Article
Chemistry, Multidisciplinary
Hulya Gizem Ozkan, Vanrajsinh Thakor, Hong-Gui Xu, Galyna Bila, Rostyslav Bilyy, Daria Bida, Martin Boettcher, Dimitrios Mougiakakos, Rainer Tietze, Andriy Mokhir
Summary: Elevated levels of reactive oxygen species (ROS) and deficient mitochondria are weak points of cancer cells. Designing highly potent anticancer drugs that target both ROS and mitochondria is a valid therapeutic strategy. However, limiting the drug effects to cancer cells without affecting normal ones remains a challenge. In this study, we developed novel aminoferrocene derivatives that are chemically stable in the presence of ROS, generate mitochondrial ROS in cancer cells but not normal cells, and exhibit anticancer effects in vivo.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Plant Sciences
Rishi Kant Singh, Praveen Kumar Verma, Amit Kumar, Sandeep Kumar, Arbind Acharya
Summary: This study aimed to investigate the effect of Achyranthes aspera L. leaf extracts on Non-Hodgkin lymphomas (NHLs). The results demonstrated that A. aspera methanolic leaf extract suppressed cell proliferation, induced apoptosis, and inhibited the PKC alpha signaling pathway in DL cells, suggesting a potential therapeutic role in NHL treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Weiping Li, Xia Xu
Summary: "Treatment of Glioblastoma: Targeting Mitophagy and Mitochondrial Apoptosis Pathways" is a review article that emphasizes the urgent need to develop novel methods for treating Glioblastoma (GBM). GBM exhibits intra- and inter-tumor heterogeneity, leading to drug resistance and tumor recurrence. Recent studies have shown that drugs targeting mitophagy and mitochondrial apoptosis pathways, along with nanotechnology, offer promising approaches for GBM treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Przemyslaw Sitarek, Ewelina Synowiec, Tomasz Kowalczyk, Gabrielle Bangay, Tomasz Sliwinski, Laurent Picot, Salvatore Princiotto, Patricia Rijo
Summary: This study investigates the anticancer features of compounds isolated from Plectranthus ornatus, and finds that they exhibit cytotoxicity and induce apoptosis in cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Cho-Won Kim, Kyung-Chul Choi
Summary: Mitochondria are crucial organelles for energy production in cells and play a vital role in cellular homeostasis. Some anticancer drugs can cause toxicity to cardiac mitochondria, leading to potential cardiac disorders.
Article
Biochemistry & Molecular Biology
Xicheng Liu, Zihan Wang, Xinru Zhang, Xiaocai Lv, Yong Sun, Ruixiao Dong, Guangxiao Li, Xueyan Ren, Zhongyin Ji, Xiang-Ai Yuan, Zhe Liu
Summary: Half-sandwich IrIII-Fc heteronuclear metal complexes exhibit promising anticancer activity and possess a different mechanism from platinum-based drugs, indicating their potential as alternative agents.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Review
Engineering, Biomedical
Tianyuan Zhong, Jie Yu, Yong Pan, Ning Zhang, Yanxin Qi, Yubin Huang
Summary: Platinum drugs are widely used in cancer treatment, but their toxicity and drug resistance pose challenges. Combination therapy with platinum drugs can effectively inhibit tumor growth and metastasis, reducing toxicity and overcoming resistance. This review summarizes the current progress and challenges in platinum-based combination therapy, including gene editing, ROS-based therapy, thermal therapy, immunotherapy, and imaging modality. It hopes to inspire researchers for the development of more effective platinum-based anti-cancer complexes in the future.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Tushar Ranjan Panda, M. Manikandan, Shreyas P. Vaidya, Sushanta Chhatar, Suman Sinha, Megha Mehrotra, Sourav Chakraborty, Shubhankar Gadre, Prakash Duari, Pritha Ray, Malay Patra
Summary: Even in the era of precision medicine and immunotherapy, chemotherapy with platinum drugs is still widely used against various cancers. However, the efficacy of these drugs is limited by resistance and toxicity. In this study, we designed kinetically inert organometallic platinum anticancer agents with a novel mechanism of action. Our best candidate showed promising antitumor efficacy and could mitigate nephrotoxicity associated with cisplatin. This study demonstrates the importance of kinetic inertness in improving the therapeutic benefits of platinum-based anticancer therapy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Food Science & Technology
Juanjuan Wei, Yurong Li, Zimao Ye, Yi Li, Zhiqin Zhou
Summary: Citrus carotenoids have antioxidant and anticancer properties, making them potentially effective in the prevention and treatment of breast cancer. Different citrus species contain abundant carotenoids, which exhibit good antioxidant and anticancer activities. Citrus carotenoids can induce cell oxidative stress and regulate cell apoptosis, showing potential for the development of anti-breast cancer products.
Review
Pediatrics
Luke Maese, Rachel E. Rau
Summary: Cure rates for pediatric acute lymphoblastic leukemia (ALL) have significantly improved in the past five decades, largely due to the development and understanding of combination chemotherapy. Asparaginase, a recent addition to ALL chemotherapy, plays a crucial role in therapy by depleting the essential amino acid asparagine. Its unique toxicity profile, including hypersensitivity reactions, and the need for therapeutic drug monitoring have influenced the incorporation of asparaginase into ALL treatment. Despite its long-term use and standard-of-care status, there is still room for further improvement in the utilization of asparaginase therapy.
FRONTIERS IN PEDIATRICS
(2022)
Article
Oncology
Amber Gibson, Adriana Trabal, David McCall, Sajad Khazal, Laurie Toepfer, Donna H. Bell, Michael Roth, Kris M. Mahadeo, Cesar Nunez, Nicholas J. Short, Courtney DiNardo, Marina Konopleva, Ghayas C. Issa, Farhad Ravandi, Nitin Jain, Gautam Borthakur, Hagop M. Kantarjian, Elias Jabbour, Branko Cuglievan
Summary: This study retrospectively reviewed the safety and efficacy of Venetoclax in pediatric and young adult patients with relapsed or refractory acute lymphoblastic leukemia (ALL) or lymphoma (LBL). The results showed that Venetoclax is safe and effective to use in pediatric patients with ALL/LBL and should be considered in both the relapsed and upfront settings.
Article
Cell Biology
Yanhong Wang, Xinyu Mang, Xuran Li, Zhengyu Cai, Fei Tan
Summary: This study investigated the effect and mechanism of cold atmospheric plasma (CAP) on the proliferation and apoptosis of lung cancer and colon cancer cells. The results showed that CAP treatment inhibited tumor cell proliferation and induced apoptosis through the activation of the mitochondrial pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Chemistry, Medicinal
Xiang Gao, Haonan Li, Siyu Wang, Xiaokang Long, Xuehai Guo, Huiming Hua, Dahong Li
Summary: The derivative e4 of sinomenine/8-Bis(benzylthio) octanoic acid exhibits significant cytotoxic effects on cancer cells, especially on K562 cells, with high safety. It induces apoptosis by altering the morphology of the nucleus and causing damage to the mitochondrial membrane potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Juhyun Shin, Arti Nile, Ramesh Kumar Saini, Jae-Wook Oh
Summary: The carotenoid astaxanthin (AXT) has an effect on glioblastoma multiforme (GBM) cells, particularly in combination with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). AXT sensitizes certain GBM cell lines to TRAIL treatment, inducing apoptosis. AXT acts as an ROS scavenger in GBM cells and also plays a role in decreasing mitochondrial potential, a process that can be inhibited by SOD2.
Article
Biochemistry & Molecular Biology
Yi Guo, Quan Li, Rongmu Xia, Chuanshu Cai
Summary: Farrerol has anti-tumor effects on lung adenocarcinoma cells by inducing apoptosis and cell cycle arrest, without significant impact on normal lung epithelial cells.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Qiaomei Chen, Yang Yang, Ying Yu, Huaping Xu
Summary: This novel experiment using vitrimers, a type of polymer, in undergraduate courses introduces students to the preparation and characterization of polymers, as well as the advantages and limitations of thermosets and thermoplastics. It inspires students' interest in functional materials and provides practical experience in designing and working with special thermosets.
JOURNAL OF CHEMICAL EDUCATION
(2021)
Article
Chemistry, Multidisciplinary
Cheng Liu, Yizheng Tan, Chaowei He, Shaobo Ji, Huaping Xu
Summary: The introduction of dynamic diselenide bonds into shape-memory materials allows for shape programming with light, simplifying programming setups and enabling the creation of complex 3D configurations and microscopic patterns. Light-induced stress gradients can achieve out-of-plane deformations and have great potential in various applications such as soft robots, smart actuators, and anti-counterfeiting techniques.
ADVANCED MATERIALS
(2021)
Article
Engineering, Biomedical
Shuojiong Pan, Tianyu Li, Yizheng Tan, Huaping Xu
Summary: In this study, selenium-containing nanoparticles were constructed to synergistically enhance Pem-based chemotherapy and NK cell-based immunotherapy. The selenium compounds could deliver Pem to tumor sites and improve the chemotherapy efficiency. Additionally, they can also activate NK cell's immune response. The in vitro and in vivo experiments revealed the potential mechanism, highlighting the promising prospect of this strategy in chemoimmunotherapy.
Article
Chemistry, Multidisciplinary
Chaowei He, Muqing Cao, Jianbing Liu, Zhuoxin Ge, Ruihao Zhou, Huaping Xu
Summary: Modern Olympics have increasingly utilized nanotechnologies to support athletes and enhance sports performance. Nanoscience is applied in ice skating, wearable monitoring devices, skiing sports equipment, winter protection, and Olympic printing, playing a significant role in the Olympic and Paralympic Winter Games.
Article
Polymer Science
Muqing Cao, Peng Zhao, Cheng Liu, Jiahao Xia, Huaping Xu
Summary: Dynamic covalent bonds in polymeric materials show synergistic effects and can enhance their dynamic properties.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Nanoscience & Nanotechnology
Peng Zhao, Muqing Cao, Cheng Liu, Yiheng Dai, Yizheng Tan, Shaobo Ji, Huaping Xu
Summary: This study developed underwater remote stimulus-responsive self-healing polymer materials using visible-light-responsive diselenide bonds as healing moieties. The material achieved excellent underwater transmission capability and showed rapid healing efficiency above 90% with strain recovery of nearly 200% in 5 minutes.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Chengfei Liu, Banruo Xianyu, Yiheng Dai, Shuojiong Pan, Tianyu Li, Huaping Xu
Summary: Polymerization inside living cells provides chemists with a multitude of possibilities to modulate cell activities. We reported a hyperbranched polymerization in living cells based on the oxidative polymerization of organotellurides and intracellular redox environment. The obtained hyperbranched polymer aggregated into branched nanostructures in cells, which could effectively evade drug pumps and decrease drug efflux, ensuring the polymerization for persistent treatment.
Article
Chemistry, Multidisciplinary
Shuojiong Pan, Jun Guan, Banruo Xianyu, Yizheng Tan, Tianyu Li, Huaping Xu
Summary: Self-assembled selenium-containing nanoparticles are developed to reverse NK cell exhaustion and enhance NK-cell-mediated immunotherapy, effectively inhibiting tumor growth.
ADVANCED MATERIALS
(2023)
Review
Polymer Science
Yiheng Dai, Jun Guan, Shenghan Zhang, Shuojiong Pan, Banruo Xianyu, Zhuoxin Ge, Jinyan Si, Chaowei He, Huaping Xu
Summary: Significant progress has been made in the field of tellurium-containing polymers in recent decades. These polymers exhibit unique properties and have promising applications. This review provides an overview of the diversification of tellurium-containing polymers and their synthetic methods, as well as a detailed discussion of their properties and applications in various fields. By summarizing the recent developments and trends, this review aims to popularize the concepts and serve as a comprehensive handbook for researchers in the field of chemistry and materials.
PROGRESS IN POLYMER SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Chengfei Liu, Jinyan Si, Muqing Cao, Peng Zhao, Yiheng Dai, Huaping Xu
Summary: Visualizing polymer chain growth is always a hot topic in polymer chemistry. However, current characterization methods are limited in their ability to differentiate the degree of polymerization without isolating the samples from the reaction vessel, let alone to detect insoluble polymers. This study establishes a reliable relationship between polymer chain growth and fluorescence properties through polymerization induced emission, enabling real-time monitoring of the polymerization reaction. The method can also be applied to observe the polymerization process of insoluble polymers, opening a new avenue for visualizing polymer chain growth in real-time, regardless of polymer solubility.
Article
Multidisciplinary Sciences
Ningyue Chen, Shuwei Li, Peng Zhao, Ran Liu, Yu Xie, Jin-Liang Lin, Christian A. Nijhuis, Bingqian Xu, Liang Zhang, Huaping Xu, Yuan Li
Summary: This study introduces a method to form stable gold-based self-assembled monolayers (SAMs) using selenide anchoring groups, resulting in highly stable molecular tunnel junctions. The findings demonstrate the potential application of selenide-derived stable SAMs in long-lived molecular electronic devices.
Review
Chemistry, Multidisciplinary
Muqing Cao, Yizheng Tan, Huaping Xu
Summary: In recent years, there has been extensive research and development on the mechanochemistry of polymers, specifically the reactivity of polymers under mechanical stimuli. More attention has been given to dynamic chalcogen-containing polymers due to their sensitive responsiveness and precise biofunction. This perspective provides an overview of mechanochemistry in dynamic chalcogen-containing polymers, covering fundamental mechanochemistry and applications. It focuses on mechanically induced color/fluorescence changes, drug release, and material strengthening and toughening of functional mechano-responsive polymeric materials. Additionally, currently unsolved issues, challenges, and potential opportunities for the future are summarized and discussed.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Banruo Xianyu, Shuojiong Pan, Shiqian Gao, Huaping Xu, Tianyu Li
Summary: This study developed a selenium-containing nanocomplex that can act as a dual immune checkpoint inhibitor in cancer immunotherapy. The nanocomplex targets PD-L1 and HLA-E on tumor cells to block immune checkpoints, promoting NK cell-mediated antitumoral activity.
Article
Nanoscience & Nanotechnology
Peng Zhao, Muqing Cao, Cheng Liu, Yiheng Dai, Yizheng Tan, Shaobo Ji, Huaping Xu
Summary: In this study, a remote self-healing underwater elastomer material was developed using visible-light-responsive diselenide bonds. The material exhibited excellent underwater transmission capability and fast healing speed, with a strain at break of up to 200% in 5 minutes and almost full recovery of toughness within 1 hour. This provides a new direction for underwater pipeline sealing applications.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Luo Zhang, Yiheng Dai, Shuojiong Pan, Yizheng Tan, Chenxing Sun, Muqing Cao, Huaping Xu
Summary: Researchers have developed copper-selenocysteine quantum dots (Cu-Sec QDs) using a facile and robust thermal titration process. These QDs exhibit strong photothermal enhancement of Fenton-like reaction and cytotoxicity, showing great potential for cancer treatment.
ACS APPLIED BIO MATERIALS
(2022)
