Article
Nutrition & Dietetics
Zuguo Mei, O. Yaw Addo, Maria Elena D. Jefferds, Andrea J. Sharma, Rafael C. Flores-Ayala, Christine M. Pfeiffer, Gary M. Brittenham
Summary: By analyzing data from the NHANES III, researchers found that the thresholds of serum ferritin (SF) levels determined by an immunoradiometric assay were higher than the thresholds established by WHO based on expert opinion. These higher thresholds were able to better detect the onset of iron-deficient erythropoiesis, suggesting that the current WHO thresholds may identify a later, more severe stage of iron deficiency.
JOURNAL OF NUTRITION
(2023)
Article
Nutrition & Dietetics
Sixtus Aguree, Arthur Owora, Misty Hawkins, Manju B. Reddy
Summary: Obesity is associated with health and nutritional problems, including impaired iron metabolism leading to anemia. We conducted a study to determine the prevalence of anemia, iron deficiency (ID), and iron deficiency anemia (IDA) in women aged 20-49 years based on body mass index (BMI). Analysis of data from the National Health and Nutrition Examination Survey (NHANES) showed higher levels of certain iron measures and lower levels of others in obese women compared to those with normal weight. The prevalence rates of ID and anemia (and IDA) were generally higher in obese women, but the choice of iron indices impacted the estimates.
Article
Nutrition & Dietetics
Laura Tarancon-Diez, Miguel Genebat, Manuela Roman-Enry, Elena Vazquez-Alejo, Maria de la Sierra Espinar-Buitrago, Manuel Leal, Ma Angeles Munoz-Fernandez
Summary: This study aimed to determine a clinically relevant ferritin threshold to define absolute iron deficiency. The findings suggest that serum ferritin levels below 50 ng/mL are indicative of early iron deficiency.
Article
Health Care Sciences & Services
Piotr F. Czempik, Agnieszka Wiorek
Summary: This study analyzed the association between widely available standard iron biomarkers and selected new iron biomarkers in sepsis patients. The results showed that there is no meaningful correlation between standard and new iron biomarkers in various iron status subgroups.
Article
Neurosciences
Veronica T. Cheli, Diara A. Santiago Gonzalez, Rensheng Wan, Shaina L. Rosenblum, Giancarlo E. Denaroso, Christina G. Angeliu, Zachary Smith, Congying Wang, Pablo M. Paez
Summary: By disrupting the expression of the Tf receptor gene in oligodendrocyte progenitor cells, researchers found that the Tf cycle is uniquely important for the development and function of oligodendrocytes. Deleting the Tfr gene resulted in impaired iron absorption and hypomyelination in mice. The Tf cycle plays a crucial role in iron homeostasis and energy production in oligodendrocyte progenitor cells.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Nutrition & Dietetics
Ding Ye, Zhengyang Zhu, Huijun Huang, Xiaohui Sun, Bin Liu, Xia Xu, Zhixing He, Songtao Li, Chengping Wen, Yingying Mao
Summary: The study found that genetically predicted iron status is associated with the risk of systemic lupus erythematosus (SLE). Higher iron status may be linked to a reduced risk of SLE among European populations.
JOURNAL OF NUTRITION
(2021)
Article
Nutrition & Dietetics
Seok-Hui Kang, Bo-Yeon Kim, Eun-Jung Son, Gui-Ok Kim, Jun-Young Do
Summary: The aim of this study was to evaluate the survival rates of patients on maintenance hemodialysis (HD) according to their iron status. The study analyzed data from the National HD Quality Assessment Program and claims data (n = 42,390). The patients were divided into four groups based on their transferrin saturation rate and serum ferritin levels. The results showed that patients with normal iron status had the highest survival rates, while there were minimal differences in survival rates among the groups with abnormal iron status. Subgroup analyses based on age, hemoglobin, or serum albumin levels showed different trends.
Article
Biochemistry & Molecular Biology
Ewa Skarzynska, Monika Wrobel, Hanna Zborowska, Mateusz Franciszek Kolek, Grzegorz Manka, Mariusz Kiecka, Michal Lipa, Damian Warzecha, Robert Spaczynski, Piotr Piekarski, Beata Banaszewska, Artur Jakimiuk, Tadeusz Issat, Wojciech Rokita, Jakub Mlodawski, Maria Szubert, Piotr Sieroszewski, Grzegorz Raba, Kamil Szczupak, Tomasz Kluz, Marek Kluza, Miroslaw Wielgos, Barbara Lisowska-Myjak, Piotr Laudanski
Summary: The aim of this study was to investigate the relationship between lactoferrin and iron and its binding proteins in women with endometriosis. The results showed differences in lactoferrin, transferrin, ferritin, and iron levels between plasma and peritoneal fluid. Lactoferrin levels in plasma were associated with iron and transferrin in endometriosis, while lactoferrin in peritoneal fluid correlated with lactoferrin, iron, and transferrin in patients without endometriosis. The study suggests that assessing iron metabolism may be useful in diagnosing and monitoring endometriosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Lorena Duca, Francesca Granata, Elena Di Pierro, Valentina Brancaleoni, Giovanna Graziadei, Isabella Nava
Summary: This study investigated the role of FPN and TMPRSS6 gene polymorphisms in iron homeostasis. The findings indicated that individuals with FPN SNPs had higher ferritin concentration, transferrin saturation %, and hemoglobin concentration compared to those with TMPRSS6 SNPs or wild-type individuals. Furthermore, the presence of both SLC40A1 and TMPRSS6 SNPs led to even higher ferritin concentration and TS% than TMPRSS6 SNP group alone.
Article
Biochemistry & Molecular Biology
Ben Schoettker, Xin Gao, Eugene H. J. M. Jansen, Hermann Brenner
Summary: This study found a significant positive association between ferritin levels and red/processed meat consumption, as well as between hs-CRP levels and obesity. Transferrin saturation showed a strong positive association with both overall and advanced CRA cases. The SHP concentration was significantly inversely associated with advanced CRA.
Article
Nutrition & Dietetics
Reagan M. Mogire, John Muthii Muriuki, Alireza Morovat, Alexander J. Mentzer, Emily L. Webb, Wandia Kimita, Francis M. Ndungu, Alex W. Macharia, Clare L. Cutland, Sodiomon B. Sirima, Amidou Diarra, Alfred B. Tiono, Swaib A. Lule, Shabir A. Madhi, Andrew M. Prentice, Philip Bejon, John M. Pettifor, Alison M. Elliott, Adebowale Adeyemo, Thomas N. Williams, Sarah H. Atkinson
Summary: There is a significant association between vitamin D and iron deficiency in African children. The risk of iron deficiency is increased in children with vitamin D deficiency, and vitamin D concentration variably influences iron status. Therefore, the link between vitamin D and iron status should be considered in strategies to manage these nutrient deficiencies.
Review
Genetics & Heredity
Kevin Ferrao, Najma Ali, Kosha J. Mehta
Summary: Alcohol-associated liver disease (ALD) is a common chronic liver disease that often lacks specific diagnostic markers. Glutathione transferease may serve as a potential inflammatory biomarker in ALD.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Nutrition & Dietetics
Bart Larsen, Erica B. Baller, Alexander A. Boucher, Monica E. Calkins, Nina Laney, Tyler M. Moore, David R. Roalf, Kosha Ruparel, Ruben C. Gur, Raquel E. Gur, Michael K. Georgieff, Theodore Satterthwaite
Summary: This study analyzed the relationship between iron status, cognitive performance, and brain structure in adolescents using a large dataset. The results showed that iron status changes during adolescence, with females and individuals of low socioeconomic status having the lowest iron status. Higher hemoglobin concentrations were associated with better cognitive performance and greater brain white matter integrity. This suggests that adolescence may be a critical period for intervention to reduce health disparities.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Geriatrics & Gerontology
Lum Kastrati, Dion Groothof, Hugo G. Quezada-Pinedo, Hamidreza Raeisi-Dehkordi, Lia Bally, Martin H. De Borst, Stephan J. L. Bakker, Pedro-Marques Vidal, Michele F. Eisenga, Taulant Muka
Summary: The study aimed to examine the association between iron biomarkers and menopausal status and assess whether these biomarkers can help differentiate menopausal status beyond age. The results showed that iron biomarkers were significantly associated with menopausal status in both cohorts and modestly improved a model with age alone for differentiating menopause status.
Article
Genetics & Heredity
Miriam Sandnes, Marta Vorland, Rune J. Ulvik, Hakon Reikvam
Summary: HFE hemochromatosis is primarily associated with the C282Y variant, but the H63D variant can also affect disease manifestation. There is a complex relationship between HFE genotype and biochemical findings in patients, with non-C282Y homozygotes potentially presenting with hyperferritinemia that may have been overlooked in clinical practice.