Article
Oncology
Yao Huang, Xiaoyu Huang, Jianxing Zeng, Jun Lin
Summary: This study investigated the role of MUC16 in the inhibition of migration and invasion of HepG2 and Huh7 cells, demonstrating the significance of MUC16 in this process. Knockdown of MUC16 resulted in enhanced migration and invasion of the cells, indicating its potential as a tumor biomarker for hepatocellular carcinoma.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jiamei Le, Yi Fu, Qiuqin Han, Yujie Ma, Houlin Ji, Xindong Wei, Yifan Chen, Yongning Sun, Yueqiu Gao, Hailong Wu
Summary: This study revealed that SA has significant inhibitory effects on the migration and invasion of HCC, and identified differentially expressed genes through transcriptome analysis. The findings provide new insights into the inhibitory effects and potential targets of SA on HCC metastasis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Xiaowei Chang, Chang Tian, Yuanyuan Jia, Yu Cai, Pu Yan
Summary: MLXIPL promotes the malignant progression of HCC by activating phosphorylation of mTOR, indicating the significant role of the combination of MLXIPL and mTOR in HCC.
Article
Cell Biology
Zhipeng Tang, Pei Zhao, Wanxing Zhang, Qian Zhang, Ming Zhao, He Tan
Summary: This study found that SALL4 activates the PI3K/AKT signaling pathway through targeting PTEN, thereby facilitating the migration, invasion, and proliferation of HCC cells.
Article
Oncology
Neng Tang, Xiaolin Dou, Xing You, Yixiong Li, Xi Li, Guodong Liu
Summary: The study revealed that androgen receptor can suppress HCC cells invasion and migration capacities via miR-122-5p/RABL6 signaling, providing a new potential therapeutic target for better treatment of HCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Plant Sciences
Junyi Shen, Xinrui Zhu, Zhenru Wu, Yujun Shi, Tianfu Wen
Summary: Uvangoletin can induce apoptotic and autophagic cell death, inhibit cell proliferation and metastasis on HepG2 cells through Akt/mTOR, MAPK, and TGF beta/Smad2 signal pathways.
Article
Oncology
Yan Lu, Qihua Dang, Yin Bo, Xuejin Su, Liping Wang, Jiaqi Sun, Junyuan Wei, Chengshi Quan, Yanru Li
Summary: CLDN6 was found to be highly expressed in human hepatocellular carcinoma (hHCC) and promoted the development of the cancer. Silencing of CLDN6 in hHCC cells inhibited proliferation, migration, and invasion abilities, upregulated E-cadherin expression, and downregulated N-cadherin and Vimentin expression, suggesting that CLDN6 could be a potential target for hHCC treatment.
Article
Pharmacology & Pharmacy
Huaguo Liang, Zexin Chen, Ruihui Yang, Qingsong Huang, Hongmei Chen, Wanting Chen, Li Zou, Peng Wei, Shijie Wei, Yongxia Yang, Yongli Zhang
Summary: The polyphenolic compound Methyl gallate (MG) found in plants can inhibit the proliferation, migration, and invasion of HCC cells both in vitro and in vivo. The therapeutic mechanism of MG potentially involves the regulation of the AMPK/NF-kappa B pathway, which influences the epithelial-mesenchymal transition and MMP expression.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Xiaoting Huang, Leyang Xiang, Baiyao Wang, Jijie Hu, Chunshan Liu, Anbang Ren, Kunpeng Du, Gengtai Ye, Yingying Liang, Yunqiang Tang, Dinghua Yang, Yawei Yuan
Summary: This study demonstrates that CMTM6 plays a critical role in promoting proliferation, migration, and invasion in HCC through interacting with and stabilizing vimentin. The overexpression of CMTM6 is significantly associated with poor prognosis in HCC, suggesting its potential as a biomarker and therapeutic target for treating HCC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, General & Internal
Yanjiao Ou, Yong Deng, Hong Wang, Qingyi Zhang, Huan Luo, Peng Hu
Summary: This study identified a novel lncRNA PRKAG2-AS1 as a potential therapeutic target in hepatocellular carcinoma, demonstrating its association with clinical implications and malignant behaviors. PRKAG2-AS1 may function through regulating the miR-502-3p/BICD2 axis.
FRONTIERS IN MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Zhijun Liu, Yuyu You, Qiyi Chen, Guobang Li, Wenfeng Pan, Qing Yang, Jiajun Dong, Yi Wu, Jin-Xin Bei, Chaoyun Pan, Fuming Li, Bo Li
Summary: Hepatocellular carcinoma (HCC) is characterized by metabolic and immune remodeling in the tumor microenvironment. Liver-specific deletion of fructose-1, 6-bisphosphatase 1 (FBP1) promotes liver tumorigenesis, partly due to the suppression of natural killer (NK) cells. Mechanistically, FBP1 attenuation in hepatocytes inhibits PKLR expression and reduces the activity of NK cells by transferring PKLR-attenuated extracellular vesicles (EVs) from hepatocytes.
Article
Cell Biology
Jinghua Lu, Yipei Ding, Wanqiu Zhang, Yuanyuan Qi, Jin Zhou, Naihan Xu, Yaou Zhang, Weidong Xie
Summary: Clinical analysis indicates that SQSTM1/p62 is highly expressed in HCC and affects patient prognosis. Knocking out SQSTM1/p62 using the CRISPR/Cas9 system impairs HCC migration and invasion, upregulates Keap1, and promotes the inhibitory effect of Keap1 on Nrf2. Inactivation of Nrf2 inhibits MMP expression, attenuating HCC migration and invasion. SQSTM1/p62 knockout also inhibits migration and invasion in a mouse model of lung metastasis. Cisplatin inhibits SQSTM1/p62 expression and slows down HCC migration and invasion, while the inflammatory microenvironment accelerates HCC migration and invasion. This study suggests that SQSTM1/p62 knockout inhibits HCC migration and invasion through the Keap1/Nrf2/MMP2 signaling pathway, highlighting it as a potential drug target.
Article
Biotechnology & Applied Microbiology
Zhiqing Cheng, Limei Gong, Qinghe Cai
Summary: This study found that LINC00978 is upregulated in HCC and is associated with poor prognosis. Silencing LINC00978 can inhibit the growth and metastasis of HCC cells. Mechanistically, LINC00978 functions as a sponge for miR-125b-5p and regulates the expression of SOX12, promoting liver cancer migration, invasion, and proliferation.
Article
Oncology
Wei Zhao, Bo Ma, Zhihua Tian, Haibo Han, Jintian Tang, Bin Dong, Guo An, Baoshan Cao, Boqing Wang
Summary: The study found that miR424 and its direct target CBX4 were significantly associated with stem-cell-like properties, poor survival, and clinical characteristics in sorafenib-resistant cell lines. Functional experiments demonstrated that miR424 suppressed CBX4 and induced nuclear translocation of YAP1 protein, while modulation of YAP1 and CBX4 with CA3 and UNC3866 inhibited tumorigenicity and stem-like properties, suggesting a strong anti-tumour effect in vivo against sorafenib-resistant HCC cells.
BRITISH JOURNAL OF CANCER
(2021)
Article
Cell Biology
Yuxi Ding, Xiaoling Liu, Yue Yuan, Yunjian Sheng, Decheng Li, Suvash Chandra Ojha, Changfeng Sun, Cunliang Deng
Summary: Through integrated bioinformatics analysis and experimental validation, this study identified key genes associated with prognosis in HCC patients, with THRSP selected for further investigation. Experimental results confirmed that THRSP was downregulated in HCC tissues and cell lines, and silencing of THRSP promoted HCC progression. Additionally, THRSP expression was also negatively correlated with the infiltration levels of immune cells.