HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells

The transcriptional repressor Blimp1 is expressed in rare luminal progenitors and is essential for mammary gland development

(2016) Mohammed I. Ahmed et al.   DEVELOPMENT

Interleukin-23-Induced Transcription Factor Blimp-1 Promotes Pathogenicity of T Helper 17 Cells

(2016) Renu Jain et al.   IMMUNITY

Blimp-1–mediated CD4 T cell exhaustion causes CD8 T cell dysfunction during chronic toxoplasmosis

(2016) SuJin Hwang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Loss of PRDM1/BLIMP-1 function contributes to poor prognosis of activated B-cell-like diffuse large B-cell lymphoma

(2016) Y Xia et al.   LEUKEMIA

Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response

(2016) Julie Tellier et al.   NATURE IMMUNOLOGY

Multifunctional role of the transcription factor Blimp-1 in coordinating plasma cell differentiation

(2016) Martina Minnich et al.   NATURE IMMUNOLOGY

Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes

(2016) L. K. Mackay et al.   SCIENCE

VEGF-Mediated Induction of PRD1-BF1/Blimp1 Expression Sensitizes Tumor Vasculature to Oncolytic Virus Infection

(2015) Rozanne Arulanandam et al.   CANCER CELL

Quantitative Dynamics of Chromatin Remodeling during Germ Cell Specification from Mouse Embryonic Stem Cells

(2015) Kazuki Kurimoto et al.   Cell Stem Cell

Integrative Analysis of the Acquisition of Pluripotency in PGCs Reveals the Mutually Exclusive Roles of Blimp-1 and AKT Signaling

(2015) Go Nagamatsu et al.   Stem Cell Reports

FOXO1 repression contributes to block of plasma cell differentiation in classical Hodgkin lymphoma

(2014) M. J. Vogel et al.   BLOOD

Diffuse large B-cell lymphoma: optimizing outcome in the context of clinical and biologic heterogeneity

(2014) Laurie H. Sehn et al.   BLOOD

DRE-1/FBXO11-Dependent Degradation of BLMP-1/BLIMP-1 Governs C. elegans Developmental Timing and Maturation

(2014) Moritz Horn et al.   DEVELOPMENTAL CELL

Bortezomib for the treatment of non-Hodgkin’s lymphoma

(2014) Prithviraj Bose et al.   EXPERT OPINION ON PHARMACOTHERAPY

Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis

(2014) T. Wu et al.   GENES & DEVELOPMENT

Hrd1-mediated BLIMP-1 ubiquitination promotes dendritic cell MHCII expression for CD4 T cell priming during inflammation

(2014) Heeyoung Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Cellular System that Degrades Misfolded Proteins and Protects against Neurodegeneration

(2014) Lili Guo et al.   MOLECULAR CELL

Molecular Chaperone Functions in Protein Folding and Proteostasis

(2013) Yujin E. Kim et al.   Annual Review of Biochemistry

The HSP70 family and cancer

(2013) M. E. Murphy   CARCINOGENESIS

Diffuse large B-cell lymphoma

(2013) Maurizio Martelli et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Trafficking of the Transcription Factor Nrf2 to Promyelocytic Leukemia-Nuclear Bodies

(2013) Melanie Theodore Malloy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SUMOylation of Blimp-1 is critical for plasma cell differentiation

(2012) Hsia-Yuan Ying et al.   EMBO REPORTS

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Down-regulation of BLIMP1  by the EBV oncogene, LMP-1, disrupts the plasma cell differentiation program and prevents viral replication in B cells: implications for the pathogenesis of EBV-associated B-cell lymphomas

(2011) K. Vrzalikova et al.   BLOOD

Identification of FOXO3 and PRDM1 as tumor-suppressor gene candidates in NK-cell neoplasms by genomic and functional analyses

(2011) K. Karube et al.   BLOOD

SUMOylation of Blimp-1 promotes its proteasomal degradation

(2011) Livnat Shimshon et al.   FEBS LETTERS

Analysis of the coding genome of diffuse large B-cell lymphoma

(2011) Laura Pasqualucci et al.   NATURE GENETICS

Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malignancies after Hodgkin's lymphoma

(2011) Timothy Best et al.   NATURE MEDICINE

HRD1 and UBE2J1 target misfolded MHC class I heavy chains for endoplasmic reticulum-associated degradation

(2011) Marian L. Burr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SUMO playing tag with ubiquitin

(2011) Gerrit J.K. Praefcke et al.   TRENDS IN BIOCHEMICAL SCIENCES

BLIMP1 against Lymphoma: The Verdict Is Reached

(2010) Izidore S. Lossos   CANCER CELL

Constitutive Canonical NF-κB Activation Cooperates with Disruption of BLIMP1 in the Pathogenesis of Activated B Cell-like Diffuse Large Cell Lymphoma

(2010) Dinis Pedro Calado et al.   CANCER CELL

BLIMP1 Is a Tumor Suppressor Gene Frequently Disrupted in Activated B Cell-like Diffuse Large B Cell Lymphoma

(2010) Jonathan Mandelbaum et al.   CANCER CELL

The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition

(2010) Jaclyn R. Gareau et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Aggressive Lymphomas

(2010) Georg Lenz et al.   NEW ENGLAND JOURNAL OF MEDICINE

A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells

(2009) Andrew J. Massey et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

An expanding job description for Blimp-1/PRDM1

(2009) Elizabeth K Bikoff et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Blimp1: A conserved transcriptional repressor critical for differentiation of many tissues

(2008) Shinu A. John et al.   EXPERIMENTAL CELL RESEARCH

Human HRD1 Promoter Carries a Functional Unfolded Protein Response Element to Which XBP1 but not ATF6 Directly Binds

(2008) K. Yamamoto et al.   JOURNAL OF BIOCHEMISTRY

RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

(2008) Michael H. Tatham et al.   NATURE CELL BIOLOGY