Review
Instruments & Instrumentation
Fahima Danesh Pouya, Yousef Rasmi, Maria Gazouli, Eleni Zografos, Mohadeseh Nemati
Summary: MicroRNAs play a crucial role in the development and progression of breast cancer, with their expression patterns serving as indicators of metastatic potential. The identification of key microRNAs could lead to the development of novel therapeutic molecules, while an efficient delivery system is essential for microRNA-based therapies.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Cell Biology
Songjie Shen, Yu Song, Bin Zhao, Yali Xu, Xinyu Ren, Yidong Zhou, Qiang Sun
Summary: The study identified miR-7641 as a key miRNA in cancer-derived exosomes promoting tumor progression and metastasis via intercellular communication. Exosomal miR-7641 may serve as a non-invasive diagnostic biomarker and potential therapeutic target in breast cancer treatment.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Endocrinology & Metabolism
Chen Chen, Hong-ying Wang, Cheng-yu Chu, Wei Zhang, Yi-ting Jin, Qiang Zou
Summary: Rab11a is downregulated in breast cancer under hypoxia, promoting tumor cell migration and associated with changes in the expression of epithelial-mesenchymal transition-related proteins. Additionally, Rab11a levels are downregulated in the metastatic axillary lymph nodes of breast cancer patients.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Review
Cell Biology
Euclides Jordan-Alejandre, Alma D. D. Campos-Parra, Dora Luz Castro-Lopez, Macrina Beatriz Silva-Cazares
Summary: Breast cancer is a common cancer in women, and metastasis often occurs in the bones, lungs, liver, and brain, leading to a high mortality rate. Researchers are exploring the use of miRNA molecules as biomarkers for the diagnosis and prediction of metastases. MiRNAs are small molecules that regulate gene expression and can be easily detected and replicated in the laboratory, making them a potential tool for diagnosis, prognosis, and treatment in breast cancer.
Article
Cell Biology
Kuo-Wang Tsai, Kian-Hwee Chong, Chao-Hsu Li, Ya-Ting Tu, Yi-Ru Chen, Ming-Cheng Lee, Shih-Hsuan Chan, Lu-Hai Wang, Yao-Jen Chang
Summary: This study identified a novel lncRNA, LOC550643, highly expressed in breast cancer cells, which was significantly correlated with poor prognosis in breast cancer patients. LOC550643 promoted cell migration and invasion, inhibited miR-125b-2-3p expression to promote cancer cell growth and invasiveness. Depletion of LOC550643 suppressed the lung metastatic potential of breast cancer cells, suggesting it could be a potential diagnosis biomarker and therapeutic target for breast cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Kazumichi Kitayama, Teruya Kawamoto, Yohei Kawakami, Hitomi Hara, Toshiyuki Takemori, Shuichi Fujiwara, Shunsuke Yahiro, Tomohiro Miyamoto, Yutaka Mifune, Yuichi Hoshino, Kenichiro Kakutani, Tomoyuki Matsumoto, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Toshihiro Akisue
Summary: The study found that miR-16 promoted bone destruction caused by breast cancer bone metastasis, while miR-133a and miR-223 suppressed it.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Review
Oncology
Marie-Therese Haider, Daniel J. Smit, Hanna Taipaleenmaeki
Summary: This article summarizes the recent research progress on miRNAs in breast cancer bone metastasis. MiRNAs not only affect the function of cancer cells, but also play an important role in key cells of the bone microenvironment. In addition, the article discusses the potential application of miRNAs as therapeutic targets and elaborates on the advantages and challenges of miRNA treatment.
Review
Cell Biology
Xiao He, Tao Xu, Weijie Hu, Yufang Tan, Dawei Wang, Yichen Wang, Chongru Zhao, Yi Yi, Mingchen Xiong, Wenchang Lv, Min Wu, Xingrui Li, Yiping Wu, Qi Zhang
Summary: Breast cancer remains a major threat to women worldwide and circular RNAs (circRNAs) have emerged as potential targets for early diagnosis, treatment, and prognosis of breast cancer. Understanding the biogenesis, features, and functions of circRNAs is crucial for deciphering the key mechanisms in breast cancer growth, metastasis, diagnosis, and drug resistance. Decoding the complex networks, particularly the circRNA-miRNA target gene axis, holds great potential for developing therapeutic strategies against breast cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Wenjing Ma, Pengfei Liu, Jie Zheng, Jinhui Lu, Qian Zhao, Danni Li, Yuefan Guo, Lu Qian, Qiong Wang, Xinman Miao, Zuoren Yu
Summary: This study revealed that mental stress can lead to elevated stress hormone levels, decreased T and NK cell percentages, accelerated tumor growth, and promoted cell proliferation. miRNA screening identified downregulated miRNAs in tumors of stressed mice, with miR-346 and miR-493 targeting CCND1 as the top two most significantly downregulated miRNAs. The stress-miRNA-CCND1 signaling regulation of tumor cell proliferation was confirmed in vitro, suggesting a potential therapeutic strategy for cancer patients suffering mental stress.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Mohd Shuaib, Shashank Kumar
Summary: Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer with relatively unknown pathogenesis. In this study, the researchers investigated the tumor-suppressive role of microRNA (miR)-1250-5p in TNBC cells through various experiments. They found that increased expression of miR-1250-5p in TNBC cells led to decreased cell viability, inhibited G1/S phase transition, induced apoptosis, and reduced epithelial-mesenchymal transition. The results suggest that miR-1250-5p could be a potential therapeutic target for TNBC treatment.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Review
Oncology
Coral Gonzalez-Martinez, Carmen Garrido-Navas, Miriam Alcaide-Lucena, Jose Antonio Lorente, Javier Lopez-Hidalgo, Francisco Gabriel Ortega, Maria Jose Serrano
Summary: miRNAs are important factors in cancer development and progression. This review aims to determine if metastasis in breast cancer is characterized by different miRNA signatures that can serve as specific biomarkers for each entity. After systematic search and review of literature from PubMed, Scopus, and Web of Science databases, a total of 30 records were included in this review. Results showed a genetic signature with 5 upregulated miRNAs in metastasis compared with early stages, with miR-23b and miR-200c exclusively present in relapse metastasis. A molecular signature for future studies is proposed as a complementary tool for diagnosis and characterization of metastasis in clinical trials.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Sevan Omer Majed, Suhad Asad Mustafa
Summary: This study aimed to identify differentially expressed genes and ncRNAs in breast cancer tissues compared to normal adjacent tissues, and found miR-4510 as a potential biomarker for breast cancer. The study used MACE-Seq and small RNA-Seq to analyze gene expression and identified miR-4510 as significantly down-regulated in breast cancer. Experimental data suggested that miR-4510 may function as a tumor suppressor in breast cancer.
SCIENTIFIC REPORTS
(2023)
Review
Oncology
Andrea York Tiang Teo, Xiaoqiang Xiang, Minh T. N. Le, Andrea Li-Ann Wong, Qi Zeng, Lingzhi Wang, Boon-Cher Goh
Summary: MiRNAs play important regulatory roles in breast cancer metastasis, with oncogenic miRNAs identified to potentiate key processes such as angiogenesis, epithelial-mesenchymal transition, the Warburg effect, and the tumour microenvironment. MiRNA-based therapies show promise in controlling breast cancer progression and metastasis, but challenges including toxicity and immunogenicity must be addressed before clinical trials.
Article
Cell Biology
Anli Yang, Fu Peng, Lewei Zhu, Xing Li, Shunling Ou, Zhongying Huang, Song Wu, Cheng Peng, Peng Liu, Yanan Kong
Summary: Melatonin treatment downregulated FUNDC1 and lnc049808 in TNBC cell lines, which inhibited cell proliferation, invasion, and metastasis. lnc049808 and FUNDC1 acted as competing endogenous RNAs binding to miR-101, indicating a potential therapeutic pathway for TNBC progression inhibition by melatonin.
CELL DEATH & DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Israel Martinez-Espinosa, Jose Antonio Serrato, Blanca Ortiz-Quintero
Summary: The high mortality from lung cancer is mainly due to metastasis at the time of diagnosis. Recent research suggests that tumor cell exosomes play a significant role in tumor progression and metastasis. They release biologically active components to distant organs, directing tumor metastasis.