A computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue

A predictive computational framework for direct reprogramming between human cell types

(2016) Owen J L Rackham et al.   NATURE GENETICS

Functional characterization of somatic mutations in cancer using network-based inference of protein activity

(2016) Mariano J Alvarez et al.   NATURE GENETICS

Identification of an NKX3.1-G9a-UTY transcriptional regulatory network that controls prostate differentiation

(2016) A. Dutta et al.   SCIENCE

Direct Lineage Reprogramming: Strategies, Mechanisms, and Applications

(2015) Jun Xu et al.   Cell Stem Cell

Transient acquisition of pluripotency during somatic cell transdifferentiation with iPSC reprogramming factors

(2015) Itay Maza et al.   NATURE BIOTECHNOLOGY

Lineage conversion induced by pluripotency factors involves transient passage through an iPSC stage

(2015) Ori Bar-Nur et al.   NATURE BIOTECHNOLOGY

A Systematic Approach to Identify Candidate Transcription Factors that Control Cell Identity

(2015) Ana C. D’Alessio et al.   Stem Cell Reports

Cross-Species Regulatory Network Analysis Identifies a Synergistic Interaction between FOXM1 and CENPF that Drives Prostate Cancer Malignancy

(2014) Alvaro Aytes et al.   CANCER CELL

Dissecting Engineered Cell Types and Enhancing Cell Fate Conversion via CellNet

(2014) Samantha A. Morris et al.   CELL

FOXA1 deletion in luminal epithelium causes prostatic hyperplasia and alteration of differentiated phenotype

(2014) David J DeGraff et al.   LABORATORY INVESTIGATION

Mouse liver repopulation with hepatocytes generated from human fibroblasts

(2014) Saiyong Zhu et al.   NATURE

An organized and functional thymus generated from FOXN1-reprogrammed fibroblasts

(2014) Nicholas Bredenkamp et al.   NATURE CELL BIOLOGY

Single luminal epithelial progenitors can generate prostate organoids in culture

(2014) Chee Wai Chua et al.   NATURE CELL BIOLOGY

A blueprint for engineering cell fate: current technologies to reprogram cell identity

(2013) Samantha A Morris et al.   CELL RESEARCH

Canonical Wnt signaling regulates Nkx3.1 expression and luminal epithelial differentiation during prostate organogenesis

(2013) Marianna Kruithof-de Julio et al.   DEVELOPMENTAL DYNAMICS

Leveling Waddington: the emergence of direct programming and the loss of cell fate hierarchies

(2013) Julia Ladewig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Two-factor reprogramming of somatic cells to pluripotent stem cells reveals partial functional redundancy of Sox2 and Klf4

(2012) A Nemajerova et al.   CELL DEATH AND DIFFERENTIATION

Direct Conversion of Fibroblasts into Stably Expandable Neural Stem Cells

(2012) Marc Thier et al.   Cell Stem Cell

Lineage conversion methodologies meet the reprogramming toolbox

(2012) Ignacio Sancho-Martinez et al.   NATURE CELL BIOLOGY

Brief Report: Analysis of EndogenousOct4Activation during Induced Pluripotent Stem Cell Reprogramming Using an InducibleOct4Lineage Label

(2012) Lucas V. Greder et al.   STEM CELLS

RETRACTED: Directed Conversion of Alzheimer's Disease Patient Skin Fibroblasts into Functional Neurons

(2011) Liang Qiang et al.   CELL

Integration of Regulatory Networks by NKX3-1 Promotes Androgen-Dependent Prostate Cancer Survival

(2011) P. Y. Tan et al.   MOLECULAR AND CELLULAR BIOLOGY

Direct generation of functional dopaminergic neurons from mouse and human fibroblasts

(2011) Massimiliano Caiazzo et al.   NATURE

Induction of human neuronal cells by defined transcription factors

(2011) Zhiping P. Pang et al.   NATURE

Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy

(2011) Jem A. Efe et al.   NATURE CELL BIOLOGY

Direct reprogramming of mouse fibroblasts to neural progenitors

(2011) J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrative Genomic Profiling of Human Prostate Cancer

(2010) Barry S. Taylor et al.   CANCER CELL

Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors

(2010) Masaki Ieda et al.   CELL

A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers

(2010) Celine Lefebvre et al.   Molecular Systems Biology

Direct conversion of human fibroblasts to multilineage blood progenitors

(2010) Eva Szabo et al.   NATURE

Direct conversion of fibroblasts to functional neurons by defined factors

(2010) Thomas Vierbuchen et al.   NATURE

Prevalent positive epistasis in Escherichia coli and Saccharomyces cerevisiae metabolic networks

(2010) Xionglei He et al.   NATURE GENETICS

Visualization of omics data for systems biology

(2010) Nils Gehlenborg et al.   NATURE METHODS

Differential expression analysis for sequence count data

(2010) Simon Anders et al.   GENOME BIOLOGY

Conserved Gene Expression Programs Integrate Mammalian Prostate Development and Tumorigenesis

(2009) C. Pritchard et al.   CANCER RESEARCH

The transcriptional network for mesenchymal transformation of brain tumours

(2009) Maria Stella Carro et al.   NATURE

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

FoxA1 Translates Epigenetic Signatures into Enhancer-Driven Lineage-Specific Transcription

(2008) Mathieu Lupien et al.   CELL

Mesenchymal–epithelial interactions: past, present, and future

(2008) Gerald R. Cunha   DIFFERENTIATION