Journal
ARABIAN JOURNAL OF CHEMISTRY
Volume 10, Issue -, Pages S1328-S1335Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.arabjc.2013.03.019
Keywords
8-Hydroxyquinoline; Metal complexes; Thermo gravimetric analysis (TGA); Antimicrobial activity
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Funding
- UGC (New Delhi)
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Looking to the pharmacological importance of 8-hydroxyquinolines, in the present study, a novel ligand 5-((1-methyl-1,2-dihydroquinolin-4-yloxy) methyl) quinolin-8-ol (MDMQ) was synthesized by the reaction of 1-methyl-1,2-dihydroquinolin-4-ol with 5-chloromethyl-8-hydroxyquinoline hydrochloride. Its metal complexes were also prepared with Mn(II), Fe(II), Co(II), Ni(II), Cu(II) and Zn(II) salts. All the above compounds were investigated by physicochemical analysis, thermogravimetric analysis and spectroscopic techniques. In vitro antimicrobial activity of all synthesized compounds and standard drugs has been evaluated against four strains of bacteria which include two gram +ve bacteria such as Staphylococcus aureus, Bacillus megaterium and two gram -ve bacteria such as Escherichia coli, Proteus vulgaris and one fungi Aspergillus niger. (C) 2013 Production and hosting by Elsevier B.V. on behalf of King Saud University.
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