CYP2C19*17 affects R-warfarin plasma clearance and warfarin INR/dose ratio in patients on stable warfarin maintenance therapy
Published 2015 View Full Article
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Title
CYP2C19*17 affects R-warfarin plasma clearance and warfarin INR/dose ratio in patients on stable warfarin maintenance therapy
Authors
Keywords
Warfarin, Enantiomers, <em class=EmphasisTypeItalic >CYP2C19</em>, <em class=EmphasisTypeItalic >CYP2C9</em>, <em class=EmphasisTypeItalic >VKORC1</em>, Gene polymorphisms, Pharmacokinetics
Journal
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
Volume 71, Issue 4, Pages 433-439
Publisher
Springer Nature
Online
2015-02-05
DOI
10.1007/s00228-015-1812-4
References
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Related references
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- The pharmacokinetics and pharmacodynamics of single dose (R)- and (S)-warfarin administered separately and together: relationship toVKORC1genotype
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- The population pharmacokinetics of R- and S-warfarin: effect of genetic and clinical factors
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- Pharmacogenetic warfarin dose refinements remain significantly influenced by genetic factors after one week of therapy
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- Variability of INR and its relationship with mortality, stroke, bleeding and hospitalisations in patients with atrial fibrillation
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- Linkage disequilibrium between the CYP2C19*17 allele and wildtype CYP2C8 and CYP2C9 alleles: identification of CYP2C haplotypes in healthy Nordic populations
- (2010) Rasmus S. Pedersen et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- The effect of CYP2C19 genotypes on the pharmacokinetics of warfarin enantiomers
- (2010) T. Uno et al. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
- Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study
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- The largest prospective warfarin-treated cohort supports genetic forecasting
- (2008) M. Wadelius et al. BLOOD
- Increased omeprazole metabolism in carriers of the CYP2C19*17 allele; a pharmacokinetic study in healthy volunteers
- (2008) R. Michael Baldwin et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Kinetics of omeprazole and escitalopram in relation to the CYP2C19*17 allele in healthy subjects
- (2008) Staffan Ohlsson Rosenborg et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
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