Review
Cardiac & Cardiovascular Systems
Gonzalo Saco-Ledo, Pedro L. Valenzuela, Luis M. Ruilope, Alejandro Lucia
Summary: Physical exercise is effective in reducing blood pressure in patients with resistant hypertension, with acute exercise leading to short-term reduction and regular exercise leading to long-term reduction.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Food Science & Technology
Elahe Mokhtari, Sahar Rafiei, Nafiseh Shokri-Mashhadi, Parvane Saneei
Summary: Astaxanthin supplementation leads to a slight decrease in diastolic blood pressure in adults, especially in patients and participants from Asian countries. This effect is more pronounced with a dosage of > 12 mg/day supplementation.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Review
Nutrition & Dietetics
Shuaishuai Zhou, Teng Xu, Xu Zhang, Junjie Luo, Peng An, Yongting Luo
Summary: The supplementation of casein hydrolysate can effectively reduce blood pressure without affecting blood lipids or glycemic status.
Review
Pharmacology & Pharmacy
Jingyi Ren, Jiaqi An, Mengyuan Chen, Haiyue Yang, Yuxia Ma
Summary: PCs supplementation can significantly reduce systolic blood pressure, diastolic blood pressure, and mean arterial pressure, but has no significant effect on pulse pressure. Stratified analysis by study duration and BMI revealed different trends in the effects. Low-dose PCs were found to significantly lower blood pressure. Meta-regression analysis did not show dose effects of PCs on blood pressure.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Mehmet Kanbay, Sidar Copur, Dimitrie Siriopol, Abdullah Burak Yildiz, Abduzhappar Gaipov, Daniel H. Van Raalte, Katherine R. Tuttle
Summary: This study demonstrates that tirzepatide significantly reduces blood pressure and lipid levels, including total cholesterol, LDL cholesterol, and triglycerides, while increasing HDL cholesterol levels.
DIABETES OBESITY & METABOLISM
(2023)
Article
Nutrition & Dietetics
Joanna Bajerska, Karolina Lagowska, Mari Mori, Julita Regula, Aleksandra Skoczek-Rubinska, Toshiya Toda, Naho Mizuno, Yukio Yamori
Summary: This systematic review and meta-analysis found evidence that soy products significantly reduce CRP concentrations in postmenopausal women, but soy intake does not affect IL-6 or TNF-α. However, the mechanisms by which soy foods and their constituents affect inflammatory biomarkers still need further investigation.
JOURNAL OF NUTRITION
(2022)
Review
Cardiac & Cardiovascular Systems
Mahdi Vajdi, Vali Musazadeh, Mohammad Zareei, Shaghayegh Adeli, Arash Karimi, Ali Hojjati, Melika Darzi, Hamed Shoorei, Mahdieh Abbasalizad Farhangi
Summary: This study conducted a systematic review and dose-response meta-analysis to summarize clinical trial data on the effects of whey protein supplementation on blood pressure in adults. The analysis revealed that whey protein intake significantly reduced systolic blood pressure, but had no significant effect on diastolic blood pressure. Subgroup analysis showed that the reduction in diastolic blood pressure was significant when the intervention used whey protein isolate powder, when the sample size was less than or equal to 100, when the intervention duration was less than or equal to 10 weeks, and when the participants had hypertension and a BMI of 25-30 kg/m(2).
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Review
Cardiac & Cardiovascular Systems
Mohammad Ahmed, Matthew Nudy, Rahul Bussa, Alexander Hajduczok, Gerald V. Naccarelli, Edward J. Filippone, Andrew J. Foy
Summary: Renal denervation (RD) is a novel treatment for lowering blood pressure. This meta-analysis examined the efficacy of RD and factors associated with treatment effect heterogeneity. The results showed that RD was associated with significant reductions in most blood pressure measures. Studies with longer follow-up had smaller reductions, but there were no significant differences between subgroups.
TRENDS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Nutrition & Dietetics
Piotr Machowiec, Gabriela Reka, Marcela Maksymowicz, Halina Piecewicz-Szczesna, Agata Smolen
Summary: The study found that supplementation of Spirulina can significantly lower diastolic and systolic blood pressure, especially among hypertensive patients. This suggests that Spirulina administration may have a positive impact on the prevention and treatment of hypertension. Further, more precise randomized controlled trials are needed to confirm the effects of Spirulina supplementation on blood pressure.
Article
Cardiac & Cardiovascular Systems
Amy C. Ellis, Tapan Mehta, Vinoth A. Nagabooshanam, Tanja Dudenbostel, Julie L. Locher, Kristi M. Crowe-White
Summary: This study aimed to evaluate the effects of 100% watermelon juice on measures of vascular function in healthy postmenopausal women. However, results showed that supplementation with watermelon juice did not significantly impact vascular function in this cohort.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Review
Food Science & Technology
Deming Looi, Mohanambal Moorthy, Nathorn Chaiyakunapruk, Uma Devi Palanisamy
Summary: The consumption of ellagitannin-rich fruits may have a significant effect in reducing diastolic blood pressure, especially in patients with hypertension and metabolic syndrome. There is a positive correlation between polyphenol dosage and changes in systolic blood pressure.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Review
Food Science & Technology
Haohai Huang, Guanghui Zhou, Rong Pu, Yejia Cui, Dan Liao
Summary: The meta-analysis study found that sesame consumption can reduce the risk of cardiovascular disease and improve blood lipids, blood pressure, and body weight management. This conclusion is stable and reliable, but further large-scale studies are needed to verify it.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Physiology
Yi-Bang Cheng, Jia-Hui Xia, Yan Li, Ji-Guang Wang
Summary: Newer antihypertensive agents, such as RAS inhibitors and CCBs, were found to be significantly more efficacious than older agents in their effects on central hemodynamics.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Endocrinology & Metabolism
Jia-Li Zhang, Christina Chui-Wa Poon, Man-Sau Wong, Wen-Xiong Li, Yi-Xun Guo, Yan Zhang
Summary: This systematic review and meta-analysis examines the effects of vitamin D supplementation on muscle strength and mobility in postmenopausal women. The results suggest that vitamin D supplementation improves muscle strength, but has no significant effect on mobility.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Food Science & Technology
Zeinab Gholami, Zamzam Paknahad
Summary: This systematic review and meta-analysis explored the impact of psyllium consumption on metabolic syndrome indices. The findings indicate that psyllium consumption significantly reduces fasting blood glucose and systolic blood pressure, while the effects on high-density lipoprotein cholesterol, diastolic blood pressure, and waist circumference are not statistically significant. The level of triglycerides also slightly decreases.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Davide Risso, Gillian Dunngalvin, Sameer Saxena, Andrea Doolan, Lisa Spence, Kavita Karnik
Summary: This study investigated the gastrointestinal tolerance of low-calorie sugar D-allulose in young children and found that it was well tolerated. It can be considered as a candidate for replacing added sugars with lower caloric content in commercially produced goods.
Article
Biochemistry & Molecular Biology
Xinying Suo, Anna Baggio, Nicoletta Pellegrini, Silvia Vincenzetti, Elena Vittadini
Summary: This study investigated the effects of shape, gluten, and structural breakdown on the starch digestibility and glycemic index of gluten-containing and gluten-free pasta. The results showed that mastication effort, shape, and gluten content had significant impacts on starch digestion and glycemic index, with gluten being the major factor affecting the amount of digested starch.
Article
Biochemistry & Molecular Biology
Xinnuo Hu, Yanjun Yang, Cuihua Chang, Junhua Li, Yujie Su, Luping Gu
Summary: Fish collagen was enzymatically hydrolyzed using alkaline, papain, and ginger protease. The addition of ginger protease increased the degree of hydrolysis and resulted in changes in the amino acid composition and molecular weight distribution of the peptides. Combined hydrolysis with ginger protease improved the ACE inhibitory activity of the sample but affected fibroblast proliferation activity.
Article
Biochemistry & Molecular Biology
Tong Nie, Xin Wang, Aqun Li, Anshan Shan, Jun Ma
Summary: This study investigated the mechanism by which hesperidin prevents nonalcoholic fatty liver disease (NAFLD) by modulating fatty acid beta oxidation. The results suggest that hesperidin promotes fatty acid beta oxidation by activating SIRT1/PGC1 alpha, thus improving NAFLD.
Article
Biochemistry & Molecular Biology
Li Li, Jing Zhao, Jinxue Wang, Qianqian Xiong, Xuechun Lin, Xiaolei Guo, Fan Peng, Wangqun Liang, Xuezhi Zuo, Chenjiang Ying
Summary: The daily administration of 10 g d-1 inulin-type fructans significantly reduced the circulating arsenic retention in end-stage renal disease by increasing the arsenic clearance rate through urine and dialysis. However, it was found to be ineffective for other trace elements.
Article
Biochemistry & Molecular Biology
Chuanchuan Wang, Weixuan Chen, Yishan Jiang, Xiao Xiao, Qianhui Zou, Jiarui Liang, Yu Zhao, Qianxu Wang, Tian Yuan, Rui Guo, Xuebo Liu, Zhigang Liu
Summary: Autism Spectrum Disorder (ASD) symptoms may be improved through modulation of gut microbiota. This study investigated the effects of a synbiotic treatment on an ASD-like mouse model, and found that it rectified social impairments, attenuated inflammatory cytokine expressions, protected gut barrier integrity, and altered gut microbiota composition. The synbiotic treatment elevated beneficial metabolites and upregulated genes associated with their synthesis. Overall, the synbiotic combination mitigated ASD-related social impairments through regulation of the gut-brain axis.
Review
Biochemistry & Molecular Biology
Chunli Kong, Caiping Duan, Yixuan Zhang, Yiying Wang, Zheng Yan, Sumei Zhou
Summary: This review critically discusses the physicochemical properties of bioactive molecules in kidney beans and focuses on the current knowledge of non-starch polysaccharide (NSP) structure and function on intestinal health and metabolism. It also provides suggestions for further investigation and development of NSPs as novel plant carbohydrate resources.
Article
Biochemistry & Molecular Biology
Fei Shen, Qianqian Wang, Sami Ullah, Ya Pan, Minjie Zhao, Jing Wang, Ming Chen, Fengqin Feng, Hao Zhong
Summary: This study investigated the peristalsis-promoting potential of Ligilactobacillus acidipiscis YJ5 and its underlying molecular mechanism in relieving constipation. The results showed that L. acidipiscis YJ5 intervention increased intestinal peristalsis in zebrafish and mouse models, reduced colonic aquaporin expression, repaired intestinal morphological damage, enhanced the colonic mucosal barrier, and reversed the gut microbiota structure. The positive effects of L. acidipiscis YJ5 were attributed to its metabolites such as malic acid and heliangin.
Article
Biochemistry & Molecular Biology
Zhuo Qu, Jiahui Tian, Jiachen Sun, Ying Shi, Jianqiang Yu, Wannian Zhang, Chunlin Zhuang
Summary: Smoking is the main risk factor for lung cancer, but garlic oil compound DATS shows potential as a chemopreventive agent. DATS can inhibit the carcinogenic effects of tobacco and regulate gut microbiota, as well as activate the PPAR-gamma pathway to suppress tumor growth.
Article
Biochemistry & Molecular Biology
Yanli Zhang, Jielun Hu, Yadong Zhong, Shuai Liu, Liandi Liu, Xinyi Mu, Chunhua Chen, Shenji Yang, Guohao Li, Duoduo Zhang, Xinru Huang, Jinrui Yang, Xiaojun Huang, Shuigen Bian, Shaoping Nie
Summary: The study found that different ratios of insoluble and soluble dietary fiber have distinct effects on gut microbiota and serum metabolites. Increasing the ratio of insoluble dietary fiber increases the relative abundance and acid production of specific bacterial genera, while increasing the ratio of soluble dietary fiber increases the diversity and relative abundance of other bacterial genera and regulates metabolic pathways.
Article
Biochemistry & Molecular Biology
Enhui Tang, Tong Hu, Zhaokang Jiang, Xiaojun Shen, Huan Lin, Haiyan Xian, Xinlan Wu
Summary: Isoquercitrin alleviates lipopolysaccharide-induced intestinal mucosal barrier damage in mice by inhibiting the TLR4/MyD88/NF-kappa B signaling pathway and modulating the intestinal flora.
Article
Biochemistry & Molecular Biology
Nesma A. Abd Elrazik, Sahar A. Helmy
Summary: This study found that betanin, the major pigment in red beetroot, has a protective effect against bleomycin-induced pulmonary fibrosis in rats. The protective effect may be attributed to the attenuation of the NLRP3/IL-1 beta/TGF-beta 1 signaling pathway and the suppression of the EMT process.
Article
Biochemistry & Molecular Biology
Sha Li, Longchen Shang, Yuanyuan Chen, Rong Song, Jing Li, Bin Li
Summary: A new form of konjac fiber was prepared that could instantly expand in contact with digestive fluid, inhibiting the digestion of food. The digestion regulation ability of the fiber was influenced by the freezing temperature used during preparation, with the fiber prepared at -20 degrees C showing the best performance in delaying gastric emptying and preventing intestinal starch hydrolysis.
Article
Biochemistry & Molecular Biology
Xian Xia, Jiangdong Li, Rui Liang, Yi Li, Xiaojuan Ma, Ying Yang, Daniel Lozano-Ojalvo
Summary: This study aimed to reduce the allergenicity of ovomucoid through unfolding-assisted glycation. The results showed that maltose glycation effectively reduced the IgG-binding capacity of the allergen. Unfolded and glycated ovomucoid exhibited enhanced antioxidant activity and metal ion chelating ability.