Article
Dentistry, Oral Surgery & Medicine
Farah Asa'ad, Natalia Petrenya, Birgitta Joensson, Gro Eirin Holde, Nils Oscarson, Elin Hadler-Olsen, Alexandre R. Vieira, Max Petzold, Lena Larsson
Summary: This study investigated the association between periodontitis and four single nucleotide polymorphisms (SNPs) in genes related to DNA methylation, as well as the association between these SNPs and tooth loss, hs-CRP, and HbA1c levels. The results showed that there were associations between polymorphism in genes related to DNA methylation and periodontitis, tooth loss, low-grade inflammation, and hyperglycemia in this Norwegian population.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Plant Sciences
Lin Cheng, Mengge Li, Yachao Wang, Qunwei Han, Yanlin Hao, Zhen Qiao, Wei Zhang, Lin Qiu, Andong Gong, Zhihan Zhang, Tao Li, Shanshan Luo, Linshuang Tang, Daliang Liu, Hao Yin, Song Lu, Tiago Santana Balbuena, Yiyong Zhao
Summary: Tea, as one of the world's top three popular non-alcoholic beverages, has significant economic and cultural value. Xinyang Maojian, a famous Chinese tea, has a long history and its cultivation history and genetic differentiation from other tea varieties remain unclear. Through transcriptome analysis, this study successfully resolved the phylogenetic relationships of tea samples and identified selection sweeps during differentiation. This study provides important insights into the cultivation history of Xinyang Maojian and the genetic basis of physiological and ecological differences between the two major tea subspecies.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Bhanu Sharma, Shabab Angurana, Amrita Bhat, Sonali Verma, Divya Bakshi, Ghulam Rasool Bhat, Rajeshwer Singh Jamwal, Asif Amin, Raies Ahmed Qadri, Ruchi Shah, Rakesh Kumar
Summary: This study conducted SNP genotyping in the Jammu and Kashmir population to investigate the association with colorectal cancer, identifying 5 SNPs significantly correlated with the disease. The results suggest that MassARRAY(TM) technology could be valuable in understanding genetic complexity.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Lizhen Li, Jinlan Rao, Jingjing Lan, Yan Zhu, Aimei Gong, Liepeng Chu, Fei Feng, Chao Xue
Summary: This study aimed to investigate the association between AKT1 single nucleotide polymorphisms (SNPs) and the risk of microscopic polyangiitis (MPA) in Guangxi, China. Genotypes of 8 loci in AKT1 were evaluated in 416 individuals, including 208 MPA patients and 208 healthy volunteers. The study found that three AKT1 loci (rs2498786, rs2494752, and rs5811155) were associated with MPA risk, and a specific haplotype (G-G-T) was negatively associated with MPA risk. These findings suggest that further studies on the role of AKT1 are needed to identify intervention targets for MPA/AAV.
MOLECULAR GENETICS AND GENOMICS
(2023)
Article
Cell Biology
Marlena Typiak, Bartlomiej Rekawiecki, Krzysztof Rebala, Anna Dubaniewicz
Summary: The clinical outcome of sarcoidosis (SA) and tuberculosis (TB) is similar, but they are treated differently. Previous research has shown changes in the phagocytic activity of monocytes in SA and TB, with a higher expression of Fc?R receptors in these patients. However, despite the presence of these receptors, SA patients have high levels of immune complexes (ICs), indicating a dysfunction in Fc?R potentially caused by FCGR gene polymorphisms. This study analyzed the occurrence of FCGR2A, FCGR2B, FCGR2C, FCGR3A, and FCGR3B variants to differentiate between SA and TB and potentially serve as markers for SA progression.
Article
Plant Sciences
Narayana Bhat Devate, Hari Krishna, Sunil Kumar V. Parmeshwarappa, Karthik Kumar Manjunath, Divya Chauhan, Shweta Singh, Jang Bahadur Singh, Monu Kumar, Ravindra Patil, Hanif Khan, Neelu Jain, Gyanendra Pratap Singh, Pradeep Kumar Singh
Summary: This study conducted a genome-wide association study to identify markers associated with traits under heat and drought stress in bread wheat. The results provide valuable markers that can be used for marker-assisted breeding to develop climate-resilient cultivars.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Public, Environmental & Occupational Health
Ziwei Chen, Xinxin Shen, Ji Wang, Xiang Zhao, Yuan Gao, Ruiqin Zhang, Jinrong Wang, Leping Liu, Xinmin Nie, Xuejun Ma
Summary: The PDRA assay discussed in this study is a rapid, convenient, sensitive, and specific method to detect the D614G mutation of COVID-19 virus, with good reproducibility and specificity. The assay showed 100% sensitivity and specificity in clinical samples when compared with direct sequencing as a reference.
Article
Biochemistry & Molecular Biology
Maria Radanova, Mariya Levkova, Galya Mihaylova, Rostislav Manev, Margarita Maneva, Rossen Hadgiev, Nikolay Conev, Ivan Donev
Summary: There is a growing interest in studying single nucleotide polymorphisms (SNPs) in microRNA (miRNA) genes, as they may be associated with susceptibility, prognosis, and treatment response in colorectal cancer (CRC). These miRNA-SNPs could serve as non-invasive biomarkers for early detection of CRC. However, contradictory findings have been reported when different research groups investigated the same SNP in a gene for a specific miRNA, highlighting the need for more case-control studies involving participants from different ethnic backgrounds. According to our review, three miRNA-SNPs - miR-146a rs2910164, miR-27a rs895819, and miR-608 rs4919510 - appear to be promising prognostic, diagnostic, and predictive biomarkers for CRC.
Review
Plant Sciences
Zheng Ying, Muhammad Awais, Reshmi Akter, Fengjiao Xu, Sul Baik, Daehyo Jung, Deok Chun Yang, Gi-Young Kwak, Wenying You
Summary: Discriminating plant species, cultivars, and landraces is challenging, but SNP markers have proven to be a reliable tool for differentiating Panax ginseng and similar species. This article provides a cost-effective guide for SNP marker analysis in a traditional laboratory setting.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Julia P. A. S. Tormin, Bruno R. Nascimento, Craig A. Sable, Jose Luiz P. da Silva, Camilo Brandao-de-Resende, Luiz Paulo C. Rocha, Cecilia H. R. Pinto, Eula Graciele A. Neves, Frederico V. B. Macedo, Clara L. Fraga, Kaciane K. B. Oliveira, Adriana C. Diamantino, Antonio Luiz P. Ribeiro, Andrea Z. Beaton, Maria Carmo P. Nunes, Walderez O. Dutra
Summary: Inflammation associated with rheumatic heart disease is influenced by gene polymorphisms and inflammatory cytokines. Serum levels of cytokines were found to be higher in clinical RHD patients compared to latent RHD patients, with IL-4, IL-8, and IL-1RA emerging as the best predictors of clinical disease. Gene polymorphisms in IL2, IL4, IL6, and IL10 were associated with clinical RHD, suggesting a potential role in discriminating between latent and clinical RHD.
Article
Cardiac & Cardiovascular Systems
Matthew R. Alexander, Samuel Hank, Bethany L. Dale, Lauren Himmel, Xue Zhong, Charles D. Smart, Daniel J. Fehrenbach, Yuhan Chen, Nitin Prabakaran, Brian Tirado, Megan Centrella, Mingfang Ao, Liping Du, Yu Shyr, Daniel Levy, Meena S. Madhur
Summary: Research suggests that the Trp encoding allele of rs3184504 may be causal for hypertension and renal dysfunction, in part due to the loss of SH2B3-mediated repression of T cell IL-12 signaling leading to enhanced IFNg production.
CIRCULATION RESEARCH
(2022)
Article
Medicine, Research & Experimental
Ching-Lung Ko, Wei-Zhi Lin, Meng-Ting Lee, Yu-Tien Chang, Hung-Che Lin, Yi-Syuan Wu, Jun-Fu Lin, Ke-Ting Pan, Yu-Chuan Chang, Ko-Han Lee, Yi-Lun Lee, Tsung-Ting Hsieh, Jia-Hsin Huang, Chih-Hung Wang, Sung-Sen Yang, Hsiang-Cheng Chen, Chi-Ming Chu
Summary: This study explored the race-specific SNP susceptibility of AS in Taiwanese individuals and found an association between HLA-B27 and AS susceptibility SNPs. The study also found differences in AS SNPs between Taiwanese individuals and other races, and that Taiwanese individuals with HLA-B27 positivity had a higher proportion of minor alleles. Additionally, AS polygenic risk score models were developed and individuals with high polygenic risk had a fivefold increased risk of developing AS.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, General & Internal
Dong-Won Lee, Yong-Bae Ji, Chang-Myeon Song, Jeong-Kyu Kim, Seung-Hwan Lee, Kyung Tae
Summary: This study investigated the association between single nucleotide polymorphisms (SNPs) of the ADH7 gene and the risk of head and neck squamous cell carcinoma (HNSCC). The results showed that the ADH7 rs3737482T>C and rs1154460G>A SNPs were associated with the risk of HNSCC in Koreans, and they could serve as molecular biological markers to screen high-risk groups for HNSCC.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Agriculture, Dairy & Animal Science
Kasita Listyarini, Cece Sumantri, Sri Rahayu, Md. Aminul Islam, Syeda Hasina Akter, Muhammad Jasim Uddin, Asep Gunawan
Summary: This study analyzed the transcriptome of high- and low-lamb tenderness samples and identified potential hepatic genes and polymorphisms affecting lamb tenderness. These findings could be used in selection programs for lamb tenderness improvement. Tenderness is a crucial meat quality trait for public acceptance of lamb consumption, and genetic improvement towards higher tenderness is pivotal for a sustainable sheep industry.
Article
Agriculture, Dairy & Animal Science
Jingmin Zhang, Jiaoyan Tan, Chunlei Zhang, Yanhong Wang, Xi Chen, Chuzhao Lei, Hong Chen, Xingtang Fang
Summary: The Aquaporin 9 gene plays critical roles in the growth traits of cattle, and three novel SNPs were found to be significantly associated with traits like body weight and height. These new SNPs could serve as perfect molecular markers for marker-assisted selection breeding.
ANIMAL BIOTECHNOLOGY
(2021)
