Journal
ONCOLOGY LETTERS
Volume 13, Issue 6, Pages 4641-4650Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2017.6065
Keywords
Philadelphia-negative myeloproliferative neoplasms; genetic susceptibility; base excision repair genes polymorphisms; DNA repair
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Funding
- Science and Technology Foundation of Portugal [UID/BIM/00009/2013, SFRH/BPD/80462/2011]
- Fundação para a Ciência e a Tecnologia [SFRH/BPD/80462/2011, UID/BIM/00009/2013] Funding Source: FCT
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The role of base excision repair (BER) genes in Philadelphia-negative (PN)-myeloproliferative neoplasms (MPNs) susceptibility was evaluated by genotyping eight polymorphisms [apurinic/apyrimidinic endodeoxyribonuclease 1, mutY DNA glycosylase, earlier mutY homolog (E. coli) (MUTYH), 8-oxoguanine DNA glycosylase 1, poly (ADP-ribose) polymerase (PARP) 1, PARP4 and X-ray repair cross-complementing 1 (XRCC1)] in a case-control study involving 133 Caucasian Portuguese patients. The results did not reveal a correlation between individual BER polymorphisms and PN-MPNs when considered as a whole. However, stratification for essential thrombocythaemia revealed i) borderline effect/tendency to increased risk when carrying at least one variant allele for XRCC1_ 399 single-nucleotide polymorphism (SNP); ii) decreased risk for Janus kinase 2-positive patients carrying at least one variant allele for XRCC1_ 399 SNP; and iii) decreased risk in females carrying at least one variant allele for MUTYH SNP. Combination of alleles demonstrated an increased risk to PN-MPNs for one specific haplogroup. These findings may provide evidence for gene variants in susceptibility to MPNs. Indeed, common variants in DNA repair genes may hamper the capacity to repair DNA, thus increasing cancer susceptibility.
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