Article
Biotechnology & Applied Microbiology
Li-Zhi Wu, Mao-Ling Huang, Cheng-Lin Qi, Li-Jun Shen, You Zou, Rui Yang, Jian-Fei Sheng, Shi-Ming Chen
Summary: Overexpression of Notch2 can increase the radiosensitivity of NPC cells by inhibiting the AKT/mTOR pathway, leading to enhanced apoptosis and cell cycle arrest in G2/M phase.
Article
Medicine, Research & Experimental
Li-Zhi Wu, You Zou, Bin-Ru Wang, Hai-Feng Ni, Yong-Gang Kong, Qing-Quan Hua, Shi-Ming Chen
Summary: Investigating the impact of CENP-N on the radiosensitivity of NPC cells, this study found that knockdown of CENP-N can enhance NPC radiosensitivity by inhibiting the AKT/mTOR pathway. The combination of CENP-N knockdown and radiotherapy showed significant suppression of proliferation, induction of apoptosis, and G2/M phase arrest in NPC cells, with increased levels of Bax and gamma H2AX proteins and decreased levels of Cyclin D1 protein.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Qianping Chen, Wang Zheng, Lin Zhu, Hongxia Liu, Yimeng Song, Songling Hu, Yang Bai, Yan Pan, Jianghong Zhang, Jian Guan, Chunlin Shao
Summary: The study identified LACTB2 as a potential biomarker for radioresistance in NPC, showing that its overexpression can promote PINK1-dependent mitophagy, enhancing radioresistance.
Article
Biochemistry & Molecular Biology
Hao Chen, Min Luo, Xiangping Wang, Ting Liang, Chaoyuan Huang, Changjie Huang, Lining Wei
Summary: This research revealed that PAD4 overexpression promotes radioresistance, survival, migration, and invasion of NPC cells, while treatment with the PAD4 inhibitor GSK484 exerted inhibitory effects on these processes. Importantly, GSK484 significantly reduced tumor size, weight, and volume in mice following irradiation, indicating its potential as a therapeutic strategy for NPC.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Xiangqi Zhou, Guangjin Yuan, Yangjie Wu, Sijia Yan, Qingshan Jiang, Sanyuan Tang
Summary: This study found that EIF4A3-induced circFIP1L1 inhibits NPC cell proliferation, promotes NPC cell apoptosis, and enhances NPC radiosensitivity through miR-1253.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Oncology
Zhuang Sun, Xiaohui Wang, Jingyun Wang, Jing Wang, Xiao Liu, Runda Huang, Chunyan Chen, Meiling Deng, Hanyu Wang, Fei Han
Summary: This study identified 1182 differentially expressed genes between radioresistant and radiosensitive NPC tissue samples, with 22 genes upregulated and 1160 genes downregulated in the radioresistant group. Integration analysis revealed 10 major NPC radiation resistance network models, with three core genes DOCK4, MCM9, and POPDC3 identified among 12 common downregulated genes. Further experimental studies on these core genes are warranted to deepen the understanding of NPC radioresistance mechanisms.
Article
Medicine, Research & Experimental
Pengfei Zhang, Yuan Shao, Fang Quan, Lifeng Liu, Jin Yang
Summary: FBP1 promotes radiosensitivity in NPC cells by inhibiting glycolysis through the FBXW7/mTOR axis.
Article
Otorhinolaryngology
Wei Zhang, Lingling Li, Ergang Guo, Haiting Zhou, Jun Ming, Lu Sun, Guoqing Hu, Linli Zhang
Summary: This study found that overexpression of PDK1 is associated with poor prognosis in nasopharyngeal carcinoma (NPC). Depletion of PDK1 can enhance the radiosensitivity of NPC cells, while a PDK1 inhibitor has the potential to enhance radiosensitivity in radioresistant NPC cells.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Review
Immunology
Wenting Li, Xiaobing Duan, Xingxing Chen, Meixiao Zhan, Haichuan Peng, Ya Meng, Xiaobin Li, Xian-Yang Li, Guofu Pang, Xiaohui Dou
Summary: Epstein-Barr virus (EBV) is the first tumor virus in humans, and nasopharyngeal carcinoma (NPC) accounts for 60% of new tumor cases caused by EBV worldwide annually. Over 90% of patients with undifferentiated NPC are infected with EBV. Immunotherapy has shown significant breakthroughs in the treatment of recurrent or metastatic NPC, providing a broad prospect for NPC immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Xinyu Hu, Jianfeng Wu, Yong Feng, Hongxia Ma, Erbao Zhang, Chang Zhang, Qi Sun, Tingting Wang, Yizhi Ge, Dan Zong, Wei Chen, Xia He
Summary: This study found that upregulated SUCLG2-AS1 in nasopharyngeal carcinoma promotes tumor cell invasion and metastasis, while repressing apoptosis and radiosensitivity, by regulating the expression of SOX2. These findings suggest that SUCLG2-AS1 may serve as a therapeutic target for nasopharyngeal carcinoma.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Lin Shen, Chao Li, Fang Chen, Liangfang Shen, Zhanzhan Li, Na Li
Summary: The study revealed the essential role of the LUC7L2 gene in regulating radioresistance of nasopharyngeal carcinoma cells. Overexpression promoted cell viability, while knockdown slowed down DNA replication and impaired cell survival, making cells more sensitive to radiation.
CELL DEATH DISCOVERY
(2021)
Article
Nanoscience & Nanotechnology
Chunlin Ke, Chuanshu Cai, Peirong Wang, Feng Dong
Summary: Radioresistance is a major problem in radiation therapy for PDAC. This study found that PRSS1 gene mutations may increase cell radiosensitivity by decreasing p-AKT and p-ERK, providing a molecular basis for optimizing radiation in PDAC patients.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Peiying Huang, Mengmeng Li, Qinglai Tang, Kang Jiang, Yuchao Luo
Summary: This study investigated the biological functions and mechanisms of circular RNA_0000523 (circ_0000523) in nasopharyngeal carcinoma (NPC). The results showed that circ_0000523 facilitates NPC progression through regulating the miR-1184/COL1A1 axis.
Article
Oncology
Jiacai Ye, Quanxing Liao, Xiaohui Zeng, Chang Liu, Yan Ding, Xuefeng Liu, Lisi Zeng, Tianpei Guan, Yawei Yuan
Summary: The study demonstrates that miR-124-3p inhibits proliferation and colony formation in NPC by interacting with PCDH8, thus suppressing the activation of the PI3K/AKT/mTOR signaling pathway. Therefore, PCDH8 may serve as a potential molecular target to impede NPC proliferation and colony formation.
Article
Biochemistry & Molecular Biology
Junhu Tai, Jaehyung Park, Munsoo Han, Tae Hoon Kim
Summary: This study identified the hub genes and biological pathways of nasopharyngeal carcinoma (NPC) through bioinformatics analysis, potentially leading to new therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)