Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 45, Issue 10, Pages 2712-2720Publisher
WILEY
DOI: 10.1002/eji.201545759
Keywords
Autoimmunity; Central nervous system; Inflammation; Neurodegeneration; Neurons; Tcells; Viral infection
Categories
Funding
- FAPESP [2013/22196-4]
- INSERM
- CNRS
- Toulouse III University
- ARSEP
- ANR T cell-CNS
- European Union
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [13/22196-4] Funding Source: FAPESP
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Central nervous system (CNS) inflammation occurs in a large number of neurological diseases. The type and magnitude of CNS inflammation, as well as the T-cell contribution, vary depending on the disease. Different animal models of neurological diseases have shown that Tcells play an important role in CNS inflammation. Furthermore, recent studies of human neurological disorders have indicated a significant role for Tcells in disease pathology. Nevertheless, how individual T-cell subsets affect neuronal survival, damage and/or loss remains largely unclear. In this review we discuss the processes by which Tcells mediate either beneficial or deleterious effects within the CNS, with emphasis on the direct interaction between Tcells and neurons, as occurs in multiple sclerosis, paraneoplastic cerebellar degeneration, and viral encephalitis. The therapeutic approaches targeting Tcells and their mediators as treatment for neurological diseases are also described here.
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