Article
Developmental Biology
Hannah L. Morgan, Arwa Aljumah, Charlene Rouillon, Adam J. Watkins
Summary: The study found that paternal low-protein diet can affect fetal weight and placental development, while supplementation with methyl-donors can alter placental morphology and gene expression. Understanding the impact of paternal diet and micronutrient supplementation on placental development is crucial for determining the connections to offspring health.
Article
Agriculture, Dairy & Animal Science
Wellison J. S. Diniz, Alison K. Ward, Kacie L. McCarthy, Cierrah J. Kassetas, Friederike Baumgaertner, Lawrence P. Reynolds, Pawel P. Borowicz, Kevin K. Sedivec, James D. Kirsch, Sheri T. Dorsam, Tammi L. Neville, J. Chris Forcherio, Ronald Scott, Joel S. Caton, Carl R. Dahlen
Summary: Maternal nutrient supply during the periconceptual period has long-term effects on fetal development and tissue function. Our study investigated the impacts of maternal vitamin and mineral supplementation and rate of body-weight gain during early pregnancy on fetal liver development and gene expression profiles. We found that maternal nutrition during the periconceptual period affects fetal hepatic function through altered expression of energy- and lipid-related genes.
Article
Biochemistry & Molecular Biology
Ana Paula Varela Sanches, Josilene Lopes de Oliveira, Maira Schuchter Ferreira, Bruna de Souza Lima, Josiane Erica Miyamoto, Lais Angelica de Paula Simino, Marcio Alberto Torsoni, Adriana Souza Torsoni, Marciane Milanski, Leticia Ignacio-Souza
Summary: The aim of this study was to investigate the parameters of maternal-fetal outcomes in a diet-induced obesity model. Females who were obese and glucose intolerant prior to pregnancy had lower placental efficiency and lower birth weight pups compared to the controls. The study found that maternal obesity disrupts the proportionality between maternal and fetal outcomes during pregnancy, which could be due to hormonal signaling issues and inflammation in the maternal metabolic environment. Maternal obesity also alters placental thickness, fatty acid transport, and the expression of growth factors. Lower expression of epidermal growth factor receptor (EGFR) mRNA in obese mothers may have contributed to placental rupture and adverse fetal outcomes. Maintaining maternal glucose homeostasis and overexpression of placental growth factor (PGF) likely protected the placenta and fetuses from damage.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Bruna de Souza Lima, Ana Paula Varela Sanches, Maira Schuchter Ferreira, Josilene Lopes de Oliveira, Jane K. Cleal, Leticia Ignacio-Souza
Summary: Maternal obesity can have an impact on the health of offspring, particularly during critical periods. Studies have shown that diet and nutritional status play a crucial role in fetal outcomes and placental development. Specifically, a high-fat diet can be considered as a nutritional insult that impairs the maternal-placental axis, thus affecting offspring development and outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Immunology
Yonghong Zhang, Zhaozhao Liu, Haixiang Sun
Summary: A successful human pregnancy requires the maternal immune system to recognize and tolerate the semi-allogeneic fetus. Dysfunctional maternal-fetal interactions might be associated with the development of pregnancy complications. This review elaborates the interactions between trophoblasts and decidual immune cells, and the role of commensal bacteria in promoting pregnancy progression.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Catalina Amadora Pomar, Catalina Pico, Andreu Palou, Juana Sanchez
Summary: This study finds that the diet of nursing mothers can affect lipid metabolism in their offspring and attenuate their ability to burn calories from an obesogenic diet in adulthood.
Review
Nutrition & Dietetics
Natassia Rodrigo, Sonia Saad, Carol Pollock, Sarah J. Glastras
Summary: Maternal obesity has serious implications for both mother and offspring, with potential transgenerational effects. Research using rodent models plays a crucial role in studying the impacts of maternal obesity and exploring intervention strategies to mitigate these effects. Further understanding of the pathophysiology of obesity and its interaction with reproductive health is essential for public health efforts.
Review
Endocrinology & Metabolism
Vidyadharan Alukkal Vipin, Chellakkan Selvanesan Blesson, Chandra Yallampalli
Summary: Maternal nutrition plays a crucial role in fetal health and metabolic health in adulthood. Impaired nutrition during pregnancy has been linked to metabolic diseases like type 2 diabetes. Recent studies have focused on understanding the causes and mechanisms of lean type 2 diabetes, with a particular emphasis on the effects of low protein diet during pregnancy. Observational studies in humans and experiments on animals suggest that maternal low protein diet may be associated with lean type 2 diabetes. Understanding the etiology and pathophysiology of lean type 2 diabetes is important for developing effective prevention and treatment strategies.
WORLD JOURNAL OF DIABETES
(2022)
Article
Biochemistry & Molecular Biology
Szu-Wei Huang, Yu-Che Ou, Kuo-Shu Tang, Hong-Ren Yu, Li-Tung Huang, You-Lin Tain, I-Chun Lin, Jiunn-Ming Sheen, Chih-Yao Hou, Ching-Chou Tsai, Mao-Meng Tiao
Summary: Maternal high-fat diet can lead to weight gain, intrahepatic lipid accumulation, alterations in serum short-chain fatty acid profile, intestinal tight junctions, and dysbiosis. Prenatal metformin alleviates the effects of high-fat diet on maternal rats and reduces inflammation and apoptosis in fetal liver and intestines, indicating potential benefits for pregnant obese women.
LIPIDS IN HEALTH AND DISEASE
(2021)
Article
Pharmacology & Pharmacy
Hana Horackova, Rona Karahoda, Lukas Cerveny, Veronika Vachalova, Ronja Ebner, Cilia Abad, Frantisek Staud
Summary: Depression is common during pregnancy and many women are prescribed antidepressants. These drugs may disrupt serotonin homeostasis in the placenta or fetus, potentially leading to adverse effects of antidepressant use during pregnancy.
Article
Medicine, General & Internal
Daniel Boron, Jakub Kornacki, Ewa Wender-Ozegowska
Summary: Intima-media thickness (IMT) measurement is a non-invasive method to assess arterial wall, and it is associated with atherosclerosis and endothelial dysfunction. Pre-existing conditions like diabetes, chronic hypertension, and obesity may impair the adaptation to pregnancy and influence fetal IMT. Increased fetal abdominal aorta IMT (aIMT) has been correlated with placental dysfunctions, which may lead to gestational hypertension, preeclampsia, and fetal growth restriction. Understanding the underlying pathomechanism is crucial for developing targeted therapies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Kate J. Claycombe-Larson, Amy N. Bundy, Terry Kuntz, Junguk Hur, Kathleen M. Yeater, Shanon Casperson, Dale C. Brunelle, James N. Roemmich
Summary: Maternal dietary fat and vegetable substitution can have significant effects on placental and fetal growth as well as fetal brain gene expression. The findings suggest that vegetable supplementation may protect against the negative impacts of a high-fat diet on fetal development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Review
Genetics & Heredity
Beguem Harmancioglu, Seray Kabaran
Summary: Maternal high-fat diet during pregnancy is associated with excessive weight gain and fetal fat mass increase. It also leads to increased activation of proinflammatory cytokines. Maternal insulin resistance and inflammation contribute to increased adipose tissue lipolysis, resulting in elevated levels of free fatty acids in the fetus (>35% of energy from fat).
FRONTIERS IN GENETICS
(2023)
Article
Physiology
Namareq Widatalla, Ahsan Khandoker, Mohanad Alkhodari, Kunihiro Koide, Chihiro Yoshida, Yoshiyuki Kasahara, Yoshitaka Kimura, Masatoshi Saito
Summary: This study examines the association between maternal and fetal heart rate and its importance in fetal development. The analysis of non-invasive electrocardiogram data reveals the similarity in heart rate variability between mothers and infants, which increases as gestational age advances. Furthermore, the study suggests a potential involvement of maternal hormones in regulating this similarity.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Nutrition & Dietetics
Pedro Castillo, Catalina Amadora Pomar, Andreu Palou, Mariona Palou, Catalina Pico
Summary: The study aimed to analyze the long-term metabolic effects of leptin supplementation during suckling in the offspring of diet-induced obese rats and the potential benefits of improving maternal diet during lactation. The results showed that leptin treatment significantly improved metabolic profile and body fat accumulation under standard diet conditions, with stronger effects in male offspring. However, under high-fat diet conditions, the offspring of dams fed as high-fat diet showed metabolic alterations that were not observed in the offspring of dams switched to standard diet during lactation. Leptin supplementation improved glucose homeostasis in male offspring but impaired insulin sensitivity in female offspring born to high-fat diet-fed dams. These findings highlight the importance of balanced maternal diet during the perinatal period, especially lactation, for the metabolic health of offspring, and the beneficial effects of leptin supplementation during suckling, particularly in male offspring.
Article
Agronomy
Dario Fornara, Elizabeth M. E. Ball, Christina Mulvenna, Henry Reyer, Michael Oster, Klaus Wimmers, Hanne Damgaard Poulsen, Arno Rosemarin
Summary: The over-supplementation of animal feeds with phosphorus leads to high rates of P excretion and negative environmental impacts. Adding phytase to pig and poultry diets can reduce P excretion, but the effects on plant-soil systems are poorly understood. This study found that phytase supplementation significantly influenced P content of animal waste and plant P dynamics, with intermediate phytase levels contributing to higher P use efficiency and lower soil P availability. The effects of dietary P content on P losses from soils varied depending on the type of organic amendment.
Article
Agriculture, Dairy & Animal Science
Christina C. Mulvenna, Ursula M. McCormack, Elizabeth Magowan, John McKillen, Mike R. Bedford, Carrie L. Walk, Michael Oster, Henry Reyer, Klaus Wimmers, Dario A. Fornara, M. Elizabeth E. Ball
Summary: Phytase has been a common addition to poultry diets for over 20 years, showing benefits in growth performance, nutrient digestibility, and bone parameters. This study found that superdosing phytase in rapeseed meal and maize dried distiller grains with solubles diets can improve performance, increase digestibility, and reduce P excretion by 15% compared to birds without phytase.
Article
Biochemistry & Molecular Biology
Maruf Hasan, Michael Oster, Henry Reyer, Siriluck Ponsuksili, Eduard Murani, Petra Wolf, Dagmar-Christiane Fischer, Klaus Wimmers
Summary: This study investigated the tissue-wide expression patterns of key genes related to vitamin D metabolism and FGF23 signaling in pigs fed different phosphorus diets. The results showed that non-renal tissues and cells have specific requirements for active vitamin D formation. Low phosphorus diet suppressed vitamin D signaling locally, while high phosphorus diet stimulated local vitamin D synthesis and regulation of FGF23 signaling in bone.
Article
Oncology
Yixuan Ma, Benjamin Schulz, Nares Trakooljul, Moosheer Al Ammar, Anett Sekora, Sina Sender, Frieder Hadlich, Dietmar Zechner, Frank Ulrich Weiss, Markus M. Lerch, Robert Jaster, Christian Junghanss, Hugo Murua Escobar
Summary: Small molecule inhibitors and targeted therapy have significant potential for pancreatic ductal adenocarcinoma (PDAC) treatment. The study found that two KRAS inhibitors, BI-3406 and sotorasib, demonstrated different anti-tumor efficacy and displayed synergistic or additive effects when combined with downstream inhibitors, emphasizing the importance of KRAS as a therapeutic target for PDAC.
Article
Agriculture, Dairy & Animal Science
Siriluck Ponsuksili, Frieder Hadlich, Alvaro Perdomo-Sabogal, Henry Reyer, Michael Oster, Nares Trakooljul, Muhammad Arsalan Iqbal, Sonja Schmucker, Volker Stefanski, Christoph Roth, Amelia Camarinha Silva, Korinna Huber, Vera Sommerfeld, Markus Rodehutscord, Klaus Wimmers
Summary: Aggregation of various data sets provides a comprehensive understanding of lifelong adaptation processes in laying hens. Two strains of laying hens, LB and LSL, were analyzed at different ages, revealing strain-specific and stage-specific biosignatures, including molecular pathways. Although the strains performed similarly, they showed differences in immunological and metabolic functions, as well as gut-microbiota interactions, indicating different strategies under high performance conditions. The integrative analysis not only provides insights into functional biodiversity, but also offers guidance for further manual review of the data.
Article
Agriculture, Dairy & Animal Science
Adewunmi O. Omotoso, Henry Reyer, Michael Oster, Steffen Maak, Siriluck Ponsuksili, Klaus Wimmers
Summary: Phosphorus inclusion in broiler diets needs to be tailored to their physiological demands at different developmental stages. A timed nutritional conditioning strategy, such as P depletion, may enhance mineral homeostasis mechanisms and reduce dietary P supply. This study investigated the effects of dietary P depletion on broiler chickens at different developmental stages, revealing marked responses early on, but indications of compensatory mechanisms later. Endocrine control mediated by calcitriol, intestinal P uptake, and mineral mobilization from bones were identified as potential mechanisms for maintaining mineral homeostasis. Precise timing, duration, and extent of P depletion should be considered for optimized nutrient utilization in broiler husbandry.
Article
Chemistry, Analytical
Mohd. Rahil Hasan, Pradakshina Sharma, Shifa Shaikh, Saumitra Singh, Roberto Pilloton, Jagriti Narang
Summary: We have developed a paper-based experimental platform for analyzing dengue virus, which incorporates screen-printing technology and black carbon conductive ink. The platform utilizes both two-electrode and three-electrode systems, with an LOD of 0.1 μg/mL for detecting the virus. The three-electrode system exhibits a significantly higher current range and amplification compared to the two-electrode system, making it a viable option for sensitive detection of dengue virus and other diseases.
Article
Nutrition & Dietetics
Maruf Hasan, Michael Oster, Henry Reyer, Klaus Wimmers, Dagmar-Christiane Fischer
Summary: Vitamin D-3 (Vit D-3) and 25(OH)D-3 are used as dietary sources of active vitamin D in pig husbandry, and while their primary effects are on the intestine, kidney, and bone, they also have wide-ranging effects on peripheral tissues. The use of Vit D-3 and 25(OH)D-3 in pig nutrition has been shown to have different outcomes in terms of reproductive capacities, growth performance, immunity, and bone development.
BRITISH JOURNAL OF NUTRITION
(2023)
Correction
Nutrition & Dietetics
Maruf Hasan, Michael Oster, Henry Reyer, Klaus Wimmers, Dagmar-Christiane Fischer
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Agriculture, Dairy & Animal Science
Hanne Honerlagen, Henry Reyer, Ibrahim Abou-Soliman, Dierck Segelke, Siriluck Ponsuksili, Nares Trakooljul, Norbert Reinsch, Bjoern Kuhla, Klaus Wimmers
Summary: Improving the nitrogen-utilization efficiency (NUE) of dairy cows through breeding selection has benefits in terms of nutrition, environment, and economics. The individual milk urea concentration (MU) of cows has been proposed as an indicator trait for NUE. This study aimed to identify different microbial genera in the rumen of Holstein cows with divergent genomic breeding values for MU (GBVMU). The identified microbial genera were further investigated for their correlations with MU and other NUE-associated traits, providing insight into genetically determined N-utilization in Holstein cows.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Cell Biology
Julia Brenmoehl, Elli Brosig, Nares Trakooljul, Christina Walz, Daniela Ohde, Antonia Noce, Michael Walz, Martina Langhammer, Stefan Petkov, Monika Roentgen, Steffen Maak, Christina E. E. Galuska, Beate Fuchs, Bjoern Kuhla, Siriluck Ponsuksili, Klaus Wimmers, Andreas Hoeflich
Summary: This study investigated the contribution of non-mitochondrial and mitochondrial metabolic pathways in contracting muscles during repeated training. The results showed that marathon mice displayed increased glucose and fatty acid oxidation, reduced lactate dehydrogenase activity, and inhibited lactate formation compared to trained control mice. This suggests that marathon mice have enhanced metabolic flexibility towards lipid catabolism regulated by lactate dehydrogenase.
Review
Agriculture, Dairy & Animal Science
Benjamin Diehl, Michael Oster, Andreas Vernunft, Klaus Wimmers, Hartwig Bostedt
Summary: The losses of piglets in commercial pig farming remain a concern and sustainable breeding and management strategies are needed. This review systematically presents the three phases of neonatal adaptation in piglets and highlights the key developments and influencing factors in each phase.
ARCHIVES ANIMAL BREEDING
(2022)
Review
Biochemistry & Molecular Biology
Fabio Sarais, Alvaro Perdomo-Sabogal, Klaus Wimmers, Siriluck Ponsuksili
Summary: This review focuses on the latest discoveries of tsRNAs, with special attention to molecules initially thought to be associated with tiRNAs. The paper outlines their biological functions, provides a collection of useful databases, and discusses future research perspectives and applications in livestock basic and applied research.
