Review
Immunology
Olga Sierawska, Paulina Niedzwiedzka-Rystwej
Summary: It is increasingly believed that diabetes in cats may belong to both metabolic and autoimmune diseases due to the involvement of the immune system and secretion of adipokines. Risk factors include age, sex, breed, obesity, and insulin resistance. Diagnosis of diabetes in cats is more complicated than in humans.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Lulu Wang, Xue Liu, Jian Hou, Dandan Wei, Pengling Liu, Keliang Fan, Li Zhang, Luting Nie, Xing Li, Wenqian Huo, Tao Jing, Wenjie Li, Chongjian Wang, Zhenxing Mao
Summary: This study found a negative correlation between serum vitamin D and impaired fasting glucose (IFG) and type 2 diabetes mellitus (T2DM), as well as a negative correlation between serum 25(OH)D-2 and total 25(OH)D levels. The lipid profile, specifically total cholesterol (TC) and triglyceride (TG), partially mediated the relationship between vitamin D and IFG or T2DM. Additionally, there were interactive effects of serum 25(OH)D-2, total 25(OH)D, and testosterone on T2DM in females.
Review
Biochemistry & Molecular Biology
Carmen Purdel, Anca Ungurianu, Denisa Margina
Summary: Dietary factors, such as omega-3 polyunsaturated fatty acids, have been found to influence Type 1 diabetes mellitus. Understanding the role of omega-3 PUFAs in the development and progression of T1DM can help improve clinical management.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Food Science & Technology
Xiaxia Cai, Qinyu Dang, Lan Liu, Zhihong Ma, Xiaoyan Zhao, Mingyuan Zhang, Zhuoran Xiao, Aliya Yijiati, Leilei Ren, Huanling Yu
Summary: This study aimed to evaluate the effects of oat nutritious meal (ONM) on blood glucose and lipid metabolism in elderly patients with type 2 diabetes mellitus (T2DM). The results showed that ONM significantly reduced total cholesterol and low-density lipoprotein cholesterol levels, but had no effect on glucose metabolism in elderly patients.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Food Science & Technology
Hao Yue, Wei Liu, Wenlong Zhang, Min Jia, Fenghong Huang, Fangling Du, Tongcheng Xu
Summary: Lower ratios of n-6/n-3 PUFA diets were found to improve symptoms associated with T2DM by increasing BAT mass, lowering blood glucose and lipid levels, and enhancing glucose tolerance. Further investigations revealed that these diets could activate BAT and improve lipid and glucose metabolism in T2DM mice.
JOURNAL OF FOOD SCIENCE
(2021)
Article
Medicine, Research & Experimental
Zhiqi Zhao, Yizhang Chen, Xiaoqiong Li, Liying Zhu, Xin Wang, Li Li, Haibiao Sun, Xiaoqiang Han, Jinjun Li
Summary: In this study, myricetin was found to alleviate symptoms of type 2 diabetes, increase SOD levels, and regulate the intestinal flora in mice with type 2 diabetes.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Sanjeela R. Guru, Suchetha Aghanashini
Summary: This study compared and correlated salivary and serum levels of PAI-1 and α2MG in patients with periodontitis with and without T2DM, and assessed the impact of periodontal treatment on these biomarkers. The results showed that levels of salivary and serum PAI-1 and α2MG were higher in patients with periodontitis and diabetes compared to periodontitis alone, and these biomarkers decreased after periodontal treatment. The study suggests that salivary PAI-1 could be a diagnostic biomarker and can track the response to periodontal therapy.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Medicine, General & Internal
Yi-Wei Lee, Ting-Teng Yang, Yan-Yu Lin, Yu-Shan Hsieh
Summary: This study aimed to explore the relationship between elevated thyroid hormone levels and lipid profile in insulin resistance in patients with type 2 diabetes mellitus (T2DM) with hyperthyroidism. The results showed that elevated thyroid hormone levels were positively correlated with insulin resistance and triglyceride levels. Additionally, decreased high-density lipoprotein levels were associated with insulin resistance. In conclusion, elevated thyroid hormone levels due to hyperthyroidism may alter the lipid profile and insulin resistance in patients with T2DM.
Review
Biochemistry & Molecular Biology
Jinjoo Lee, Seungjin Noh, Suhyun Lim, Bonglee Kim
Summary: Type 2 diabetes mellitus is a major global public health issue, with plant extracts being a potential therapeutic agent due to their antidiabetic effects and fewer side effects. These extracts regulate blood glucose, possess anti-inflammatory and antioxidant properties, and can alleviate complications caused by insulin resistance through various pathways.
Article
Immunology
Hui Wang, Kangli Cao, Siyu Liu, Yuanhong Xu, Ling Tang
Summary: The study found that the frequency and absolute number of NK cells in patients with type 2 diabetes mellitus were significantly lower than in healthy individuals. The expression of surface receptors and cytokine production in NK cells were affected in patients, and correlated with high blood glucose levels.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Mingyue Xu, Ruiying Feng, Ruoqi Feng, Xiaofei Yin, Lei Zhang, Chuan Wang, Jinbo Liu
Summary: This study aimed to investigate the relationship between Ism-1 levels and glomerular filtration rate (GFR) in patients with type 2 diabetes mellitus (T2DM). The results showed that serum Ism-1 levels were inversely correlated with GFR, and high levels of Ism-1 may serve as a potential biomarker for predicting kidney function impairment in patients with T2DM.
BMJ OPEN DIABETES RESEARCH & CARE
(2023)
Review
Biochemistry & Molecular Biology
Michalis Michailidis, Despina Moraitou, Despina A. Tata, Kallirhoe Kalinderi, Theodora Papamitsou, Vasileios Papaliagkas
Summary: This review article discusses the shared pathophysiological connections between Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM), emphasizing the role of insulin in the brain and the mechanistic interplay between the two diseases. The findings highlight the need for routine evaluation and treatment of cognitive impairment in T2DM patients and the evaluation of insulin levels or T2DM in AD patients. The hypothesis of AD as a type 3 diabetes is strongly supported.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Opeyemi Soremekun, Ville Karhunen, Yiyan He, Skanda Rajasundaram, Bowen Liu, Apostolos Gkatzionis, Chisom Soremekun, Brenda Udosen, Hanan Musa, Sarah Silva, Christopher Kintu, Richard Mayanja, Mariam Nakabuye, Tafadzwa Machipisa, Amy Mason, Marijana Vujkovic, Verena Zuber, Mahmoud Soliman, Joseph Mugisha, Oyekanmi Nash, Pontiano Kaleebu, Moffat Nyirenda, Tinashe Chikowore, Dorothea Nitsch, Stephen Burgess, Dipender Gill, Segun Fatumo
Summary: This study used Mendelian Randomization to investigate the causal effect of lipid traits on the susceptibility to type 2 diabetes mellitus (T2DM) in individuals of African ancestry. The results showed that increased levels of low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) were associated with increased T2DM liability, while increased levels of high-density lipoprotein cholesterol (HDL-C) were associated with reduced T2DM liability. The study also found that inhibition of 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR), a lipid-lowering drug target, was associated with increased T2DM liability.
Article
Multidisciplinary Sciences
Dyah Purnamasari, Cindya Klarisa Simanjuntak, Christian Tricaesario, Dicky Levenus Tahapary, Dante Saksono Harbuwono, Em Yunir
Summary: This study aimed to compare the adipokine profiles between first-degree relatives (FDR) of type 2 diabetes and non-FDR. The results showed that non-obese FDR had a higher L/A ratio, and the FDR status was significantly associated with adiponectin level. This suggests that FDR status may contribute to the development of adipokine dysregulation before obesity occurs.
Article
Endocrinology & Metabolism
Annika Vestergaard Kvist, Mohamad I. Nasser, Peter Vestergaard, Morten Frost, Andrea M. Burden
Summary: A study in Denmark from 1997 to 2017 found that the incidence rates of fractures were higher in patients with type 1 and type 2 diabetes compared to those without diabetes, except for foot fractures. The incidence of hip fractures decreased by 35.2%, 47.0%, and 23.4% in patients with type 1 diabetes, type 2 diabetes, and without diabetes, respectively, over the last 5 years. However, vertebral fractures increased by 14.8%, 18.5%, and 38.9% in the same groups. After age adjustment, patients with type 1 diabetes still had a higher risk of fractures compared to those without diabetes, while patients with type 2 diabetes had a risk similar to those without diabetes.
Article
Biochemistry & Molecular Biology
Medhavi Ranatunga, Rajeev Rai, Simon C. W. Richardson, Paul Dyer, Laurence Harbige, Andrew Deacon, Lauren Pecorino, Giulia T. M. Getti
Article
Endocrinology & Metabolism
Laura E. Gutierrez-Pliego, Beatriz E. Martinez-Carrillo, Aldo A. Resendiz-Albor, Roxana Valdes-Ramos
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2020)
Article
Endocrinology & Metabolism
Elias Cardoso-Pena, Alexandra E. Soto Pina, Angel Gomez Villanueva, Gerardo Emilio Lopez Chavez, Pablo Ramirez Martinez, Humberto Ramirez Montoya, Maria Guadalupe Berumen Lechuga, Alejandra Donaji Benitez Arciniega, Maria de Lourdes Alarcon Fortepiani, Roxana Valdes Ramos, Jose de Jesus Garduno Garcia
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Leila Khalili, Roxana Valdes-Ramos, Laurence S. Harbige
Summary: The meta-analysis showed that n-3 supplementation significantly improves glycemic factors and lipid profile in patients with type 2 diabetes mellitus (T2DM), but does not have a significant impact on weight and BMI.
Article
Biochemistry & Molecular Biology
Lutfiye Karcioglu Batur, Ahmet Ozaydin, Murat Emrah Mavis, Gokce Goksu Gursu, Laurence Harbige, Nezih Hekim
Summary: The study investigated the impact of rs7041 and rs4588 polymorphisms in the GC gene on vitamin D parameters, with the most common genotypes of GT and AC found in Turkish individuals. This variation in genotypes may be linked to differences in free and bioavailable 25(OH)D levels.
Article
Food Science & Technology
Beatriz Elina Martinez-Carrillo, Talia Mondragon-Velasquez, Ninfa Ramirez-Duran, Jose Felix Aguirre-Garrido, Roxana Valdes-Ramos, Ana Laura Guadarrama-Lopez, Arturo Castillo-Cardiel
Summary: This study investigated the effects of different fatty acids on metabolic regulation and microbiota composition. EPA/DHA from microalgae improved systemic inflammatory status but reduced small intestine microbiota diversity. Coconut oil had unfavorable effects on hormonal and lipid profiles.
INTERNATIONAL JOURNAL OF FOOD SCIENCE
(2022)
Review
Nutrition & Dietetics
Mariana Roman-Casas, Roxana Valdes Ramos, Beatriz E. Martinez-Carrillo, Laura S. Gaona Valle, Itzelt Perez Malpica
Summary: Vitamin D supplementation may help improve glycemic control, insulin secretion, oxidative stress, and antioxidant markers in patients with type 2 diabetes mellitus.
CURRENT NUTRITION & FOOD SCIENCE
(2022)
Review
Nutrition & Dietetics
Abril Sanchez-Rosales, Ana L. Guadarrama-Lopez, Laura S. Gaona-Valle, Beatriz E. Martinez-Carrillo, Roxana Valdes-Ramos
Summary: The presence of chronic low-grade inflammation is associated with the development of type 2 diabetes mellitus, and certain dietary patterns have been found to have favorable effects on inflammatory biomarkers. This systematic review and meta-analysis indicates that adherence to healthy dietary patterns is associated with reduced levels of C-reactive protein and increased levels of adiponectin, suggesting a reduction in inflammation.
Review
Biochemistry & Molecular Biology
Michael A. Crawford, Andrew J. Sinclair, Barbara Hall, Enitan Ogundipe, Yiqun Wang, Dimitrios Bitsanis, Ovrang B. Djahanbakhch, Laurence Harbige, Kebreab Ghebremeskel, Ivan Golfetto, Therishnee Moodley, Ahmed Hassam, Anniebelle Sassine, Mark R. Johnson
Summary: This review discusses the role of arachidonic acid (ArA) in foetal and early growth and development. ArA is a principal component in the membrane lipids of various fetal cells and the placenta, and it has been shown to relax foetal mesenteric arteries. However, despite its importance, the recommendation to include ArA in infant formula was rejected by the European Food Standard Agency in 2014. Urgent re-evaluation of the importance of ArA in reproductive biology is needed.
PROGRESS IN LIPID RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Yizel Becerril Alarcon, Fernando Bastida Gonzalez, Isidro Roberto Camacho Beiza, Eduardo Davila Gonzalez, Jose Alfonso Cruz Ramos, Alejandra Donaji Benitez Arciniega, Roxana Valdes Ramos, Alexandra Estela Soto Pina
Summary: There is an association between breast cancer and cardiometabolic diseases, and GST variants may serve as emerging biomarkers to differentiate breast cancer cases with cardiometabolic disease factors.
Meeting Abstract
Endocrinology & Metabolism
A. D. Benitez-Arciniega, R. Valdes-Ramos, A. Zambrano-Moreno, C. L. Ceballos-Juarez, R. Escobar-Gonzalez, I. Vizcarra-Bordi
ANNALS OF NUTRITION AND METABOLISM
(2020)
Meeting Abstract
Nutrition & Dietetics
Roxana Valdes-Ramos, Beatriz Elina Martinez-Carrillo, Laura Elisa Gutierrez-Pliego, Jorge Alberto Escoto-Herrera, Talia Mondragon-Velazquez
PROCEEDINGS OF THE NUTRITION SOCIETY
(2020)
Meeting Abstract
Nutrition & Dietetics
Alejandra Donaji Benitez-Arciniega, Ivonne Vizcarra-Bordi, Roxana Valdes-Ramos, Leidi Rocio Mercado-Garcia, Carmen Liliana Ceballos-Juarez, Raquel Escobar-Gonzalez, Jaqueline Hernandez-Ramirez
PROCEEDINGS OF THE NUTRITION SOCIETY
(2020)
Article
Psychology, Developmental
Constantino Flores-Resendiz, Alexandra E. Soto-Pina, Roxana Valdes-Ramos, Alejandra D. Benitez-Arciniega, Patricia Tlatempa-Sotelo, Ana Laura Guadarrama-Lopez, Beatriz E. Martinez-Carrillo, Caroline C. Pulido-Alvarado
JOURNAL OF PEDIATRIC PSYCHOLOGY
(2019)