiklinska-Jurkowska, Wiktor Drozdz
Summary: The main aim of this systematic review and meta-analysis is to investigate the correlation between the level of brain-derived neurotrophic factor (BDNF) and electroconvulsive therapy (ECT) treatment in patients with schizophrenia. The findings showed a statistically significant increase in BDNF levels after ECT treatment in two studies, but not in four other studies.This meta-analysis suggests that ECT therapy and antipsychotic medication may increase serum BDNF levels in patients with drug-resistant schizophrenia, although the effect is not statistically significant.
JOURNAL OF CLINICAL MEDICINE
(2023)