Review
Chemistry, Multidisciplinary
Marcelo O. Rodrigues, Marcos N. Eberlin, Brenno A. D. Neto
Summary: Elucidating multicomponent reactions (MCRs) mechanisms presents significant challenges and requires innovative approaches and unique techniques. Common methods are often inadequate for clarifying MCRs mechanisms, thus only a few clever methods are currently used to determine these mysterious mechanisms.
Review
Chemistry, Multidisciplinary
Brenno A. D. Neto, Rafael O. Rocha, Alexandre A. M. Lapis
Summary: This tutorial review presents the application and importance of ionic liquids (ILs) as catalysts or reaction media in multicomponent reactions (MCRs). It discusses the effect of ion-pairing formation and its influence on the reaction outcomes. ILs not only improve yields and selectivities, but also aid in the formation, stabilization, and reactivity of reagents and intermediates during MCRs.
CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Chaorong Wang, Zhencheng Lai, Hujun Xie, Sunliang Cui
Summary: This study demonstrated the use of triazenyl alkynes as versatile building blocks in multicomponent reactions, leading to the synthesis of beta-amino amides with high diastereoselectivity and structural diversity. The bifunctionality of triazenyl alkynes, acting as both C2 fragment and directing group, played a crucial role in achieving the desired outcomes. Furthermore, the triazenyl group allowed for diverse late-stage transformations, opening up new possibilities for building block discovery and rational design of MCRs.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Chemistry, Organic
Sita Monika, Pawan K. Chander, Sita Ram, Pawan Sharma
Summary: Multicomponent reactions catalyzed by molecular iodine offer a green alternative for synthetic organic chemistry, enabling the synthesis of structurally complex molecules in a mild, efficient, and relatively nontoxic manner.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Parisa Mofatehnia, Dawood Elhamifar, Ghodsi Mohammadi Ziarani
Summary: A novel copper-containing Fe3O4@Gelatin material was prepared, characterized, and its catalytic activity was studied. The Fe3O4@Gelatin-Cu was prepared by coating natural gelatin polymer on magnetic Fe3O4 NPs followed by treatment with copper salt. The Fe3O4@Gelatin-Cu exhibited high yield of desired products, good recoverability, reusability, and stability, making it a valuable material in the catalytic world.
RESEARCH ON CHEMICAL INTERMEDIATES
(2023)
Article
Chemistry, Applied
Yanlu Hu, Yongfei Ji, Zhiwei Qiao, Lianpeng Tong
Summary: In this study, novel phenothiazine-linked covalent triazine frameworks (CTFs) were successfully synthesized through direct polycondensation. Among them, TPDH-PTBA showed a relatively broad band gap and excellent photocatalytic activity. The photocatalytic pathways of these CTFs were proposed based on experimental and theoretical evidences. The findings highlight the potential of structural design at the molecular level to improve the intrinsic properties and photocatalytic performance of CTFs, which offer promise for green and sustainable applications in organic synthesis and pollutant degradation.
MICROPOROUS AND MESOPOROUS MATERIALS
(2023)
Article
Chemistry, Applied
Mozhgan Esmati, Behzad Zeynizadeh
Summary: Modified graphene oxide and composite nanomaterial were synthesized and applied as catalysts in multicomponent coupling reactions, showing efficient catalytic activity and good reusability.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Chemistry, Physical
Robina Begum, Zahoor H. Farooqi, Jianliang Xiao, Ejaz Ahmed, Ahsan Sharif, Ahmad Irfan
Summary: In this study, Pd nano crystals were loaded into polymer microgels and used as catalysts for reductive transformations of organic compounds. The experiments showed that the catalytic reactions had high conversion rates under mild conditions, and the catalyst exhibited good stability and reusability.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Review
Polymer Science
Hongxu Liu, Pintu Kanjilal, S. Thayumanavan
Summary: Supramolecular assemblies from synthetic polymers have wide applications in materials science and biology. Convenient and efficient methods to control polymer structures and architectures are important for achieving desired self-assembly behaviors. Multicomponent reactions have attracted significant interest due to their high efficiency, selectivity, atom economy, and one-pot manner. This review summarizes recent advances in using multicomponent reactions to assemble polymers and discusses their applications in polymerization and post-polymerization modifications, as well as the challenges and perspectives in this field.
POLYMER INTERNATIONAL
(2022)
Article
Chemistry, Organic
Wenhua Huang, Jinglong Jiang, Tanmay Mandal
Summary: Multicomponent reactions are an efficient synthetic strategy where multiple reactants come together to form a new complex molecule or biological product. Ferrite nanoparticles, known for their high stability and activity, are used as catalysts in various organic transformations.
SYNTHETIC COMMUNICATIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Merangmenla Aier, Firdaus Rahaman Gayen, Amrit Puzari
Summary: An environmentally friendly copper (II) coordination polymer [Cu(2-pic)2]2H2O}n] (CP1) catalytic system was developed for a facile multicomponent reaction to synthesize diverse tetrahydropyridines (THPs). The CP1 catalyst loading of 10 mol% successfully yielded tetrahydropyridines with up to 98% yield in the tandem reaction of aldehydes, amines, and beta-ketoesters. The findings demonstrate the highly effective CP1 catalytic system for diversified THPs synthesis, which is promoted by CP1 and H+ ion from acetic acid serving as a solvent.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Philip J. Chevis, Chi Bong Eric Chao, Christopher Richardson, Christopher Hyland, Richmond Lee, Stephen G. Pyne
Summary: The crotylation reactions of chiral α-F, α-OBz and α-OH aldehydes were carried out under Petasis-borono-Mannich conditions using (E)- or (Z)-crotylboronates and primary amines. The reactions resulted in γ-addition products with high diastereoselectivity and enantioselectivity. The stereochemical outcomes of the reactions could be explained using transition state models and were supported by DFT calculations. Representative products were transformed into highly functionalized 1,2,3,6-tetrahydropyridines and 3H-oxazolo[3,4-a]pyridine-3-ones, which are valuable scaffolds in synthesis.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Review
Chemistry, Organic
Sainan Qiao, Ning Zhang, Hong Wu, Martyan Hanas
Summary: The recovery and reusability of catalysts are crucial in modern catalysis research, especially in organic synthesis. Magnetic nanoparticles, particularly ferrite nanoparticles, show great potential in multi-component reactions and can be easily separated and recovered using an external magnet.
SYNTHETIC COMMUNICATIONS
(2021)
Review
Chemistry, Inorganic & Nuclear
Mahmoud Nasrollahzadeh, Fahimeh Soleimani, Nayyereh Sadat Soheili Bidgoli, Zahra Nezafat, Yasin Orooji, Talat Baran
Summary: Polymer-supported ruthenium (Ru) catalysts play a significant role in oxidation reactions, with applications in various reaction parameters, advantages, and differences. Advances have been made in the preparation of these catalyst systems in complex and nano forms, allowing for efficient oxidation of a variety of compounds.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Enbo Xu, Shuohan Ma, Zhengzong Wu, Wenjun Wang, Ximing Zhang, Jinhu Tian, Dandan Li, Jianwei Zhou, Donghong Liu
Summary: Starch was used as a green and renewable matrix for the preparation of Zn-St-MOCP/nFe(3)O(4) composite, with Fe3O4 NPs serving as both magnet and pore-inducer. The composite exhibited a microstructure with submicronic and nanopores, showing promising potential for practical adsorption with rapid magnetic separation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Inorganic & Nuclear
Hadi Kargar, Reza Behjatmanesh-Ardakani, Vajiheh Torabi, Asiyehalsadat Sarvian, Zahra Kazemi, Zahra Chavoshpour-Natanzi, Valiollah Mirkhani, Atefeh Sahraei, Muhammad Nawaz Tahir, Muhammad Ashfaq
Summary: Eight novel complexes containing four bidentate N,O-donor halogenated bis-Schiff base ligands were synthesized and their structures were confirmed by various spectroscopic techniques. Both experimental and theoretical results demonstrated that the DNA-binding affinity of the complexes increases with decreasing electronegativity of the substituted halogen atom.
INORGANICA CHIMICA ACTA
(2021)
Article
Chemistry, Physical
Mostafa Khajehzadeh, Majid Moghadam, Pardis Noorbakhsh
Summary: In this study, a novel [Mn(TPP)Cl]@AP-MWC heterogeneous catalyst was prepared by immobilizing manganese(III) tetraphenylporphyrinato choloride on multiwall carbon nanotubes. The catalyst showed high efficiency, easy separation, and high reusability in the oxidation of sulfides.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Inorganic & Nuclear
Hadi Kargar, Azar Kaka-Naeini, Mehdi Fallah-Mehrjardi, Reza Behjatmanesh-Ardakani, Hadi Amiri Rudbari, Khurram Shahzad Munawar
Summary: New oxovanadium and dioxomolybdenum Schiff base complexes were synthesized and characterized by various analytical techniques. Distorted octahedral geometry around the central metal ions was observed in both complexes as revealed by X-ray diffraction studies.
JOURNAL OF COORDINATION CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Hadi Kargar, Atefeh Moghimi, Mehdi Fallah-Mehrjardi, Reza Behjatmanesh-Ardakani, Hadi Amiri Rudbari, Khurram Shahzad Munawar
Summary: A new ONO-tridentate Schiff base ligand was synthesized and characterized, with its molecular structure further investigated. Additionally, the catalytic efficiencies of the ligand's complexes with dioxomolybdenum(VI) and oxovanadium(V) were explored for sulfide oxidation. The homogeneous catalysts exhibited excellent catalytic activities for both aromatic and aliphatic sulfides oxidation using aqueous H2O2 as the oxygen source.
JOURNAL OF SULFUR CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Saeid Menati, Reza Azadbakht, Hadi Amiri Rudbari, Giuseppe Bruno
Summary: In this study, four new azo-Schiff base ligands and their corresponding nickel(II) complexes were synthesized and characterized using various analytical techniques. X-ray results revealed that the structures of the nickel(II) metal complexes are slightly distorted square-planar structures.
Article
Chemistry, Inorganic & Nuclear
Hadi Kargar, Maryam Bazrafshan, Mehdi Fallah-Mehrjardi, Reza Behjatmanesh-Ardakani, Hadi Amiri Rudbari, Khurram Shahzad Munawar, Muhammad Ashfaq, Muhammad Nawaz Tahir
Summary: This study reported the synthesis of two new oxovanadium and dioxomolybdenum Schiff base complexes for the first time. The complexes were characterized using various spectroscopic techniques and single crystal X-ray diffraction, revealing their crystal structure and catalytic activities. Theoretical calculations were consistent with experimental findings, and non-covalent interactions responsible for crystal packing were explored.
Article
Chemistry, Multidisciplinary
Maryam Taherzadeh, Mehrdad Pourayoubi, Banafsheh Vahdani Alviri, Samad Shoghpour Bayraq, Maral Ariani, Marek Necas, Michal Dusek, Vaclav Eigner, Hadi Amiri Rudbari, Giuseppe Bruno, Teresa Mancilla Percino, Marco A. Leyva-Ramirez, Krishnan Damodaran
Summary: The study evaluated the differences in the N-H...O, H...O=P, and H...O=C angles in structures based on [C(O)NH](N)(2)P(O), comparing N-H bond lengths determined by X-ray diffraction to neutron normalized values. By considering nine new X-ray crystal structures and 204 analogous structures, the role of hydrogen-bonded motifs in the symmetry of crystals and the probability of obtaining centrosymmetric crystal structures were investigated.
ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE CRYSTAL ENGINEERING AND MATERIALS
(2021)
Article
Chemistry, Medicinal
Hadi Amiri Rudbari, Arezoo Saadati, Mahnaz Aryaeifar, Isabel Correia, Fernanda Marques, Olivier Blacque, Nicola Micale
Summary: A series of oxidovanadium(IV) complexes were synthesized and characterized, showing good anticancer activity in ovarian and breast cancer cells. The newly synthesized V(IV)O complexes exhibited the highest cytotoxicity among all tested compounds.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Inorganic & Nuclear
Hamta Mosallaei, Hassan Hadadzadeh, Annette Foelske, Markus Sauer, Hadi Amiri Rudbari, Olivier Blacque
Summary: Water electrolysis is an efficient process for producing clean fuel. In this study, a novel Ru(ii)-Fe(ii) complex was synthesized and used to fabricate a RuO2-Fe2O3 nanocomposite. The prepared nanocomposite showed excellent electrocatalytic performance for water-splitting reactions, including hydrogen and oxygen evolution reactions, in alkaline solutions. The heterostructured RuO2-Fe2O3 nanocomposite can be considered as a bifunctional electrocatalyst for HER and OER due to the synergistic effects of the heterostructures and active sites at its interface.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Multidisciplinary
Hadi Amiri Rudbari, Nazanin Kordestani, Jose V. Cuevas-Vicario, Min Zhou, Thomas Efferth, Isabel Correia, Tanja Schirmeister, Fabian Barthels, Mohammed Enamullah, Alexandra R. Fernandes, Nicola Micale
Summary: In this study, four pairs of enantiomeric Pd(ii) complexes were synthesized and their composition and structure were confirmed by various analyses. Two of the complexes showed activity in inhibiting leukemia cell proliferation and proteasome activity, indicating potential anti-cancer properties.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Hadi Kargar, Mehdi Fallah-Mehrjardi, Muhammad Ashfaq, Khurram Shahzad Munawar, Muhammad Nawaz Tahir, Reza Behjatmanesh-Ardakani, Hadi Amiri Rudbari, Amir Adabi Ardakani, Samaneh Sedighi-Khavidak
Summary: The synthesis of new zinc(II) Schiff base complexes Z1 and Z2 and their antimicrobial activities were investigated in this study. Characterization of the complexes was performed using analytical methods, theoretical calculations, and spectroscopic techniques. Results showed that the zinc(II) complexes exhibited slightly higher antibacterial activity compared to the free ligands.
JOURNAL OF COORDINATION CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Nazanin Kordestani, Hadi Amiri Rudbari, Isabel Correia, Andreia Valente, Leonor Corte-Real, Mohammad Khairul Islam, Nicola Micale, Jason D. Braun, David E. Herbert, Nikolay Tumanov, Johan Wouters, Mohammed Enamullah
Summary: Seven enantiomeric pairs of palladium complexes were synthesized and characterized, followed by testing their anticancer activity in human breast cancer cell lines. The cell death mechanism was also investigated to understand the potential of these complexes for cancer treatment.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Nazanin Kordestani, Hadi Amiri Rudbari, Alexandra R. Fernandes, Luis R. Raposo, Andre Luz, Pedro Baptista, Giuseppe Bruno, Rosario Scopelliti, Zohreh Fateminia, Nicola Micale, Nikolay Tumanov, Johan Wouters, Abolghasem Abbasi Kajani, Abdol-Khalegh Bordbar
Summary: The study on the anticancer activity of copper complexes against different tumor cell lines revealed that complexes with a 2-pycolylamine-type motif were more cytotoxic and induced reactive oxygen species. Among the complexes, Cu(Cl-2-L-1)NO3 was identified as the most promising candidate for additional biological applications.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Multidisciplinary
Forough Gorginpour, Hassan Zali-Boeini, Hadi Amiri Rudbari
Summary: The novel porous organic polymer Q-POP and CuNPs@Q-POP exhibited high surface area, hierarchical porosity, and excellent thermal and chemical stability. The synthesized catalyst showed good performance in Ullmann C-N coupling reaction, with aryl iodides producing the best results. Additionally, the catalyst showed no copper leaching from the support and could be recycled and reused for five consecutive runs without significant activity loss.
Article
Chemistry, Applied
Nazanin Kordestani, Hadi Amiri Rudbari, Zohreh Fateminia, Guy Caljon, Louis Maes, Placido G. Mineo, Annalaura Cordaro, Antonino Mazzaglia, Angela Scala, Nicola Micale
Summary: A series of newly synthesized silver(I) complexes were evaluated for their biological activity against a panel of pathogens, showing potential antiprotozoal activity; among them, Ag2 and Ag7 were selected for incorporation into poly (lactic acid) nanoparticles, demonstrating good physicochemical properties and reduced cytotoxicity.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
