Article
Reproductive Biology
Surawich Jeensuk, M. Sofia Ortega, Muhammad Saleem, Briana Hawryluk, Tracy L. Scheffler, Peter J. Hansen
Summary: WNT5A is a cell-signaling ligand abundantly expressed in the endometrium, which plays a crucial role in regulating early development of the bovine embryo. It improves the competence of the preimplantation embryo to develop into the blastocyst stage and increases the number of cells in the inner cell mass. WNT5A exerts its effects through the RhoA/ROCK signaling pathway and is independent of the canonical beta-catenin and RAC1/JNK signaling pathways.
BIOLOGY OF REPRODUCTION
(2022)
Article
Biotechnology & Applied Microbiology
Qinglin Zhang, Jiadong Pan, Fangmei An, He Nie, Qiang Zhan
Summary: This study found that decreased expression of SLC39A1 is associated with clinical features and survival rates in early-stage hepatocellular carcinoma (EHCC), with patients showing lower expression having poorer prognosis. The expression level of SLC39A1 may serve as a potential diagnostic and prognostic biomarker for EHCC patients.
Article
Oncology
Yan Huang, Min Gu, Qi Wu, Juanfen Zhu, Jian Wu, Peipei Wang, Meihua Wang, Judong Luo
Summary: This study conducted a systematic review and meta-analysis to investigate the association between Helicobacter pylori infection in the larynx and laryngeal cancer. The results showed that Helicobacter pylori infection significantly increased the risk of malignant tumors in the larynx, even when controlling for smoking factors.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Diana Marzic, Blazen Marijic, Tamara Braut, Stefan Janik, Manuela Avirovic, Ita Hadzisejdic, Filip Tudor, Katarina Radobuljac, Miran Coklo, Boban M. Erovic
Summary: IMP3 expression is higher in malignant laryngeal lesions compared to dysplasia and benign lesions, serving as a useful marker to differentiate between invasive and noninvasive lesions. Higher IMP3 expression is associated with worse clinical outcomes in patients with squamous cell carcinoma of the larynx.
Article
Oncology
Akimichi Minesaki, Keita Kai, Yuichiro Kuratomi, Shinichi Aishima
Summary: In patients with advanced laryngeal cancer undergoing total laryngectomy, the infiltration of CD1a(+) DCs is associated with unfavorable clinical outcomes. CD1a(+) DCs infiltration serves as an independent unfavorable prognostic factor for disease-specific survival and overall survival.
Article
Cell Biology
Xiaoxuan Duan, Yihuan Chen, Kai Zhang, Wei Chen, Jun Zhao, Xiaoshuo Dai, Wenbo Cao, Ziming Dong, Saijun Mo, Jing Lu
Summary: This study found that phosphoglycerate dehydrogenase (PHGDH) was highly expressed in esophageal squamous carcinoma (ESCC), and high expression was associated with poor prognosis. In vitro and in vivo experiments demonstrated that PHGDH knockdown inhibited ESCC progression by suppressing Wnt/beta-catenin signaling pathway. These results indicate that PHGDH may be a potential therapeutic target for ESCC.
CELLULAR SIGNALLING
(2023)
Article
Oncology
Minsun Jung, Seokhyeon Lee, Kyung Chul Moon
Summary: This study identified c-Met and EPHA7 as receptor tyrosine kinases associated with myoferlin in clear cell renal cell carcinoma (ccRCC). High expression of c-Met and EPHA7 was independently associated with poor prognosis, indicating their potential as prognostic biomarkers. The study also suggests that the myoferlin/c-Met pathway could be a novel therapeutic target in ccRCC.
Article
Biotechnology & Applied Microbiology
Hui-Ching Lau, Yujie Shen, Qiang Huang, Hui-Ying Huang, Liang Zhou
Summary: Research identified and validated two novel glycolytic gene signatures, DDIT4 and PLOD2, as potential independent risk factors for predicting overall survival in laryngeal squamous cell carcinoma (LSCC). These findings may provide a therapeutic target and survival prediction marker for LSCC patients.
Article
Oncology
Leonardo Franz, Lorenzo Nicole, Anna Chiara Frigo, Giancarlo Ottaviano, Piergiorgio Gaudioso, Tommaso Saccardo, Francesca Visconti, Rocco Cappellesso, Stella Blandamura, Ambrogio Fassina, Gino Marioni
Summary: The mechanism of epithelial-mesenchymal transition (EMT) plays a crucial role in cancer development, tumor progression, and therapy resistance. In laryngeal carcinoma, the predictive value of pN+ status and Slug expression on disease-free survival was identified, supporting the hypothesis of a mutual concurrence of EMT and angiogenesis in driving aggressive phenotype in LSCC. Further studies are needed to characterize the predictive performance of prognostic models based on EMT and angiogenesis.
Article
Multidisciplinary Sciences
Nan Wang, Xuanyu Huang, Jinsheng Cheng
Summary: The study found that BIRC5 was strongly correlated with higher tumor grade and differentiation in Laryngeal squamous cell carcinoma (LSCC), and increased expression of BIRC5 was associated with overall survival in LSCC patients. Suppression of BIRC5 induced cell apoptosis and cell cycle arrest, inhibiting proliferation of LSCC cells. Higher level of BIRC5 expression predicted poor prognosis of LSCC patients, suggesting BIRC5 as a promising prognostic biomarker for LSCC.
Article
Oncology
Yong Shi, Dongli Yang, Yixiao Qin
Summary: This study revealed a ceRNA regulatory network in LSCC and identified four lncRNAs associated with patient prognosis. These lncRNAs play a significant role in the progress of LSCC by affecting the proliferation and metastasis of tumor cells.
Review
Hematology
Thomas J. Kipps
Summary: ROR1 is a cell receptor with significant importance in embryonic development and cancer. It plays a crucial role in the pathophysiology of CLL and has distinctive expression in this malignancy. Researchers have conducted studies on the expression, biology, and therapeutic strategies targeting ROR1.
Article
Oncology
Cheng Zhang, Bin Shen, Xinwei Chen, Shang Gao, Xinjiang Ying, Pin Dong
Summary: This study identified a four-mRNA signature that could serve as a biomarker for predicting prognosis in LSCC, especially in the long term. The gene signature was validated and shown to stratify patients into high- and low-risk groups with significantly different overall survival rates.
Article
Oncology
Xiaoyuan Wang, Yang Liu, Xue Leng, Kui Cao, Wentao Sun, Jinhong Zhu, Jianqun Ma
Summary: The study revealed significantly increased expression levels of UBE2T in ESCC tissues and its association with multiple signaling pathways. Prognostic signatures based on UBE2T-associated genes could stratify ESCC patients into different risk groups with significant prognostic differences. Additionally, the low-risk group showed higher sensitivity to chemotherapy.
PATHOLOGY & ONCOLOGY RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Juan P. Rodrigo, Mario Sanchez-Canteli, Fernando Lopez, Gregory T. Wolf, Juan C. Hernandez-Prera, Michelle D. Williams, Stefan M. Willems, Alessandro Franchi, Andres Coca-Pelaz, Alfio Ferlito
Summary: Tumor-infiltrating lymphocytes (TIL) have been shown to be prognostically significant in Laryngeal Squamous Cell Carcinoma (LSCC), with high stromal TIL, CD8+ TIL, and CD3+/CD4+ TIL associated with better clinical outcomes. Evaluation of TIL in HE sections and assessment of CD3+, CD4+, and/or CD8+ TIL levels may serve as predictive markers for patient prognosis in LSCC.
