Article
Oncology
Xingtong Wang, Wei Guo, Xiaoju Shi, Yujia Chen, Youxi Yu, Beibei Du, Min Tan, Li Tong, Anna Wang, Xianying Yin, Jing Guo, Robert C. C. Martin, Ou Bai, Yan Li
Summary: Excess body weight is associated with an increased risk of lymphomas, and sphingosine-1-phosphate (S1P) may play a role in linking obesity and lymphomas. Obesity negatively impacts prognosis in lymphoma patients, and targeting S1P could potentially be effective against obesity-lymphomagenesis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Timon Eckes, Sammy Patyna, Alexander Koch, Anke Oftring, Stefan Gauer, Nicholas Obermueller, Stephanie Schwalm, Liliana Schaefer, Jerold Chun, Hermann-Josef Groene, Josef Pfeilschifter
Summary: This study found that S1P(5) deficiency can improve tubular damage and tubulointerstitial fibrosis in a mouse model of adenine-induced nephropathy, and reduce inflammation. Therefore, targeting S1P(5) may be a promising therapeutic target for kidney diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Xuefeng Xu, Yi Han, Tianxin Zhu, Faxin Fan, Xin Wang, Yuqing Liu, Duosheng Luo
Summary: Osteoporosis is a common disease worldwide with significant economic burden. Understanding the role of SphK/S1P/S1PR signaling in regulating osteoblasts and osteoclasts is crucial for the treatment of osteoporosis. This review summarizes the effects of S1P on proliferation, differentiation, apoptosis, and functions, and focuses on S1P-based therapeutic approaches in bone metabolism.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Oncology
Eileen M. McGowan, Yiguang Lin, Size Chen
Summary: Obesity is closely associated with inflammation and increased cancer risk in the digestive system. Saturated fat diets and being overweight can cause chronic inflammation. Bioactive sphingolipids, signaling molecules made from saturated fats, play essential roles in maintaining healthy gastrointestinal immunity. Excessive levels of these molecules can lead to chronic inflammation, but drugs that block their activity have the potential to reduce gastrointestinal cancer risk.
Review
Cell Biology
Maryam Jamil, Lauren Ashley Cowart
Summary: In this review, the vital roles of sphingolipids in cellular membranes and cell signaling are discussed, with a focus on their diverse effects on mitochondrial dynamics, cellular bioenergetics, and important cell processes such as apoptosis and mitophagy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Endocrinology & Metabolism
Ilona Juchnicka, Mariusz Kuzmicki, Jacek Szamatowicz
Summary: Obesity is a growing global concern, significantly contributing to the development of diseases like type 2 diabetes and cardiovascular disorders. Excessive lipid accumulation in tissues leads to inflammation and metabolic dysfunction.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Kan Xiao, Mohan Zhou, Qingqing Lv, Pengwei He, Xu Qin, Dan Wang, Jiangchao Zhao, Yulan Liu
Summary: This study found that plant polyphenols can attenuate inflammation and intestinal damage caused by enterotoxigenic Escherichia coli (ETEC) infection by inhibiting necroptosis and pyroptosis signaling pathways. Plant polyphenols including protocatechuic acid (PCA) and quercetin (Que) can reduce ETEC adhesion and endotoxin level, increase the number of intestinal epithelial cells, decrease lactate dehydrogenase activity, improve intestinal barrier function, and reduce cell necrosis ratio. These findings have important implications for the prevention and treatment of gastrointestinal disorders.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Medicine, Research & Experimental
Mohamed Shalaby, Rania R. Abdelaziz, Hamdy A. Ghoneim, Ghada M. Suddek
Summary: The study evaluated the effects of tyrosine kinase inhibitor (imatinib) on experimentally induced ulcerative colitis (UC) in rats. Imatinib pretreatment significantly reduced UC-induced damage and inflammation markers, as well as oxidative stress levels. Imatinib also suppressed the activity of the NF-kB/JAK2/ STAT3/COX2 signaling pathway. Therefore, imatinib may be a potential therapeutic option for UC.
Article
Biochemistry & Molecular Biology
Xuan Zhu, Xinlin Wang, Tianhao Ying, Xiaoli Li, Yidi Tang, Yanfang Wang, Tao Yu, Mengmeng Sun, Jianing Zhao, Yuan Du, Leiming Zhang
Summary: This study investigated the anti-sepsis effects and mechanisms of kaempferol in a lipopolysaccharide-induced sepsis model. The results demonstrated that kaempferol alleviated inflammatory response and stabilized the endothelial barrier in LPS-induced sepsis by regulating the SphK1/S1P signaling pathway. The study also revealed that kaempferol exhibited cell-specific effects on the regulation of SphK1 expression.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Agriculture, Dairy & Animal Science
Xiaoyan Cui, Sheng Zhang, Shouqun Jiang, Zhongyong Gou, Yibing Wang
Summary: The addition of Protocatechuic acid (PCA) in feed has been found to improve gut health in chickens infected with Salmonella typhimurium (ST). PCA enhances body weight, average daily gain, and feed to gain ratio in ST-challenged Yellow broilers. It also reduces intestinal mucosal injury, inflammatory response, and improves the composition of intestinal microbiota.
Article
Ophthalmology
Sarah E. Nicholas, Alexander J. Choi, Thi N. Lam, Sandip K. Basu, Nawajes Mandal, Dimitrios Karamichos
Summary: Corneal haze caused by fibrosis can lead to vision loss. Corneal transplantation is currently used to treat severe fibrosis, but it has limitations. This study investigates the role of sphingolipids and their interactions with TGF-beta signaling in corneal fibrosis.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yuki Nagata, Kazuaki Miyagawa, Yasuhisa Ohata, Daniela N. Petrusca, Gabriel M. Pagnotti, Khalid S. Mohammad, Theresa A. Guise, Jolene J. Windle, G. David Roodman, Noriyoshi Kurihara
Summary: Research has shown that Paget's disease patients' osteoclasts express elevated levels of MVNP and SphK-1, and IL-6 is identified as a factor influencing SphK-1 production, ultimately leading to abnormal bone formation.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Oncology
Min Zhang, Ruoxuan Hei, Zhou Zhou, Wendi Xiao, Xi Liu, Yanwei Chen
Summary: This study found that macrophages in COPD patients differentiate into M1 phenotype, with increased expression of S1PR1 and decreased expression of HDAC1. The results provide new insights into the pathogenesis and potential treatment options of COPD.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Plant Sciences
Guiming Li, Qiaoling Wang, Qian Meng, Guanhua Wang, Fan Xu, Qian Chen, Fang Liu, Yulin Hu, Ming Luo
Summary: Cotton is an important natural fiber crop worldwide, and the ceramide synthase gene GhCS1 plays a crucial role in cotton fiber cell development. GhCS1 affects fiber cell initiation and elongation by modulating substrate utilization.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Xuebin Yang, Xin Sun, Feng Zhou, Shuiping Xiao, Lulu Zhong, Shian Hu, Zhe Zhou, Ling Li, Yang Tan
Summary: Protocatechuic acid (PCA) is a natural component with multiple biological activities. This study investigated the effects of PCA on anti-ulcerative colitis (UC) and found that PCA reduced the levels of disease activity index, inflammatory factors, and histological damage in UC mice. The regulation of intestinal flora and the inhibition of ferroptosis were suggested as potential mechanisms underlying the protective effects of PCA against UC.
Article
Hospitality, Leisure, Sport & Tourism
Sergio Maroto-Izquierdo, Jeffrey M. McBride, Nacho Gonzalez-Diez, David Garcia-Lopez, Javier Gonzalez-Gallego, Jose Antonio de Paz
Summary: The purpose of this study was to examine the effects of two non-gravity-dependent training modalities on muscle structure and function. Both flywheel training and pneumatic resistance training resulted in similar improvements in shoulder strength, power, and throwing speed. However, flywheel training appeared to potentially result in a slightly greater level of muscle hypertrophy of the anterior and middle deltoid.
RESEARCH QUARTERLY FOR EXERCISE AND SPORT
(2022)
Review
Cell Biology
Beatriz San-Miguel, Paula Fernandez-Palanca, Jose L. Mauriz, Maria J. Tunon, Javier Gonzalez-Gallego
Summary: Melatonin has shown beneficial effects in liver fibrosis, by reducing profibrogenic markers, modulating cellular processes and molecular pathways, acting as an antioxidant and anti-inflammatory agent. It has the potential to ameliorate the development and progression of liver fibrosis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Oncology
Paula Fernandez-Palanca, Tania Payo-Serafin, Flavia Fondevila, Carolina Mendez-Blanco, Beatriz San-Miguel, Marta R. Romero, Maria J. Tunon, Jose J. G. Marin, Javier Gonzalez-Gallego, Jose L. Mauriz
Summary: This study evaluated the prognostic, diagnostic and clinicopathological value of NRP1 in liver cancer and CRC patients, showing that NRP1 overexpression is significantly correlated with lower survival and tumor development, suggesting NRP1 may be a potential and useful biomarker in both types of cancer.
Review
Oncology
Jose J. G. Marin, Maria J. Monte, Rocio I. R. Macias, Marta R. Romero, Elisa Herraez, Maitane Asensio, Sara Ortiz-Rivero, Candela Cives-Losada, Silvia Di Giacomo, Javier Gonzalez-Gallego, Jose L. Mauriz, Thomas Efferth, Oscar Briz
Summary: Hepatobiliary, pancreatic, and gastrointestinal cancers account for 36% of the approximately 10 million cancer-related deaths worldwide each year. One primary reason for this high mortality is the lack of response of these cancers to pharmacological treatment. More than 100 genes have been identified as responsible for seven mechanisms of chemoresistance, but only a few play a critical role, including ABC proteins (mainly MDR1, MRP1-6, and BCRP), whose expression pattern greatly determines individual tumor sensitivity to pharmacotherapy.
Review
Nutrition & Dietetics
Brisamar Estebanez, Chun-Jung Huang, Marta Rivera-Viloria, Javier Gonzalez-Gallego, Maria J. Cuevas
Summary: Childhood obesity is a major public health issue that increases the risk for cardiometabolic diseases and related complications in adulthood. Inflammation and oxidative stress are identified as the primary mechanisms underlying obesity-related diseases. Physical activity has consistently been shown to improve obesity-mediated inflammation and oxidative stress status.
FRONTIERS IN NUTRITION
(2022)
Article
Ophthalmology
Carmen L. Avendano-Monje, Miguel Cordero-Coma, Jose L. Mauriz, Sara Calleja-Antolin, Alex Fonollosa, Ana Garrote Llorden, Juan Martin Garcia-Sancho, Maria Sanchez-Salazar, Jose G. Ruiz de Morales
Summary: The study aimed to measure, characterize, and evaluate the clinical significance of anti-retinal antibodies in patients with sarcoid uveitis. The results showed that anti-retinal antibodies recognizing carbonic anhydrase II are common in sarcoid uveitis. Although not fully sensitive and specific, they might be a useful non-invasive diagnostic tool for the diagnosis of sarcoid uveitis.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2022)
Article
Chemistry, Multidisciplinary
Paula Fernandez-Palanca, Tania Payo-Serafin, Beatriz San-Miguel, Carolina Mendez-Blanco, Maria J. Tunon, Javier Gonzalez-Gallego, Jose L. Mauriz
Summary: Despite pharmacological advances, therapeutic failure in hepatocellular carcinoma (HCC) remains a challenge due to its complex molecular mechanisms. This study investigates the interplay among neuropilin-1 (NRP1), autophagy, and hypoxia in the development of lenvatinib resistance in HCC cell lines. The results show that NRP1 is significantly increased in HCC samples and correlated with advanced tumor and metastasis stages. Additionally, NRP1 silencing enhances the anticancer effects of lenvatinib, and hypoxia-induced autophagy further enhances lenvatinib's effectiveness through HIF-1 alpha modulation.
ACTA PHARMACOLOGICA SINICA
(2023)
Review
Gastroenterology & Hepatology
Paula Fernandez-Palanca, Tania Payo-Serafin, Carolina Mendez-Blanco, Beatriz San-Miguel, Maria J. Tunon, Javier Gonzalez-Gallego, Jose L. Mauriz
Summary: This study systematically reviews the role of neuropilins (NRPs) NRP1 and NRP2 in hepatocellular carcinoma (HCC). The findings suggest that NRPs are potential biomarkers for diagnosis and prognosis in HCC patients, as they are involved in multiple cellular and molecular processes associated with tumor progression. NRPs mainly regulate angiogenesis, invasion, migration, immune response, tumor microenvironment, and interplay with hypoxia response and microRNAs in HCC.
CLINICAL AND MOLECULAR HEPATOLOGY
(2023)
Review
Cell Biology
Elisa Lozano, Paula Sanchon-Sanchez, Ana Morente-Carrasco, Luis Miguel Chinchilla-Tabora, Jose L. Mauriz, Paula Fernandez-Palanca, Jose J. G. Marin, Rocio I. R. Macias
Summary: The poor prognosis of advanced cholangiocarcinoma (CCA) presents a significant challenge in modern oncology due to increasing incidence and late diagnosis. The heterogeneity of CCA subtypes and complex mechanisms involved in CCA contribute to the difficulty in treating this deadly tumor. The Wnt/beta-catenin pathway plays a crucial role, and understanding its alteration in relation to the heterogeneous forms of CCA is essential for advancing diagnostic and therapeutic strategies.
Editorial Material
Oncology
Paula Fernandez-Palanca, Jose L. Mauriz
CHINESE CLINICAL ONCOLOGY
(2023)
Article
Nutrition & Dietetics
Brisamar Estebanez, Francisco J. Amaro-Gahete, Cristina Gil-Gonzalez, Javier Gonzalez-Gallego, Maria J. Cuevas, David Jimenez-Pavon
Summary: Exosome release is influenced by the physiological state of the cell and may play a significant role in obesity. Exercise-induced exosomes may contribute to the beneficial effects of physical activity on weight and cardiovascular parameters. This study investigated the impact of a 12-week concurrent training intervention on exosome cargo modifications in obese men and explored the relationship between changes in exosomes and cardiometabolic health parameters. Although no significant changes in exosomal markers and proteins were observed, there were associations between certain proteins (CD81, Flot-1, HSP70, CD14) and various health parameters. The findings suggest a potential relationship between exosome-carried proteins and obesity treatment.
Meeting Abstract
Gastroenterology & Hepatology
Paula Fernandez-Palanca, Tania Payo-Serafin, Flavia Fondevila, Carolina Mendez-Blanco, Javier Gonzalez-Gallego, Jose Luis Mauriz
JOURNAL OF HEPATOLOGY
(2022)