The ubiquitin ligase ZNRF1 promotes caveolin-1 ubiquitination and degradation to modulate inflammation

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Innate Immune Programing by Endotoxin and Its Pathological Consequences

(2015) Matthew C. Morris et al.   Frontiers in Immunology

Co-operation of TLR4 and raft proteins in LPS-induced pro-inflammatory signaling

(2014) Agnieszka Płóciennikowska et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

News from the caves: update on the structure and function of caveolae

(2014) Elena Shvets et al.   CURRENT OPINION IN CELL BIOLOGY

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

Ubiquitination of the N-terminal Region of Caveolin-1 Regulates Endosomal Sorting by the VCP/p97 AAA-ATPase

(2013) Philipp Kirchner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caveolin-1 Tyr14 Phosphorylation Induces Interaction with TLR4 in Endothelial Cells and Mediates MyD88-Dependent Signaling and Sepsis-Induced Lung Inflammation

(2013) H. Jiao et al.   JOURNAL OF IMMUNOLOGY

LPS or ethanol triggers clathrin- and rafts/caveolae-dependent endocytosis of TLR4 in cortical astrocytes

(2013) Maya Pascual-Lucas et al.   JOURNAL OF NEUROCHEMISTRY

Role of caveolin-1 and caveolae signaling in endotoxemia and sepsis

(2013) Hong Feng et al.   LIFE SCIENCES

Caveolae as plasma membrane sensors, protectors and organizers

(2013) Robert G. Parton et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Liposomal Lipopolysaccharide Initiates TRIF-Dependent Signaling Pathway Independent of CD14

(2013) Sachiko Watanabe et al.   PLoS One

Caveolin targeting to late endosome/lysosomal membranes is induced by perturbations of lysosomal pH and cholesterol content

(2012) Dorothy I. Mundy et al.   MOLECULAR BIOLOGY OF THE CELL

The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock

(2012) Ezra Aksoy et al.   NATURE IMMUNOLOGY

Caveolin-1 suppresses Human Immunodeficiency virus-1 replication by inhibiting acetylation of NF-κB

(2012) Glenn E. Simmons Jr. et al.   VIROLOGY

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

Akt-Mediated Proinflammatory Response of Mononuclear Phagocytes Infected with Burkholderia cenocepacia Occurs by a Novel GSK3 -Dependent, I B Kinase-Independent Mechanism

(2011) T. J. Cremer et al.   JOURNAL OF IMMUNOLOGY

Convergence of the Mammalian Target of Rapamycin Complex 1- and Glycogen Synthase Kinase 3- -Signaling Pathways Regulates the Innate Inflammatory Response

(2011) H. Wang et al.   JOURNAL OF IMMUNOLOGY

ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation

(2011) Shuji Wakatsuki et al.   NATURE CELL BIOLOGY

Caveolin-1 Deficiency Dampens Toll-Like Receptor 4 Signaling through eNOS Activation

(2010) Muhammad K. Mirza et al.   AMERICAN JOURNAL OF PATHOLOGY

Caveolin-1 Protects against Sepsis by Modulating Inflammatory Response, Alleviating Bacterial Burden, and Suppressing Thymocyte Apoptosis

(2010) Hong Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caveolin-1 is ubiquitinated and targeted to intralumenal vesicles in endolysosomes for degradation

(2010) Arnold Hayer et al.   JOURNAL OF CELL BIOLOGY

Lipopolysaccharide-Mediated IL-10 Transcriptional Regulation Requires Sequential Induction of Type I IFNs and IL-27 in Macrophages

(2010) S. S. Iyer et al.   JOURNAL OF IMMUNOLOGY

IL-1β-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKβ

(2010) Li-Chung Hsu et al.   NATURE IMMUNOLOGY

Staphylococcus aureus Induces Microglial Inflammation via a Glycogen Synthase Kinase 3 -Regulated Pathway

(2009) Y.-L. Cheng et al.   INFECTION AND IMMUNITY

Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines

(2009) Ping-Hui Tseng et al.   NATURE IMMUNOLOGY

Immunodesign of experimental sepsis by cecal ligation and puncture

(2009) Daniel Rittirsch et al.   Nature Protocols

Caveolin-1-Mediated Expression and Secretion of Kallikrein 6 in Colon Cancer Cells

(2008) Rebecca S. Henkhaus et al.   NEOPLASIA