Review
Biochemistry & Molecular Biology
Shermaine W. Y. Low, Thomas B. Connor, Iris S. Kassem, Deborah M. Costakos, Shyam S. Chaurasia
Summary: Small leucine-rich proteoglycans (SLRPs) serve a crucial role in maintaining retinal homeostasis by participating in the organization of extracellular matrix, regulation of cell growth, and cell-matrix interactions in several upstream signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Aikaterini Berdiaki, Eirini-Maria Giatagana, George Tzanakakis, Dragana Nikitovic
Summary: Cancer is a complex disease involving changes in cells and the surrounding environment. The tumor microenvironment consists of tumor cells, normal tissue cells, blood vessels, immune system cells, stromal cells, and the extracellular matrix (ECM). Small leucine-rich proteoglycans (SLRPs) are molecules released by cells into the surrounding matrix. They can interact with cell surface molecules and secreted biomolecules, altering signaling pathways and regulating cell behavior. This review focuses on the roles of two SLRP members, biglycan and lumican, and their impact on cancer cell survival, growth, and metastasis.
Article
Clinical Neurology
Shanmuganathan Rajasekaran, Dilip Chand Raja Soundararajan, Chitraa Tangavel, Sharon Miracle Nayagam, Sri K. S. Vijayanand, R. Sunmathi, Monica Steffi Matchado, Raveendran Muthurajan, Ajoy Prasad Shetty, Rishi Mugesh Kanna, K. Dharmalingam
Summary: This study utilized proteomic analysis to compare the expression of SLRPs in fetal, healthy adult, and degenerated discs. The results showed a universal decrease in SLRPs abundance in degenerated discs, associated with an increase in MMPs and a reduction in TIMPs. Fetal discs were mainly engaged in ribosomal pathways, while healthy adult discs primarily participated in ECM maintenance and basic metabolic pathways.
Article
Dermatology
Xue Xu, Pin Ha, Emily Yen, Chenshuang Li, Zhong Zheng
Summary: Small leucine-rich proteoglycans (SLRPs) play a crucial role in regulating tendon structure and biomechanics, offering a promising method for tendon injury management. However, current knowledge on the role of SLRPs in tendon development and regeneration is limited, requiring further investigations.
ADVANCES IN WOUND CARE
(2022)
Article
Oncology
Filipe Pinto, Liliana Santos-Ferreira, Marta T. Pinto, Catarina Gomes, Celso A. Reis
Summary: Approximately 80% of gastric cancer patients are diagnosed at advanced stages with poor prognosis. The aggressiveness of gastric cancer is associated with biglycan, an extracellular proteoglycan, which requires further research to explore its therapeutic potential.
Article
Cell Biology
Sandeep Appunni, Muni Rubens, Venkataraghavan Ramamoorthy, Vivek Anand, Madhuram Khandelwal, Alpana Sharma
Summary: Biglycan, as a class I SLRP, is a key component of the ECM involved in scaffolding collagen fibrils and mediating cell signaling. Dysregulation of its expression can lead to various clinical conditions including metabolic disorders, inflammatory disorders, musculoskeletal defects, and malignancies. Biglycan interacts with TLR-2 and TLR-4 on immune cells to induce inflammation, and its dysregulation is also observed in inflammatory metabolic conditions and cancer, where high expression levels facilitate tumor growth and metastasis.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Cell Biology
Romain Rivet, Rajas Mallenahalli Rao, Pierre Nizet, Nicolas Belloy, Louise Huber, Manuel Dauchez, Laurent Ramont, Stephanie Baud, Stephane Brezillon
Summary: This study characterized the structure and dynamics of four SLRPs using in silico 3D modeling, and evaluated their capacity to bind to MMP-14 and regulate its activity. The results demonstrated that each SLRP exhibited significant inhibition of MMP-14 activity, which was related to the core protein conformation as well as the glycan chain structures and dynamics.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Eirini-Maria Giatagana, Aikaterini Berdiaki, Aristidis Tsatsakis, George N. Tzanakakis, Dragana Nikitovic
Summary: Lumican, a proteoglycan involved in the formation of the extracellular matrix, plays an important role in cellular processes associated with tumorigenesis and tumor progression. It has been reported to have either a positive or negative correlation with tumor progression in various cancer tissues. There is potential for lumican to serve as a cancer prognosis marker, chemoresistance regulator, and cancer therapy target.
Article
Multidisciplinary Sciences
Shao-Wei Chen, Shing-Hsien Chou, Ying-Chang Tung, Fu-Chih Hsiao, Chien-Te Ho, Yi-Hsin Chan, Victor Chien-Chia Wu, An-Hsun Chou, Ming-En Hsu, Pyng-Jing Lin, Winston W. Y. Kao, Pao-Hsien Chu
Summary: The study found altered LUM expression in patients with AD, leading to increased s-LUM levels in blood. Lum(-/-) mice exhibited augmented AD pathogenesis, while no significant pathologic changes in AA were observed.
Article
Biochemistry & Molecular Biology
Geyang Dai, Yue Sun, Rui Wei, Ling Xi
Summary: PODNL1, a member of SLRP family, plays a crucial role in the tumor microenvironment and has significant correlations with prognosis and immunotherapeutic responses in various cancers. It is closely associated with cancer-associated fibroblast infiltration levels and participates in the complex regulation network of tumor progression, indicating its potential as a biomarker for cancer treatment and prognosis.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Review
Ophthalmology
Mei-Chi Tsui, Hsin-Yu Liu, Hsiao-Sang Chu, Wei-Li Chen, Fung-Rong Hu, Winston W. -Y. Kao, I-Jong Wang
Summary: Lumican, a keratan sulfate proteoglycan, plays versatile roles in the pathogenesis of eye diseases. It is involved in the maintenance of tissue homogeneity and shows upregulation in pathological conditions such as fibrosis, scar tissue formation, inflammatory responses, and immune anomaly. This review focuses on the role of lumican in the pathogenesis of inherited congenital and acquired eye diseases such as cornea dystrophy, cataract, glaucoma, and chorioretinal diseases.
Review
Biochemistry & Molecular Biology
Chidambra D. Halari, Michael Zheng, Peeyush K. Lala
Summary: This review highlights the important roles of two small leucine-rich proteoglycans in the placenta and fetal membranes, discussing their alterations and associations with pregnancy-related diseases. The expression and actions of these proteoglycans in pathological pregnancies are explored, along with unanswered questions for further research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Huijie Gao, Chao Liu, Qiang Ren, Litao Zhang, Wei Qin, Huiyun Wang, Yuntao Zhang
Summary: Previous studies showed that lumican was important in pancreatic cancer, but the underlying mechanisms were unknown. This study demonstrated that lumican may suppress PDAC tumor growth by regulating P53 and P21.
Article
Anatomy & Morphology
Wei Qin, Jing Zhang, Ruixue Rong, Litao Zhang, Huijie Gao, Chao Liu, Qiang Ren, Gongpu Zheng, Jian Wang, Lingxin Meng, Sen Qiao, Ruikun Qian, Caiju Zhou, Huiyun Wang, Yuntao Zhang
Summary: OGN is found to be significantly upregulated in pancreatic cancer tissues and cell lines, and its expression is closely associated with TNM stage and patient survival rate. Overexpression of OGN promotes proliferation, migration, and invasion, and inhibits apoptosis of pancreatic cancer cells. Further experiments reveal that OGN upregulates ID4. OGN may serve as a potential biomarker and targeting the OGN/ID4 axis may be a promising strategy in pancreatic cancer therapy.
Article
Oncology
Lei Meng, Yu-Ting Hu, A-Man Xu
Summary: This study found that FBXL6 expression is increased in gastric cancer tissues and positively correlated with clinicopathological characteristics. Experimental results showed that silencing FBXL6 inhibited proliferation and migration of gastric cancer cells, and affected the epithelial-mesenchymal transition pathway through the expression of related proteins. Therefore, FBXL6 may serve as a potential target for diagnosis and targeted therapy of gastric cancer.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2023)
