Article
Physics, Multidisciplinary
J. Misek, J. Jakus, K. Hamza Sladicekova, L. Zastko, M. Veternik, V. Jakusova, I. Belyaev
Summary: Cell phones expose significant parts of the human brain and head to extremely low frequency (ELF) magnetic fields (MF) classified by the IARC as a 2B carcinogen. Measurements and simulations showed that the ELF MF emitted by cell phones can reach levels comparable to those known to induce biological and health effects, including carcinogenesis. Understanding the exposure and combined effects of radiofrequency and ELF electromagnetic fields is important for future studies.
FRONTIERS IN PHYSICS
(2023)
Article
Biochemistry & Molecular Biology
Anqi Du, Na Li, Zhilu Li, Ruowu Shen, Nan Li, Yu Zhou
Summary: Ghrelin and its receptor GHS-R1a regulate synaptic function of hippocampal neurons, potentially impacting memory formation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Immunology
Liu Yang, Huimin Zhou, Lei Huang, Yong Su, Liangliang Kong, Pengmin Ji, Ran Sun, Chao Wang, Weiping Li, Weizu Li
Summary: Chronic glucocorticoid exposure can accelerate neuronal damage and beta-amyloid production by activating oxidative stress and NLRP1 inflammasome, leading to the deterioration of Alzheimer's disease. Inhibition of NLRP1 inflammasome may be an important strategy in improving chronic glucocorticoid-induced neuronal injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Yi-Wen Wang, Qian Li, Xiao-Yue Li, Ying-Cai Zhao, Cheng-Cheng Wang, Chang-Hu Xue, Yu-Ming Wang, Tian-Tian Zhang
Summary: This study evaluated the neuroprotective effects of DHA-PS and EPA-PS against oxidative damage in primary hippocampal neurons. The results showed that DHA-PS and EPA-PS could significantly improve cell morphology, promote neural network structure restoration, and alleviate oxidative stress-induced mitochondrial dysfunction. EPA-PS played an anti-apoptotic role by inhibiting ERK phosphorylation and had a neuroprotective effect by increasing the expression of p-TrkB and p-CREB. Furthermore, EPA-PS enhanced synaptic plasticity by increasing SYN expression, while both DHA-PS and EPA-PS reduced the expression levels of p-GSK3β and p-Tau.
Article
Biochemistry & Molecular Biology
Jessica Maiuolo, Irene Bava, Cristina Carresi, Micaela Gliozzi, Vincenzo Musolino, Miriam Scicchitano, Roberta Macri, Francesca Oppedisano, Federica Scarano, Maria Caterina Caterina Zito, Francesca Bosco, Stefano Ruga, Saverio Nucera, Sara Ilari, Ernesto Palma, Carolina Muscoli, Vincenzo Mollace
Summary: Interest in natural compounds has grown due to their beneficial properties in treating diseases. Terpenic compounds, like ferutinin, extracted from plants like Ferula L., have antioxidant, anti-inflammatory, and estrogenic properties. Ferutinin may be useful in neurodegenerative and demyelinating diseases, but more research is needed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Lingxue Meng, Jian Liu, Congcong Wang, Zedong Ouyang, Jiahua Kuang, Qihua Pang, Ruifang Fan
Summary: The study showed that BPA and its analogs may cause oxidative damage to rat hippocampal neurons, but BPS has lower toxicity. Additionally, there are nonmonotonic dose-effect relationships between the concentrations of BPs and cytotoxic effects on hippocampal neurons, with males being more sensitive to BPs than females.
Article
Environmental Sciences
Raffaella Lazzarini, Maria Elexpuru-Zabaleta, Francesco Piva, Matteo Giulietti, Gianluca Fulgenzi, Maria Fiorella Tartaglione, Laura Zingaretti, Adriano Tagliabracci, Matteo Valentino, Lory Santarelli, Massimo Bracci
Summary: This study analyzed the effects of exposure to extremely low-frequency electromagnetic fields (ELF-MF) on breast cancer cells. The results showed that ELF-MF increased cell viability, cellular morphology, oxidative stress response, and altered proteomic profile in breast cancer cells. Moreover, ELF-MF exposure also affected cell adhesion, migration, and invasion abilities, as well as induced changes in mitochondrial function.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Biochemistry & Molecular Biology
Hariprasath Ragupathy, Manasvi Vukku, Sandeep Kumar Barodia
Summary: Neurodegeneration is a progressive phenomenon associated with aging, where activated microglia and neuroinflammation play crucial roles. Mitochondrial dysfunction and excessive neuroinflammatory responses are important factors contributing to age-dependent neurodegeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Yunkyung Eom, Sung Rae Kim, Yeong-Kyeong Kim, Sung Hoon Lee
Summary: Mitochondria play a critical role in cellular Ca2+ homeostasis and their dysfunction has been implicated in psychological and neurological disorders. This study investigated mitochondrial Ca2+ waves in hippocampal neurons and found that they are regulated by action potentials and frequency of electrical stimulation. The results provide new insights into the mechanisms underlying mitochondrial Ca2+ buffering and the molecular basis of mitochondrial Ca2+ waves.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Medicine, Research & Experimental
Qiang Luo, Panpan Xian, Tian Wang, Shengxi Wu, Tangna Sun, Wenting Wang, Bo Wang, Hao Yang, Yanping Yang, Han Wang, Weiping Liu, Qianfa Long
Summary: The study demonstrates that MSC-EVs exhibit significant antioxidant and restorative effects against oxidative stress-induced neuronal damage, aiding in the reconstruction of hippocampal neurons' structure and function. Through involvement of the Nrf2 signaling pathway, MSC-EVs facilitate the repair of neurons damaged by oxidative stress.
Article
Neurosciences
Wei Yang, Cao Chen, Jia Chen, Ying Xia, Chao Hu, Lin Wang, Yue-Zhang Wu, Qi Shi, Zhi-Bao Chen, Xiao-Ping Dong
Summary: This study evaluated the effects of 3,4-dihydroxybenzalacetone (DBL) on prion-infected cells and found that DBL can decrease PrPSc levels, activate cellular protective mechanisms, and alleviate cellular stress and dysfunction. These findings suggest that DBL has potential as a therapeutic agent for prion diseases.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Ophthalmology
Cody R. R. Fisher, Mara C. C. Ebeling, Deborah A. A. Ferrington
Summary: The retinal pigment epithelium plays a crucial role in maintaining a healthy retina, but its loss is associated with various visual disorders. Primary RPE cultures are used to study disease mechanisms, but have limitations. To overcome these limitations, researchers used an AAV vector to express a fluorescent protein and developed an image analysis pipeline to accurately quantify the protein. These techniques provide a roadmap for investigating disease mechanisms using fluorescent probes in an important cell culture model.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yeon Joo Choi, Min Jea Shin, Gi Soo Youn, Jung Hwan Park, Hyeon Ji Yeo, Eun Ji Yeo, Hyun Jung Kwon, Lee Re Lee, Na Yeon Kim, Su Yeon Kwon, Hyo Young Jung, Yong-Jun Cho, Dae Won Kim, Jinseu Park, Kyu Hyung Han, Keun Wook Lee, Jong Kook Park, Chan Hee Lee, Won Sik Eum, Soo Young Choi
Summary: In this study, the role of GSTA2 in preventing ischemic injury was investigated using the cell-permeable PEP-1-GSTA2 protein. It was found that PEP-1-GSTA2 protected HT-22 cells from cell death induced by oxidative stress through the inhibition of ROS production and DNA damage. Additionally, PEP-1-GSTA2 promoted MAPK and NF-κB activation, and regulated the expression levels of Bcl-2, Bax, cleaved Caspase-3 and -9 proteins. In an in vivo ischemic animal model, PEP-1-GSTA2 prevented hippocampal neuron loss and reduced microglia and astrocyte activation. These findings suggest that PEP-1-GSTA2 suppresses hippocampal cell death by regulating MAPK and apoptotic signaling pathways, potentially offering a new therapeutic strategy for oxidative stress-induced ischemic injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pediatrics
David Garcia, Jennifer F. Carr, Felix Chan, Abigail L. Peterson, Kimberlyn A. Ellis, Alejandro Scaffa, Andrew J. Ghio, Hongwei Yao, Phyllis A. Dennery
Summary: This research reveals that even a very short exposure to high oxygen concentrations can lead to long-term cellular injury in lung epithelial cells, affecting mitochondrial function and alveolarization. The study highlights the long-term residual effects of a short period of hyperoxia on cellular metabolism and the development of alveolar simplification in neonatal mice. The findings suggest that any exposure to clinical hyperoxia can result in persistent lung dysfunction.
PEDIATRIC RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Hyun Joo Shin, Eun Ae Jeong, Jong Youl Lee, Hyeong Seok An, Hye Min Jang, Yu Jeong Ahn, Jaewoong Lee, Kyung Eun Kim, Gu Seob Roh
Summary: The deficiency of LCN2 reduces neuronal cell death, BBB leakage, iron overload, and oxidative stress in KA-induced hippocampal cell death, and inhibits related neuroinflammatory responses, indicating a significant role of LCN2 in this process.