Human LACC1 increases innate receptor-induced responses and a LACC1 disease-risk variant modulates these outcomes

How to enjoy laccases

(2015) Cinzia Pezzella et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Properties of bacterial laccases and their application in bioremediation of industrial wastes

(2015) Ram Chandra et al.   Environmental Science-Processes & Impacts

Polyphenols and mitochondria: An update on their increasingly emerging ROS-scavenging independent actions

(2014) Cristian Sandoval-Acuña et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Variants in Nicotinamide Adenine Dinucleotide Phosphate Oxidase Complex Components Determine Susceptibility to Very Early Onset Inflammatory Bowel Disease

(2014) Sandeep S. Dhillon et al.   GASTROENTEROLOGY

Activation of Pattern Recognition Receptors Up-Regulates Metallothioneins, Thereby Increasing Intracellular Accumulation of Zinc, Autophagy, and Bacterial Clearance by Macrophages

(2014) Amit Lahiri et al.   GASTROENTEROLOGY

Pattern Recognition Receptor Signaling in Human Dendritic Cells is Enhanced by ICOS Ligand and Modulated by the Crohn’s Disease ICOSLG Risk Allele

(2014) Matija Hedl et al.   IMMUNITY

Powerhouse down: Complex II dissociation in the respiratory chain

(2014) Ming-Shih Hwang et al.   MITOCHONDRION

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense

(2014) K. G. Lassen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATNFSF15disease-risk polymorphism increases pattern-recognition receptor-induced signaling through caspase-8–induced IL-1

(2014) Matija Hedl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of autophagy by polyphenolic compounds as a potential therapeutic strategy for cancer

(2014) N Hasima et al.   Cell Death & Disease

Phytocompounds for the control of human enteric viruses

(2014) Doris H. D'Souza   Current Opinion in Virology

Association of a Mutation inLACC1With a Monogenic Form of Systemic Juvenile Idiopathic Arthritis

(2014) Salma M. Wakil et al.   Arthritis & Rheumatology

Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection

(2013) John R Grainger et al.   NATURE MEDICINE

Laccase versus Laccase-Like Multi-Copper Oxidase: A Comparative Study of Similar Enzymes with Diverse Substrate Spectra

(2013) Renate Reiss et al.   PLoS One

Unearthing the secrets of mitochondrial ROS and glutathione in bioenergetics

(2013) Ryan J. Mailloux et al.   TRENDS IN BIOCHEMICAL SCIENCES

Nod2-Induced Autocrine Interleukin-1 Alters Signaling by ERK and p38 to Differentially Regulate Secretion of Inflammatory Cytokines

(2012) Matija Hedl et al.   GASTROENTEROLOGY

Mitochondrial Complex II Can Generate Reactive Oxygen Species at High Rates in Both the Forward and Reverse Reactions

(2012) Casey L. Quinlan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crohn's Disease Susceptibility Genes are Associated With Leprosy in the Vietnamese Population

(2012) A. V. Grant et al.   JOURNAL OF INFECTIOUS DISEASES

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Interactions Between the Host Innate Immune System and Microbes in Inflammatory Bowel Disease

(2011) Clara Abraham et al.   GASTROENTEROLOGY

Distinct Roles for Nod2 Protein and Autocrine Interleukin-1β in Muramyl Dipeptide-induced Mitogen-activated Protein Kinase Activation and Cytokine Secretion in Human Macrophages

(2011) Matija Hedl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

(2011) Ariel C. Bulua et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

(2011) A. Phillip West et al.   NATURE

Genomewide Association Study of Leprosy

(2010)   NEW ENGLAND JOURNAL OF MEDICINE

Association of Variants at 1q32 and STAT3 with Ankylosing Spondylitis Suggests Genetic Overlap with Crohn's Disease

(2010) Patrick Danoy et al.   PLoS Genetics

Chronic Granulomatous Disease

(2009) Steven M. Holland   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Mutations in the heme b-binding residue of SDHC inhibit assembly of respiratory chain complex II in mammalian cells

(2009) Anthony Lemarie et al.   MITOCHONDRION

Inflammatory Bowel Disease

(2009) Clara Abraham et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genomewide Association Study of Leprosy

(2009) Fu-Ren Zhang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Polyphenols in the prevention and treatment of sepsis syndromes: Rationale and pre-clinical evidence

(2009) Haim Shapiro et al.   NUTRITION

The Cytosolic Sensors Nod1 and Nod2 Are Critical for Bacterial Recognition and Host Defense after Exposure to Toll-like Receptor Ligands

(2008) Yun-Gi Kim et al.   IMMUNITY

Ferulaldehyde, a Water-Soluble Degradation Product of Polyphenols, Inhibits the Lipopolysaccharide-Induced Inflammatory Response in Mice

(2008) Balazs Radnai et al.   JOURNAL OF NUTRITION