Article
Multidisciplinary Sciences
Rocio Gallego-Duran, Javier Ampuero, Helena Pastor-Ramirez, Leticia Alvarez-Amor, Jose Antonio del Campo, Douglas Maya-Miles, Rocio Montero-Vallejo, Antonio Cardenas-Garcia, Ma Jesus Pareja, Sheila Gato-Zambrano, Raquel Millan, Maria del Carmen Rico, Amparo Luque-Sierra, Antonio Gil-Gomez, Angela Rojas, Rocio Munoz-Hernandez, Maria Garcia-Lozano, Rocio Aller, Raul J. Andrade, Carmelo Garcia-Monzon, Fausto Andreola, Francisco Martin, Rajiv Jalan, Manuel Romero-Gomez
Summary: This study aimed to evaluate changes in urea cycle enzymes in NAFLD patients and animal models, and found that liver fibrosis and steatosis were associated with a reduction in both gene and protein expression patterns of mitochondrial urea cycle enzymes.
SCIENTIFIC REPORTS
(2022)
Article
Gastroenterology & Hepatology
Shao-Jung Hsu, Chihao Zhang, Jain Jeong, Seong-il Lee, Matthew McConnell, Teruo Utsumi, Yasuko Iwakiri
Summary: This study demonstrated that enhancing meningeal lymphatic drainage can reduce neuroinflammation and ameliorate hepatic encephalopathy, suggesting a new therapeutic strategy for the treatment of HE.
Article
Radiology, Nuclear Medicine & Medical Imaging
Wei Zhang, Chengwu Huang, Tinghui Yin, Xiaoyan Miao, Huan Deng, Rongqin Zheng, Jie Ren, Shigao Chen
Summary: This study aimed to evaluate the feasibility of ultrasensitive US microvessel imaging in visualizing and quantifying hepatic microvessels in healthy and cirrhotic rats. The findings showed that ultrasensitive US microvessel imaging could detect minute vessels below the liver capsule and quantify the perfusion, tortuosity, and integrity of microvessels. Cirrhotic rats had lower vessel density and fractional moving blood volume, and higher tortuosity compared to control rats, which were strongly correlated with pathologically derived vessel density and hepatic tissue hypoxia.
Article
Genetics & Heredity
Magda Mohamad, Islam A. Desoky, Kamelia Ahmed Zaki, Doaa R. Sadek, Samar Kamal Kassim, Dalia Abdel-Wahab Mohamed
Summary: This study revealed that pterostilbene can attenuate DEN-induced liver injury by improving various liver indicators and mitigating the aberrant expression of Adar enzymes, shedding light on its potential chemopreventive effects and the need for further research on its molecular mechanisms.
Article
Chemistry, Multidisciplinary
Zhen-ning Lu, Wei-xiao Niu, Na Zhang, Mao-xu Ge, Yun-yang Bao, Yu Ren, Xiu-li Guo, Hong-wei He
Summary: This study found that pantoprazole (PPZ) could inhibit the expression of liver fibrosis-related genes, through affecting the expression and degradation of Yes-associated protein (YAP), thus preventing HSC activation and alleviating liver tissue pathological damage and fibrosis.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Endocrinology & Metabolism
Qingcai Zhen, Qijian Liang, Hongchun Wang, Yan Zheng, Zhongting Lu, Chunyong Bian, Xiulan Zhao, Xin Guo
Summary: Nonalcoholic steatohepatitis (NASH) is a clinical syndrome characterized by liver inflammation and hepatocyte injury, which is closely related to metabolic disorders. This study investigated the effects of theabrownin, a pigment substance in fermented tea, on NASH. The results showed that theabrownin could improve liver injury, reduce liver inflammatory response, alleviate liver oxidative stress and fibrosis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tilman Pfeffer, Charlotte Wetzel, Philip Kirschner, Maria Bartosova, Tanja Poth, Constantin Schwab, Gernot Poschet, Johanna Zemva, Ruben Bulkescher, Ivan Damgov, Christian Thiel, Sven F. F. Garbade, Kristina Klingbeil, Verena Peters, Claus Peter Schmitt
Summary: Supplementation of carnosine and anserine can effectively reduce diabetic nephropathy in rodents. However, the exact mechanism of their nephroprotective action in diabetes, whether it is through local protection or improved systemic glucose homeostasis, remains uncertain.
Article
Cell Biology
Szu-Yu Liu, Chia-Chang Huang, Shiang-Fen Huang, Tsai-Ling Liao, Nai-Rong Kuo, Ying-Ying Yang, Tzu-Hao Li, Chih-Wei Liu, Ming-Chih Hou, Han-Chieh Lin
Summary: Activation of systemic, renal vessel and renal tissue levels of PPAR gamma by chronic pioglitazone treatment has beneficial effects on endotoxemia-related TNF alpha/NF kappa B-mediated acute and chronic renal inflammation in cirrhosis. This study revealed that normalization of renal and renal arterial levels of PPAR gamma effectively prevented LPS-induced acute and chronic renal dysfunction in cirrhotic ascitic rats.
Article
Chemistry, Multidisciplinary
Youcui Xu, Jing Chen, Wei Jiang, Yangyang Zhao, Chen Yang, Yi Wu, Qianming Li, Chen Zhu
Summary: A novel multifunctional nanodrug CD-Dex is developed targeting pathological microstructures, scavenging ROS, and suppressing inflammation, showing great potential in liver fibrosis therapy by eliminating ROS and inhibiting inflammation.
Article
Medicine, Research & Experimental
Han Ding, Xuhan Yang, Jiaming Tian, Xinran Wang, Yongsheng Ji, Saeed El-Ashram, Cuiping Ren, Jijia Shen, Miao Liu
Summary: The study demonstrated that treatment with JQ-1 significantly reduced liver fibrosis induced by S. japonicum eggs in mice by suppressing HSC activation and proliferation through inhibition of JAK2/STAT3 signaling pathway. This finding suggests a potential novel approach for the treatment and control of liver fibrosis caused by S. japonicum.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Pablo Alvarez Auth, Gustavo Ratti da Silva, Eduarda Carolina Amaral, Victor Fajardo Bortoli, Mariana Inocencio Manzano, Lauro Mera de Souza, Evellyn Claudia Wietzikoski Lovato, Joao Tadeu Ribeiro-Paes, Arquimedes Gasparotto Junior, Francislaine Aparecida dos Reis Livero
Summary: Metabolic associated fatty liver disease (MAFLD) affects a large portion of the global population, and there are currently no drug therapies available. The study looked into the effects of Croton urucurana extract on a rat model of MAFLD and found promising hepatoprotective and lipid-lowering effects, indicating its potential as a future treatment option for MAFLD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Lenan Xu, Meiling Zhang, Junzhi Pan, Xiangwei Xu, Yawen Zhang, Xue Han, Lina Yin, Lingfeng Chen, Juan Ren, Jie Yu, Yanmei Zhang, Guang Liang, Yi Zhang
Summary: Liver fibrosis is a compensatory repair response to chronic liver injury, with hepatic stellate cell (HSC) activation and phenotypic transformation considered crucial. Ferroptosis, a novel form of programmed cell death, is also closely related to liver diseases. This study investigated the effect of doxofylline (DOX) on liver fibrosis and found that it attenuated liver injury, inhibited fibrosis indicators, and downregulated HSC activation markers through the TGF-beta/Smad signaling pathway, partly by inducing ferroptosis in HSCs. The inhibition of ferroptosis abolished DOX-induced effects, indicating its potential as an anti-hepatic fibrosis agent.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Toru Miyoshi, Kazufumi Nakamura, Naofumi Amioka, Omer F. Hatipoglu, Tomoko Yonezawa, Yukihiro Saito, Masashi Yoshida, Satoshi Akagi, Hiroshi Ito
Summary: LCZ696 ameliorated DOX-induced cardiotoxicity in rat hearts in vivo and in vitro, possibly by mediating a decrease in oxidative stress.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, Research & Experimental
Pin-Ho Pan, Ya-Yu Wang, Shih-Yi Lin, Su-Lan Liao, Yu-Fang Chen, Wei-Chi Huang, Chun-Jung Chen, Wen-Ying Chen
Summary: Plumbagin has the potential to protect the liver from cholestatic damage by regulating multiple intracellular signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Gastroenterology & Hepatology
Changle Ke, Changchen Xiao, Jiamin Li, Xianpeng Wu, Yu Zhang, Yongjian Chen, Shuyuan Sheng, Zaiyang Fu, Lingjun Wang, Cheng Ni, Jing Zhao, Yanna Shi, Yan Wu, Zhiwei Zhong, Jinliang Nan, Wei Zhu, Jinghai Chen, Rongrong Wu, Xinyang Hu
Summary: FMO2 deficiency is associated with increased lipogenesis and worsened hepatic steatosis, inflammation, and fibrosis in NAFL/NASH, whereas FMO2 overexpression improves these conditions. Mechanistically, FMO2 interacts with SREBP1 competitively with SCAP to inhibit lipogenesis, making it a promising target for NAFL/NASH treatment.
Article
Obstetrics & Gynecology
Mohammad Mehdi Ommati, Samira Sabouri, Socorro Retana-Marquez, Hassan Nategh Ahmadi, Abdollah Arjmand, Sepideh Alidaee, Sahra Mazloomi, Alireza Akhlagh, Narges Abdoli, Hossein Niknahad, Akram Jamshidzadeh, Yanqin Ma, Negar Azarpira, Yaser Asefi, Reza Heidari
Summary: Lead (Pb) exposure can cause toxic effects on the male reproductive system, including oxidative stress and mitochondrial impairment. Taurine (TAU) has positive effects on oxidative stress and mitochondrial function. This study evaluated the effects of TAU on Pb-induced reproductive toxicity in mice. TAU significantly improved oxidative stress biomarkers, sperm mitochondrial function, and the expression of genes involved in steroidogenesis, suggesting its effectiveness as a protective agent against Pb-induced reproductive toxicity.
REPRODUCTIVE SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sheida Jahanbekam, Negin Mozafari, Azar Bagheri-Alamooti, Soliman Mohammadi-Samani, Saeid Daneshamouz, Reza Heidari, Negar Azarpira, Hajar Ashrafi, Amir Azadi
Summary: An injectable thermo-ultrasound-triggered drug carrier based on Pluronic® F-127, hyaluronic acid, and gelatin was designed for the treatment of arthritis. The thermo-responsive hydrogel showed a prolonged drug release and improved the disease status in an animal model. This study highlights the potential of ultrasound-responsive in situ-forming hydrogels for efficient treatment of arthritis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Multidisciplinary
Reza Heidari, Zeinab Sepahi, Soliman Mohammadi-Samani, Lobat Tayebi, Negar Azarpira, Mohammad Doroudian, Fatemeh Farjadian
Summary: Amino-functionalized mesoporous silica (MS-NH2) was successfully synthesized and characterized. The material showed high porosity and nano-sized pores. It was found to have a strong adsorption capacity for methotrexate (MTX). In in vivo experiments on mice, administration of MS-NH2 effectively reduced MTX toxicity. Long-term administration of MS-NH2 did not cause organ injury or cytotoxicity in cell lines.
JOURNAL OF MATERIALS RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Mana Heidari, Mohsen Salmanpour, Haniyeh Najafi, Maryam Monajati, Zahra Rahiminezhad, Negar Azarpira, Samira Sadat Abolmaali, Ali Mohammad Tamaddon
Summary: Over-expression of miR21a is shown to drive cancer progression by promoting cancer cell proliferation, migration, invasion, and metastasis. In this study, a beta cyclodextrin-polyethyleneimine-graphene quantum dot (beta CD-PEI-GQD) nanocarrier was developed for efficient delivery of miR21a, leading to significant downregulation of miR21 expression levels.
Review
Immunology
Mahdi Malekpour, Shaghayegh Khanmohammadi, Mohammad Javad Entezari Meybodi, Dorsa Shekouh, Mohammad Reza Rahmanian, Sina Kardeh, Negar Azarpira
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can trigger Guillain-Barre syndrome (GBS) after infection, and patients with simultaneous COVID-19 and GBS have more severe symptoms. SARS-CoV-2 can trigger GBS through various pathways, including direct neurotropism and neurovirulence, microvascular dysfunction and oxidative stress, immune system disruption, molecular mimicry, and autoantibody production.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Food Science & Technology
Milad Mohkam, Nazanin Afifi, Aida Roshan Zamir, Reza Heidari, Mohammad Reza Zamani, Navid Nezafat, Younes Ghasemi
Summary: The primary cause of metabolic syndrome is obesity, which can be addressed by suppressing lipase enzyme to promote weight loss. In this study, 21 isolates of lactic acid bacteria (LAB) were evaluated for potential probiotic features, including bile salt tolerance, acid tolerance, adhesion and lipase inhibitory activity. The findings showed that L. fermentum sp D9, L. fermentum sp S14, L. fermentum sp S8, L. paracasei S11, and L. brevis S15 demonstrated significant probiotic features and lipase inhibitory activity. These isolates showed similar traits to L. rhamnosus PTCC 1637, which has anti-diabetic potential. These results suggest that these selected isolates can be used as effective anti-obesity probiotics. Further investigations are needed to evaluate the lipase inhibitory activity of these strains.
JOURNAL OF MICROBIOLOGY BIOTECHNOLOGY AND FOOD SCIENCES
(2023)
Article
Neurosciences
Nahid Jashire Nezhad, Anahid Safari, Mohammad Reza Namavar, Mohammad Nami, Saeideh Karimi-Haghighi, Sareh Pandamooz, Mehdi Dianatpour, Negar Azarpira, Zahra Khodabandeh, Shahrokh Zare, Etrat Hooshmandi, Mahnaz Bayat, Maryam Owjfard, Seyedeh Shaghayegh Zafarmand, Nima Fadakar, Abbas Rahimi Jaberi, Mohammad Saied Salehi, Afshin Borhani-Haghighi
Summary: Cell therapy, particularly the use of stem cell-based derivatives like cell-free secretome, is gaining increasing attention in regenerative medicine. This study evaluated the short-term therapeutic effects of human dental pulp stem cells (DPSCs) and their secretome in a rat model of mild ischemic stroke.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2023)
Article
Materials Science, Multidisciplinary
Zahra Asvar, Milad Fadaie, Negar Azarpira, Esmaeil Mirzaei
Summary: A double-faced hernia mesh composed of electrospun polycaprolactone fibers (PCL) and chitosan nanofibers (CS) is developed to address the mechanical limitations of currently available hernia meshes. The PCL-CS scaffold shows better mechanical properties, cellular behavior, tissue regeneration, and lower adverse adhesion rate compared to the commercial Prolene mesh.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2023)
Review
Endocrinology & Metabolism
Niloofar Dehdari Ebrahimi, Alireza Sadeghi, Moein Ala, Fatemeh Ebrahimi, Sara Pakbaz, Negar Azarpira
Summary: Male infertility is a complex issue that has attracted scientific interest due to its increasing prevalence. Studies have shown that oxidative stress plays a role in the development of male infertility. Metabolic disorders, such as obesity and diabetes, are risk factors for male infertility, and oxidative stress is believed to contribute to this association. Melatonin, as an antioxidant, may offer a promising therapeutic approach for the prevention and treatment of metabolic disorder-associated male infertility.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Integrative & Complementary Medicine
Ahmad Gholami, Nima Montazeri-Najafabady, Yousef Ashoori, Kimia Kazemi, Reza Heidari, Navid Omidifar, Iman Karimzadeh, Mohammad Mehdi Ommati, Seyedeh Narjes Abootalebi, Nasim Golkar
Summary: This study aimed to evaluate the efficacy of Limosilactobacillus fermentum (L. fermentum) and its postbiotic in an animal model of cisplatin-induced chronic kidney disease (CKD). The results showed that the administration of L. fermentum probiotic and its postbiotic significantly improved renal function by reducing blood urea nitrogen (BUN) and creatinine levels, decreasing oxidative stress and lipid peroxidation, and increasing the antioxidant capacity in the kidneys. Interestingly, the postbiotic showed greater effectiveness than the probiotic in some assays. Probiotics and postbiotics are considered as promising alternative supplements for CKD.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Pharmacology & Pharmacy
Mohammad mehdi Ommati, Hossein Niknahad, Asma Najibi, Abdollah Arjmand, Sepideh Alidaee, Sahra Mazloomi, Parinaz Ahmadi, Alireza Ghiasvand, Maral Javadi, Jamal Yazdani, Samira Sabouri, Heresh Rezaei, Negar Azarpira, Reza Heidari
Summary: Cholestasis-induced lung injury is a severe complication that could lead to tissue fibrosis and respiratory distress. This study found that the level of inflammatory cells, pro-inflammatory cytokines, and IgG in the bronchoalveolar lavage fluid (BALF) of bile duct-ligated mice reached their maximum level on day 28 after surgery. AGM significantly ameliorated cholestasis-induced lung injury.
Article
Environmental Sciences
Xin Hu, Xiaohong Yuan, Mingyu Yang, Mingsheng Han, Mohammad Mehdi Ommati, Yanqin Ma
Summary: Arsenic contamination in drinking water is a global public health problem and may act as an environmental risk factor for anxiety disorders. This study aimed to evaluate anxiety-like behaviors in mice exposed to arsenic trioxide and explore the link between the GABAergic system and behavioral manifestations.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Reza Heidari, Hamid Reza Mohammadi, Fazel Goudarzi, Fatemeh Farjadian
Summary: Aluminum phosphide (AlP) is commonly used as a pesticide for saving grains from pests. However, it can release toxic phosphine gas (PH3) when exposed to humidity. This study shows that sevelamer, a medication used for treating hyperphosphatemia in patients with chronic kidney disease, can be repurposed as an effective antidote for phosphine gas poisoning. The evaluation on rats demonstrates that sevelamer treatment significantly increases survival rate and reduces organ injury and toxicity caused by AlP poisoning. These results suggest that sevelamer could be a potential antidote for managing aluminum phosphide poisoning, and a possible mechanism for the interaction between sevelamer and phosphine gas is proposed.
Article
Gastroenterology & Hepatology
Hossein Niknahad, Pooria Sayar Mehrabani, Abdollah Arjmand, Sepideh Alidaee, Sahra Mazloomi, Parinaz Ahmadi, Narges Abdoli, Mohsen Saeed, Mohammad Rezaei, Mohammad Mehdi Ommati, Reza Heidari
Summary: The aim of this study was to evaluate the effect of taurine on erythrocytes in cirrhotic rats. Results showed that taurine significantly improved erythrocyte parameters and mitigated erythrocyte damage and anemia induced by cirrhosis.
CLINICAL AND EXPERIMENTAL HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Leonard Depotte, Juliette Palle, Cosimo Rasola, Chloe Broudin, Vlad-Adrian Afrasanie, Antoine Mariani, Aziz Zaanan
Summary: Advanced gastric adenocarcinoma is a disease with poor prognosis. In recent years, new drugs, such as trastuzumab for HER2-positive tumors, ramucirumab alone or in combination with paclitaxel, and trifluridine-tipiracil, have improved patient survival. Other drugs, including monoclonal antibodies and targeted therapies, are also being evaluated.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2024)
