Review
Clinical Neurology
Sherief Ghozy, Amr Ehab El-Qushayri, Joseph Varney, Salah Eddine Oussama Kacimi, Eshak I. Bahbah, Mostafa Ebraheem Morra, Jaffer Shah, Kevin M. Kallmes, Alzhraa Salah Abbas, Mohamed Elfil, Badrah S. Alghamdi, Ghulam Ashraf, Rowa Alhabbab, Adam A. Dmytriw
Summary: NLR has been shown to be a sensitive biomarker in predicting clinical outcomes in TBI patients, especially in pediatric cases. However, there is considerable heterogeneity in the current literature, warranting further studies to confirm the reliability of NLR in predicting TBI outcomes.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, Research & Experimental
George A. Alexiou, Aggeliki Tzima, Georgios D. Lianos, Marios Lampros, Athanasios Sotiropoulos, Dimitrios Rizos, Olga Ygropoulou, Jiolanda Zika, Eleutherios-Spyridon Alexiou, Spyridon Voulgaris
Summary: This study investigates the value of neutrophil-to-lymphocyte ratio (NLR) as a biomarker to predict coagulopathy occurrence after traumatic brain injury (TBI) and concludes that NLR might be a novel and inexpensive biomarker for decision making in the management of TBI. Combination of NLR with other low-cost biomarkers and the clinical findings might further increase accuracy in the prediction of coagulopathy.
BIOMARKERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Marina Levochkina, Leah McQuillan, Nabil Awan, David Barton, John Maczuzak, Claudia Bianchine, Shannon Trombley, Emma Kotes, Joshua Wiener, Audrey Wagner, Jason Calcagno, Andrew Maza, Ryan Nierstedt, Stephanie Ferimer, Amy Wagner
Summary: This study examined the temporal dynamics of NLR post-TBI and its associations with hospital-acquired infections (HAIs), resource utilization, and outcomes. It identified two distinct NLR profiles with high NLR associated with higher rates of HAIs and negative recovery outcomes. The findings highlight the importance of monitoring immune factors post-TBI for infection risk and recovery optimization.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Geriatrics & Gerontology
Xintong Ge, Luoyun Zhu, Meimei Li, Wenzhu Li, Fanglian Chen, Yongmei Li, Jianning Zhang, Ping Lei
Summary: This article investigates blood biomarkers for evaluating the deterioration risk of mild traumatic brain injury (mTBI) at the early stage. The study finds that the combinatorial indices NLR, RPR, and NLTRP may be potential risk predictors, with NLTRP having a higher prediction value and clinical benefit in medical decision-making.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Critical Care Medicine
Ehsan Alimohammadi, Alireza Zamani Foroushani, Farid Moradi, Kaveh Ebrahimzadeh, Mohammad Javad Nadersepahi, Sahel Asadzadeh, Akram Amiri, Sahar Hosseini, Sonia V. Eden, Seyed Reza Bagheri
Summary: By retrospectively evaluating the clinical data of 374 pediatric patients with moderate to severe TBI, the study found that the dynamics of NLR are correlated with clinical outcomes. ΔNLR could be a predictor of poor clinical outcome in pediatric patients with moderate to severe TBI.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2022)
Article
Medicine, General & Internal
Sang-Hwa Lee, Jong-Ho Kim, Young-Suk Kwon, Jong-Hee Sohn
Summary: The study found that peripheral inflammatory markers (PIMs) significantly increased during migraine attacks, indicating that inflammation may play a role in migraines. Among different markers, NLR and NMR had poor ability to differentiate between migraine and non-migraine headaches, but performed well in distinguishing migraines from other types of headaches.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Qiang Hu, Weipu Mao, Tiange Wu, Zhipeng Xu, Junjie Yu, Can Wang, Saisai Chen, Shuqiu Chen, Bin Xu, Yueshuang Xu, Ming Chen
Summary: In RCC patients undergoing laparoscopic partial or radical nephrectomy, NLR and PLR were identified as biomarkers of systemic inflammation associated with increased risk of sarcopenia. The best cutoff points for predicting sarcopenia risk were NLR >2.88 and PLR >135.63, with higher levels indicating a greater risk. Adjusting for various variables, patients with NLR >2.88 and PLR >135.63 had significantly higher risks of developing sarcopenia compared to those with lower NLR or PLR levels.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Murat Sahin, Ayten Oguz, Dilek Tuzun, Okay Isiktas, Songul Isiktas, Cansu ulgen, Hatice Sahin, Kamile Gul
Summary: This study aimed to investigate whether the neutrophil-lymphocyte ratio (NLR), an indicator of systemic inflammation, could predict gestational diabetes mellitus (GDM). The results showed a significant increase in NLR in the 1st and 3rd trimesters in the GDM group, supporting the presence of systemic inflammation in early pregnancy and throughout pregnancy. The study also found a positive correlation between NLR and fasting plasma glucose and body mass index in both trimesters. The first trimester NLR was found to independently predict the development of GDM.
Article
Immunology
Qian Song, Song-Xiao Xu, Jun-Zhou Wu, Lin Ling, Sheng Wang, Xin-Hua Shu, Dan-Ni Ying, Wang-Wei Pei, Yu-Chen Wu, Su-Fang Sun, Yi-Ning Zhang, Si-Hang Zhou, Zhu-Yan Shao
Summary: This study analyzed data from 991 ovarian cancer patients and found that the lymphocyte to monocyte ratio (LMR) and platelet to neutrophil ratio (PNR) were independent prognostic indicators of ovarian cancer. In contrast, the platelet to lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) had limited prognostic value. In conclusion, LMR and PNR are superior prognostic indicators in ovarian cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Tetsuya Akaishi, Tatsuro Misu, Kazuo Fujihara, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Fumi Itabashi, Ikumi Kanno, Toshiyuki Takahashi, Hiroshi Kuroda, Juichi Fujimori, Yoshiki Takai, Shuhei Nishiyama, Kimihiko Kaneko, Tadashi Ishii, Masashi Aoki, Ichiro Nakashima, Atsushi Hozawa
Summary: Patients with multiple sclerosis showed elevated counts of total white blood cells, monocytes, basophils, and neutrophils at the time of diagnosis. However, the clinical relevance of these biomarkers in the context of the development and progression of MS remains unclear.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Aysun Firat, Aysegul Ercan, Cengiz Mordeniz, Fatma Ferda Verit Atmaca
Summary: This study aimed to investigate whether the pretreatment hemogram parameters and their ratios can predict the endometrial transformation in patients with abnormal uterine bleeding. The study found that age, postmenopausal state, obesity, diabetes, and increased estrogen exposure were risk factors for endometrial atypia and carcinoma. Hemoglobin and hematocrit levels were significantly higher in early and advanced endometrial cancer groups, while platelet value was significantly higher in atypia and carcinoma groups.
Review
Immunology
Tracy Bhikram, Paul Sandor
Summary: The review found that NLR is elevated in certain adult psychiatric disorders like schizophrenia, major depressive disorder, and bipolar disorder, but the associations with symptom severity and clinical parameters are not entirely clear. Results in youth populations are similar to those in adults, indicating a need for further research to better understand the relationship between NLR and specific psychiatric disorders. Future work is required to determine the neuroinflammatory mechanisms underlying these disorders.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Immunology
Sandy R. Shultz, Anup D. Shah, Cheng Huang, Larissa K. Dill, Ralf B. Schittenhelm, M. Cristina Morganti-Kossmann, Bridgette D. Semple
Summary: In this study, the changes in the cerebrospinal fluid (CSF) proteome after severe traumatic brain injury (TBI) were evaluated using high-resolution mass spectrometry. The results showed a robust innate immune response and downregulated pathways involved in nervous system development after TBI. Additionally, several proteins were identified as potential biomarkers or therapeutic targets for brain damage based on their differential regulation after severe TBI.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Clinical Neurology
Kanchan Bilgi, Kadarapura Nanjundaiah Gopalakrishna, Dhritiman Chakrabarti, G. S. Umamaheswara Rao
Summary: International normalized ratio, total leukocyte count, and blood transfusion were identified as predictors of mortality and unfavorable neurological outcomes in traumatic brain injury (TBI) at 6 months. Their addition to the IMPACT and CRASH prognostic models resulted in a modest improvement in predicting outcomes in TBI.
WORLD NEUROSURGERY
(2021)
Article
Psychiatry
Qi Zheng, Jin Liu, YaJuan Ji, Yan Zhang, XinChao Chen, BangShan Liu
Summary: This study compared the levels of inflammatory indicators derived from blood routine tests between adolescents with and without non-suicidal self-injury (NSSI). The results showed that adolescents with NSSI had significantly higher MLR and PLR compared to those without NSSI. MLR and PLR were independently associated with NSSI. ROC curve analysis demonstrated that MLR and PLR can be used to differentiate NSSI from non-NSSI.