Article
Chemistry, Applied
Stephane Dubascoux, Janique Richoz Payot, Paul Sylvain, Marine Nicolas, Esther Campos Gimenez
Summary: The new method accurately quantifies vitamin B12 in human milk with high sensitivity and accuracy. It can be used for monitoring vitamin B12 in clinical studies and assessing infant intake in breastfeeding.
Article
Biology
Zuzanna Rzepka, Jakub Rok, Mateusz Maszczyk, Artur Beberok, Justyna Magdalena Hermanowicz, Dariusz Pawlak, Dorota Gryko, Dorota Wrzesniok
Summary: Vitamin B12 plays a crucial role in DNA synthesis for cell division, with deficiency particularly impacting rapidly dividing cells like glioblastoma cells. Antagonists of cobalamin have potential as anti-glioma agents, as shown by inducing cobalamin deficiency to inhibit glioblastoma cell growth and promote cell cycle arrest. This study suggests that cobalamin deprivation could be a promising therapeutic strategy for glioblastoma, with further exploration warranted.
Review
Pharmacology & Pharmacy
Ramyia Elangovan, Julien Baruteau
Summary: This review summarizes the complex metabolic pathway of Vitamin B12 deficiency, describes the causes of inherited and acquired Vitamin B12 deficiency, and highlights the differences in international practice regarding prescribing Vitamin B12 replacement therapy. Furthermore, the review discusses the evidence supporting novel modes of B12 replacement such as sublingual, intranasal, and subcutaneous routes, and compares them to intramuscular and oral routes in terms of patient compliance and cost-saving.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Applied
A. J. M. Santos, S. Khemiri, S. Simo, C. Prista, I. Sousa, A. Raymundo
Summary: Vitamins are essential organic compounds that are necessary for good health but cannot be synthesized by the human body. Vitamins B6 and B12 are hydrophilic vitamins that play vital roles in cellular operation, growth, and development. This review focuses on the important aspects of vitamins B6 and B12, including their roles, consequences of deficiency, food sources, and chromatographic techniques developed in the last two decades for their determination.
Article
Food Science & Technology
Sara Al-Musharaf, Ghadeer S. Aljuraiban, Lama Al-Ajllan, Noura Al-Khaldi, Esra'a A. Aljazairy, Syed Danish Hussain, Abdullah M. Alnaami, Shaun Sabico, Nasser Al-Daghri
Summary: This study found that the abundance and diversity of gut microbiota are associated with vitamin B12 levels and obesity in young females.
Review
Plant Sciences
Soojin Oh, Gareth Cave, Chungui Lu
Summary: Developing a resilient food supply is crucial in delivering necessary nutrients to consumers and addressing micronutrient deficiencies that can lead to severe health issues. Therefore, focus should be on enhancing minerals and nutrients in food through various methods to improve the sustainability of the food system.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Nutrition & Dietetics
Alessandra Vincenti, Laura Bertuzzo, Antonio Limitone, Giuseppe D'Antona, Hellas Cena
Summary: Vitamin B12 is essential and obtained exclusively from diet, with certain population groups at risk of subclinical deficiency. Poor intake of animal products and age-related decrease in intestinal B12 uptake contribute to the risk of deficiency in elderly population.
Article
Food Science & Technology
Giulia Rampazzo, Elisa Zironi, Giampiero Pagliuca, Teresa Gazzotti
Summary: The analysis of natural cobalamins in dairy products is challenging due to the complexity of the matrix, low concentration level, light sensitivity, and binding to proteins. This study developed a sensitive and selective method using UHPLC-MS/MS to quantitate vitamin B12 in ripened cheeses from different species, revealing species-dependent differences in vitamin B12 concentrations.
Article
Biochemistry & Molecular Biology
Olga M. Sokolovskaya, Tanja Plessl, Henry Bailey, Sabrina Mackinnon, Matthias R. Baumgartner, Wyatt W. Yue, D. Sean Froese, Michiko E. Taga
Summary: This study examined the impact of various cobamide cofactors on the function of MMUT and found differences in how they support the enzyme, as well as variations in the catalytic rescue of disease-associated MMUT variants. The findings challenge the sole focus on cobalamin in human physiology, suggesting that diverse cobamides can play a role in supporting human enzyme function.
Article
Biotechnology & Applied Microbiology
Alexandra Lukacova, Terezia Beck, Lenka Koptasikova, Ales Benda, Lucia Tomeckova, Miriam Trnikova, Diana Lihanova, Juergen Michael Steiner, Juraj Krajcovic, Matej Vesteg
Summary: Euglena gracilis, a freshwater protist, has various biotechnological applications and can be used for biofuel production, pharmaceuticals, and water remediation. However, its large-scale cultivation is limited by the high cost of adding vitamins B1 and B12 to the media. This study demonstrates that E. gracilis can be grown for long periods without the need for added vitamins B1 and B12 in a co-culture system involving the filamentous fungus Cladosporium westerdijkiae and the bacteria Lysinibacillus boronitolerans and Pseudobacillus badius. This finding significantly reduces the cultivation costs and the fungus C. westerdijkiae can be used for effective harvesting of E. gracilis through bioflocculation.
JOURNAL OF BIOTECHNOLOGY
(2022)
Review
Food Science & Technology
Linnea Barebring, Christel Lamberg-Allardt, Birna Thorisdottir, Alfons Ramel, Fredrik Soderlund, Erik Kristoffer Arnesen, Bright I. Nwaru, Jutta Dierkes, Agneta Akesson
Summary: This systematic review aimed to assess the evidence for whether habitual or different levels of experimental intake of vitamin B12 from diet and supplements is sufficient to ensure adequate B12 status in groups most susceptible to vitamin B12 deficiency. The search yielded 18 included studies, and the conclusion was that the evidence is currently insufficient to determine if or which level of B12 intake is sufficient to maintain adequate status for all included populations.
FOOD & NUTRITION RESEARCH
(2023)
Article
Agronomy
Hiromi Katsura, Kyohei Koseki, Tomohiro Bito, Shigeo Takenaka, Fumio Watanabe
Summary: The study found that various commercially available fermented poultry manure fertilizer products contained vitamin B-12, along with minor inactive cobamides, suggesting that edible plants can be enriched with vitamin B-12 using these organic fertilizer products.
Article
Andrology
Mevlut Keles, Abdullah Cirakoglu, Erdal Benli, Ibrahim Yazici, Nurullah Kadim, Hasan Durmus
Summary: This study aimed to investigate the correlation between serum vitamin B12 levels and erectile dysfunction (ED). The results showed no significant correlation between vitamin B12 levels and ED.
Article
Engineering, Chemical
Caroline Ceribeli, Jeanette Otte, Daniel Rodrigues Cardoso, Lilia Maria Ahrne
Summary: Cow's milk, with approximately 0.54μg of B12/100g of milk, is an important source of B12 in our diets. However, there is limited research on the thermal degradation of B12 in milk. This study investigated the kinetics of this degradation and found that it follows a first-order kinetic reaction. The results suggest that the milk matrix may protect B12 from thermal degradation.
JOURNAL OF FOOD ENGINEERING
(2023)
Article
Nutrition & Dietetics
Seongmin Choi, Jinmann Chon, Seung Ah Lee, Myung Chul Yoo, Sung Joon Chung, Ga Yang Shim, Yunsoo Soh, Chang Won Won
Summary: The long-term impact of B12 insufficiency on sarcopenia in older adults was investigated in this study. The results showed that in women, the group with B12 insufficiency had a significantly higher incidence of low SPPB scores and sarcopenia. However, there was no significant correlation between the B12 insufficiency group and sarcopenia or other parameters in men.
Article
Nutrition & Dietetics
Merryn J. Netting, Najma A. Moumin, Emma J. Knight, Rebecca K. Golley, Maria Makrides, Tim J. Green
Summary: The Australian Feeding Infants and Toddler Study 2021 provides insights into breastfeeding rates, duration, introduction of solid foods, and the use of breastmilk substitutes in Australian caregivers. The study found that while the initiation of breastfeeding was high, exclusive breastfeeding to six months was low. However, a significant percentage of children continued to receive breastmilk beyond one year. The study also found that a quarter of infants were introduced to solid foods between 4 to 5 months, and by 7 months, nearly all infants had received solid foods. Importantly, more than 90% of children had been given potential food allergens like eggs and peanuts by the age of 12 months. Additionally, one-third of children did not receive any breastmilk substitutes during their first year.
Article
Nutrition & Dietetics
Najma A. Moumin, Merryn J. Netting, Rebecca K. Golley, Chelsea E. Mauch, Maria Makrides, Tim J. Green
Summary: This study found that the majority of nutrients were sufficient in the diets of Australian infants and children, except for iron which was lacking in infants aged 6-11.9 months and toddlers aged 12-24 months. Excessive sodium intake among toddlers was also a concern.
Review
Nutrition & Dietetics
Jacqueline F. Gould, Robert A. Gibson, Tim J. Green, Maria Makrides
Summary: Depression is a common mood disorder associated with childbirth and may be influenced by vitamin D levels. The evidence from two randomized controlled trials on vitamin D supplementation for treating or preventing depressive symptoms in the perinatal period is inconclusive due to small sample sizes. Observational studies on vitamin D exposure and depression in the antenatal and postnatal periods have mixed findings and are limited by their study quality. More research is needed to draw firm conclusions.
Article
Oncology
Miroslava Ondicova, Rachelle E. Irwin, Sara-Jayne Thursby, Luke Hilman, Aoife Caffrey, Tony Cassidy, Marian McLaughlin, Diane J. Lees-Murdock, Mary Ward, Michelle Murphy, Yvonne Lamers, Kristina Pentieva, Helene McNulty, Colum P. Walsh
Summary: This study reveals clear alterations in DNA methylation at specific neurodevelopmental genes in children born to mothers who were supplemented with folic acid during pregnancy. These changes play an important role in transcriptional regulation and provide supporting evidence for continued folic acid supplementation throughout later gestation.
CLINICAL EPIGENETICS
(2022)
Article
Nutrition & Dietetics
Najma A. Moumin, Merryn J. Netting, Rebecca K. Golley, Chelsea E. Mauch, Maria Makrides, Tim J. Green
Summary: Most toddlers aged 1-2 years do not meet the recommended servings of the five food groups, except for fruit and dairy. Many toddlers consume discretionary foods, which may replace nutritious family foods. Breastfed toddlers consume fewer servings from the five food groups. There is a need for dietary modeling that includes breastmilk as the primary milk source and provides practical advice on incorporating breastmilk in a toddler's diet while optimizing food consumption.
Article
Nutrition & Dietetics
Harry Jarrett, Helene McNulty, Catherine F. Hughes, Kristina Pentieva, J. J. Strain, Adrian McCann, Liadhan McAnena, Conal Cunningham, Anne M. Molloy, Albert Flynn, Sinead M. Hopkins, Geraldine Horigan, Ciara O'Connor, Janette Walton, Breige A. McNulty, Michael J. Gibney, Yvonne Lamers, Mary Ward
Summary: The concentration of vitamin B-6 is lower in older adults, and riboflavin levels affect the status of vitamin B-6, especially in older individuals. The combination of the MTHFR 677TT genotype with riboflavin deficiency leads to a decrease in vitamin B-6 levels. Intake of vitamin B-6, supplement use, and EGRac are associated with PLP levels.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Pathology
Lulu X. Pei, Hou Kroeun, Crystal D. Karakochuk
Summary: This study investigated the potential of reticulocyte haemoglobin equivalent (RET-He) as an early marker of responsiveness to iron supplementation. The results showed that single timepoint RET-He measures had poor predictive ability, however, the change in RET-He after 1 week was a strong predictor of haemoglobin response among Cambodian women receiving 60 mg elemental iron.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Editorial Material
Nutrition & Dietetics
Yvonne Lamers
JOURNAL OF NUTRITION
(2022)
Editorial Material
Nutrition & Dietetics
Merryn J. Netting, Najma A. Moumin, Maria Makrides, Tim J. Green
Summary: The 2021 Australian Feeding Infants and Toddlers Study found that nearly half of the infants were exclusively breastfed to 4 months, and breastfeeding duration was long. Infants were introduced to complementary foods at the appropriate time. However, there was a mismatch between the dietary intake of toddlers and the recommended servings from each food group in the Australian Dietary Guidelines.
Review
Nutrition & Dietetics
Jordie A. J. Fischer, Arlin M. Cherian, Jeffrey N. Bone, Crystal D. Karakochuk
Summary: This study found that ferrous bisglycinate supplementation, compared to other iron supplements, can increase hemoglobin concentration and reduce gastrointestinal adverse events in pregnant women. However, there was no significant impact on hemoglobin and ferritin concentrations in children. More research is needed to evaluate the efficacy of ferrous bisglycinate compared to other iron supplements in other populations.
Article
Nutrition & Dietetics
Karen P. Best, Thomas R. Sullivan, Anoja W. Gunaratne, Jacqueline F. Gould, Robert A. Gibson, Carmel T. Collins, Maria Makrides, Tim J. Green
Summary: This study aimed to determine the effects of higher dose docosahexaenoic acid (DHA) supplementation on growth, body composition, and blood pressure of premature infants at 7 years old. The results showed no significant difference in these outcomes between the high-DHA and standard-DHA groups. However, the high-DHA group had a higher risk of obesity.
Correction
Nutrition & Dietetics
Najma A. A. Moumin, Merryn J. J. Netting, Rebecca K. K. Golley, Chelsea E. E. Mauch, Maria Makrides, Tim J. J. Green
Article
Nutrition & Dietetics
A. Caffrey, Y. Lamers, M. M. Murphy, N. Letourneau, R. E. Irwin, K. Pentieva, M. Ward, A. Tan, A. Rojas-Gomez, L. A. Santos-Calderon, J. Canals-Sans, B. M. Y. Leung, R. Bell, G. F. Giesbrecht, D. Dewey, C. J. Field, M. Kobor, C. P. Walsh, H. McNulty
Summary: The suboptimal status of folate and/or interrelated B vitamins can negatively impact brain development and function. Maternal folate status during pregnancy is associated with cognitive development in children, and optimal B vitamin status can help prevent cognitive dysfunction in later life. Understanding the epigenetic mechanisms related to folate and B vitamins is crucial for improving brain health at different stages of life.
NUTRITION BULLETIN
(2023)
Article
Nutrition & Dietetics
Najma A. Moumin, Jessica A. Grieger, Merryn J. Netting, Maria Makrides, Tim J. Green
Summary: Iron intake is low in Australian infants, especially in breastfed infants. Adding iron-fortified foods can improve iron intake in infants, while iron-fortified infant cereal can reduce the prevalence of iron inadequacy without significant impact on the intake of other nutrients.
JOURNAL OF NUTRITION
(2023)
Review
Nutrition & Dietetics
Kelsey M. Cochrane, Jeffrey N. Bone, Brock A. Williams, Crystal D. Karakochuk
Summary: This study aims to analyze the dose-response relationship of vitamin D supplementation among women with PCOS. The results indicate that while vitamin D supplementation is associated with benefit in PCOS patients, doses greater than 3000 IU/day may not provide significant advantage.
