Article
Immunology
Jing-Ying Li, Zi-Xing Zheng, Lin Liu, Ou Du, Neng-Wei Yu, Yunyun Zou, Seung-Yong Seong, Jun-Rong Du
Summary: This study demonstrates the involvement of ALPK1 in sterile inflammatory injury after acute brain ischemia, and its neuroprotective effects through inhibition of the TIFA/TRAF6/NF-KB pathway and neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yeo Jin Park, Hye Jin Yang, Wei Li, You-Chang Oh, Younghoon Go
Summary: In this study, the effects of Menthae Herba (MH) on the inflammatory response and molecular mechanisms in activated microglia were evaluated. The results showed that MH inhibited the production of proinflammatory enzymes and mediators, reduced reactive oxygen species (ROS) levels, and activated antioxidant signaling pathways. These findings suggest the potential therapeutic use of MH in neuroinflammatory diseases.
Article
Toxicology
Trong Thuan Ung, Thi Thinh Nguyen, Shinan Li, Jae-Young Han, Young Do Jung
Summary: Nicotine stimulates CYP1A1 expression through transcription factors and signaling pathways, although antioxidant compounds can inhibit nicotine-induced reactive oxygen species production and CYP1A1 expression. Inhibition of NADPH oxidase activity also affects CYP1A1 expression.
TOXICOLOGY LETTERS
(2021)
Article
Cell Biology
Xiaolian Li, Mingkun Xu, Jiaojiao Shen, Yuqin Li, Shaoping Lin, Min Zhu, Qiongni Pang, Xiujuan Tan, Jing Tang
Summary: Sorafenib is a drug used for anti-tumor treatment. It has been found to inhibit inflammatory reactions and reduce the expression of inflammatory factors possibly by inhibiting the phosphorylation of specific enzymes.
CELL DEATH DISCOVERY
(2022)
Article
Immunology
Jie Cui, Weifeng Tang, Wenqian Wang, La Yi, Fangzhou Teng, Fei Xu, Mihui Li, Mengyu Ma, Jingcheng Dong
Summary: Asthma is a difficult-to-cure disease and there is an urgent need for more reliable and effective medications. Acteoside, a phenylpropanoid glycoside found in various herbs, has been shown to have anti-inflammatory and antioxidant properties. However, there have been few studies on the impact of acteoside on asthma. Therefore, this study aimed to investigate the protective effects of acteoside on asthma and explore the underlying mechanisms both in vivo and in vitro.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Zixuan Lin, Chen Chen, Dongqin Yang, Jianqing Ding, Guanghui Wang, Haigang Ren
Summary: DJ-1 plays a crucial role in neuroinflammation by facilitating the interaction between IκBα and p65 in microglia, resulting in the repression of microglial activation and the protection of DA neurons from inflammation-induced injury in Parkinson's disease.
CELL DEATH & DISEASE
(2021)
Article
Medicine, Research & Experimental
Ming-Cheng Lee, Yin-Kai Chen, Jyy-Jih Tsai-Wu, Yih-Jen Hsu, Bor-Ru Lin
Summary: NF-KB inhibitors can reduce the expression of ACE2 in human lung cells, with ROS and NF-KB signaling playing important roles in the regulation of ACE2. The combination of zinc with NF-KB inhibitors may have potential for clinical treatment of ACE2-related diseases.
Article
Pharmacology & Pharmacy
Taskeen Fathima Docrat, Savania Nagiah, Anil A. Chuturgoon
Summary: The study found that Metformin (MF) promotes neuroprotection in diabetic mice by regulating the miR-141/protein phosphatase 2A (PP2A) axis and associated NF-KB-mediated inflammasome expression in the brain. MF counteracted inflammatory responses by regulating the expressions of miR-141, PP2A, and p-tau at Ser396 protein, and showed inhibitory effects on various signaling pathways.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Immunology
Ying Tang, Shiyi Yang, Minshan Yao, Minxuan Yang, Lixiang Wei, Hong Chen, Junyan Lin, Yao Huang, Li Lin, Zhendong Qin
Summary: Hemolytic disease in grass carp leads to oxidative damage and cell death, mediated by the release of cell-free hemoglobin and activation of inflammatory pathways.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Food Science & Technology
Qian Zhou, Ying Zhang, Lu Lu, Hu Zhang, Chao Zhao, Yuepu Pu, Lihong Yin
Summary: This study investigates the effects of copper exposure on microglial activation and neuroinflammation, as well as the underlying mechanism of copper-induced microglial activation. The results show that copper exposure leads to inflammatory activation of microglia and the release of inflammatory factors, which results in the death of dopaminergic neurons.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Medicine, Research & Experimental
Ji-Cheng Huang, Zhan-Peng Yue, Hai-Fan Yu, Zhan-Qing Yang, Yu-Si Wang, Bin Guo
Summary: TAZ plays an important role in anti-inflammation by preventing microglia from producing proinflammatory cytokines. It interacts with Nrf2 to enhance antioxidant capacity and inhibit mitochondrial dysfunction, leading to a reduction in oxidative stress and the inflammatory response. Nrf2 acts as a downstream target of TAZ to repress NF-kappa B activation and improve the microglia-mediated inflammatory response.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Neurosciences
Demao Cao, Bing Li, Cheng Cao, Juyi Zhang, Xiang Li, Haiying Li, Zhengquan Yu, Haitao Shen, Ming Ye
Summary: In this study, the researchers investigated the role and molecular mechanism of Caveolin-1 (CAV1) in brain injury using a rat autologous whole blood injection model and an in vitro model of intracerebral hemorrhage (ICH). The results showed that CAV1 overexpression worsened neurological dysfunction and cellular apoptosis in ICH rats, while CAV1 knockdown ameliorated these effects. Additionally, CAV1 overexpression aggravated neuroinflammation, while CAV1 knockdown inhibited microglia activation and neuroinflammatory response. The in vitro experiments also revealed the involvement of CAV1 in regulating the C-Src, IKK-beta, and NF-kappa B signaling pathways.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dhiraj Kumar Sah, Pham Ngoc Khoi, Shinan Li, Archana Arjunan, Jae-Uk Jeong, Young Do Jung
Summary: EGCG can inhibit the invasion ability of bladder cancer cells induced by IL-1β by suppressing the expression of uPAR through the inhibition of ERK1/2, JNK, AP-1, and NF-κB activities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Multidisciplinary
Jie Qu, Shuangshuang Zhang, Wenmiao He, Shuiping Liu, Xinru Mao, Liuwen Yin, Dongmei Yue, Ping Zhang, Kehe Huang, Xingxiang Chen
Summary: Deoxynivalenol (DON) is a contaminating mycotoxin that causes intestinal damage. The study found that DON exposure leads to oxidative stress, NLRP3 inflammasome activation, pyroptosis, and inflammation. The protein Cav-1 plays a pivotal role in DON-induced pyroptosis by regulating oxidative stress. These findings provide a novel strategy to counteract DON-induced enterotoxicity.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Geriatrics & Gerontology
H-C Hsu, Y-L Ke, Y-H Lai, W-C Hsieh, C-H Lin, S-S Huang, J-Y Peng, C-H Chen
Summary: In this study, it was demonstrated that chondroitin sulfate (CS) can induce the proliferation and migration of chondrocytes by activating beta-catenin and enhancing reactive oxygen species (ROS) production. Additionally, CS was found to increase chondrocyte activity and aid in restoring cartilage function in patients with osteoarthritis.
JOURNAL OF NUTRITION HEALTH & AGING
(2022)
Review
Biochemistry & Molecular Biology
Camila C. Portugal, Tiago O. Almeida, Renato Socodato, Joao B. Relvas
Summary: c-Src was the first protein kinase identified as phosphorylating tyrosine residues. Microglia, as the resident innate immune cells of the CNS, play essential roles in brain tissue homeostasis and are affected by SFK stimulation in conditions related to neurological diseases like Alzheimer's and Parkinson's.
Article
Biology
Eder Alves Barbosa, Alexandra Placido, Daniel C. Moreira, Lucas Albuquerque, Anderson Dematei, Amandda E. Silva-Carvalho, Wanessa F. Cabral, Sonia N. Bao, Felipe Saldanha-Araujo, Selma A. S. Kuckelhaus, Tatiana K. Borges, Camila C. Portugal, Renato Socodato, Catia Teixeira, Filipe Camargo D. A. Lima, Augusto Batagin-Neto, Antonio Sebben, Peter Eaton, Paula Gomes, Guilherme D. Brand, Joao B. Relvas, Massuo J. Kato, Jose Roberto S. A. Leite
Summary: Amphibians undergoing metamorphosis experience morphophysiological changes and environmental constraints when transitioning from water to land. Pithecopus azureus secretes a peptide named PaT-2 before terrestrial behavior onset, which belongs to the tryptophyllins family and exhibits antioxidant activity, as confirmed by cell-based assays.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Cell Biology
Joana Bravo, Ines Ribeiro, Ana Filipa Terceiro, Elva B. Andrade, Camila Cabral Portugal, Igor M. Lopes, Maria M. Azevedo, Mafalda Sousa, Catia D. F. Lopes, Andrea C. Lobo, Teresa Canedo, Joao Bettencourt Relvas, Teresa Summavielle
Summary: This study demonstrates the interaction between neurons and glial cells in the activation of microglia in response to methamphetamine. Neurons require astrocyte mediation to activate microglia, and they can partially prevent methamphetamine-induced microglia activation through increased expression of arginase 1 and strengthening of the CD200/CD200r pathway. Contact-dependent mechanisms between neurons and microglia attenuate pro-inflammatory events associated with methamphetamine-induced microglia activation.
Article
Biochemistry & Molecular Biology
Ana Bela Campos, Sara Duarte-Silva, Bruno Fernandes, Sofia Pereira das Neves, Fernanda Marques, Andreia Teixeira-Castro, Andreia Neves-Carvalho, Daniela Monteiro-Fernandes, Camila Cabral Portugal, Renato Socodato, Teresa Summavielle, Antonio Francisco Ambrosio, Joao Bettencourt Relvas, Patricia Maciel
Summary: Microglia in Machado-Joseph disease (MJD) show morphological alterations and disease-specific transcriptional profile, involving genes and pathways related to oxidative stress, immune response, cell proliferation, cell death, and lipid metabolism.
Article
Developmental Biology
Joana Paes de Faria, Raquel S. Vale-Silva, Reinhard Fassler, Hauke B. Werner, Joao B. Relvas
Summary: Pinch2 plays a crucial role in central nervous system myelination, preventing excessive myelin wrapping and promoting myelin stability. Loss of Pinch2 results in hypermyelination and pathological myelin outfoldings.
Article
Cell Biology
Pedro Melo, Renato Socodato, Mariana S. Silveira, Miguel Antonio Dias Neves, Joao Bettencourt Relvas, Ines Mendes Pinto
Summary: Microglia, the primary immune cells in the CNS, play a crucial role in maintaining tissue homeostasis by changing their morphology and producing inflammatory mediators. Recent studies have highlighted the importance of actin and myosin II in controlling microglial cell shape.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2022)
Article
Psychiatry
Renata L. Alves, Camila C. Portugal, Igor M. Lopes, Pedro Oliveira, Cecilia J. Alves, Fernando Barbosa, Teresa Summavielle, Ana Magalhaes
Summary: Research has revealed that depressive mothers may find it challenging to interact with their children. Maternal stress may worsen mother-child attachment, increasing the likelihood of negative developmental consequences.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
A. S. Salsinha, R. Socodato, A. Rodrigues, R. Vale-Silva, J. B. Relvas, M. Pintado, L. M. Rodriguez-Alcala
Summary: High-fat diet-induced obesity has negative effects on brain function by causing chronic low-grade inflammation, which is likely mediated by microglia, the primary immune cell population in the brain. Different fatty acids can modulate microglia activity, and fructose and palmitic acid together induce inflammation in human microglia. However, omega-3, conjugated linoleic acid (CLA), and conjugated linolenic acid (CLNA) have potential neuroprotective and antioxidant effects.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2023)
Article
Cell Biology
Renato Socodato, Artur Rodrigues-Santos, Joana Tedim-Moreira, Tiago O. Almeida, Teresa Canedo, Camila C. Portugal, Joao B. Relvas
Summary: Microglia, the largest myeloid cell population in the brain, play a crucial role in regulating the response and survival during inflammation. RhoA activity is essential for microglial metabolic reprogramming and their reaction to inflammation.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Renato Socodato, Tiago O. Almeida, Camila C. Portugal, Evelyn C. S. Santos, Joana Tedim-Moreira, Joao Galvao-Ferreira, Teresa Canedo, Filipa I. Baptista, Ana Magalhaes, Antonio F. Ambrosio, Cord Brakebusch, Boris Rubinstein, Irina S. Moreira, Teresa Summavielle, Ines Mendes Pinto, Joao B. Relvas
Summary: This study demonstrates that Rac1 in microglia is crucial for sensing and interpreting the brain microenvironment, as well as for the communication between microglia and synapses that drives experience-dependent plasticity and cognitive performance.
Meeting Abstract
Biochemistry & Molecular Biology
Camila Cabral Portugal, Ana Monteiro-Pacheco, Evelyn S. Santos, Teresa Canedo, Tiago O. Almeida, Joana Tedim Moreira, Fabiana Oliveira, Renato Socodato, Teresa Summavielle, Joao B. Relvas
JOURNAL OF NEUROCHEMISTRY
(2023)
