Article
Nutrition & Dietetics
Richard C. Baybutt, Joseph T. Standard, Daniel Dim, Tim Quinn, Hana Hamdan, Dingbo Lin, Kyle Kunz, Zachary S. Bomstein, Benjamin J. Estorge, Betty Herndon, Hamid Zia, Ahmad Mansour, Manesha Lankachandra, Agostino Molteni
Summary: The study aimed to evaluate the impact of replenishing vitamin A on bone thickness in vitamin A-deficient rats, with results showing that cod liver oil (COD) supplementation more effectively restored abnormal bone thickness in the rats compared to retinoic acid (RA) treatment.
Article
Chemistry, Medicinal
Laia Josa-Cullere, Katrina S. Madden, Thomas J. Cogswell, Thomas R. Jackson, Tom S. Carter, Douzi Zhang, Graham Trevitt, Stephen G. Davies, Paresh Vyas, Graham M. Wynne, Thomas A. Milne, Angela J. Russell
Summary: A novel compound, OXS007417, identified through a phenotypic high-throughput screen, shows promise in decreasing tumor volume in acute myeloid leukemia.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Andrew G. Woodman, Richard L. Mah, Samantha Kinney, Claudia D. Holody, Alyssa R. Wiedemeyer, Ronan M. N. Noble, Robin D. Clugston, Stephane L. Bourque
Summary: Perinatal iron deficiency alters renal vitamin A metabolism in a sex-dependent manner, resulting in reduced nephron endowment in male offspring. Male offspring exhibit enhanced retinoic acid pathway signaling components, while females show unchanged or decreased expression. These findings highlight the importance of vitamin A in kidney development and the potential long-term effects of perinatal iron deficiency.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Maryam Honarbakhsh, Aaron Ericsson, Guo Zhong, Nina Isoherranen, Chengsheng Zhu, Yana Bromberg, Charlene Van Buiten, Kiana Malta, Laurie Joseph, Harini Sampath, Atreju Lackey, Judith Storch, Costantino Vetriani, Michael L. Chikindas, Paul Breslin, Loredana Quadro
Summary: The deficiency of lecithin:retinol acyltransferase and retinol-binding protein in mice leads to intestinal vitamin A deficiency, compromising gut morphology, barrier function, and microbial composition.
JOURNAL OF LIPID RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Q. Dai, S. Sun, A. Jin, X. Gong, H. Xu, Y. Yang, X. Huang, X. Wang, Y. Liu, J. Gao, X. Gao, J. Liu, Q. Bian, Y. Wu, L. Jiang
Summary: Retinoid signaling disorders cause craniofacial deformity. Conditional expression of dominant-negative RAR alpha mutation in mice mimicked VAD craniofacial defects and confirmed abnormalities in craniofacial bones. Inhibition of RAR in osteoblasts impaired bone formation and bone resorption.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Mei Tan, Ting Yang, Huan Liu, Lu Xiao, Cheng Li, Jiang Zhu, Jie Chen, Tingyu Li
Summary: Maternal vitamin A deficiency during pregnancy can lead to significant reductions in cholinergic and nitrergic enteric neurons density in the colon of rat offspring, resulting in gastrointestinal dysfunction. Interestingly, maternal vitamin A supplementation during pregnancy can rescue these changes. In vitro experiments showed that retinoic acid exposure promoted the differentiation of enteric neurospheres into cholinergic and nitrergic neurons, possibly through upregulating RAR beta expression and enhancing SOX10 expression.
Review
Nutrition & Dietetics
Xiangrong Guo, Hui Wang, Jian Xu, Hui Hua
Summary: Vitamin A is crucial for brain function and has important roles in vision, immunity, and reproduction. Previous research has shown that retinoic acid, the active form of vitamin A, plays a role in regulating biological rhythms. However, limited evidence exists regarding the impact of vitamin A deficiency on biological rhythms, with most studies conducted on animals. This review explores the physiological functions of biological rhythms, the pathways/mechanisms involved in regulating these rhythms, and the associations between vitamin A deficiency and biological rhythm disorders/diseases.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Marta Melis, Xiao-Han Tang, Nabeel Attarwala, Qiuying Chen, Carlos Prishker, Lihui Qin, Steven S. Gross, Lorraine J. Gudas, Steven E. Trasino
Summary: The study showed that the use of the retinoic acid receptor agonist AC261 could reduce the severity of alcohol liver disease (ALD) and decrease liver damage. Although AC261 did not prevent alcohol-induced hepatic retinoid depletion, it was able to reduce the increase in serum retinol caused by alcohol. These findings suggest the potential of AC261 in preventing ALD.
Review
Immunology
Peiyue Luo, Liying Zheng, Junrong Zou, Tao Chen, Jun Zou, Wei Li, Qi Chen, Biao Qian
Summary: Recent research has found that bladder cancer patients have reduced serum vitamin A levels and an imbalance of gut microbiota, indicating a complex regulatory mechanism between the two in the development and occurrence of bladder cancer. Further exploration of their interaction may guide the use of vitamin A for preventive purposes.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Meng Li, Yonggang Huang, Huimin Jin, Daixiu Yuan, Ke Huang, Jing Wang, Bie Tan, Yulong Yin
Summary: Vitamin A and its metabolite retinoic acid have important regulatory effects on intestinal mucosal immunity and enteric nervous system function. This study found that vitamin A can protect the gut barrier, reduce diarrhea incidence, and alleviate enteric gliosis, immune cell infiltration, and inflammatory responses induced by CPT-11.
Article
Nutrition & Dietetics
Yaqi Li, Cheng-Hsin Wei, J. Kalina Hodges, Michael H. Green, A. Catharine Ross
Summary: The study investigated the unique effect of retinoic acid (RA) on intestinal vitamin A (VA) kinetics by administering an RA dose before VA supplementation. The results showed that RA pretreatment could stimulate the influx of supplemental VA into the intestine, leading to increased VA accumulation in neonatal rats' intestines.
Article
Biochemistry & Molecular Biology
Anais Marie, Remi Kinet, Jean-Christophe Helbling, Morgane Darricau, Serge Alfos, Mathieu Di Miceli, Maria-Florencia Angelo, Aline Foury, Emmanuel Richard, Pierre Trifilieff, Nicolas P. Mallet, Clementine Bosch-Bouju
Summary: This study investigated the impact of vitamin A supply on striatal function and found that adult rats with vitamin A deficiency exhibited altered cholinergic synthesis and mu-opioid receptor expression in the striatum. This deficiency also resulted in subtle alterations in fine motor skills.
Article
Biochemistry & Molecular Biology
Anais Marie, Remi Kinet, Jean-Christophe Helbling, Morgane Darricau, Serge Alfos, Mathieu Di Miceli, Maria-Florencia Angelo, Aline Foury, Emmanuel Richard, Pierre Trifilieff, Nicolas P. Mallet, Clementine Bosch-Bouju
Summary: This study investigates the impact of vitamin A supply on striatal function. The results show that sub-deficiency of vitamin A in adult rats leads to impaired fine motor skills and significantly affects acetylcholine synthesis and μ-opioid receptor expression in the striatum.
Review
Pharmacology & Pharmacy
Noriko Takahashi, Daisuke Saito, Shinya Hasegawa, Masahiro Yamasaki, Masahiko Imai
Summary: This paper introduces the circulation of vitamin A in the body, the actions and mechanisms of retinal and RA, retinoylation as an RA mechanism independent of RA receptors, the relationship between cancer and the actions of retinol or beta-carotene, and the anti-cancer actions of vitamin A derivatives derived from fenretinide. The study suggests that nutritional management of vitamin A is effective in cancer prevention.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Agriculture, Dairy & Animal Science
Pengkang Song, Xiaoyou Chen, Jiamin Zhao, Qiang Li, Xinrui Li, Yu Wang, Bo Wang, Junxing Zhao
Summary: This study investigates the effects of early intramuscular vitamin A injection on the muscle growth of lambs. The results suggest that vitamin A treatment accelerates lamb growth and increases loin eye area.
Article
Anatomy & Morphology
Laura Ariza, Ana Canete, Anabel Rojas, Ramon Munoz-Chapuli, Rita Carmona
DEVELOPMENTAL DYNAMICS
(2018)
Review
Cardiac & Cardiovascular Systems
Rita Carmona, Laura Ariza, Ana Canete, Ramon Munoz-Chapuli
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2018)
Review
Cell Biology
Rita Carmona, Laura Ariza, Elena Cano, Manuel Jimenez-Navarro, Ramon Munoz-Chapuli
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2019)
Article
Genetics & Heredity
Laura Ariza, Anabel Rojas, Ramon Munoz-Chapuli, Rita Carmona
Article
Cell Biology
Rita Carmona, Sandra Diaz del Moral, Silvia Barrena, Ramon Munoz-Chapuli
Review
Peripheral Vascular Disease
Sandra Diaz del Moral, Silvia Barrena, Ramon Munoz-Chapuli, Rita Carmona
Review
Biochemistry & Molecular Biology
Sandra Diaz del Moral, Maha Benaouicha, Ramon Munoz-Chapuli, Rita Carmona
Summary: The translation introduces the importance of insulin and insulin-like growth factors during embryonic development and their role in cardiac development and cardiomyocyte proliferation. The study also discusses the clinical potential of utilizing the IGF signaling pathway for adult cardiac repair and regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Noelia Arroyo, Laura Villamayor, Irene Diaz, Rita Carmona, Mireia Ramos-Rodriguez, Ramon Munoz-Chapuli, Lorenzo Pasquali, Miguel G. Toscano, Franz Martin, David A. Cano, Anabel Rojas
Summary: GATA4 plays a crucial role in the deactivation and activation of hepatic stellate cells, and therefore in liver fibrosis. Inducing deactivation of hepatic stellate cells, GATA4 may serve as a promising therapeutic target for liver fibrosis.
Article
Cardiac & Cardiovascular Systems
Sandra Diaz del Moral, Maha Benaouicha, Cristina Villa del Campo, Miguel Torres, Nicole Wagner, Kay-Dietrich Wagner, Ramon Munoz-Chapuli, Rita Carmona
Summary: The Wilms tumor suppressor gene (Wt1) encodes a C2H2-type zinc-finger transcription factor involved in various cellular processes. It has a crucial role in the development of multiple organs. Silencing or deletion of Wt1 in cardiomyocytes leads to abnormal cardiac development and increased susceptibility to damage. These findings suggest that WT1 plays a novel role in cardiac physiology and protection against damage.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Review
Developmental Biology
Rita Carmona, Silvia Barrena, Ramon Munoz-Chapuli
JOURNAL OF DEVELOPMENTAL BIOLOGY
(2019)