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Biochemistry & Molecular Biology
Ifat Alsharif, Loubna Boukhzar, Benjamin Lefranc, David Godefroy, Juliette Aury-Landas, Jean-Luc do Rego, Jean-Claude do Rego, Frederic Naudet, Arnaud Arabo, Abdeslam Chagraoui, David Maltete, Abdelhamid Benazzouz, Catherine Bauge, Jerome Leprince, Abdel G. Elkahloun, Lee E. Eiden, Youssef Anouar
Summary: PSELT, derived from SELENOT, shows promise as a therapeutic candidate for Parkinson's disease by targeting oxidative stress at multiple intracellular levels.
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Multidisciplinary Sciences
Lindsay Willmore, Courtney Cameron, John Yang, Ilana Witten, Annegret Falkner
Summary: This research reveals differences in DA neuron activity and behavior between resilient and susceptible individuals after experiencing stress. Resilient mice show more activity near the aggressor, while susceptible mice exhibit more activity at the end of attacks and the beginning of fleeing. Optogenetic stimulation of NAc-projecting DA neurons can promote resilience and alter behavior during defeat.
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Pharmacology & Pharmacy
Kun Li, Meng Wang, Zi-Han Huang, Min Wang, Wan-Yang Sun, Hiroshi Kurihara, Rui-Ting Huang, Rong Wang, Feng Huang, Lei Liang, Yi-Fang Li, Wen-Jun Duan, Rong-Rong He
Summary: In this study, it was found that (-)-Clausenamide (Clau) can protect dopaminergic neurons by interacting with ALOX5 and inhibiting its nuclear translocation. The inhibition of ALOX5 was also found to improve behavioral defects in a PD mouse model. These findings suggest that targeting ALOX5 to prevent ferroptotic death in dopaminergic neurons is an attractive strategy for PD therapy.
PHARMACOLOGICAL RESEARCH
(2023)
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Medicine, Research & Experimental
Sora Kang, Ying Piao, Young Cheol Kang, Suyeol Lim, Youngmi Kim Pak
Summary: DA-9805 is a potential therapeutic candidate for Parkinson's disease, able to prevent neuroinflammation and ER stress. It demonstrates neuroprotective effects by alleviating mitochondrial damage and inhibiting NF-Kappa B activation, in both cell and mouse models.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
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Biochemistry & Molecular Biology
Won Sik Eum, Dae Won Kim, Eun Ji Yeo, Hyeon Ji Yeo, Yeon Joo Choi, Hyun Ju Cha, Jinseu Park, Kyu Hyung Han, Duk-Soo Kim, Yeon Hee Yu, Sung-Woo Cho, Oh-Shin Kwon, Yong-Jun Cho, Min Jea Shin, Soo Young Choi
Summary: This study demonstrated that Tat-PRAS40 protects against dopaminergic neuronal cell death through various mechanisms and shows protective effects in a Parkinson's disease animal model.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
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Immunology
Bingxu Huang, Guiqiu Hu, Xiaofeng Zong, Shuo Yang, Dewei He, Xiyu Gao, Dianfeng Liu
Summary: Our study demonstrates that alpha-Cyperone alleviates dopaminergic neurodegeneration by inhibiting neuroinflammation and oxidative stress in LPS-induced PD rat model via activating Nrf2/HO-1 and suppressing NF-kappa B signaling pathway. Alpha-Cyperone ameliorated motor dysfunction, protected dopaminergic neurons, and inhibited the reduction of dopamine and its metabolites. It also suppressed the activation of microglia and the expression of neuroinflammatory factors.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
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Biochemistry & Molecular Biology
Tingxu Yan, Qianqian Mao, Xiaozhuo Zhang, Bo Wu, Kaishun Bi, Bosai He, Ying Jia
Summary: The study revealed that Schisandra chinensis protects against dopaminergic neurodegeneration in 6-OHDA-induced Parkinson's disease mice by modulating the BDNF/Nrf2/NF-kappa B signaling pathway to suppress oxidative stress, neuroinflammation, and apoptosis.
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Biochemistry & Molecular Biology
Ziying Ye, Chuna Li, Shuqiong Liu, Hongbin Liang, Jialiang Feng, Danyu Lin, Ying Chen, Sudan Peng, Lulu Bu, Enxiang Tao, Xiuna Jing, Yanran Liang
Summary: This study demonstrated that Dl-3-n-butylphthalide (NBP) protected dopaminergic neurons in Parkinson's disease by inhibiting ferroptosis. This protective effect may be achieved by regulating ferritin expression, promoting Nrf2 nuclear translocation, and inhibiting NCOA4-mediated ferritinophagy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
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Cell Biology
Ke Yan, Kexin Cui, Junyu Nie, Hengye Zhang, Lumin Sui, Huiting Zhang, Xiaogan Yang, Chang-Long Xu, Xingwei Liang
Summary: This study demonstrates that MV can protect oocytes from LPS-induced meiotic defects in part by reducing oxidative stress and maintaining m(6)A levels.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
George Jitca, Bianca E. Osz, Amelia Tero-Vescan, Camil E. Vari
Summary: The increasing desire of young people to experiment with illegal, psychoactive substances without awareness of the risks poses a significant threat to their social life and health. Drug abuse can lead to neural cell damage and the development of neurodegenerative diseases, highlighting the importance of understanding the link between oxidative stress, neurotoxicity, and substance abuse for developing new therapeutic strategies.
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Integrative & Complementary Medicine
Wen Jing, Zhang Yuan-Qiang, Liu Dong-Qing, Yao Xu-Tao, Jiang Hua, Zhang Yu-Bin
Summary: This study aimed to explore the neuroprotective effects and pharmacological mechanism of Demethylenetetrahydroberberine (DMTHB) on Parkinson's disease. The results showed that DMTHB could alleviate behavioral disorders, protect dopaminergic neurons, and exhibit multiple-target effects including anti-apoptotic, anti-inflammatory, and antioxidant properties.
CHINESE JOURNAL OF NATURAL MEDICINES
(2022)
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Cell Biology
Wakana Oda, Yuki Fujita, Kousuke Baba, Hideki Mochizuki, Hitoshi Niwa, Toshihide Yamashita
Summary: Inhibiting RGMa can attenuate neuronal loss and inflammation in a mouse model of Parkinson's disease, suggesting that RGMa antibodies could be a potential therapeutic option.
CELL DEATH & DISEASE
(2021)
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Cardiac & Cardiovascular Systems
Huijing Yu, Fang Zhang, Pengyi Yan, Shasha Zhang, Yingmei Lou, Zilong Geng, Zixuan Li, Yan Zhang, Yuejuan Xu, Yanan Lu, Chen Chen, Daowen Wang, Wei Zhu, Xinyang Hu, Jian'an Wang, Tao Zhuang, Yuzhen Zhang, Gengze Wu, Junling Liu, Chunyu Zeng, William T. Pu, Kun Sun, Bing Zhang
Summary: LARP7 plays a crucial role in mitochondrial biogenesis, energy production, and cardiac function by modulating SIRT1 homeostasis and activity. Reduction of LARP7 in diseased hearts contributes to heart failure pathogenesis, while restoring LARP7 in the injured heart confers myocardial protection, identifying the ATM-LARP7-SIRT1 pathway as a potential therapeutic target in heart failure.
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Biochemistry & Molecular Biology
Kaori Suyama, Daisuke Sakai, Shogo Hayashi, Ning Qu, Hayato Terayama, Daisuke Kiyoshima, Kenta Nagahori, Masahiko Watanabe
Summary: In this study, we found that Bag-1 binds to HSP70 but not to Raf-1 in NP cells, and this interaction enhances cell viability and mitochondrial function while suppressing p38/MAPKs phosphorylation during oxidative stress. However, inhibition of the Bag-1 C-terminal binding site decreases cell viability and mitochondrial function. In addition, the phosphorylation of ERK/MAPKs is significantly increased in the absence of H2O2 treatment, while the phosphorylation of Raf-1 is not affected by Bag-1.
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Biochemistry & Molecular Biology
Limin Shi, Lu Jia, Yiyun Wang, Minxia Xiu, Junxia Xie
Summary: In this study, it was found that 4-AP could inhibit MPTP-induced dopaminergic neuronal loss and attenuate motor deficits in PD. The neuroprotective effect of 4-AP is achieved by reducing oxidative stress and apoptosis.
NEUROCHEMICAL RESEARCH
(2023)