Article
Peripheral Vascular Disease
Paolo Palatini, Lucio Mos, Francesca Saladini, Marcello Rattazzi
Summary: This study found that an exaggerated systolic blood pressure response to standing is associated with sympatho-adrenergic hyperreactivity and is an independent predictor of major adverse cardiovascular and renal events in young hypertensive subjects. Orthostatic blood pressure assessment provides prognostic information in addition to ambulatory blood pressure monitoring.
Article
Peripheral Vascular Disease
Corey K. Bradley, Eunhee Choi, Marwah Abdalla, Hiroyuki Mizuno, Michael Lam, Maria Cepeda, Dona Sangapalaarachchi, Justin Liu, Paul Muntner, Kazuomi Kario, Anthony J. Viera, Joseph E. Schwartz, Daichi Shimbo
Summary: For most people, high home blood pressure can be identified or ruled out with a high degree of confidence within 3 days or less of monitoring.
Article
Peripheral Vascular Disease
Tali Elfassy, Charles A. German, Paul Muntner, Eunhee Choi, Gabriel Contreras, Daichi Shimbo, Eugene Yang
Summary: This study found that the association between blood pressure and cardiovascular disease mortality is sex-specific, with women having a higher risk of cardiovascular disease mortality at lower levels of systolic blood pressure compared to men.
Article
Peripheral Vascular Disease
Keisuke Narita, Satoshi Hoshide, Kazuomi Kario
Summary: This study analyzed the association between home and ambulatory blood pressure monitoring and cardiovascular risk in hypertensive outpatients, and found that both home blood pressure and ambulatory blood pressure were independently associated with cardiovascular risk. Home blood pressure had a modest superiority to predict cardiovascular prognosis compared to ambulatory blood pressure.
Article
Peripheral Vascular Disease
Muhammad B. Khan, Rebecca Scherzer, Cora E. Lewis, Rakesh Malhotra, Joachim H. Ix, Michael G. Shlipak, Orlando M. Gutierrez
Summary: This study examined the associations between urine biomarkers and incident hypertension in young adults, and found that higher levels of urine EGF were associated with a lower risk of developing hypertension and lower increases in blood pressure over a 10-year period.
Article
Peripheral Vascular Disease
Sadeer G. Al-Kindi, Robert D. Brook, Udayan Bhatt, Michael Brauer, William C. Cushman, Heidi A. Hanson, John Kostis, James P. Lash, Robert Paine, Kalani L. Raphael, Stephen Rapp, Leonardo Tamariz, Jackson T. Wright, Sanjay Rajagopalan
Summary: This study examined the impact of fine particulate matter (PM2.5) exposure on cardiovascular events in the context of intensive blood pressure lowering intervention. The results showed that the benefits of intensive blood pressure lowering on cardiovascular events were greater in patients exposed to higher levels of PM2.5.
Article
Peripheral Vascular Disease
Ramachandran S. Vasan, Rebecca J. Song, Vanessa Xanthakis, Alexa Beiser, Charles DeCarli, Gary F. Mitchell, Sudha Seshadri
Summary: This study examined the prevalence, correlates, and prognosis of hypertension-mediated organ damage (HMOD) in a community-based study. The findings showed that the prevalence of HMOD varied across different blood pressure guidelines and that the presence of HMOD increased the risk of cardiovascular disease.
Article
Peripheral Vascular Disease
Eva Munoz Aguilera, Jean Suvan, Marco Orlandi, Queralt Miro Catalina, Jose Nart, Francesco D'Aiuto
Summary: Recent evidence suggests a close relationship between hypertension and periodontitis, with individuals suffering from periodontitis showing higher systolic and diastolic blood pressure compared to those without. The diagnosis of periodontitis is associated with higher systolic blood pressure independently from common cardiovascular risk factors. Promoting periodontal and systemic health strategies may help reduce the burden of hypertension and its complications.
Article
Peripheral Vascular Disease
Han Ma, Fangchao Liu, Jianxin Li, Jichun Chen, Jie Cao, Shufeng Chen, Xiaoqing Liu, Xueli Yang, Keyong Huang, Chong Shen, Ling Yu, Yingxin Zhao, Xianping Wu, Liancheng Zhao, Ying Li, Dongsheng Hu, Jianfeng Huang, Xiangfeng Lu, Dongfeng Gu
Summary: Based on a study conducted in China, the association between socioeconomic status (SES) and hypertension remains uncertain. Individuals with lower SES are at a higher risk of developing hypertension compared to those with higher SES. Moreover, women are more susceptible to the adverse effects of lower SES on hypertension.
Article
Peripheral Vascular Disease
Guoying Wang, Jessie P. Buckley, Tami R. Bartell, Xiumei Hong, Colleen Pearson, Xiaobin Wang
Summary: This study found that cord blood insulin concentration is associated with the occurrence of hypertension in childhood. Fetuses with higher blood insulin concentration are more likely to develop hypertension later in life. Elevated cord blood insulin concentration beyond the normal range may increase the risk of hypertension.
Review
Peripheral Vascular Disease
Gonzalo Saco-Ledo, Pedro L. Valenzuela, Miguel Ramirez-Jimenez, Javier S. Morales, Adrian Castillo-Garcia, James A. Blumenthal, Luis M. Ruilope, Alejandro Lucia
Summary: Studies have shown that a single bout of acute aerobic exercise can effectively reduce 24-hour, daytime, and nighttime blood pressure in hypertensive patients, with similar effects in both medicated and non-medicated individuals. Aerobic exercise has the most significant impact on blood pressure, while resistance or combined (aerobic and resistance) exercise has no significant effects on blood pressure.
Article
Peripheral Vascular Disease
Christopher E. Clark, Fiona C. Warren, Kate Boddy, Sinead T. J. McDonagh, Sarah F. Moore, Maria Teresa Alzamora, Rafel Ramos Blanes, Shao-Yuan Chuang, Michael H. Criqui, Marie Dahl, Gunnar Engstrom, Raimund Erbel, Mark Espeland, Luigi Ferrucci, Maelenn Guerchet, Andrew Hattersley, Carlos Lahoz, Robyn L. McClelland, Mary M. McDermott, Jackie Price, Henri E. Stoffers, Ji-Guang Wang, Jan Westerink, James White, Lyne Cloutier, Rod S. Taylor, Angela C. Shore, Richard J. McManus, Victor Aboyans, John L. Campbell
Summary: The study found that using blood pressure readings from the higher arm instead of the lower arm can more accurately diagnose and manage hypertension. Models based on higher arm BP performed better in predicting cardiovascular events and resulted in a higher reclassification rate of participants.
Article
Peripheral Vascular Disease
Chloe Douglas, Jennifer T. Roem, Joseph L. Flynn, Susan A. Furth, Bradley M. Warady, Susan Halbach
Summary: Using data from the CKiD Study, this study found that younger children with chronic kidney disease are more likely to have unrecognized and untreated hypertensive blood pressure, highlighting the need for efforts to improve blood pressure control in this population.
Article
Peripheral Vascular Disease
Eun Hui Bae, Sang Yeob Lim, Bongseong Kim, Tae Ryom Oh, Su Hyun Song, Sang Heon Suh, Hong Sang Choi, Eun Mi Yang, Chang Seong Kim, Seong Kwon Ma, Kyung-Do Han, Soo Wan Kim
Summary: This study found that higher blood pressure is associated with an increased risk of end-stage renal disease (ESRD) in patients with diabetes. The risk is particularly higher in younger individuals. Age, sex, use of antihypertensive medication, and history of chronic kidney disease have different effects on the risk of ESRD.
Article
Cardiac & Cardiovascular Systems
Shishir Rao, Milad Nazarzadeh, Dexter Canoy, Yikuan Li, Jing Huang, Mohammad Mamouei, Gholamreza Salimi-Khorshidi, Aletta E. Schutte, Bruce Neal, George Davey Smith, Kazem Rahimi
Summary: This study analyzed health data from 475,442 individuals in the UK aged 60-90 who had at least one prescription of paracetamol. It found that paracetamol formulations containing sodium bicarbonate were associated with increased blood pressure, cardiovascular diseases, and all-cause mortality. However, further analysis showed that this association was primarily due to confounding by indication related to dysphagia and related conditions. Therefore, this study concludes that short-term use of sodium bicarbonate paracetamol in routine clinical practice does not increase the risk of elevated blood pressure and cardiovascular events.
EUROPEAN HEART JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Carlos Diaz-Arocutipa, Jose Saucedo-Chinchay, Massimo Imazio, Edgar Argulian
Summary: The systematic review and meta-analysis showed that BNP and NT-proBNP levels were significantly lower in patients with constrictive pericarditis (CP) compared to restrictive cardiomyopathy (RCM). The pooled area under the curve (AUC) of the BNP level demonstrated good diagnostic accuracy in differentiating both conditions.
CLINICAL CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Akhil Vaid, Kipp W. Johnson, Marcus A. Badgeley, Sulaiman S. Somani, Mesude Bicak, Isotta Landi, Adam Russak, Shan Zhao, Matthew A. Levin, Robert S. Freeman, Alexander W. Charney, Atul Kukar, Bette Kim, Tatyana Danilov, Stamatios Lerakis, Edgar Argulian, Jagat Narula, Girish N. Nadkarni, Benjamin S. Glicksberg
Summary: This study developed deep learning models to comprehensively quantify left and right ventricular dysfunction from ECG data. The models can assist in the rapid evaluation of ventricular function, aid in diagnosis, and predict the risk of heart disease.
JACC-CARDIOVASCULAR IMAGING
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Alaa Mabrouk Salem Omar, Loba Alam, Soheila Talebi, Adolfo Garcia-Sastre, Jagat Narula, Edgar Argulian
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Letter
Cardiac & Cardiovascular Systems
Loba Alam, Alaa Mabrouk Salem Omar, Soheila Talebi, Jagat Narula, Edgar Argulian
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Iain S. Forrest, Ghislain Rocheleau, Shantanu Bafna, Edgar Argulian, Jagat Narula, Pradeep Natarajan, Ron Do
Summary: The genetic predisposition and presence of supranormal left ventricular ejection fraction (snLVEF) are associated with decreased survival and underdiagnosed heart failure.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Edgar Argulian, Jagat Narula
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Alaa Mabrouk Salem Omar, Diana Maria Ronderos Botero, Javier Arreaza Caraballo, Ga Hee Kim, Yeraz Khachatoorian, Jaclyn Kliewer, Mohamed Ahmed Abdel Rahman, Osama Rifaie, Jonathan N. Bella, Edgar Argulian, Johanna Contreras
Summary: The PRE and POE velocities of heart failure patients are more abnormal than those of normal individuals, and are associated with worsened cardiac function and increased clinical symptoms.
CARDIOVASCULAR ULTRASOUND
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Ashish Correa, Aditya A. Joshi, Edgar Argulian
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Article
Cardiac & Cardiovascular Systems
Richard Ro, Francesca R. Prandi, Syed Zaid, Malcolm O. Anastasius, Gilbert H. L. Tang, Karthik Seetharam, Edgar Argulian, Gianluca Massaro, Samin Sharma, Annapoorna Kini, Stamatios Lerakis
Summary: The study has shown that acute changes in left heart strain and volumes with percutaneous edge-to-edge MitraClip repair can significantly improve health status in patients with primary mitral regurgitation and secondary mitral regurgitation, by increasing LVGLS and reducing LVEDV, LVESV, and left atrial strain conduit.
JOURNAL OF CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Karan Sud, Navneet Narula, Elena Aikawa, Eloisa Arbustini, Philippe Pibarot, Giampaolo Merlini, Robert S. Rosenson, Surya Seshan, Edgar Argulian, Amir Ahmadi, Fang Zhou, Andre L. Moreira, Nancy Cote, Sotirios Tsimikas, Valentin Fuster, Sam Gandy, Robert O. Bonow, Olga Gursky, Jagat Narula
Summary: This Perspective explores the potential relationship between amyloid deposits, calcification, and the development of aortic valve stenosis. The presence of amyloid deposits may contribute to the inflammatory cycle in the aortic valve and further investigation is needed to characterize these deposits. Targeting these deposits with antisense oligonucleotides and/or isotype gene therapies could be a potential approach for the prevention and/or treatment of calcific aortic valve disease.
NATURE REVIEWS CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Alaa Mabrouk Salem Omar, Swiri Konje, Alba Munoz-Estrella, Loba Alam, Kruti Gandhi, Errol Moras, Brissete Mancero, Arpanjeet Kaur, Elizabeth Zipf, David Meister, Maria Pena, Christopher Perez-Lizardo, Ga Hee Kim, Joseph Elias, Edgar Argulian
Summary: This retrospective study compared the prognostic value of resting and post-exercise e' velocity in the assessment of exercise-induced diastolic dysfunction. The results suggest that incorporating post-exercise e' velocity can improve the prognostic utility of diastolic function assessment.
ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Edgar Argulian, Vikram Agarwal
Summary: Spectral Doppler examination is essential for assessing the hemodynamics of patients with systolic heart failure. In this manuscript, two uncommon findings are described in patients with severe left ventricular systolic dysfunction: notched aortic regurgitation and merged mitral regurgitation.
ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES
(2023)
Correction
Cardiac & Cardiovascular Systems
Karan Sud, Navneet Narula, Elena Aikawa, Eloisa Arbustini, Philippe Pibarot, Giampaolo Merlini, Robert S. Rosenson, Surya V. Seshan, Edgar Argulian, Amir Ahmadi, Fang Zhou, Andre L. Moreira, Nancy Cote, Sotirios Tsimikas, Valentin Fuster, Sam Gandy, Robert O. Bonow, Olga Gursky, Jagat Narula
NATURE REVIEWS CARDIOLOGY
(2023)
Review
Biology
Chayakrit Krittanawong, Alaa Mabrouk Salem Omar, Sukrit Narula, Partho P. Sengupta, Benjamin S. Glicksberg, Jagat Narula, Edgar Argulian
Summary: Exponential growth in data storage and computational power is narrowing the gap between advanced clinical informatics and cardiovascular clinical practice. Deep learning (DL) has shown promise in image recognition and video classification, and can help automate human tasks and extract clinically useful data from collected imaging data. This technology has the potential to revolutionize echocardiographic research and enable contactless exams.
Article
Medicine, Research & Experimental
Akhil Vaid, Edgar Argulian, Stamatios Lerakis, Brett K. Beaulieu-Jones, Chayakrit Krittanawong, Eyal Klang, Joshua Lampert, Vivek Y. Reddy, Jagat Narula, Girish N. Nadkarni, Benjamin S. Glicksberg
Summary: The valves of the heart play a crucial role in maintaining the correct flow of blood. Valvular disease, such as backflow or narrowing, can lead to heart failure. Current methods for diagnosis involve echocardiograms, but a new computer software using deep learning neural networks can potentially diagnose valvular disease from electrocardiograms (ECGs), allowing for earlier detection and improved prognosis.
COMMUNICATIONS MEDICINE
(2023)