Article
Surgery
Ji-Soo Kim, Won Lee, Wook Oh, Jung-Ah Park, Eun-Jung Yang
Summary: Using anatomical studies and ultrasound examination, injecting filler into the dorsal intermediate lamina of the hands is safe and effective. Results from cadaveric hands and patients treated with the filler support this technique, confirming it as an appropriate method for hand rejuvenation.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2021)
Article
Surgery
Nabil Fakih-Gomez, Jonathan Kadouch
Summary: The study demonstrates that the combination of CaHA and CPM-HA is effective in volumizing and lifting the cheeks and jawline, with no reported adverse events.
AESTHETIC PLASTIC SURGERY
(2022)
Article
Dermatology
Irem Yanatma, Gulbahar Sarac, Mehmet Gul, Semir Gul, Yelda Kapicioglu
Summary: The study compared the effects of PCL and CaHA fillers on rat skin, finding that both are effective in increasing dermal collagen density and amount, preventing dermis atrophy, and showed no advantage over each other in this respect. PCL filler provides more fibroblast increase compared to CaHA filler, but the effect of stimulating fibroblast proliferation takes longer.
DERMATOLOGIC THERAPY
(2021)
Article
Dermatology
Enrico Massidda
Summary: This report examines the use of Radiesse (R) for skin rejuvenation and regeneration in 50 patients, and finds that it effectively improves skin thickness, laxity, and wrinkles with high tolerability and no significant adverse effects.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2023)
Article
Surgery
J. Sarah Crowley, Elizabeth Kream, Sabrina Fabi, Steven R. Cohen
Summary: Facial rejuvenation requires a multi-modality approach to address the sun damage, volume loss, and thinning of skin that occurs with aging, with fillers and fat grafting being common techniques with their own advantages.
AESTHETIC SURGERY JOURNAL
(2021)
Review
Nanoscience & Nanotechnology
Yue Pan, Ying Hao, Yao Xiao, Kun Shi, Ying Qu, ZhiYong Qian
Summary: Soft tissue augmentation is a method to restore lost tissue and boost confidence for patients. Injectable fillers have gained attention in facial cosmetic fields, and there is a high demand for improved fillers in the medical cosmetology market. This review introduces various fillers used in clinical settings and provides updates on recent advancements in injectable filling materials, aiming to contribute to further developments in the field.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2021)
Article
Dermatology
Marion Moers-Carpi, Marie-Odile Christen, Henry Delmar, Patrick Brun, Isaac Bodokh, Philippe Kestemont
Summary: A European, multicenter, prospective study evaluated the long-term safety and efficacy of polycaprolactone-dermal filler (PCL-filler) in correcting age-related changes affecting facial areas. The study demonstrated high satisfaction, long-lasting improvement in nasolabial folds, and improved skin quality, with no severe adverse events reported. The safety of PCL-filler was confirmed for up to 30 months.
DERMATOLOGIC SURGERY
(2021)
Article
Surgery
Steven R. Cohen, Sarah Patton, Jordan Wesson, K. Tunc Tiryaki, Alexandra Mora
Summary: This study presents a simple and reliable technique for removing excess calcium hydroxyapatite (CaHA) filler that can cause nodules and vascular compression. The technique involves using a specific cannula and negative pressure to suction out the excess material, and has been successfully applied in clinical practice.
AESTHETIC SURGERY JOURNAL
(2023)
Article
Dermatology
Stefania Guida, Sabrina Longhitano, Marco Spadafora, Andrea Lazzarotto, Francesca Farnetani, Nicola Zerbinati, Giovanni Pellacani, Hassan Galadari
Summary: This study investigated the efficacy and safety of hyperdiluted calcium hydroxyapatite (hy-CaHA) for treating neck skin laxity (NSL). The results showed that hy-CaHA was effective according to the newly developed NSL scale and safe, with no major adverse events reported. The study also highlighted the utility of the NSL scale as a useful tool for evaluating NSL before treatment and measuring outcomes.
DERMATOLOGIC THERAPY
(2021)
Review
Dermatology
Kathryn Rentfro, Dillon Clarey, Emily J. Glenn, Ronald Sulewski, Ashley Wysong
Summary: This study systematically compiles cases of necrosis caused by soft tissue fillers and collects data on injection, treatment, and outcomes. The majority of necrosis cases analyzed were a result of hyaluronic acid injections in the nasolabial fold. Hyaluronidase was the most commonly used initial treatment agent for necrosis. This review serves as a valuable reference for clinicians and providers encountering necrosis from soft tissue fillers.
DERMATOLOGIC SURGERY
(2022)
Article
Surgery
Z. Paul Lorenc, Jeanette M. Black, Jessie S. Cheung, Annie Chiu, Roberta Del Campo, Alan James Durkin, Miles Graivier, Jeremy B. Green, Gideon P. Kwok, Keith Marcus, Charalambos 'Babis' Rammos, William Philip Werschler
Summary: This study provides practical guidance for expert physicians on the use of hyperdilute CaHA, including patient selection, dilution practices, and injection techniques, to facilitate the incorporation of this technology into clinical practice. The minimally invasive nature and quick recovery time of this technique increase its appeal, but adherence to previously published consensus guidelines and expert experience is important.
AESTHETIC SURGERY JOURNAL
(2022)
Article
Dermatology
Bartosch Nowag, Daniela Schaefer, Thomas Hengl, Niamh Corduff, Kate Goldie
Summary: The study aims to investigate the in vitro macrophage response to two biostimulatory fillers, CaHA and PLLA, and evaluate their inflammatory potential. The findings indicate that CaHA induces a non-inflammatory response, while PLLA triggers the expression of several cytokines involved in inflammation. These results suggest that CaHA and PLLA follow distinct pathways and should be considered individually in terms of mechanism of action.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Review
Dermatology
Niamh Corduff
Summary: Skin aging is caused by immunological responses to tissue deterioration and damage. Anti-aging aesthetic medicine uses biomaterial-based fillers to influence these responses and renew aged tissue. By understanding this process, we can develop aesthetic injectable biomaterials to direct healing towards tissue regeneration instead of scarring.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Dermatology
Stefania Guida, Marco Spadafora, Sabrina Longhitano, Giovanni Pellacani, Francesca Farnetani
Summary: The study developed a 4-point photonumeric neck skin laxity (NSL) scale based on the frontal neck photographic images of 110 subjects. The scale showed excellent intraobserver and interobserver reliability, making it a reliable and reproducible scoring system for the aesthetic evaluation of neck skin laxity.
DERMATOLOGIC SURGERY
(2021)
Article
Biochemistry & Molecular Biology
Killian Flegeau, Jing Jing, Romain Brusini, Melanie Gallet, Capucine Moreno, Lee Walker, Francois Bourdon, Jimmy Faivre
Summary: In this study, a novel rheological procedure was used to evaluate the degradation kinetics of TEOSYAL RHA((R)) filler in contact with HAase. Mathematical analyses were developed to determine the optimal time between injections and number of enzymatic units for maximizing degradation kinetics.
Article
Surgery
Jonathan Kadouch, Leonie W. Schelke, Arthur Swift
Summary: The use of doppler-ultrasound (DUS) imaging for autologous fat transplantation in facial surgery is safe and reliable, aiding in avoiding vascular complications and providing valuable information for the procedure.
AESTHETIC SURGERY JOURNAL
(2021)
Article
Dermatology
Jani van Loghem, David Funt, Tatjana Pavicic, Kate Goldie, Yana Yutskovskaya, Sabrina Fabi, Pieter Siebenga, Job Thuis, Joseph Hkeik, Jonathan Kadouch, Welf Prager, Nabila Azib, Gabriela Casabona, Steve Dayan, Shino Bay Aguilera, Philippe Snozzi, Peerooz Saeed
JOURNAL OF COSMETIC DERMATOLOGY
(2020)
Article
Surgery
Peter J. Velthuis, Oscar Jansen, Leonie W. Schelke, Hyoungjin J. Moon, Jonathan Kadouch, Benjamin Ascher, Sebastian Cotofana
Summary: Duplex mode ultrasound imaging is essential for detecting variations in facial vascular structures and preventing complications such as skin necrosis or vision loss. We predict that in the future, ultrasound technology will become standard equipment in cosmetic doctors' offices, especially for vascular imaging.
AESTHETIC SURGERY JOURNAL
(2021)
Article
Surgery
Peter J. Velthuis, Oscar Jansen, Leonie W. Schelke, Hyoungjin J. Moon, Jonathan Kadouch, Benjamin Ascher, Sebastian Cotofana
Summary: Interest in Doppler ultrasound analysis of the face has increased in cosmetic medicine, especially for injectable fillers. Ultrasound-guided injections with hyaluronidase can precisely target problems, while also preventing intravascular injections. It is predicted that in the future, Doppler ultrasound will become a standard equipment in cosmetic doctors' offices, as it allows for easy visualization and analysis of relevant anatomical structures in the face.
AESTHETIC SURGERY JOURNAL
(2021)
Article
Surgery
Nabil Fakih-Gomez, Jonathan Kadouch
Summary: The study demonstrates that the combination of CaHA and CPM-HA is effective in volumizing and lifting the cheeks and jawline, with no reported adverse events.
AESTHETIC PLASTIC SURGERY
(2022)
Review
Dermatology
Yara Bachour, Marcel W. Bekkenk, Thomas Rustemeyer, Jonathan A. Kadouch
Summary: This review examines the late inflammatory reactions (LIRs) caused by soft tissue fillers after SARS-CoV-2 infection or vaccination. The results show a relationship between these adverse events and Moderna and Pfizer vaccinations. These reactions are generally minor and self-limiting, and patients with soft tissue fillers are encouraged to participate in vaccination programs.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Surgery
Leonie W. Schelke, Peter J. Velthuis, Tom Decates, Jonathan Kadouch, Michael Alfertshofer, Konstantin Frank, Sebastian Cotofana
Summary: This study compared the ultrasound-guided targeted and flooding protocols for managing adverse vascular events following hyaluronic acid-based aesthetic injections. The results showed that the ultrasound-guided targeted protocol utilized less hyaluronidase and restored clinical symptoms faster.
AESTHETIC SURGERY JOURNAL
(2023)
Article
Dermatology
Tom Decates, Jonathan Kadouch, Peter Velthuis, Thomas Rustemeyer
Summary: The exact etiology of late inflammatory reactions (LIRs) to hyaluronic acid (HA) fillers is currently unknown, and the results suggest that immediate or delayed type hypersensitivity reaction does not play a role in these reactions.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2021)
