Article
Chemistry, Medicinal
Bin Zheng, Yakun Yang, Jinghan Li, Jing Li, Saijie Zuo, Xi Chu, Shan Xu, Donglai Ma, Li Chu
Summary: The study demonstrated that MgIG could significantly reduce ATO-induced cardiac toxicity through its anti-inflammation, anti-oxidation, and anti-apoptosis effects. Additionally, MgIG exerted its protective effects by modulating the Nrf2 pathway and suppressing the TLR4/NF-kappa B pathway.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Immunology
Qing Liao, Bao Jian Li, Yang Li, Yu Xiao, Hui Zeng, Jie Mei Liu, Li Xia Yuan, Gang Liu
Summary: Studies have shown that LIPUS-mediated BMSC-derived exosomes can promote cartilage regeneration, increase chondrocyte proliferation and extracellular matrix synthesis, and suppress inflammation. The underlying mechanism may involve the inhibition of IL-1 beta-induced activation of the NF-Kappa B pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Environmental Sciences
Zhonggui Gong, Wenjing Liu, Ruilong Song, Wenxuan Dong, Kanglei Zhang, Jiahui Li, Hui Zou, Jiaqiao Zhu, Yonggang Ma, Gang Liu, Zongping Liu
Summary: Cadmium (Cd) is a heavy metal pollutant that targets the kidney. Previous studies have shown that Cd-induced nephrotoxicity is caused by apoptosis and autophagy disorders. The regulatory mechanisms of NF-kappa B in Cd-induced kidney injury are still unclear. This study found that Cd promotes the activation of NF-kappa B, which mediates the survival of NRK-52E cells through promoting autophagy and inhibiting apoptosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Jing Tang, Chenjuan Yao, Yingqi Liu, Jiaming Yuan, Li Wu, Kazuo Hosoi, Shali Yu, Chunyan Huang, Haiyan Wei, Gang Chen
Summary: In this study, it was elucidated that BCL-2, as a pro-apoptotic factor, plays a role in As2O3-induced apoptosis in BEAS-2B cells through NF-kappa B and p38 MAPK signaling pathways. The upregulation, nuclear localization, and phosphorylation of BCL-2 during apoptosis were found to be crucial factors in As2O3-induced cell death.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Chemistry, Multidisciplinary
Wei Zhou, Fei Wang, Aimin Li, Silei Bai, Xinxin Feng, Qing He
Summary: A superphane-based carcerand with 18 anion binding sites and a fully enclosed interior space was designed and synthesized. The carcerand was capable of imprisoning H2PO4- anion and highly toxic arsenate anion, resulting in non-toxic arsenate carceplex in HEK293T cell line.
CELL REPORTS PHYSICAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Dinh Hoa Hoang, Ralf Buettner, Melissa Valerio, Lucy Ghoda, Bin Zhang, Ya-Huei Kuo, Steven T. Rosen, John Burnett, Guido Marcucci, Vinod Pullarkat, Le Xuan Truong Nguyen
Summary: This study found that the combination of arsenic trioxide (ATO) and Venetoclax (VEN) synergistically induced apoptosis of leukemia stem cells (LSCs) in patients with acute myeloid leukemia (AML), by potentiating the induction of reactive oxygen species (ROS) and inhibiting the Nrf2 antioxidant pathway. This suggests that ATO+VEN could be a promising regimen for treating VEN-sensitive and -resistant AML.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Xiaoji Hao, Xiaohui Liu, Shunfei Yu, Chang Qin, Ruonan Wang, Chunna Li, Jing Shao
Summary: This study evaluated the efficacy and mechanisms of intravenous arsenic trioxide (As2O3) for treating an imiquimod-induced psoriasis-like mouse model. The results showed that clinical doses of As2O3 significantly improved abnormal symptoms and pathological changes in psoriasis-like skin lesions. The study also identified the NF-kappa B signaling pathway as a key mechanism underlying the effectiveness of As2O3 treatment.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2022)
Article
Cell Biology
Dong Guo, Yingying Tong, Xiaoming Jiang, Ying Meng, Hongfei Jiang, Linyong Du, Qingang Wu, Shan Li, Shudi Luo, Min Li, Liwei Xiao, Haiyan He, Xuxiao He, Qiujing Yu, Jing Fang, Zhimin Lu
Summary: High glucose promotes PD-L1 expression in tumor cells, leading to tumor immune evasion. Inhibition of HK2 and PD-1 can eliminate tumor immune evasion and enhance the anti-tumor effect of immune checkpoint blockade.
Article
Immunology
Mahmoud Darweesh, Shady Younis, Zamaneh Hajikhezri, Arwa Ali, Chuan Jin, Tanel Punga, Soham Gupta, Magnus Essand, Leif Andersson, Goran Akusjarvi
Summary: ZC3H11A protein is involved in the regulation of NF-κB signaling pathway, and its depletion leads to enhanced signaling and accumulation defects of IκBα mRNA and protein.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Dayong Han, Lei Teng, Xiaoxiong Wang, Yunbo Zhen, Xiaofeng Chen, Mingchun Yang, Ming Gao, Guang Yang, Mingyang Han, Ligang Wang, Jiajun Xu, Yue Li, Alina Shumadalova, Shiguang Zhao
Summary: Arsenic trioxide demonstrated good safety and tolerability in glioma patients, with a recommended dose of 1.5 mg for a phase II trial.
FRONTIERS IN NEUROLOGY
(2022)
Article
Immunology
Tracy Dagher, Nabih Maslah, Valerie Edmond, Bruno Cassinat, William Vainchenker, Stephane Giraudier, Florence Pasquier, Emmanuelle Verger, Michiko Niwa-Kawakita, Valerie Lallemand-Breitenbach, Isabelle Plo, Jean-Jacques Kiladjian, Jean-Luc Villeval, Hugues de The
Summary: Research shows that arsenic trioxide (ATO) can significantly enhance IFNα-induced growth suppression of JAK2 (V617F) patient or mouse hematopoietic progenitors, predicting potent clinical efficacy of the IFNα+ATO combination in patients. This combination therapy has the potential to eradicate Myeloproliferative neoplasms by targeting disease-initiating cells.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Dijun Ou, Wenbin Ding, Changjun Tong, Weihong Yi
Summary: Silencing of LINC00473 protects CHON-001 cells from IL-1 beta-induced cell injury by inhibiting the methylation of LMP-1 and interfering with the JNK/NF-kappa B signaling pathway. Therefore, LINC00473 may serve as a potential therapeutic target for osteoarthritis.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Liangli Jin, Quanyi Li, Jing Li, Yang Pan, Jue Zou, Xiaoyuan Wu, Zhi Wang
Summary: This study demonstrated that apela can improve cardiorenal function and reduce systemic and renal inflammatory response in type I CRS mice. The apela/APJ system may alleviate renal inflammatory responses by inhibiting the NF kappa B signalling pathway.
Article
Pharmacology & Pharmacy
Xiangyu Wang, Zhuoma Dongzhi, Yan Li, Mi Xie, Xinyu Li, Ruiying Yuan, Bin Li, Pharkphoom Panichayupakaranant, Shan Huang
Summary: Ajania purpurea Shih. ethanol extract (EAPS) suppresses inflammation by inhibiting the NF-kappa B pathway in RAW264.7 cells and mice with peritonitis, reducing the release of inflammatory factors and recruitment of immune cells.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2022)
Article
Oncology
Yu Zheng, Yuan-Fei Mao, Hui-Jin Zhao, Li Chen, Li-Ning Wang, Yun-Xiang Zhang, Jiong Hu, Jun-Min Li, Xiao-Yang Li, Hong-Ming Zhu
Summary: This study investigated the arsenic metabolism in APL patients who completed ATO treatment and found a decreased arsenic methylation capacity after treatment. The increased proportion of iAs(III) in urine was associated with chronic liver toxicity, highlighting the importance of monitoring urine PMI and considering SNPs of the AS3MT gene in determining ATO dosage.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2021)
Article
Oncology
Fei-Yuan Yu, Qian Xu, Qi-Yao Wei, Hai-Ying Mo, Qiu-Hua Zhong, Xiao-Yun Zhao, Andy T. Y. Lau, Yan-Ming Xu
Summary: ACC2 is under-expressed in cancerous tissue and negatively correlated with tumor size, lymph-node metastases, and clinical stage in lung adenocarcinoma. Knocking down ACC2 promotes cell proliferation and migration, and affects the expression of cell cycle-related genes. Lung adenocarcinoma patients with under-expressed ACC2 have a worse prognosis.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Review
Environmental Sciences
Xiao-Hui Yin, Yan-Ming Xu, Andy T. Y. Lau
Summary: Since the late 1980s, nanomaterials have been widely used in various fields, providing convenience to people's lives. However, the negative effects of nanomaterials, known as nano pollution, are becoming increasingly apparent. This review introduces the types and applications of nanoparticles, airborne nanoparticle pollution, and its relationship with human diseases. Exposure to airborne nanoparticles has been found to cause respiratory diseases, cardiovascular diseases, and neurological disorders.
Review
Oncology
Qiu-Hua Zhong, Si-Wei Zha, Andy T. Y. Lau, Yan-Ming Xu
Summary: NFATc4, a transcription factor, plays a crucial role in various cancers. It is involved in the initiation and progression of cancer, making it a potential molecular therapeutic target.
CANCER CELL INTERNATIONAL
(2022)
Review
Oncology
Xu-Li Chen, Yan-Ming Xu, Andy T. Y. Lau
Summary: Epithelial-mesenchymal transition (EMT) is a crucial process in which epithelial cells transform into motile mesenchymal cells. Environmental heavy metals can affect the progress of EMT, but their effects may vary depending on the form, dose, and exposure time.
CANCER CELL INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Hai-Ying Mo, Qi-Yao Wei, Qiu-Hua Zhong, Xiao-Yun Zhao, Dan Guo, Jin Han, Wachiraporn Noracharttiyapot, Lydia Visser, Anke van den Berg, Yan-Ming Xu, Andy T. Y. Lau
Summary: CYP27C1 expression levels vary in lung cancer cell lines. Silencing CYP27C1 enhances cell proliferation, colony formation, migration, and tolerance towards anticancer agents in lung cancer cells. This study reveals that CYP27C1 impacts lung cancer cell development by participating in the regulation of the IGF-1R/Akt/p53 signaling pathway and determines cellular sensitivity towards multiple anticancer agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Environmental Sciences
Jia-Xun Wu, Andy T. Y. Lau, Yan-Ming Xu
Summary: Smoking is recognized by the WHO as the fifth highest threat to humanity, as it promotes non-communicable diseases and poses a health risk to both smokers and those exposed to second-hand smoke. Air pollution, including the secondary pollutant third-hand smoke, also contributes to global health problems. Understanding the components and hazards of third-hand smoke is crucial for implementing smoking bans and raising public awareness.
Article
Multidisciplinary Sciences
Dan-Dan Wu, Li-Juan Dai, Heng Wee Tan, Xiao-Yun Zhao, Qi-Yao Wei, Qiu-Hua Zhong, Yan-Chen Ji, Xiao-Hui Yin, Fei-Yuan Yu, Dong-Yan Jin, Sheng-Qing Li, Andy T. Y. Lau, Yan-Ming Xu
Summary: The expression level of MAPK15 is positively correlated with sensitivity to cisplatin in human lung cancer cells by affecting DNA repair capacity. The TNF-alpha-activated NF-kappa B signaling pathway transcriptionally regulates the expression of MAPK15, and TNF-alpha enhances the cytotoxicity of cisplatin in a MAPK15-dependent manner. Manipulation of MAPK15 could improve the therapeutic efficacy of chemotherapeutic drugs.
Review
Environmental Sciences
Xiao-Xia Chen, Yan-Ming Xu, Andy T. Y. Lau
Summary: This review examines the changes in metabolic profiles of humans and rodents under long-term cadmium exposure and discusses the relationship between the disturbance of metabolic pathways and the toxic mechanism of cadmium. This information is useful for the development of reliable metabolic biomarkers for early detection and diagnosis of cadmium-related diseases.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Qi-Yao Wei, Andy T. Y. Lau, Hai-Ying Mo, Qiu-Hua Zhong, Xiao-Yun Zhao, Fei-Yuan Yu, Jin Han, Yu-Yao Wu, Yan-Ming Xu
Summary: CYP3A43 plays a suppressive role in the progression of lung adenocarcinoma and may provide new possibilities for targeted therapy of this disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Dan-Dan Wu, Andy T. Y. Lau, Yan-Ming Xu, Marjan Reinders-Luinge, Mihaly Koncz, Antal Kiss, Wim Timens, Marianne G. Rots, Machteld N. Hylkema
Summary: Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) is highly expressed in smokers and its molecular mechanism in airway epithelium and its role in extracellular matrix (ECM) remodeling are not well understood. Our study showed that cigarette smoke extract (CSE) stimulated UCHL1 expression in vitro and the methylation status of the UCHL1 gene was negatively associated with UCHL1 transcription at specific sites in airway epithelium. Inhibition of UCHL1 activity prevented the TGF-beta 1-induced upregulation of the ECM gene COL1A1, and downregulation of UCHL1 by epigenetic editing reduced mRNA expression of COL1A1 and fibronectin. These findings suggest that UCHL1 may serve as a therapeutic target in fibrosis-related disease.
Article
Biochemistry & Molecular Biology
Yu-Yao Wu, Gao-Qi Wu, Na-Li Cai, Yan-Ming Xu, Andy T. Y. Lau
Summary: The EIF5A family consists of EIF5A1, EIF5A2, and EIF5AL1. Recent studies have shown that EIF5As are involved in various human diseases. EIF5A1 can act as a tumor suppressor or oncogene in different cancers, while EIF5A2 promotes cancer development. EIF5AL1's biological function has not been studied, but it has been found to inhibit cell proliferation and migration. The differences in hypusination and protein turnover between EIF5A1 and EIF5AL1 may explain their differential protein expression levels. This research fills gaps in EIF5As research and provides insights for future studies on EIF5AL1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Qi Ding, Yan-Ming Xu, Andy T. Y. Lau
Summary: This review discusses the epigenetic effects of coffee extract and its three essential active ingredients (caffeine, chlorogenic acid, and caffeic acid). Coffee, as a popular beverage, contains active ingredients with various biological functions such as insulin sensitization, improvement of sugar metabolism, antidiabetic properties, and liver protection. However, recent studies have shown that coffee can have both beneficial and detrimental effects on human health due to its complex components. It has been found that coffee extract and its components can potentially influence gene expression through epigenetic modifications, such as DNA methylation, histone modifications, and ncRNA expression, which can have long-lasting impacts on the epigenome. Importantly, the consumption of coffee during pregnancy has been associated with negative effects on offspring due to epigenetic modifications, while it has also been linked to improvements in various diseases, including cancer. Therefore, understanding the epigenetic effects associated with coffee components is crucial for improving human health.
Review
Oncology
Yu-Yao Wu, Yan-Ming Xu, Andy T. Y. Lau
Summary: Recent research has shown that traditional herbal medicine has the potential to modify the epigenome and treat chronic diseases such as cancer, diabetes, and inflammation. Understanding the effect of herbal medicine on the epigenome may lead to new therapeutic approaches and diagnostics for human diseases.
CLINICAL EPIGENETICS
(2023)
Review
Biochemical Research Methods
Xiu-Yun Wang, Yan-Ming Xu, Andy Lau
Summary: This review mainly summarizes and discusses the workflow of proteogenomics, its applications in cancer research, and the SWOT analysis in cancer research. Proteogenomics clarifies the functional consequences of unannotated genomic abnormalities, identifies driver genes and novel therapeutic targets, and accelerates the development of precision oncology.
JOURNAL OF PROTEOME RESEARCH
(2023)