Article
Food Science & Technology
Dan Li, Zhi Li, Caiyi Qiu, Bo Peng, Yan Zhang, Hongwen Sun, Shuo Wang
Summary: This study investigated the hepatotoxicity of 2-amino-3-methylimidazole[4,5-f] quinoline (IQ) in zebrafish models and found that IQ exposure led to significant increases in liver enzymes, oxidative stress, and inflammation levels, while decreasing antioxidant levels. The study also revealed the pathological changes in zebrafish liver tissue induced by IQ exposure and elucidated the underlying molecular mechanisms involved in IQ-induced liver damage.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Food Science & Technology
Yaxi Zhou, Diandian Wang, Hao Duan, Shiqi Zhou, Jinhong Guo, Wenjie Yan
Summary: Silkworm pupa peptides (SPP) have been shown to protect against DSS-induced colitis in mice by reducing cell apoptosis, attenuating inflammatory responses, and improving oxidative stress levels. These findings provide potential candidates for the development of new drugs for the treatment of colitis.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Oncology
Lionel Loubaki, Mahmoud Rouabhia, Mohamed Al Zahrani, Abdullah Al Amri, Abdelhabib Semlali
Summary: Cannabinoids, the active components of cannabis, have palliative effects on cancer patients and may also be helpful in treating certain rare forms of cancer. This study investigated the cytotoxic effect of a cannabinoid mixture (CM) on oral cells. The results showed that CM had high cytotoxicity in oral cancer cells at a concentration higher than 0.1 μg/mL but not in normal gingival cells. Low concentrations of CM increased apoptosis, autophagy, antioxidant levels, mitochondrial stress, and DNA damage in oral cells. Furthermore, CM inhibited major signaling pathways involved in cancer progression and cell migration. These findings suggest that cannabinoids could potentially be beneficial in oral cancer therapy.
Review
Food Science & Technology
Manuel Adrian Picos-Salas, Luis Angel Cabanillas-Bojorquez, Cristina Alicia Elizalde-Romero, Nayely Leyva-Lopez, Luis Aurelio Montoya-Inzunza, J. Basilio Heredia, Erick P. Gutierrez-Grijalva
Summary: This review summarizes the current knowledge on the protective effects of naringenin against oxidative stress and inflammation and its mechanisms of action.
FOOD REVIEWS INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Ni Shi, Tong Chen
Summary: Esophageal cancer is a deadly malignancy, with esophageal squamous cell carcinoma and esophageal adenocarcinoma being the two main types. Tobacco and alcohol use, along with limited intake of fresh fruits and vegetables, contribute to the prevalence of esophageal cancer. A food-based approach can help prevent esophageal cancer by targeting multiple processes in carcinogenesis. Black raspberries and strawberries have been found to be potent inhibitors of esophageal cancer.
Article
Nutrition & Dietetics
Mengyao Wang, Feng Zhang, Jie Zhou, Ke Gong, Shasha Chen, Xinran Zhu, Mengxue Zhang, Yajun Duan, Chenzhong Liao, Jihong Han, Zequn Yin
Summary: Licorice is a versatile herbal medicine and food, and glabridin (Gla) extracted from licorice root has various health benefits. The research discovered the positive effect of Gla in treating alcoholic liver disease (ALD) in mice and liver cells. Gla alleviated liver injury caused by ethanol, reduced inflammation and oxidative stress, and restored antioxidant enzyme activity. Gla also regulated specific molecular pathways involved in ALD. Overall, Gla shows promise as a potential health product or drug for ALD.
Article
Cardiac & Cardiovascular Systems
Lingxi Zhang, Chenghong Hu, Bo Jin, Bin Bai, Jing Liao, Leiming Jin, Minxiu Wang, Weiwei Zhu, Xuedan Wu, Li Zheng, Xuelian Xu, Yongsheng Jiang, Yi Wang, Ying He
Summary: Bicyclol, a traditional Chinese medicine, shows promising therapeutic effects in diabetic cardiomyopathy (DCM) by inhibiting inflammation and oxidative stress through the MAPK and NF-kappa B pathways.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Food Science & Technology
Dan Liu, Ye Cheng, Junliang Chen, Xueying Mei, Zhipeng Tang, Xiangyu Cao, Jianli Liu
Summary: This study investigated the mechanism of luteolin in inhibiting acrolein-induced cytotoxicity in human bronchial epithelial cells. The results showed that luteolin reduced oxidative stress, inhibited MAPK/I kappa B alpha/NF-kappa B and DDR pathways, and decreased DNA damage and apoptosis.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Medicine, Research & Experimental
Kai Aoki, Koki Yanazawa, Katsuyuki Tokinoya, Takehito Sugasawa, Takuji Suzuki, Yasuko Yoshida, Takuro Nakano, Naomi Omi, Yasushi Kawakami, Kazuhiro Takekoshi
Summary: Renalase expression is upregulated in fasting conditions and localized in the crypt. Overexpression of renalase protects intestinal cells from oxidative stress induced by H2O2, suggesting a potential protective role of renalase against oxidative stress. NF-kappa B p65 may play a role in regulating renalase expression in response to oxidative stress in the small intestine.
Article
Biochemistry & Molecular Biology
Lili Liu, Liangyou Zhao, Yuan Liu, Xiaoli Yu, Xinyuan Qiao
Summary: This study found that rutin may prevent cadmium-induced necroptosis in chicken liver by inhibiting oxidative stress and the MAPK/NF-kappa B pathway.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Dahu Qi, Hui Liu, Xuying Sun, Danni Luo, Meipeng Zhu, Tenghui Tao, Chenghao Gao, Chuankun Zhou, Wei Zhou, Jun Xiao
Summary: Pristimerin exerts potential therapeutic effects on osteoporosis by inhibiting NF-kappa B and MAPK signaling pathways, reducing ROS production, activating Nrf2/HO-1 signaling pathway, and affecting osteoclast differentiation and function.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Guobin Qi, Zengxin Jiang, Wei Lu, Defang Li, Weibing Chen, Xiuying Yang, Lei Ding, Hengfeng Yuan
Summary: Berbamine, a natural product from Berberis amurensis Rupr, was found to have a protective effect against osteoporosis by inhibiting osteoclastogenesis and bone resorption without affecting osteogenesis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Zhengle Zhang, Longjiang Chen, Chuanbing Zhao, Qiong Gong, Zhigang Tang, Hanjun Li, Jing Tao
Summary: This study reveals that CASC9 plays a key role in driving resistance to gemcitabine in pancreatic cancer. CASC9 forms a positive feedback loop with the NRF2-antioxidant signaling pathway and activates the NF-kappa B signaling pathway, contributing to gemcitabine resistance.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Oncology
Dongfang Dai, Hongping Zhou, Li Yin, Fei Ye, Xiao Yuan, Tao You, Xiaohui Zhao, Weiguo Long, Deqiang Wang, Xia He, Jifeng Feng, Deyu Chen
Summary: PELI1 regulates the sensitivity of tumor cells to radiotherapy by modulating the expression of noncanonical NF-kappa B induced by IR, ultimately promoting apoptosis in tumor cells.
MOLECULAR ONCOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Weilai Tao, Xin Yue, Ruiling Ye, Fazul Nabi, Yangfei Shang, Zhaorong Zhu, Bhutto Zohaib Ahmed, Juan Liu
Summary: This study investigated the therapeutic effects of Penthorum Chinense Pursh extract (PCPE) on carbon tetrachloride (CCl4) induced acute liver injury (ALI) in dogs. The results showed that PCPE reduced pathological symptoms and liver tissue lesions, improved serum biochemical indicators, and alleviated inflammatory response and oxidative stress. The study also revealed that the NF-kappa B and MAPK signaling pathways are involved in the antioxidant and anti-inflammatory effects of PCPE treatment.
