Review
Biochemistry & Molecular Biology
Alfonso Rodriguez-Gil, Estrella Carrillo-Cruz, Cristina Marrero-Cepeda, Guillermo Rodriguez, Jose A. Perez-Simon
Summary: Vitamin D plays a dual role in the immune system and tumor cells, potentially decreasing graft-versus-host disease and relapse rates.
Article
Veterinary Sciences
Dohee Lee, Yoonhoi Koo, Yeon Chae, Yeongeun Choi, Taesik Yun, Byeong-Teck Kang, Mhan-Pyo Yang, Hakhyun Kim
Summary: This study compared the concentrations of serum 25-hydroxyvitamin D (25[OH]D), vitamin D receptor (VDR), and vitamin D-binding protein (VDBP) between healthy dogs and dogs with acute pancreatitis (AP), and identified correlations between these concentrations and ionized calcium, C-reactive protein (CRP), and canine-specific pancreatic lipase (Spec cPL) concentrations. The results showed that dogs with AP had lower serum 25(OH)D and VDR concentrations compared to healthy dogs. Additionally, the study suggests a potential role of VDR expression in the inflammatory process of AP in dogs.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Anna Markowska, Pawel Kurzawa, Wieslawa Bednarek, Anna Grybos, Marcin Mardas, Monika Krzyzaniak, Jan Majewski, Janina Markowska, Marian Grybos, Jakub Zurawski
Summary: Vitamin D deficiency is involved in the development of uterine fibroids. Supplementing with vitamin D can reduce the size of fibroids. Lower expression of VDR in fibroid tissue may indicate the potential for new fibroids.
Article
Biochemistry & Molecular Biology
Jiezhong Deng, Yusheng Yang, Jinyue He, Zhao Xie, Fei Luo, Jianzhong Xu, Zehua Zhang
Summary: This study demonstrates that activation of VDR by VD administration inhibits M. tuberculosis-induced bone destruction, suggesting that VD and VDR are potential therapeutic targets for this condition.
Review
Biochemistry & Molecular Biology
Alessandra Mirarchi, Elisabetta Albi, Tommaso Beccari, Cataldo Arcuri
Summary: Microglia, accounting for 5-20% of glial cells in the adult brain, have multiple functions in maintaining neural environment, responding to injury, and regulating immune response. They are involved in various neurological disorders and neurodegenerative diseases. Vitamin D3 (VD3) plays a role in the brain's pathophysiology, influencing neurotrophic and neuroprotective actions, neurotransmission, and synaptic plasticity. Studies have focused on the involvement of VD3 and microglia in neurodegeneration and aging-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Jose Luis Perez-Castrillon, Antonio Duenas-Laita, Carlos Gomez-Alonso, Esteban Jodar, Javier del Pino-Montes, Maria Luisa Brandi, Fernando Cereto Castro, Jose Manuel Quesada-Gomez, Laura Gallego Lopez, Jose Manuel Olmos Martinez, Maria Rosa Alhambra Exposito, Bernat Galarraga, Jesus Gonzalez-Macias, Jose Luis Neyro, Roger Bouillon, Gonzalo Hernandez-Herrero, Nieves Fernandez-Hernando, Sandra P. Chinchilla
Summary: This report presents the results of a 1-year clinical trial comparing the efficacy and safety of monthly calcifediol and cholecalciferol in postmenopausal women with vitamin D deficiency. The study found that monthly calcifediol is an effective and safe treatment, maintaining stable vitamin D levels.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Immunology
Renwei Lu, Ziqi Peng, Panpan Lian, Junaid Wazir, Chaode Gu, Chujun Ma, Lulu Wei, Li Li, Wenyuan Pu, Jun Liu, Hongwei Wang, Zhonglan Su
Summary: This study found that vitamin D has a significant therapeutic effect in the treatment of atopic dermatitis, possibly by inhibiting the phosphorylation of STAT3, reducing inflammatory cell infiltration and chemokine release, decreasing AQP3 protein expression, and inhibiting cell proliferation to restore the skin barrier function.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Nutrition & Dietetics
Jose-Luis Perez-Castrillon, Ricardo Usategui-Martin, Pawel Pludowski
Summary: Calcifediol is the prohormone of the vitamin D endocrine system, used to prevent and treat vitamin D deficiency. It is more efficient and safe than cholecalciferol, with a rapid onset of action and greater potency. The increase in 25-OH vitamin D depends on the dose and frequency of calcifediol administration, while cholecalciferol administration is influenced by additional factors such as obesity and malabsorption.
Review
Nutrition & Dietetics
Ricardo Usategui-Martin, Daniel-Antonio De Luis-Roman, Jose Maria Fernandez-Gomez, Marta Ruiz-Mambrilla, Jose-Luis Perez-Castrillon
Summary: This study evaluated the impact of polymorphisms in the vitamin D receptor gene on the response to vitamin D supplementation through a systematic review and meta-analysis. The results suggest that the TaqI and FokI polymorphisms may play a role in modulating the response to vitamin D supplementation.
Article
Nutrition & Dietetics
Addolorata Corrado, Cinzia Rotondo, Daniela Cici, Stefano Berardi, Francesco Paolo Cantatore
Summary: This study demonstrated that supplementation with calcifediol is more effective and faster than cholecalciferol in increasing 25(OH)D serum levels and improving muscular function in post-menopausal women. Weekly administration of cholecalciferol showed the best results in this regard.
Article
Nutrition & Dietetics
Antonio Gazquez, Maria Sanchez-Campillo, Alejandro Barranco, Ricardo Rueda, Jia P. Chan, Matthew J. Kuchan, Elvira Larque
Summary: Oral 25-OH-D3 provides better vitamin D availability for both mother and fetus during pregnancy compared to vitamin D3. No adverse effects on pregnancy outcomes were observed. The effects of 25-OH-D3 on the expression of VDR and GAD67 in fetal brain require further investigation.
FRONTIERS IN NUTRITION
(2022)
Article
Urology & Nephrology
Michael J. Germain, Subir K. Paul, George Fadda, Varshasb Broumand, Andy Nguyen, November H. McGarvey, Matthew D. Gitlin, Charles W. Bishop, Philipp Csomor, Stephen Strugnell, Akhtar Ashfaq
Summary: ERC is more effective than other vitamin D therapies in increasing levels of 25D and reducing levels of PTH.
Article
Biology
Jose Manuel Garcia-Martinez, Ana Chocarro-Calvo, Javier Martinez-Useros, Maria Jesus Fernandez-Acenero, M. Carmen Fiuza, Jose Caceres-Rentero, Antonio De la Vieja, Antonio Barbachano, Alberto Munoz, Maria Jesus Larriba, Custodia Garcia Jimenez
Summary: Posttranslational modifications of epigenetic modifiers provide a mechanism for rapid adaptations in cancer cells. The study shows that 1,25(OH)(2)D-3 activates SIRT1 by auto-deacetylation in colon cancer cells, inhibiting cell proliferation.
Review
Nutrition & Dietetics
Carsten Carlberg
Summary: The vitamin D metabolite 1 alpha,25-dihydroxyvitamin D-3 acts as a ligand for the transcription factor vitamin D receptor (VDR), and regulates the expression of target genes through chromatin changes. VDR binds to genomic DNA and interacts with partner proteins.
Article
Biochemistry & Molecular Biology
Salah Gariballa, Ghada S. M. Al-Bluwi, Javed Yasin
Summary: A study on 277 healthy individuals in the United Arab Emirates found an association between vitamin D receptor gene polymorphisms and vitamin D levels. However, this association became non-significant after adjusting for clinical parameters that influence vitamin D levels. Additionally, no association was found between obesity and related pathologies and the vitamin D receptor gene polymorphisms.
Article
Endocrinology & Metabolism
Francesca Marta Elli, Deborah Mattinzoli, Camilla Lucca, Matteo Piu, Maria A. Maffini, Jole Costanza, Laura Fontana, Carlo Santaniello, Concetta Forino, Donatella Milani, Maria Teresa Bonati, Andrea Secco, Roberto Gastaldi, Carlo Alfieri, Piergiorgio Messa, Monica Miozzo, Maura Arosio, Giovanna Mantovani
Summary: Skeletal disorders are caused by genetic defects that affect the pathways involved in skeletogenesis and growth-plate development. A study identified novel genetic variants associated with skeletal malformations similar to Albright's hereditary osteodystrophy and confirmed their pathogenic impact. The study highlights the importance of interdisciplinary collaboration in rare patients.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Nutrition & Dietetics
Anna Regalia, Matteo Benedetti, Silvia Malvica, Carlo Alfieri, Mariarosaria Campise, Donata Cresseri, Maria Teresa Gandolfo, Federica Tripodi, Giuseppe Castellano, Piergiorgio Messa
Summary: In kidney transplanted patients, those with SARS-CoV-2 infection had lower levels of 25(OH)D compared to controls, but there was no significant association between vitamin D status and severity or outcomes of the infection.
Article
Nutrition & Dietetics
Lara Caldiroli, Simone Vettoretti, Silvia Armelloni, Deborah Mattinzoli, Masami Ikehata, Paolo Molinari, Carlo Alfieri, Piergiorgio Messa, Giuseppe Castellano
Summary: This study compared the effects of low protein and normal protein diets on the nutritional status and metabolic complications related to the progression of kidney damage in older patients with advanced chronic kidney disease. The results showed that the low protein diet may have greater benefits on the progression of kidney disease and some of its metabolic complications.
FRONTIERS IN NUTRITION
(2022)
Review
Urology & Nephrology
Carlo Alfieri, Silvia Malvica, Matteo Cesari, Simone Vettoretti, Matteo Benedetti, Elisa Cicero, Roberta Miglio, Lara Caldiroli, Alessandro Perna, Angela Cervesato, Giuseppe Castellano
Summary: This study aims to describe the issue of frailty in kidney transplantation and explore the evaluation methods, the impact on patients, and the long-term effects on survival.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Endocrinology & Metabolism
C. Crotti, F. Zucchi, C. Alfieri, R. Caporali, M. Varenna
Summary: This case report describes the long-term efficacy and safety profile of burosumab in a TIO patient who had three unsuccessful surgical attempts in tumor removal. Burosumab showed promising results in improving pain, physical performance, and normalizing serum phosphate levels in TIO patients refractory to surgery or not eligible for surgical treatment.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Immunology
Mariarosaria Campise, Carlo Maria Alfieri, Matteo Benedetti, Alessandro Perna, Roberta Miglio, Paolo Molinari, Angela Cervesato, Silvia Giuliani, Maria Teresa Gandolfo, Anna Regalia, Donata Cresseri, Laura Alagna, Andrea Gori, Giuseppe Castellano
Summary: Kidney transplant recipients are at high risk of COVID-19 infection, but mRNA COVID-19 vaccines have greatly improved their outcomes. Vaccination reduced the incidence of death and hospitalization among transplanted patients. Age and dyspnea were associated with increased risk of hospitalization, while vaccination provided certain protection and significantly improved infection outcomes.
Article
Microbiology
Marta Perego, Samuele Iesari, Maria Teresa Gandolfo, Carlo Alfieri, Serena Delbue, Roberto Cacciola, Mariano Ferraresso, Evaldo Favi
Summary: This study observed the outcomes of kidney transplant surgeries during the COVID-19 pandemic in Italy. The results show that kidney transplant surgeries can be safely performed during the pandemic, with excellent outcomes for both patients and transplanted organs. However, there was a higher mortality rate among patients on the transplant waiting list during the pandemic compared to before.
Review
Biochemistry & Molecular Biology
Barbara Infante, Silvia Mercuri, Andrea Dello Strologo, Rossana Franzin, Valeria Catalano, Dario Troise, Emanuela Cataldo, Paola Pontrelli, Carlo Alfieri, Valentina Binda, Giulia Frontini, Giuseppe Stefano Netti, Elena Ranieri, Loreto Gesualdo, Giuseppe Castellano, Giovanni Stallone
Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that often affects the kidney. The immune system disturbances and tissue damage play important roles in the pathogenesis of SLE. This review discusses the immune-regulatory function of Type-I-interferons in SLE and lupus nephropathy, as well as the recent advancements in biologic therapy for lupus nephropathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Endocrinology & Metabolism
C. Crotti, F. Zucchi, C. Alfieri, R. Caporali, M. Varenna
OSTEOPOROSIS INTERNATIONAL
(2022)
Review
Endocrinology & Metabolism
Barbara Infante, Francesca Conserva, Paola Pontrelli, Serena Leo, Alessandra Stasi, Marco Fiorentino, Dario Troise, Andrea dello Strologo, Carlo Alfieri, Loreto Gesualdo, Giuseppe Castellano, Giovanni Stallone
Summary: Several insults, especially diabetes, can lead to acute kidney injury (AKI) in both native kidney and transplant patients. High glucose levels disrupt signaling pathways within the kidney, causing maladaptive repair and kidney dysfunction. Diabetic kidneys are often vulnerable to hypoxia due to reduced oxygenation, vascular damage, and increased inflammation. Patients with a history of AKI have a worse prognosis, highlighting the importance of monitoring diabetic patients for AKI. This review focuses on the molecular mechanisms underlying increased susceptibility to AKI in diabetes and the potential biomarkers for diagnosis and prognosis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Nutrition & Dietetics
Adamasco Cupisti, Domenico Giannese, Claudia D'Alessandro, Alessia Benedetti, Vincenzo Panichi, Carlo Alfieri, Giuseppe Castellano, Piergiorgio Messa
Summary: Complementary and alternative medicine (CAM), including herbal remedies, probiotics, and vitamins, is often used in the treatment of kidney stone patients. However, most dietary supplements claiming to treat or prevent kidney stones lack scientific evidence. Clinicians should inform patients that the effects of these supplements are largely unknown and that absence of evidence does not mean lack of potential harm. Despite the popularity of CAM products among kidney stone patients, the lack of knowledge in this field prevents their recommendation in daily clinical practice, with only a weak suggestion for their use being reasonable.
Review
Nutrition & Dietetics
Jordi Bover, Elisabet Masso, Laia Gifre, Carlo Alfieri, Jordi Soler-Majoral, Maria Fusaro, Jordi Calabia, Rosely Rodriguez-Pena, Nestor Rodriguez-Chitiva, Victor Lopez-Baez, Maya Sanchez-Baya, Iara da Silva, Armando Aguilar, Misael C. Bustos, Natacha Rodrigues, Jonathan S. Chavez-Iniguez, Gregorio Romero-Gonzalez, Jose Manuel Valdivielso, Pablo Molina, Jose L. Gorriz
Summary: Chronic kidney disease (CKD) is a common condition that impairs kidney function and can lead to vitamin D (VD) deficiency. While studies have shown a link between low VD levels and negative outcomes, recent research has lowered expectations for the benefits of VD supplementation. However, guidelines still recommend VD supplementation for CKD patients. It is important to carefully balance the adverse effects of VD derivatives with the prevention of severe secondary hyperparathyroidism.
Review
Urology & Nephrology
Deborah Mattinzoli, Paolo Molinari, Gregorio Romero-Gonzalez, Jordi Bover, Elisa Cicero, Francesco Pesce, Matteo Abinti, Costanza Conti, Giuseppe Castellano, Carlo Alfieri
Summary: Cardio-renal syndrome is a well-defined clinical condition that involves interactions between the heart and kidney. Acute kidney injury can lead to chronic cardiovascular events and the progression of kidney disease. The role of bone in this relationship, as well as the impact on long-term outcomes, is an important topic of research.
CLINICAL KIDNEY JOURNAL
(2023)
Review
Hematology
Rossana Franzin, Alessandra Stasi, Gianvito Caggiano, Elena Squiccimarro, Vincenzo Losappio, Marco Fiorentino, Carlo Alfieri, Giovanni Stallone, Loreto Gesualdo, Giuseppe Castellano
Summary: ESRD is associated with immune dysregulation caused by factors such as uremia and hemodialysis membrane biocompatibility. Understanding the molecules involved in altered immune response is important for therapeutic intervention. PMMA-based membranes have adsorptive properties for uremic toxins and can modulate adaptive immune response.
BLOOD PURIFICATION
(2023)
Review
Surgery
Matteo Abinti, Evaldo Favi, Carlo Maria Alfieri, Francesca Zanoni, Silvia Armelloni, Mariano Ferraresso, Vincenzo Cantaluppi, Giuseppe Castellano
Summary: Kidney transplantation is the best treatment for end-stage kidney disease, but early diagnosis of graft injury and improving graft outcomes remain challenging. Extracellular vesicles have shown potential as precise markers of damage and therapeutic targets in the field of kidney transplantation. They can be used to determine organ quality and aging, identify transplant-related pathologies, and are suitable for drug delivery and therapy development.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
