Article
Biology
Marion Rosello, Juliette Vougny, Francois Czarny, Marina C. Mione, Jean-Paul Concordet, Shahad Albadri, Filippo Del Bene
Summary: Researchers have successfully generated precise point mutations in zebrafish models using gene editing technology, mimicking oncogenic mutations in human genes and creating new disease models.
Article
Biochemistry & Molecular Biology
Hongzao Ni, Daofei Ji, Jing Li, Zongren Zhao, Jiandong Zuo
Summary: The study revealed that IPO11 knockdown suppressed the malignant phenotypes of glioma cells by inactivating the Wnt/beta-catenin pathway, leading to inhibition of cell proliferation, promotion of apoptosis, and suppression of invasion.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Huanhuan Li, Fan Tong, Rui Meng, Ling Peng, Jiaojiao Wang, Ruiguang Zhang, Xiaorong Dong
Summary: In this study, WNT5A protein was found to be significantly downregulated in BM tissues and EGFR-mutant samples of NSCLC patients, with overexpression inhibiting the growth and migration of EGFR-mutant cells. Further research revealed that WNT5A is negatively regulated by E2F1 and that its repression is dependent on the ERK1/2 pathway in EGFR-mutant cells. These findings suggest that targeting the ERK1/2-E2F1-WNT5A pathway could be an effective strategy for treating BM in EGFR-mutant NSCLC.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Oncology
Arnaud Carrier, Cecile Desjobert, Valerie Lobjois, Lise Rigal, Florence Busato, Jorg Tost, Miquel Ensenyat-Mendez, Diego M. Marzese, Anne Pradines, Gilles Favre, Laurence Lamant, Luisa Lanfrancone, Chantal Etievant, Paola B. Arimondo, Joelle Riond
Summary: Protocadherin proteins play an important role in cell adhesion and signaling pathways. The study found that the PCDHB15 gene's specific exon is hypermethylated in melanoma, leading to its silencing. This silencing contributes to the aggressiveness of melanoma.
CLINICAL EPIGENETICS
(2022)
Article
Pharmacology & Pharmacy
Zhibao Zheng, Na Luan, Kai Tu, Feiyan Liu, Jianwei Wang, Jianguo Sun
Summary: PCDH7 expression in colorectal cancer cells is positively correlated with cell proliferation and drug resistance, while negatively correlated with cell migration and invasion. PCDH7 mediates drug resistance by inhibiting cell apoptosis through upregulating Mcl-1 expression and activating the Wnt signaling pathway. The Mcl-1 inhibitor S63845 can attenuate the anti-apoptotic effect of PCDH7 and sensitizes PCDH7-overexpressing colorectal cancer cells to ABT-263.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Yijiao Ning, Chaoqun Deng, Chunhong Li, Weiyan Peng, Chun Yan, Jing Ran, Weihong Chen, Yujia Liu, Jiuyi Xia, Lin Ye, Zhengqiang Wei, Tingxiu Xiang
Summary: PCDH20 expression is attenuated in esophageal cancer, possibly due to promoter methylation. PCDH20 exerts anti-tumor effects through MAP3K9 downregulation and inhibition of AKT/β-catenin signaling in ESCC cells.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Chunhua Wan, Sylvia Mahara, Claire Sun, Anh Doan, Hui Kheng Chua, Dakang Xu, Jia Bian, Yue Li, Danxi Zhu, Dhanya Sooraj, Tomasz Cierpicki, Jolanta Grembecka, Ron Firestein
Summary: The aberrant activation of the Wnt/beta-catenin pathway is a key driver of colorectal cancer growth, and in this study, KMT2A is identified as a promising target for CRC therapy due to its unique epigenetic regulation of beta-catenin transcriptional output.
Article
Multidisciplinary Sciences
Chen Shen, Anmada Nayak, Leif R. Neitzel, Amber A. Adams, Maya Silver-Isenstadt, Leah M. Sawyer, Hassina Benchabane, Huilan Wang, Nawat Bunnag, Bin Li, Daniel T. Wynn, Fan Yang, Marta Garcia-Contreras, Charles H. Williams, Sivanesan Dakshanamurthy, Charles C. Hong, Nagi G. Ayad, Anthony J. Capobianco, Yashi Ahmed, Ethan Lee, David J. Robbins
Summary: This study reveals how the Wnt ligand can enhance CRBN-dependent protein degradation and highlights the importance of CRBN in physiological Wnt signaling.
NATURE COMMUNICATIONS
(2021)
Article
Biotechnology & Applied Microbiology
Yi Liu, Jun Ma, Jiu-Shan Song, Hai-Ying Zhou, Jing-Hui Li, Cheng Luo, Xin Geng, He-Xiang Zhao
Summary: TOP2A plays a critical role in the metastatic characteristics of glioma. High expression of TOP2A is associated with poor survival in glioma patients, while silencing TOP2A impairs glioma cell proliferation and aggressiveness. Mechanistically, TOP2A interacts with beta-catenin and promotes its translocation into the nucleus, affecting glioma cell growth and invasion through the Wnt/beta-catenin pathway.
Article
Cell Biology
Zhihua Ye, Yingyu Yang, Ying Wei, Lamei Li, Xinyi Wang, Junkai Zhang
Summary: This study identified PCDH1 as a new prognostic marker in pancreatic ductal adenocarcinoma (PDAC) patients. PCDH1 expression was upregulated in PDAC tissues and was associated with tumor invasion depth and lymph node metastasis. Mechanistically, PCDH1 enhanced p65 nuclear localization by interacting with KPNB1, activating the NF-kappa B signaling pathway and promoting PDAC progression.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Tadas K. Rimkus, Austin B. Arrigo, Dongqin Zhu, Richard L. Carpenter, Sherona Sirkisoon, Daniel Doheny, Angelina T. Regua, Grace L. Wong, Sara Manore, Calvin Wagner, Hui-Kuan Lin, Guangxu Jin, Jimmy Ruiz, Michael Chan, Waldemar Debinski, Hui-Wen Lo
Summary: The study found that TUSC2 protein expression is reduced in glioblastoma compared to normal brain due to protein destabilization. NEDD4-mediated polyubiquitination is a novel mechanism for TUSC2 degradation in glioblastoma. TUSC2 loss promotes glioblastoma progression through upregulation of Bcl-xL and its knockout gene signature predicts poor patient survival.
Article
Multidisciplinary Sciences
Ahmet Acar, Ana Hidalgo-Sastre, Michael K. Leverentz, Christopher G. Mills, Simon Woodcock, Martin Baron, Giovanna M. Collu, Keith Brennan
Summary: Notch and Wnt are two essential signaling pathways in animals, with typically opposing effects on cell fate decisions. Notch can limit Wnt signaling through mechanisms at the cell membrane and in the cell nucleus, contributing to the robustness of cell fate decisions by sharpening the distinction between opposing Notch/Wnt responses.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Janine H. van Ree, Karthik B. Jeganathan, Raul O. Fierro O. Velasco, Cheng Zhang, Ismail Can, Masakazu Hamada, Hu Li, Darren J. Baker, Jan M. van Deursen
Summary: PTEN is a sensitive tumor suppressor that is affected by changes in expression or function. The phosphorylation of PTEN at its C-tail domain plays a role in its stability, localization, catalytic activity, and protein interactions. The hyperphosphorylation of the C-tail promotes neoplastic growth through the activation of WNT signaling.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Meng Chen, Liying Shan, Ying Gan, Lijie Tian, Jie Zhou, Endong Zhu, Hairui Yuan, Xiaoxia Li, Baoli Wang
Summary: MTSS1 plays a role in osteoblast differentiation and bone homeostasis by regulating Src-Wnt/beta-catenin signaling.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Zhi Nie, Shan Cai, Zhimin Wei, Yanxi Li, Li Bian, Chenyang Wang, Chunyan Wang
Summary: SH3BGRL2 is weakly expressed in GBM and IDH1 wildtype GBM, and its ectopic expression inhibits GBM cell growth, migration, and GSCs self-renewal both in vitro and in vivo, by suppressing key regulators like SOX2 and CD133. This suggests SH3BGRL2 has potential as a biomarker and therapeutic target for glioma patients.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)