Conjugation of squalene to gemcitabine as unique approach exploiting endogenous lipoproteins for drug delivery

Self-assembly drug conjugates for anticancer treatment

(2016) Gaia Fumagalli et al.   DRUG DISCOVERY TODAY

Protein adsorption is required for stealth effect of poly(ethylene glycol)- and poly(phosphoester)-coated nanocarriers

(2016) Susanne Schöttler et al.   Nature Nanotechnology

Therapeutic Modalities of Squalenoyl Nanocomposites in Colon Cancer: An Ongoing Search for Improved Efficacy

(2014) Andrei Maksimenko et al.   ACS Nano

Peptide-functionalized nanoparticles for selective targeting of pancreatic tumor

(2014) Sabrina Valetti et al.   JOURNAL OF CONTROLLED RELEASE

Squalenoyl adenosine nanoparticles provide neuroprotection after stroke and spinal cord injury

(2014) Alice Gaudin et al.   Nature Nanotechnology

A unique squalenoylated and nonpegylated doxorubicin nanomedicine with systemic long-circulating properties and anticancer activity

(2014) A. Maksimenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

hENT1 expression is predictive of gemcitabine outcome in pancreatic cancer: A systematic review

(2014) Stina Nordh   WORLD JOURNAL OF GASTROENTEROLOGY

Selective Targeting Capability Acquired with a Protein Corona Adsorbed on the Surface of 1,2-Dioleoyl-3-trimethylammonium Propane/DNA Nanoparticles

(2013) Giulio Caracciolo et al.   ACS Applied Materials & Interfaces

Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology

(2013) Stefan Tenzer et al.   Nature Nanotechnology

Self-Assembled Squalenoylated Penicillin Bioconjugates: An Original Approach for the Treatment of Intracellular Infections

(2012) Nicolas Sémiramoth et al.   ACS Nano

Adsorption of Surfactant Lipids by Single-Walled Carbon Nanotubes in Mouse Lung upon Pharyngeal Aspiration

(2012) Alexander A. Kapralov et al.   ACS Nano

Effects of the Presence or Absence of a Protein Corona on Silica Nanoparticle Uptake and Impact on Cells

(2012) Anna Lesniak et al.   ACS Nano

Squalenoyl prodrug of paclitaxel: Synthesis and evaluation of its incorporation in phospholipid bilayers

(2012) Maria Grazia Sarpietro et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Biomolecular coronas provide the biological identity of nanosized materials

(2012) Marco P. Monopoli et al.   Nature Nanotechnology

Improving the Antitumor Activity of Squalenoyl-Paclitaxel Conjugate Nanoassemblies by Manipulating the Linker between Paclitaxel and Squalene

(2012) Joachim Caron et al.   Advanced Healthcare Materials

Lipoprotein-Inspired Nanoparticles for Cancer Theranostics

(2011) Kenneth K. Ng et al.   ACCOUNTS OF CHEMICAL RESEARCH

Nanoparticle Size Is a Critical Physicochemical Determinant of the Human Blood Plasma Corona: A Comprehensive Quantitative Proteomic Analysis

(2011) Stefan Tenzer et al.   ACS Nano

Squalenoylation: A generic platform for nanoparticular drug delivery

(2011) Didier Desmaële et al.   JOURNAL OF CONTROLLED RELEASE

Synthesis, Characterization, and in Vivo Delivery of siRNA-Squalene Nanoparticles Targeting Fusion Oncogene in Papillary Thyroid Carcinoma

(2011) Mouna Raouane et al.   JOURNAL OF MEDICINAL CHEMISTRY

Interaction of Self-Assembled Squalenoyl Gemcitabine Nanoparticles with Phospholipid−Cholesterol Monolayers Mimicking a Biomembrane

(2011) Anshuman Ambike et al.   LANGMUIR

Novel Nanoassemblies Composed of Squalenoyl−Paclitaxel Derivatives: Synthesis, Characterization, and Biological Evaluation

(2010) Franco Dosio et al.   BIOCONJUGATE CHEMISTRY

Transmembrane diffusion of gemcitabine by a nanoparticulate squalenoyl prodrug: An original drug delivery pathway

(2010) L. Bildstein et al.   JOURNAL OF CONTROLLED RELEASE

Extracellular-protein-enhanced cellular uptake of squalenoyl gemcitabine from nanoassemblies

(2010) Lucien Bildstein et al.   Soft Matter

Complete high-density lipoproteins in nanoparticle corona

(2009) Erik Hellstrand et al.   FEBS Journal

Anticancer Efficacy of Squalenoyl Gemcitabine Nanomedicine on 60 Human Tumor Cell Panel and on Experimental Tumor

(2009) L. Harivardhan Reddy et al.   MOLECULAR PHARMACEUTICS

Understanding biophysicochemical interactions at the nano–bio interface

(2009) Andre E. Nel et al.   NATURE MATERIALS

Preclinical Toxicology (Subacute and Acute) and Efficacy of a New Squalenoyl Gemcitabine Anticancer Nanomedicine

(2008) L. H. Reddy et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts

(2008) M. Lundqvist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of New Hexagonal Supramolecular Nanostructures Formed by Squalenoylation of an Anticancer Nucleoside Analogue

(2008) Patrick Couvreur et al.   Small

Impact of lipoproteins on the biological activity and disposition of hydrophobic drugs: implications for drug discovery

(2007) Kishor M. Wasan et al.   NATURE REVIEWS DRUG DISCOVERY