Journal
BIOMEDICAL OPTICS EXPRESS
Volume 8, Issue 2, Pages 1025-1035Publisher
OPTICAL SOC AMER
DOI: 10.1364/BOE.8.001025
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Funding
- University at Albany , SUNY, NIH [R01DE022467]
- NIH [C06 RR015464]
- NSF [DV10922830]
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Core/shell nanofibers are becoming increasingly popular for applications in tissue engineering. Nanofibers alone provide surface topography and increased surface area that promote cellular attachment; however, core/shell nanofibers provide the versatility of incorporating two materials with different properties into one. Such synthetic materials can provide the mechanical and degradation properties required to make a construct that mimics in vivo tissue. Many variations of these fibers can be produced. The challenge lies in the ability to characterize and quantify these nanofibers post fabrication. We developed a noninvasive method for the composition characterization and quantification at the nanoscale level of fibers using Confocal Raman microscopy. The biodegradable/biocompatible nanofibers, Poly (glycerol-sebacate)/Poly (lactic-co-glycolic) (PGS/PLGA), were characterized as a part of a fiber scaffold to quickly and efficiently analyze the quality of the substrate used for tissue engineering. (C) 2017 Optical Society of America
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