Editorial Material
Medicine, General & Internal
Hai-yan Zhou, Ze-Hu Liu
Summary: A 5-year-old boy presented with painful skin ulcerations characterized by a red base and purple border. Biopsy samples revealed a dense infiltration of neutrophils, and tissue cultures were negative.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Tridip Dutta Baruah, Rubik Ray, R. Manju
Summary: Pyoderma gangrenosum is a rare, reactive, non-infectious inflammatory skin disease characterized by extensive cutaneous ulcerations. Diagnosing it involves ruling out other possibilities, and early detection and treatment are crucial for recovery.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Immunology
Samreen Jatana, Andras K. Ponti, Erin E. Johnson, Nancy A. Rebert, Jordyn L. Smith, Clifton G. Fulmer, Edward V. Maytin, Jean-Paul Achkar, Anthony P. Fernandez, Christine McDonald
Summary: This study describes the development of the first experimental drug-induced mouse model of Pyoderma gangrenosum (PG) with concomitant intestinal inflammation. The mice display skin ulcers enriched in neutrophil extracellular traps (NETs) as well as pro-inflammatory cellular and soluble mediators, mimicking human PG. They also develop spontaneous intestinal inflammation. The novel murine PG model is expected to help researchers probe common disease mechanisms and identify more effective targets for treatment in PG patients with inflammatory bowel disease (IBD).
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Filipa David, Rafaela Lopes Freitas, Rute Bras-Cruz, Joana Rocha, Cristina Rosario
Summary: This article presents a case of difficult-to-treat pyoderma gangrenosum (PG), a rare skin condition. The patient underwent synovial cyst removal surgery but later developed a non-healing wound and painful ulcer. With a combination of treatments, the patient's condition improved. The article highlights the impact of PG on patients' quality of life and emphasizes the importance of high suspicion and timely treatment to minimize complications.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Dermatology
Jianing Wang, Shiyao Jiang, Xin Shi, Wenlin Li, Qianchun Yu, Ting Pan, Yuzhu Mu, Lingling Chen
Summary: Pyoderma gangrenosum (PG) is a rare inflammatory disease with unknown causes that affects the skin and mucous membranes. Postoperative development of PG is uncommon and can resemble infectious complications. Early detection and conservative treatment are crucial for patient recovery.
ADVANCES IN SKIN & WOUND CARE
(2023)
Article
Rheumatology
Vanitha Agrahara Sathyanarayana, Debaditya Roy, Bhavya Nagaraju, Vijay K. R. Rao
Summary: Pyoderma gangrenosum (PG) is a rare autoinflammatory disorder characterized by distinctive non-infective, non-neoplastic skin ulceration. Effective treatment options for PG are lacking, but we have presented three cases successfully treated with Tofacitinib, a JAK/STAT pathway inhibitor, without relapse in follow up.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Medicine, General & Internal
Maha Salih Alj, Madiha Eljazouly, Fatimazahra Chahboun, Abderahmane Al Bouzidi, Soumiya Chiheb
Summary: Neutrophilic dermatoses are a group of skin diseases characterized by a cutaneous infiltrate of mature polymorphonuclear cells. Our observation reports a case of both erythema elevatum diutinum and chronic recurrent annular neutrophilic dermatosis in a patient with a history of pyoderma gangrenosum. This case is important as it illustrates the concept of neutrophilic disease and the existence of overlapping forms.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Review
Dermatology
Akshay Flora, Emily Kozera, John W. Frew
Summary: This systematic review critically evaluates the current molecular observations and associations with clinical characteristics in the pathogenesis of pyoderma gangrenosum, as well as the emerging evidence supporting novel cell types and immune pathways in the disease.
EXPERIMENTAL DERMATOLOGY
(2022)
Review
Medicine, General & Internal
Bo Chen, Wei Li, Bin Qu
Summary: Pyoderma gangrenosum (PG) is a rare autoinflammatory ulcerative neutrophilic skin disease characterized by rapidly progressing painful ulcers with ill-defined borders and surrounding erythema. The pathogenesis of PG is complex and not completely understood. Patients with PG often have various systemic diseases, with inflammatory bowel disease (IBD) and arthritis being the most common. Accurate diagnosis of PG is challenging due to the lack of specific biological markers, but validated diagnostic criteria have been useful in clinical practice. Treatment for PG mainly involves immunosuppressive and immunomodulatory agents, particularly biological agents, which show promising prospects. Once the systemic inflammatory response is controlled, wound management becomes the main concern in PG treatment, and reconstructive surgery has demonstrated increasing benefits when combined with adequate systemic treatment.
FRONTIERS IN MEDICINE
(2023)
Review
Pharmacology & Pharmacy
P. Garieri, M. Marcasciano, A. Greto Ciriaco, R. Spagnuolo, T. Vitagliano, J. Kaciulyte, D. Casella, F. Lo Torto, P. Parisi, D. Ribuffo, M. Greco
Summary: Dedicated multidisciplinary teams should be involved in the treatment of PG, with every specialist playing a crucial role from diagnosis to treatment and long-term follow-up.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Ambra Di Altobrando, Cosimo Misciali, Beatrice Raone, Luciano Attard, Valeria Gaspari
Summary: Pyoderma gangrenosum is the most common type of reactive skin lesions in patients with inflammatory bowel disease, but infectious or malignant causes should be considered in cases of persistent cutaneous ulcerations despite treatment with biologic and immunosuppressive therapy.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Dermatology
Maurice Moelleken, Cornelia Erfurt-Berge, Moritz Ronicke, Dorothee Busch, Ursula Hertha Huebner, Jens Huesers, Mareike Przysucha, Joachim Dissemond
Summary: This retrospective study analyzed the predilection sites of PG in patients with clear diagnosis using the PARACELSUS score. The study found that the lower legs and extensor sides were the most common predilection sites for PG. This is the first study to identify predilection sites for PG using the PARACELSUS score.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Joachim Dissemond, Angelo V. Marzano, Philip J. Hampton, Alex G. Ortega-Loayza
Summary: Pyoderma gangrenosum is a rare neutrophilic dermatosis characterized by painful skin ulcers. The exact cause is not fully understood, but auto-inflammatory processes involving increased activity of neutrophils have been observed. Diagnosing the condition is no longer based on exclusion, but can be done using scoring systems. A multidisciplinary approach is required for treatment, including immunosuppressive therapies and topical pharmacologic therapy, wound management, and pain control. Biologic therapies such as tumor necrosis factor-a inhibitors have shown promise in recent studies.
Editorial Material
Medicine, General & Internal
Raquel Lalanda
Summary: Key aspects for the diagnosis of Postoperative pyoderma gangrenosum include pathergy phenomenon at surgical site incisions, skip lesions, lack of response to antibiotics or debridement, and immediate response to corticosteroid therapy.
CLINICAL CASE REPORTS
(2022)
Article
Dermatology
Toshiyuki Yamamoto, Kenshi Yamasaki, Keiichi Yamanaka, Mayumi Komine, Tamihiro Kawakami, Osamu Yamamoto, Takuro Kanekura, Tetsuya Higuchi, Toshiya Takahashi, Yoshiaki Matsushima, Nobuyuki Kikuchi
Summary: The Japanese clinical practice guidance for PG provides a comprehensive overview of clinical aspects, pathogenesis, current therapies, and clinical questions on PG based on current knowledge and evidence-based medicine. The English version of this guidance is intended to be widely referred to in the clinical examination and treatment of PG.
JOURNAL OF DERMATOLOGY
(2023)
Review
Dermatology
Eran Shavit, Uwe Wollina, Afsaneh Alavi
INTERNATIONAL WOUND JOURNAL
(2018)
Article
Dermatology
Eran Shavit, Afsaneh Alavi, Falk G. Bechara, Richard G. Bennett, Marc Bourcier, Ricardo Cibotti, Steven Daveluy, John W. Frew, Amit Garg, Iltefat Hamzavi, Lauren K. Hoffman, Jenny Hsaio, Joslyn Sciacca Kirby, Hadar Lev-Tov, Erin Martinez, Robert Micheletti, Haley B. Naik, Aude Nassif, Cynthia Nicholson, Angie Parks-Miller, Zarine Patel, Vincent Piguet, Mayur Ramesh, Barry Resnik, Christopher Sayed, Gregory Schultz, Aamir Siddiqui, Jerry Tan, Ximena Wortsman, Michelle A. Lowes
EXPERIMENTAL DERMATOLOGY
(2019)
Review
Dermatology
Eran Shavit, Afsaneh Alavi, R. Gary Sibbald
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2018)
Article
Dermatology
Eran Shavit, Mona Alkallabi, Afsaneh Alavi
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2019)
Letter
Dermatology
Eran Shavit, Afsaneh Alavi
INTERNATIONAL WOUND JOURNAL
(2019)
Article
Pharmacology & Pharmacy
Eran Shavit, Neil H. Shear
EXPERT OPINION ON DRUG SAFETY
(2020)
Editorial Material
Oncology
Eran Shavit, Afsaneh Alavi, Ralph George
Review
Dermatology
Eran Shavit, Angelo Valerio Marzano, Afsaneh Alavi
Summary: Panniculitis presents a diagnostic challenge, with classification based on histology and terminology causing difficulty. Many cases show mixed infiltration without clear distinction. A novel clinical algorithm is proposed to aid in diagnosis and guidelines for clinicians.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2021)
Review
Dermatology
Eran Shavit, Michael Cecchini, James J. Limacher, Scott Walsh, Ashely Wentworth, Mark Denis P. Davis, Afsaneh Alavi
Summary: Pyoderma gangrenosum (PG) is a rare skin disease characterized by painful and ulcerating lesions, with few cases involving the face. This study reviewed 5 cases of PG involving the face, with superficial granulomatous PG being the most common form observed.
JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
(2021)
Letter
Dermatology
Eran Shavit, Or Dagan, Arnon D. Cohen, Yuliya Valdman-Grinshpoun, Khalaf Kridin
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Khalaf Kridin, Yochai Schonmann, Erez Onn, Dana Tzur Bitan, Orly Weinstein, Eran Shavit, Arnon D. Cohen
Summary: Patients with psoriasis have a slightly higher risk of contracting SARS-CoV-2 infection, but they are equally susceptible to COVID-19-related hospitalization and mortality compared to the control group. Patients with psoriasis are more likely to have type-2 diabetes mellitus and obesity when hospitalized due to COVID-19.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Dermatology
Eran Shavit, Arnon Cohen, Lilach Zoller, Erez Onn, Khalaf Kridin
Summary: Through a retrospective study, it was found that patients with acne keloidalis nuchae (AKN) have an increased risk of developing gout compared to control subjects. However, after controlling for other confounders, the increased risk of gout associated with AKN was not significant.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Review
Medicine, General & Internal
Afsaneh Alavi, Eran Shavit, Jeannine Archer, Christian Pagnoux
SAGE OPEN MEDICAL CASE REPORTS
(2019)
Review
Medicine, General & Internal
Eran Shavit, Afsaneh Alavi, James J. Limacher, R. Gary Sibbald
SAGE OPEN MEDICAL CASE REPORTS
(2018)
