Article
Engineering, Chemical
Angelica Perez Calvo, Nelson Paz Ruiz, Zuly Delgado Espinoza
Summary: This research aims to design an energy bar based on coffee pulp and other components to mitigate the environmental impact of coffee production. The study includes determining the study area, studying the nutritional and physical characteristics of the energy bar, defining the requirements and specifications, documenting the process diagram and variables, and conducting experiments to determine optimal mixing proportions.
Article
Multidisciplinary Sciences
Dominic Kaddu-Mulindwa, Marius von Martial, Angela Thiel-Bodenstaff, Vadim Lesan, Sebastian Ewen, Felix Mahfoud, Frank Lammert, Marcin Krawczyk
Summary: This study tested the feasibility and utility of transient elastography in the emergency department, and investigated its ability to predict hospitalization duration and costs for non-elective patients. The study found that transient elastography can help identify patients in need of increased healthcare resources.
Article
Radiology, Nuclear Medicine & Medical Imaging
Uday Kumar Marri, Prasenjit Das, Shalimar, Mani Kalaivani, Deep Narayan Srivastava, Kumble Seetharama Madhusudhan
Summary: The study demonstrated a strong correlation between the normalized iodine concentration of the liver at 5-minute delayed dual-energy CT and histologic stages of liver fibrosis, indicating good diagnostic performance in estimating liver fibrosis.
Article
Multidisciplinary Sciences
Dieter Broering, Mohamed Shawkat, Ali Albenmousa, Faisal Abaalkhail, Saleh Alabbad, Waleed Al-Hamoudi, Saad Alghamdi, Saleh Alqahthani, Ahmad Jaafari, Roberto Troisi, Khalid Bzeizi
Summary: This study found that CAP has high sensitivity and negative predictive values for the diagnosis of HS in living liver donors, making it a good screening test to exclude significant HS.
Article
Food Science & Technology
Agata Nolasco, Jonathan Squillante, Francesco Esposito, Salvatore Velotto, Raffaele Romano, Maria Aponte, Antonella Giarra, Maria Toscanesi, Emma Montella, Teresa Cirillo
Summary: The coffee supply chain generates a large amount of waste, including coffee silverskin (CS), which has potential as a food ingredient. This study assessed the presence of contaminants in CS and the associated risks. The results showed that CS had a low presence of contaminants and did not pose a risk for consumption. This supports the safe use of CS in functional foods.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ilias Gatos, Spyros Yarmenitis, Ioannis Theotokas, John Koskinas, Emmanuel Manesis, Spyros P. Zoumpoulis, Pavlos S. Zoumpoulis
Summary: This study evaluates the performance of a recently introduced commercial alternative of ultrasound elastography (USE) called Visual Transient Elastography (ViTE) for the diagnosis of chronic liver disease (CLD). The results show that ViTE performs comparably to established USE methods in staging CLD.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Kento Imajo, Yasushi Honda, Takashi Kobayashi, Koki Nagai, Anna Ozaki, Michihiro Iwaki, Takaomi Kessoku, Yuji Ogawa, Hirokazu Takahashi, Yusuke Saigusa, Masato Yoneda, Hiroyuki Kirikoshi, Daisuke Utsunomiya, Shinichi Aishima, Satoru Saito, Atsushi Nakajima
Summary: MRE, VCTE, and 2D-SWE all demonstrated excellent diagnostic accuracy in detecting liver fibrosis in patients with NAFLD. MRE showed the highest diagnostic accuracy for stage 4 detection and intra- and inter-observer reproducibility.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Medicine, General & Internal
Audrey Kovatsch, Hanna Honcharova-Biletska, Daniel Segna, Klaus Steigmiller, Sena Bluemel, Rudolf A. Deibel, Tobias Kuehlewindt, Georg Leinenkugel, Sandra Mueller, Eva Furrer, Khoschy Schawkat, Caecilia S. Reiner, Achim Weber, Beat Muellhaupt, Michael Scharl, Christoph Gubler, Christoph Juengst
Summary: This study evaluated the diagnostic accuracy of 2D-SWE assessed by the Canon Aplio i800 ultrasound system in liver fibrosis and compared it with traditional liver histology and transient elastography (TE). The results showed that 2D-SWE had good to excellent performance in diagnosing significant fibrosis, severe fibrosis, and cirrhosis, and its accuracy was comparable to TE. Therefore, the 2D-SWE system has a promising potential in the diagnostic workup of chronic liver disease.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Medicine, General & Internal
Piotr Nehring, Jowita Szeligowska, Adam Przybylkowski
Summary: The staging of liver fibrosis is crucial in Wilson's disease for prognosis and treatment. While histopathological examination is the standard method for fibrosis assessment, non-invasive techniques such as transient elastography and shear wave elastography are considered reliable and repetitive alternatives to liver biopsy. This article provides an overview of available elastography techniques and recent studies on liver elastography in Wilson's disease.
Article
Medicine, General & Internal
Jon Nielsen, Mette Skalshoi Kjaer, Allan Rasmussen, Deepthi Chiranth, Gro Linno Willemoe, Birthe Merete Henriksen, Lotte Borgwardt, Mia Klinten Grand, Lise Borgwardt, Vibeke Brix Christensen
Summary: USe, TE and MRe have good discriminatory ability for assessing advanced liver fibrosis in pediatric liver disease, with TE and MRe performing best. For most children, TE is a reliable and easily applicable measure.
Article
Gastroenterology & Hepatology
Anca Trifan, Cristina-Maria Muzica, Robert Nastasa, Sebastian Zenovia, Ermina Stratina, Remus Stafie, Adrian Rotaru, Ana-Maria Singeap, Camelia Cojocariu, Catalin Sfarti, Irina Girleanu, Stefan Chiriac, Tudor Cuciureanu, Laura Huiban, Carol Stanciu
Summary: Although liver cirrhosis is associated with high mortality, patients usually have a good quality of life in the compensated phase, and the disease may progress undiagnosed for many years. Vibration-controlled transient elastography with controlled attenuation parameter is a useful noninvasive tool to estimate the severity of fibrosis and steatosis. The study aimed to establish the prevalence of significant liver fibrosis diagnosed by vibration-controlled transient elastography in an apparently healthy population.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Gastroenterology & Hepatology
Davide Roccarina, Laura Iogna Prat, Giada Pallini, Marta Guerrero Misas, Elena Buzzetti, Francesca Saffioti, Francesco M. Arico, Anna Mantovani, Evangelia Koutli, Atul Goyale, Matteo Rosselli, Tu Vinh Luong, Massimo Pinzani, Emmanuel A. Tsochatzis
Summary: This study compared liver stiffness measurements between ElastPQ and F-TE in patients with NAFLD, showing excellent correlation between the two techniques, especially for lower LSM. ElastPQ demonstrated similar diagnostic accuracy to F-TE in staging liver fibrosis in patients with available liver histology.
LIVER INTERNATIONAL
(2022)
Review
Medicine, General & Internal
Ritesh Chimoriya, Milan K. Piya, David Simmons, Golo Ahlenstiel, Vincent Ho
Summary: Obesity is closely related to significant comorbidities, including non-alcoholic fatty liver disease, highlighting the importance of monitoring liver fibrosis. Developing non-invasive diagnostic methods for the rising prevalence of obesity and NAFLD is crucial. Two-dimensional shear wave elastography (2D-SWE) shows promise as a novel and non-invasive method for assessing liver fibrosis in patients with obesity and NAFLD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Letter
Gastroenterology & Hepatology
Donghee Kim, George Cholankeril, Rohit Loomba, Aijaz Ahmed
Summary: Accurate assessment and estimation of fatty liver disease and hepatic fibrosis are crucial in clinical practice. Studies have shown that the application of transient elastography and controlled attenuation parameter has improved the measurement accuracy of fatty liver disease and hepatic fibrosis.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Christophe Cassinotto, Tony Jacq, Sophie Anselme, Jose Ursic-Bedoya, Pierre Blanc, Stephanie Faure, Ali Belgour, Boris Guiu
Summary: This study compared the diagnostic performances of ultrasound machines from three different vendors in liver fat quantification. The results showed variations in the accuracy of attenuation coefficients among the vendors, with some devices demonstrating excellent diagnostic performance.
Article
Endocrinology & Metabolism
Kirthi Menon, Barbora de Courten, Danny Liew, Zanfina Ademi, Alice J. Owen, Dianna J. Magliano, Ella Zomer
Summary: The study estimated the potential productivity gains associated with the prevention of type 2 diabetes in Australia over the next 10 years, highlighting the significant impact of the disease on both economy and health. A mere 10% reduction in the incidence of type 2 diabetes could result in 2,510 PALYs and $532 million in GDP for Australia.
Article
Biochemistry & Molecular Biology
Monica D. Prakash, Sarah Fraser, Jennifer C. Boer, Magdalena Plebanski, Barbora de Courten, Vasso Apostolopoulos
Summary: Carnosine demonstrates potential anti-cancer properties by inhibiting cancer cell proliferation, upregulating expression of pro-inflammatory molecules, modulating cytokine secretion, and altering cell phenotype.
Editorial Material
Nutrition & Dietetics
Jack Feehan, Maximilian de Courten, Vasso Apostolopoulos, Barbora de Courten
Article
Medicine, General & Internal
Kirthi Menon, James D. Cameron, Maximilian de Courten, Barbora de Courten
Summary: This study aims to investigate whether carnosine supplementation can improve various health indicators in overweight and obese individuals through a double-blind randomized controlled trial, including obesity, glucose metabolism, cardiovascular risk factors, etc.
Article
Pharmacology & Pharmacy
Alemayehu Mekonnen, Bernice Redley, Kimberley Crawford, Stephanie Jones, Barbora de Courten, Elizabeth Manias
Summary: This study found that potentially inappropriate prescribing (PIP), including potentially inappropriate medication (PIM) use and potential prescribing omissions (PPO), were common among older adults at hospital discharge. Patients with PIM use had a higher risk of unplanned hospital readmission, emergency department presentation, and poor composite outcome at 3 months post-discharge. The number of PIMs was associated with increased dependency in activities of daily living (ADLs). Increased PIP use was also associated with higher mortality.
EXPERT OPINION ON DRUG SAFETY
(2022)
Article
Endocrinology & Metabolism
Aya Mousa, Kevin Huynh, Stacey J. Ellery, Boyd J. Strauss, Anju E. Joham, Barbora de Courten, Peter J. Meikle, Helena J. Teede
Summary: This study demonstrates that high levels of LPI(18:0) and low levels of DHA-containing lipids are associated with key metabolic risk factors in women with and without polycystic ovary syndrome (PCOS).
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Rohit Hariharan, Emmanuel Nene Odjidja, David Scott, Nitin Shivappa, James R. Hebert, Allison Hodge, Barbora de Courten
Summary: Research suggests that an unhealthy diet is associated with an increased risk of obesity, T2DM, and CVD, but there is limited research on the association between dietary inflammation and T2DM and its risk factors, as well as a lack of interventional studies designed to change the inflammatory potential of diets and study its effect on cardiometabolic risk factors and diseases. Interventions studies are recommended to assess whether changes in DII can independently modulate cardiometabolic risk factors and diseases.
Article
Nutrition & Dietetics
Allison M. Hodge, Md Nazmul Karim, James R. Hebert, Nitin Shivappa, Barbora de Courten
Summary: The study found that dietary inflammatory index and Alternative Healthy Eating Index-2010 were positively associated with diabetes incidence, while Mediterranean Diet Score was not. Mediation analysis indicated that body size played a moderate to large mediating role in the association between AHEI and DII and incident diabetes.
Article
Nutrition & Dietetics
Kirthi Menon, Barbora de Courten, Dianna J. Magliano, Zanfina Ademi, Danny Liew, Ella Zomer
Summary: This study assessed the cost-effectiveness of daily 1g carnosine supplementation in addition to standard care for the management of type 2 diabetes and compared it to standard care alone. The results showed that supplemental dietary carnosine may be a cost-effective treatment option for people with type 2 diabetes in Australia.
Article
Oncology
Saba Jalali, Zeinab Heidari, Barbora de Courten, Bahram Rashidkhani
Summary: This study investigated the association between dietary total antioxidant capacity (TAC) and breast cancer risk, and found no significant correlation between dietary antioxidant capacity and breast cancer.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Nutrition & Dietetics
Kaveh Naseri, Saeede Saadati, Zahra Yari, Behzad Askari, Davood Mafi, Pooria Hoseinian, Omid Asbaghi, Azita Hekmatdoost, Barbora de Courten
Summary: Curcumin offers no additional cardiometabolic benefits to patients with non-alcoholic fatty liver disease (NAFLD) undergoing lifestyle intervention.
Article
Endocrinology & Metabolism
Romana Stark, Jack Feehan, Aya Mousa, Zane B. B. Andrews, Barbora de Courten
Summary: This study identified an association between liver-expressed antimicrobial peptide 2 (LEAP2) levels and key cardiometabolic risk factors in individuals with overweight and obesity, including body fat, insulin secretion, and insulin resistance. LEAP2 may represent a potential therapeutic target to promote insulin secretion in individuals with type 2 diabetes and obesity.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Robel Hussen Kabthymer, Md Nazmul Karim, Allison M. Hodge, Barbora de Courten
Summary: This study aimed to assess the associations between total dietary fiber and fiber from different food sources (cereal, fruit, and vegetables) with the risk of diabetes. The results showed that intake of cereal fiber could reduce the risk of diabetes, while fruit and vegetable fiber had no significant effect. Specific recommendations regarding dietary fiber intake may be needed for the prevention of diabetes.
DIABETES OBESITY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Saeede Saadati, Kaveh Naseri, Omid Asbaghi, Mohsen Yousefi, Elnaz Golalipour, Barbora de Courten
Summary: Studies have shown that probiotics and synbiotics have beneficial effects on body weight and composition in adults, making them useful as add-ons to weight loss products and medications.
Article
Nutrition & Dietetics
Saeede Saadati, James Cameron, Kirthi Menon, Alexander Hodge, Zhong X. Lu, Maximilian de Courten, Jack Feehan, Barbora de Courten
Summary: This study investigated the effects of carnosine supplementation on cardiovascular and cardiometabolic risk factors in individuals with prediabetes and T2DM. The results showed that carnosine supplementation did not improve these risk factors.
