Suppression of Wnt Signaling and Osteogenic Changes in Vascular Smooth Muscle Cells by Eicosapentaenoic Acid

Early initiation of eicosapentaenoic acid and statin treatment is associated with better clinical outcomes than statin alone in patients with acute coronary syndromes: 1-year outcomes of a randomized controlled study

(2017) Kazumasa Nosaka et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Eicosapentaenoic acid prevents arterial calcification in klotho mutant mice

(2017) Kazufumi Nakamura et al.   PLoS One

Wnt signaling contributes to vascular calcification by induction of matrix metalloproteinases

(2016) Christian Freise et al.   BMC Cardiovascular Disorders

Effects of the Addition of Eicosapentaenoic Acid to Strong Statin Therapy on Inflammatory Cytokines and Coronary Plaque Components Assessed by Integrated Backscatter Intravascular Ultrasound

(2016) Toshiyuki Niki et al.   CIRCULATION JOURNAL

DHA- and EPA-derived resolvins, protectins, and maresins in airway inflammation

(2016) Melody G. Duvall et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

WNT/β-catenin signaling promotes VSMCs to osteogenic transdifferentiation and calcification through directly modulating Runx2 gene expression

(2016) Ting Cai et al.   EXPERIMENTAL CELL RESEARCH

Cardiovascular Event Prediction and Risk Reclassification by Coronary, Aortic, and Valvular Calcification in the Framingham Heart Study

(2016) Udo Hoffmann et al.   Journal of the American Heart Association

Crosstalk between Wnt/β-Catenin and NF-κB Signaling Pathway during Inflammation

(2016) Bin Ma et al.   Frontiers in Immunology

Omega-3 Fatty Acids and Cancer Cell Cytotoxicity: Implications for Multi-Targeted Cancer Therapy

(2016) Donatella D’Eliseo et al.   Journal of Clinical Medicine

Membrane-bound Klotho is not expressed endogenously in healthy or uraemic human vascular tissue

(2015) Rik Mencke et al.   CARDIOVASCULAR RESEARCH

Wnt signaling in atherosclerosis

(2015) W. Matthijs Blankesteijn et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Lipoxins and aspirin-triggered lipoxins in resolution of inflammation

(2015) Mario Romano et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

High dose and long-term statin therapy accelerate coronary artery calcification

(2015) Michael Henein et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Eicosapentaenoic Acid Prevents Saturated Fatty Acid-Induced Vascular Endothelial Dysfunction: Involvement of Long-Chain Acyl-CoA Synthetase

(2015) Takayuki Ishida et al.   Journal of Atherosclerosis and Thrombosis

Differential expression and regulation of Klotho by paricalcitol in the kidney, parathyroid, and aorta of uremic rats

(2015) Cynthia S. Ritter et al.   KIDNEY INTERNATIONAL

Eicosapentaenoic acid upregulates VEGF-A through both GPR120 and PPARγ mediated pathways in 3T3-L1 adipocytes

(2015) Arif U. Hasan et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Complement C1q-induced activation of β-catenin signalling causes hypertensive arterial remodelling

(2015) Tomokazu Sumida et al.   Nature Communications

Long-chain omega-3 fatty acids and the brain: a review of the independent and shared effects of EPA, DPA and DHA

(2015) Simon C. Dyall   Frontiers in Aging Neuroscience

Stabilizing effect of combined eicosapentaenoic acid and statin therapy on coronary thin-cap fibroatheroma

(2014) Ryo Nishio et al.   ATHEROSCLEROSIS

Early eicosapentaenoic acid treatment after percutaneous coronary intervention reduces acute inflammatory responses and ventricular arrhythmias in patients with acute myocardial infarction: A randomized, controlled study

(2014) Masayuki Doi et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

EPA and DHA Exposure Alters the Inflammatory Response but not the Surface Expression of Toll-like Receptor 4 in Macrophages

(2014) Kaori L. Honda et al.   LIPIDS

Magnesium Inhibits Wnt/β-Catenin Activity and Reverses the Osteogenic Transformation of Vascular Smooth Muscle Cells

(2014) Addy Montes de Oca et al.   PLoS One

The ω-3 Polyunsaturated Fatty Acid, Eicosapentaenoic Acid, Attenuates Abdominal Aortic Aneurysm Development via Suppression of Tissue Remodeling

(2014) Jack H. Wang et al.   PLoS One

Fibrosis and renal aging

(2014) Hai-Chun Yang et al.   Kidney International Supplements

Spironolactone ameliorates PIT1-dependent vascular osteoinduction in klotho-hypomorphic mice

(2013) Jakob Voelkl et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss of Klotho Contributes to Kidney Injury by Derepression of Wnt/ -Catenin Signaling

(2013) L. Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Palmitic Acid Induces Osteoblastic Differentiation in Vascular Smooth Muscle Cells through ACSL3 and NF-κB, Novel Targets of Eicosapentaenoic Acid

(2013) Aiko Kageyama et al.   PLoS One

Arterial Klotho Expression and FGF23 Effects on Vascular Calcification and Function

(2013) Karolina Lindberg et al.   PLoS One

Omega-3 Eicosapentaenoic Acid Decreases CD133 Colon Cancer Stem-Like Cell Marker Expression While Increasing Sensitivity to Chemotherapy

(2013) Flavia De Carlo et al.   PLoS One

Vascular Klotho Deficiency Potentiates the Development of Human Artery Calcification and Mediates Resistance to Fibroblast Growth Factor 23

(2012) Kenneth Lim et al.   CIRCULATION

Progression of Vascular Calcification Is Increased With Statin Use in the Veterans Affairs Diabetes Trial (VADT)

(2012) A. Saremi et al.   DIABETES CARE

Omega-3-Polyunsaturated Fatty Acids Suppress Pancreatic Cancer Cell Growth in vitro and in vivo via Downregulation of Wnt/Beta-Catenin Signaling

(2012) Kyoung-Sub Song et al.   PANCREATOLOGY

Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation

(2011) Sungwhan F. Oh et al.   JOURNAL OF CLINICAL INVESTIGATION

Lower estimated glomerular filtration rate and higher albuminuria are associated with all-cause and cardiovascular mortality. A collaborative meta-analysis of high-risk population cohorts

(2011) Marije van der Velde et al.   KIDNEY INTERNATIONAL

Eicosapentaenoic acid reduces warfarin-induced arterial calcification in rats

(2010) Saeko Kanai et al.   ATHEROSCLEROSIS

Preventive Effects of Eicosapentaenoic Acid on Coronary Artery Disease in Patients With Peripheral Artery Disease

(2010) Yuichi Ishikawa et al.   CIRCULATION JOURNAL

Coronary Artery Calcium Score and Risk Classification for Coronary Heart Disease Prediction

(2010) Tamar S. Polonsky   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis

(2010)   LANCET

In vitro fatty acid enrichment of macrophages alters inflammatory response and net cholesterol accumulation

(2009) Shu Wang et al.   BRITISH JOURNAL OF NUTRITION

RANKL Increases Vascular Smooth Muscle Cell Calcification Through a RANK-BMP4–Dependent Pathway

(2009) Sara Panizo et al.   CIRCULATION RESEARCH

Klotho is a target gene of PPAR-γ

(2008) Hong Zhang et al.   KIDNEY INTERNATIONAL

Mechanisms of Vascular Calcification in Chronic Kidney Disease

(2007) S. M. Moe et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY