Article
Food Science & Technology
Zhouwei Duan, Hui Xie, Shasha Yu, Shiping Wang, Hong Yang
Summary: This study investigates the molecular mechanism of PIPERIN's anti-inflammatory effect in RAW264.7 cells and finds that it may regulate key factors of the NF-kappa B and MAPK signaling pathways.
Article
Food Science & Technology
Ruting Zhong, Lingchao Miao, Haolin Zhang, Lihua Tan, Yuxin Zhao, Yanbei Tu, Miguel Angel Prieto, Jesus Simal-Gandara, Lei Chen, Chengwei He, Hui Cao
Summary: Fisetin (Fis), quercetin (Que), and myricetin (Myr) are flavonols with similar structure but different hydroxyl groups. This study demonstrates their anti-inflammatory effects in lipopolysaccharide-stimulated cells, with Fis showing the highest activity. They suppress the overproduction of nitric oxide and reduce ROS, TNF-alpha, and IL-6 levels. Mechanistically, they inhibit NF-kappa B and MAPK pathways by suppressing phosphorylation and nuclear translocation of key proteins. Additionally, their metabolism was examined, revealing different transformation patterns. These findings highlight the potential of flavonols, particularly Fis, as adjuvant medicine or food additives for inflammation.
CURRENT RESEARCH IN FOOD SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Jaejin Shin, Leo Sungwong Choi, Hyun Ju Jeon, Hyeong Min Lee, Sang Hyo Kim, Kwan-Woo Kim, Wonmin Ko, Hyuncheol Oh, Hyung Soon Park
Summary: This study investigated the anti-inflammatory effects of synthetic glabridin derivatives in LPS-stimulated macrophages. The derivatives suppressed the production of pro-inflammatory factors and inhibited the activation of MAPKs and NF-kappa B pathways. These findings suggest that glabridin derivatives may be potential therapeutics for inflammatory diseases.
Article
Biochemistry & Molecular Biology
Yeji Lee, Chang-Gu Hyun
Summary: This study investigates the anti-inflammatory potential of psoralen derivatives in macrophages and finds that 8-hydroxypsoralen exhibits strong inhibitory effects on inflammation. The compound reduces the production of inflammatory mediators through the suppression of multiple signaling pathways, making it a potential therapeutic agent for topical application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hyun-Ju Han, Chang-Gu Hyun
Summary: The anticoagulant drug acenocoumarol has the potential as a repurposed medication for the treatment of chronic inflammatory diseases. It can decrease the production of inflammatory mediators and cytokines by inhibiting the NF-kappa B and MAPK signaling pathways, leading to attenuated macrophage activation and reduced inflammation.
Article
Food Science & Technology
Kang He, Yu Zeng, Hengqun Tian, Zhuangwei Zhang, Huazhe Zhang, Fangfang Huang, Fangmiao Yu
Summary: The study found that low molecular weight peptides (MCP) from thick shell mussel protein hydrolysates exhibit immunomodulatory activity on RAW264.7 macrophages, with NF-kappa B and MAPKs signaling pathways playing a key role in this activity. This suggests that MCP has the potential to be developed as a functional food or nutraceutical.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Plant Sciences
Yifeng Shi, Jiaoxiang Chen, Sunlong Li, Yuhao Wu, Caiyu Yu, LiBin Ni, Jian Xiao, Zhenxuan Shao, Huanqing Zhu, Jianshun Wang, Xiangyang Wang, Xiaolei Zhang
Summary: Tangeretin, a natural flavonoid with anti-inflammatory properties, has been found to inhibit inflammation and extracellular matrix (ECM) degradation, effectively preventing the progression of osteoarthritis (OA). These effects are mediated through the Nrf2/NF-kappa B and MAPK/NF-kappa B pathways.
Article
Pharmacology & Pharmacy
Wei Deng, Yanbo Huang, HaiShang Li, ChiWei Chen, YueWei Lin, Min Wang, HuaSheng Huang, Teng Liu, Qiuli Qin, Yang Shao, YongChao Tang, Kai Yuan, JinYong Ding, LiangLiang Xu, YongXian Li, ShunCong Zhang
Summary: This study investigated the probable mechanism of Dehydromiltirone (DHT) in the treatment of osteoporosis through a combination of network pharmacology and cellular studies. The results showed that DHT modulated the MAPK signaling pathway and inhibited the expression of osteoclast-associated genes. DHT exhibited an anti-osteoclastogenesis effect and inhibited bone resorption in vitro.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nan Ding, Aihua Lei, Zhisheng Shi, Lin Xiang, Bo Wei, Yimou Wu
Summary: Total flavonoids from Camellia oleifera (TFCO) seed extract have a protective effect against Mycoplasma pneumoniae-induced lung damage by inhibiting the TLR2-mediated NF-kappa B and MAPK pathways.
Article
Immunology
Xiaolin Wang, Zhou Guo, Jiamin Lin, Kai Sun, Genchun Wang, Liangcai Hou, Jingting Xu, Jiachao Guo, Xiong Zhang, Fengjing Guo, Youxiu Wei
Summary: The aim of this study was to investigate the inhibitory effect of indirubin on arthritis and its cellular-level processes. The results showed that indirubin can reduce chondrocyte inflammation and improve cartilage degradation. It also inhibited the abnormal activation of NF-Kappa B and MAPK signaling pathways. These findings suggest the potential of indirubin as an anti-arthritis drug.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Yiwu Qin, Dezhi Song, Shijie Liao, Junchun Chen, Minglian Xu, Yuangang Su, Haoyu Lian, Hui Peng, Linhua Wei, Kai Chen, Jiake Xu, Jinmin Zhao, Qian Liu
Summary: In this study, it was found that Isosinensetin (Iss) inhibits the formation and hyperactive bone resorption of osteoclasts by reducing intracellular reactive oxygen species (ROS) and activating the Nrf2 antioxidant pathway. Iss also demonstrated the potential to reduce bone loss in ovariectomized (OVX) mice. Therefore, Iss may be a preventive and therapeutic option for osteoporosis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Hye Jeong Park, Tae Won Jang, So Yeon Han, Song Soo Oh, Jung Bok Lee, Sung Min Myoung, Jae Ho Park
Summary: The present study evaluated the modulatory role of ethyl acetate fraction from N. fruticans (ENF) in the MAPK signaling pathway and I kappa B/NF-kappa B signaling pathway. The results demonstrated that ENF exhibited antioxidant and anti-inflammatory activities, and attenuated cytokine production.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Medicine, Research & Experimental
Jiayuan Wu, Juanfen Mo, Wei Xiang, Xiaowen Shi, Li Guo, Yi Li, Yi Bao, Li Zheng
Summary: Polysaccharide of Tetrastigma hemsleyanum (THP) exhibits antioxidant, antibacterial, lipid-lowering, and anti-inflammatory properties, with evidence suggesting its efficacy as an anti-tumor agent. However, the immunological enhancement effects of THP on macrophages and its underlying mechanisms are still unclear. This study investigated the activation of Raw264.7 cells by THP, and demonstrated its potential as a new immunomodulator in functional foods and pharmaceuticals.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Food Science & Technology
Honglin Wang, Changyang Ma, Dongxiao Sun-Waterhouse, Jinmei Wang, Geoffrey Ivan Neil Waterhouse, Wenyi Kang
Summary: Two immunomodulatory polysaccharides (Vp2a-II and Vp3) isolated from Apocynum venetum L. flowers were found to stimulate the innate immune system of macrophages by enhancing phagocytic activity and inflammation factor secretion.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Nutrition & Dietetics
Chaiwat Monmai, Seok Go, II-Shik Shin, Sang You, Hyungjae Lee, Seok Kang, Woo Park
Summary: Fatty acids extracted from Halocynthia aurantium gonad have been shown to exert immunomodulatory effects on macrophages by enhancing immune-related gene expression and modulating multiple signaling pathways.
Article
Biochemistry & Molecular Biology
Davide Risso, Gillian Dunngalvin, Sameer Saxena, Andrea Doolan, Lisa Spence, Kavita Karnik
Summary: This study investigated the gastrointestinal tolerance of low-calorie sugar D-allulose in young children and found that it was well tolerated. It can be considered as a candidate for replacing added sugars with lower caloric content in commercially produced goods.
Article
Biochemistry & Molecular Biology
Xinying Suo, Anna Baggio, Nicoletta Pellegrini, Silvia Vincenzetti, Elena Vittadini
Summary: This study investigated the effects of shape, gluten, and structural breakdown on the starch digestibility and glycemic index of gluten-containing and gluten-free pasta. The results showed that mastication effort, shape, and gluten content had significant impacts on starch digestion and glycemic index, with gluten being the major factor affecting the amount of digested starch.
Article
Biochemistry & Molecular Biology
Xinnuo Hu, Yanjun Yang, Cuihua Chang, Junhua Li, Yujie Su, Luping Gu
Summary: Fish collagen was enzymatically hydrolyzed using alkaline, papain, and ginger protease. The addition of ginger protease increased the degree of hydrolysis and resulted in changes in the amino acid composition and molecular weight distribution of the peptides. Combined hydrolysis with ginger protease improved the ACE inhibitory activity of the sample but affected fibroblast proliferation activity.
Article
Biochemistry & Molecular Biology
Tong Nie, Xin Wang, Aqun Li, Anshan Shan, Jun Ma
Summary: This study investigated the mechanism by which hesperidin prevents nonalcoholic fatty liver disease (NAFLD) by modulating fatty acid beta oxidation. The results suggest that hesperidin promotes fatty acid beta oxidation by activating SIRT1/PGC1 alpha, thus improving NAFLD.
Article
Biochemistry & Molecular Biology
Li Li, Jing Zhao, Jinxue Wang, Qianqian Xiong, Xuechun Lin, Xiaolei Guo, Fan Peng, Wangqun Liang, Xuezhi Zuo, Chenjiang Ying
Summary: The daily administration of 10 g d-1 inulin-type fructans significantly reduced the circulating arsenic retention in end-stage renal disease by increasing the arsenic clearance rate through urine and dialysis. However, it was found to be ineffective for other trace elements.
Article
Biochemistry & Molecular Biology
Chuanchuan Wang, Weixuan Chen, Yishan Jiang, Xiao Xiao, Qianhui Zou, Jiarui Liang, Yu Zhao, Qianxu Wang, Tian Yuan, Rui Guo, Xuebo Liu, Zhigang Liu
Summary: Autism Spectrum Disorder (ASD) symptoms may be improved through modulation of gut microbiota. This study investigated the effects of a synbiotic treatment on an ASD-like mouse model, and found that it rectified social impairments, attenuated inflammatory cytokine expressions, protected gut barrier integrity, and altered gut microbiota composition. The synbiotic treatment elevated beneficial metabolites and upregulated genes associated with their synthesis. Overall, the synbiotic combination mitigated ASD-related social impairments through regulation of the gut-brain axis.
Review
Biochemistry & Molecular Biology
Chunli Kong, Caiping Duan, Yixuan Zhang, Yiying Wang, Zheng Yan, Sumei Zhou
Summary: This review critically discusses the physicochemical properties of bioactive molecules in kidney beans and focuses on the current knowledge of non-starch polysaccharide (NSP) structure and function on intestinal health and metabolism. It also provides suggestions for further investigation and development of NSPs as novel plant carbohydrate resources.
Article
Biochemistry & Molecular Biology
Fei Shen, Qianqian Wang, Sami Ullah, Ya Pan, Minjie Zhao, Jing Wang, Ming Chen, Fengqin Feng, Hao Zhong
Summary: This study investigated the peristalsis-promoting potential of Ligilactobacillus acidipiscis YJ5 and its underlying molecular mechanism in relieving constipation. The results showed that L. acidipiscis YJ5 intervention increased intestinal peristalsis in zebrafish and mouse models, reduced colonic aquaporin expression, repaired intestinal morphological damage, enhanced the colonic mucosal barrier, and reversed the gut microbiota structure. The positive effects of L. acidipiscis YJ5 were attributed to its metabolites such as malic acid and heliangin.
Article
Biochemistry & Molecular Biology
Zhuo Qu, Jiahui Tian, Jiachen Sun, Ying Shi, Jianqiang Yu, Wannian Zhang, Chunlin Zhuang
Summary: Smoking is the main risk factor for lung cancer, but garlic oil compound DATS shows potential as a chemopreventive agent. DATS can inhibit the carcinogenic effects of tobacco and regulate gut microbiota, as well as activate the PPAR-gamma pathway to suppress tumor growth.
Article
Biochemistry & Molecular Biology
Yanli Zhang, Jielun Hu, Yadong Zhong, Shuai Liu, Liandi Liu, Xinyi Mu, Chunhua Chen, Shenji Yang, Guohao Li, Duoduo Zhang, Xinru Huang, Jinrui Yang, Xiaojun Huang, Shuigen Bian, Shaoping Nie
Summary: The study found that different ratios of insoluble and soluble dietary fiber have distinct effects on gut microbiota and serum metabolites. Increasing the ratio of insoluble dietary fiber increases the relative abundance and acid production of specific bacterial genera, while increasing the ratio of soluble dietary fiber increases the diversity and relative abundance of other bacterial genera and regulates metabolic pathways.
Article
Biochemistry & Molecular Biology
Enhui Tang, Tong Hu, Zhaokang Jiang, Xiaojun Shen, Huan Lin, Haiyan Xian, Xinlan Wu
Summary: Isoquercitrin alleviates lipopolysaccharide-induced intestinal mucosal barrier damage in mice by inhibiting the TLR4/MyD88/NF-kappa B signaling pathway and modulating the intestinal flora.
Article
Biochemistry & Molecular Biology
Nesma A. Abd Elrazik, Sahar A. Helmy
Summary: This study found that betanin, the major pigment in red beetroot, has a protective effect against bleomycin-induced pulmonary fibrosis in rats. The protective effect may be attributed to the attenuation of the NLRP3/IL-1 beta/TGF-beta 1 signaling pathway and the suppression of the EMT process.
Article
Biochemistry & Molecular Biology
Sha Li, Longchen Shang, Yuanyuan Chen, Rong Song, Jing Li, Bin Li
Summary: A new form of konjac fiber was prepared that could instantly expand in contact with digestive fluid, inhibiting the digestion of food. The digestion regulation ability of the fiber was influenced by the freezing temperature used during preparation, with the fiber prepared at -20 degrees C showing the best performance in delaying gastric emptying and preventing intestinal starch hydrolysis.
Article
Biochemistry & Molecular Biology
Xian Xia, Jiangdong Li, Rui Liang, Yi Li, Xiaojuan Ma, Ying Yang, Daniel Lozano-Ojalvo
Summary: This study aimed to reduce the allergenicity of ovomucoid through unfolding-assisted glycation. The results showed that maltose glycation effectively reduced the IgG-binding capacity of the allergen. Unfolded and glycated ovomucoid exhibited enhanced antioxidant activity and metal ion chelating ability.