Article
Immunology
Chunbo Li, Keqin Hua
Summary: This study used single-cell RNA sequencing to describe the composition and functional status of immune cells and mesenchymal cells during cervical cancer progression. The results showed distinct cell subpopulations at different stages of cervical cancer, with high-grade intraepithelial neoplasia exhibiting a low, recently activated tumor microenvironment, tumor tissue displaying an immunosuppressive state, and metastatic lymph node showing an early activated phase of immune response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Yoshihisa Numata, Tetsuya Abe, Eiji Higaki, Takahiro Hosoi, Hironori Fujieda, Takuya Nagao, Nobuhiro Hanai, Hidenori Suzuki, Daisuke Nishikawa, Keitaro Matsuo, Tsutomu Fujii, Yasuhiro Shimizu
Summary: Metastases to supraclavicular lymph nodes have a significant impact on the prognosis of patients with cervical esophageal cancer. These lymph nodes may be considered extra-regional in this patient population.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maha K. Rahim, Trine Line H. Okholm, Kyle B. Jones, Elizabeth E. McCarthy, Candace C. Liu, Jacqueline L. Yee, Stanley J. Tamaki, Diana M. Marquez, Iliana Tenvooren, Katherine Wai, Alexander Cheung, Brittany R. Davidson, Vrinda Johri, Bushra Samad, William E. O'Gorman, Matthew F. Krummel, Annemieke van Zante, Alexis J. Combes, Michael Angelo, Lawrence Fong, Alain P. Algazi, Patrick Ha, Matthew H. Spitzer
Summary: CD8+ T cell responses in lymph nodes play a critical role in anti-tumor immunity in human head and neck squamous cell carcinomas. These responses are associated with specific T cells in circulation and provide important insights for immune-based therapies in cancer.
Article
Oncology
Haoliang Lin, Dongyan Wang, Hui Li, Chuling Wu, Fengqian Zhang, Zhongqiu Lin, Tingting Yao
Summary: This study investigated the survival, treatment pattern, and treatment outcome of patients with cervical cancer metastasized to lymph nodes beyond the pelvis. The results showed that patients with distant lymphatic metastasis had better survival compared to those with pelvic organ invasion or distant organ metastasis. The prognosis of these patients was significantly affected by local tumor burden and local treatment. Adequate and aggressive local radiotherapy, such as image-guided brachytherapy, may lead to better outcomes for these patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Leonardo Barbi Walter, Rafael Selbach Scheffel, Andre Borsatto Zanella, Mauricio Farenzena, Carlo Sasso Faccin, Marcia Silveira Graudenz, Jose Miguel Dora, Ana Luiza Maia
Summary: In this study, we evaluated the outcomes of active surveillance (AS) for metastatic cervical lymph nodes in differentiated thyroid cancer (DTC) patients. The results showed that most small metastatic cervical lymph nodes remained stable and could be safely managed with AS.
Article
Oncology
Xieraili Wumener, Yarong Zhang, Zhenguo Wang, Maoqun Zhang, Zihan Zang, Bin Huang, Ming Liu, Shengyun Huang, Yong Huang, Peng Wang, Ying Liang, Tao Sun
Summary: This study evaluates the diagnostic value of quantitative metabolic parameters derived from dynamic F-18-FDG PET/CT in differentiating metastatic and non-metastatic lymph nodes in lung cancer patients. The results suggest that parameters such as K-1, k(2), K-i, and K-i/K-1 show promising results for differentiation of metastatic and non-metastatic lymph nodes with high uptake.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Guang-Li Zhu, Xiao-Min Zhang, Kai-Bin Yang, Ling-Long Tang, Jun Ma
Summary: This study investigated the metastatic patterns of level II-V lymph nodes in nasopharyngeal carcinoma (NPC) patients using vertebrae as anatomical landmarks. It was found that the metastasis rate gradually decreased from higher vertebral levels to lower levels. The study suggests that the clinical target volume in radiotherapy can be reduced to two vertebral levels below the metastatic level II-V nodes.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Medicine, General & Internal
Jian Xu, Yingli Ma, Haibing Mei, Qimin Wang
Summary: Multimodal MRI showed good diagnostic performance in discriminating between metastatic and non-metastatic PLNs in cervical cancer, with high sensitivity, specificity, and accuracy. This study highlights the potential of MRI in determining PLN status and guiding treatment decisions for cervical cancer patients.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Lin Yan, Ying Zhang, Bo Jiang, Yukun Luo
Summary: This study evaluated the safety and efficacy of radiofrequency ablation (RFA) for metastatic lymph nodes (LNs) in children and adolescents with papillary Thyroid Carcinoma (PTC). The results showed that RFA may provide another less invasive and effective alternative for the existing therapeutic modalities for cervical metastatic LNs in children and adolescents with PTC.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Jiangrui Liu, Yibin Su, Xing Liu, Jinfu Zhuang, Yuanfeng Yang, Guoxian Guan
Summary: D3 or CME surgery is common for colon cancer metastasis treatment. Clinical misuse of lymph node dissection brings burdens to patients. Detailed guidance for T3 and T4 stage right colon cancer patients is needed.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Lionel Gillot, Louis Baudin, Loic Rouaud, Frederic Kridelka, Agnes Noel
Summary: Lymph node metastasis is a significant prognostic factor in various cancers, serving as a gateway for further dissemination. Prior to metastasis, the primary tumor reshapes the draining lymph node by secreting soluble factors or releasing extracellular vesicles, creating a pre-metastatic niche for the survival and growth of metastatic cells. This review highlights the structure of lymph nodes, matrix composition, cellular heterogeneity, and major processes associated with nodal pre-metastatic niche formation, offering insights into potential research directions and clinical implications.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Biotechnology & Applied Microbiology
Yuanliang Yan, Yuanhong Liu, Tongfei Li, Qiuju Liang, Abhimanyu Thakur, Kui Zhang, Wei Liu, Zhijie Xu, Yuzhen Xu
Summary: Staging lymph nodes is crucial in diagnosing and treating cancer metastasis. Magnetic nanoparticles (MNPs), particularly iron oxide nanoparticles, have emerged as promising tools in cancer bioimaging, offering improved accuracy and biological safety for nodal staging. Despite being in its initial stages, exploring the underlying mechanisms of MNPs can enhance the sensitivity and multifunctionality of lymph node mapping. This review focuses on the feasibility and current application status of MNPs for imaging metastatic nodules.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rutong Zeng, Xiang Zhang, Chushan Zheng, Jin-Hong Du, Zixiong Gao, Wei Jun, Jun Shen, Yao Lu
Summary: A new decoupling neural network based quantification method for DECT analysis was presented in this study, showing potential as a noninvasive tool to predict metastasis lymph node status for breast cancer. By introducing spectral convolution and focal loss, the AUC on the test set could be improved by 0.15 and 0.01 separately. The proposed approach demonstrated a considerably better performance compared to baseline approaches, with a test set AUC value of 0.837.
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhenhua Liu, Ronghui Wang, Jianqiao Zhou, Yuanyi Zheng, Yijie Dong, Ting Luo, Xing Wang, Weiwei Zhan
Summary: The aim of this study is to develop a lymphatic imaging technique using ultrasonography for improved detection of lymph node metastasis in papillary thyroid cancer patients. The sensitivity of detecting positive targeted nodes significantly increased with the ultrasound lymphatic imaging method. Surgical results also showed a positive correlation between the degree of metastasis and an increase in the score.
EUROPEAN RADIOLOGY
(2021)
Article
Immunology
Iwona Kwiecien, Elzbieta Rutkowska, Rafal Sokolowski, Joanna Bednarek, Agata Raniszewska, Karina Jahnz-Rozyk, Piotr Rzepecki, Joanna Domagala-Kulawik
Summary: In this study, we found that metastatic lymph nodes in lung cancer patients had a higher percentage of CD4+ and CD8+ effector memory T cells, as well as CD45RO+ T regulatory cells. Flow cytometry of lymph node samples obtained through EBUS/TBNA can be used to evaluate lymphocyte subsets and may reflect the immune status in lung cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Jinyi Zhou, Xintong Yan, Xiaowen Bi, Shuai Lu, Xianli Liu, Chen Yang, Yingying Shi, Lan Luo, Zhimin Yin
Summary: This study investigated the molecular mechanism of gamma-glutamylcysteine (gamma-GC) in regulating macrophage polarization in response to inflammation. The findings showed that gamma-GC improved survival, weight loss, and colon tissue damage in IBD mice. In addition, gamma-GC switched M1/M2-polarized macrophages by activating the AMPK/SIRT1 axis and inhibiting inflammation-related signaling pathway.
INFLAMMATION RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Xiang Li, Xuemeng Guo, Jiaxin Huang, Qing Lin, Bing Qin, Mengshi Jiang, Xinyu Shan, Zhenyu Luo, Junlei Zhang, Yingying Shi, Yichao Lu, Xu Liu, Yongzhong Du, Fuchun Yang, Lihua Luo, Jian You
Summary: Recruiting T cells to convert cold tumors into hot can prevent tumor immune evasion. However, tumors have evolved more mechanisms to achieve immune evasion, such as downregulating MHC I molecules expression or secreting immune suppression cytokines. Tumor immune evasion not only promotes tumor growth, but also weakens the efficacy of existing tumor immunotherapies.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Lihua Luo, Zhenyu Luo, Junlei Zhang, Xu Liu, Jiaxin Huang, Sijie Wang, Hang Yin, Xuemeng Guo, Yilong Hu, Yichao Lu, Xinyu Shan, Huihui Liu, Yingying Shi, Yongzhong Du, Fuchun Yang, Jian You
Summary: This passage introduces a treatment strategy for acute lung injury/acute respiratory distress syndrome (ALI/ARDS) and pulmonary fibrosis (PF). By designing a multistage targeted nanomicelle loaded with endoplasmic reticulum stress inhibitor and anti-inflammatory drug, the balance of macrophage polarization and restoration of endoplasmic reticulum homeostasis can be achieved, alleviating inflammation and ultimately resolving ALI and preventing PF.
Article
Chemistry, Medicinal
Xiaoman Liu, Mingxia Zhou, Zhenzhen Dai, Shangjian Luo, Yingying Shi, Zhenjuan He, Yingwei Chen
Summary: Salidroside effectively restricts experimental colitis by regulating macrophage pyroptosis and dysbacteriosis-derived Th17/Treg imbalance, suggesting its potential effect on UC and other immune disorders.
PHYTOTHERAPY RESEARCH
(2023)
Article
Engineering, Biomedical
Yu Liu, Xu Liu, Jiaxin Huang, Yingying Shi, Zhenyu Luo, Junlei Zhang, Xuemeng Guo, Mengshi Jiang, Xiang Li, Hang Yin, Bing Qin, Guannan Guan, Lihua Luo, Yun Zhou, Jian You
Summary: This study reports a novel mRNA vaccine delivery system using modified liposomes to efficiently induce tumor-specific immune responses. The system shows promising prophylactic effects and offers a strategy to address deficient tumor MHC-I expression.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Green & Sustainable Science & Technology
Sen Li, Yingying Shi, Lingling Wang, Enjun Xia
Summary: With the rise of the digital economy era, the relationship between consumers and brands is changing, and brand management needs to adapt to this change. Brand orientation has sparked a discussion on the dominant paradigm of market orientation and a revolution in brand management. This study conducts a scientific analysis of literature and references in the field of brand orientation to identify its major research focuses, limitations, and the evolving relationship with market orientation.
Article
Microbiology
Xu Zhong, Li Zhang, Di Ma, Yingying Shi, Jiayin Wu, Xiaosheng Xu, Weihong Chen, Beiwen Wu, Yiding Tang, Hongping Qu, Qing Xie, Yi Yang, Jialin Liu, Haiguang Xin
Summary: This study assessed the performance of the rapid antigen detection test (RADT) and found that Ediagnosis performed excellently in individuals with a higher viral load, individuals in the early symptomatic phase, and especially those with upper respiratory tract symptoms.
MICROBIOLOGY SPECTRUM
(2023)
Article
Chemistry, Multidisciplinary
Xinyu Shan, Xiang Li, Zhenyu Luo, Qing Lin, Yichao Lu, Mengshi Jiang, Junlei Zhang, Jiaxin Huang, Lin Xie, Xuemeng Guo, Xu Liu, Yingying Shi, Yu Liu, Hang Yin, Fuchun Yang, Lihua Luo, Jian You
Summary: When it comes to long-acting injections, lyotropic liquid crystals (LLCs) are considered effective and powerful. However, widely used LLC-forming materials may lead to tissue cytotoxicity and undesired immunological responses, hindering their wide application. In this study, phosphatidylcholine and alpha-tocopherol were used as carriers to increase the biocompatibility. By changing the ratios between them, crystalline types, nanosized structures, viscoelastic differences, releasing behaviors, and in vivo safety were studied. The treatment of hormone-sensitive and castration-resistant prostate cancer using the LLC platform showed promising results.
Review
Food Science & Technology
Zhimin Wang, Chao Liu, Yingying Shi, Mingming Huang, Zunyang Song, Jesus Simal-Gandara, Ningyang Li, Jingying Shi
Summary: Lipopeptides are compounds produced by Bacillus spp. with a peptide ring and a fatty acid chain. They are widely used in various industries due to their hydrophilic and oleophilic properties. However, the complex metabolic network and strict synthesis pathway of lipopeptides result in high cost and low production efficiency, limiting their large-scale application. This review explores the types and biosynthetic pathways of Bacillus-produced lipopeptides, as well as methods to improve their production, such as genetic engineering and fermentation optimization.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Yan Wei, Guohui Xiao, Hui Xu, Xuehua Sun, Yingying Shi, Fen Wang, Jinlin Kang, Jin Peng, Fuxiang Zhou
Summary: Radiation resistance is the leading cause of failure in radiotherapy for cancer patients, which is mainly due to enhanced DNA damage repair in cancer cells. Autophagy, specifically mitophagy, has been found to be linked to genome stability and radiation resistance. SIRT3 was observed to be highly expressed in colorectal cancer cells with mitochondrial dysfunction, leading to PINK1/Parkin-mediated mitophagy. Excessive activation of mitophagy promoted DNA damage repair and increased tumor cell resistance to radiation.
Article
Chemistry, Multidisciplinary
Yingying Shi, Ming Zhou, Min Kou, Kailin Zhang, Xianyi Zhang, Xianglei Kong
Summary: An artificial neural network (ANN) based approach is presented for quantitatively analyzing multiple chiral isomers from their ultraviolet photodissociation mass spectra. The results show that the network can be well-trained with limited sets and have a good performance in testing sets. This study demonstrates the potential of the new method in rapid quantitative chiral analysis aimed at practical applications, with room for improvement in the future.
FRONTIERS IN CHEMISTRY
(2023)
Article
Microbiology
Qingqing Du, Qi Xu, Fen Pan, Yingying Shi, Fangyuan Yu, Tiandong Zhang, Jie Jiang, Wenxin Liu, Xiaozhou Pan, Dingding Han, Hong Zhang
Summary: This study demonstrates a strong association between CRKP intestinal colonization and extraintestinal infection, based on whole-genome sequencing data and phenotypic assays of antimicrobial resistance and virulence.
MICROBIOLOGY SPECTRUM
(2023)
Article
Public, Environmental & Occupational Health
Na Zhao, Supen Wang, Lan Wang, Yingying Shi, Yixin Jiang, Tzu-Jung Tseng, Shelan Liu, Ta-Chien Chan, Zhiruo Zhang
Summary: The aim of this study was to analyze and compare the mortality rates of 10 notifiable respiratory infectious diseases (RID) in China from 2004 to 2020. The overall mortality rate of RIDs remained stable during this period, but there was a significant decrease in the mortality rate in 2020 compared to the previous five years, likely due to the COVID-19 pandemic. Tuberculosis was the leading cause of RID mortality, while seasonal influenza showed a significant increase in mortality. There were also variations in mortality rates among Chinese provinces and age groups.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Medicine, Research & Experimental
Shiguang Lu, Ying Zhang, Yuejun Yang, Yafang Zhang, Guangcheng Qin, Qingqing Fu, Yingying Shi, Fan Zhang, Zhe Wang, Yanhe Chen, Yuancai Liu, Lixue Chen
Summary: The present study aimed to establish and evaluate a rat model for hangover headaches caused by alcoholic drinks. Chronic migraine model rats were administered alcoholic drinks to simulate hangover headache attacks, and their pain thresholds and serum levels of relevant indicators were measured. The results showed that rats administered alcoholic drinks had a significantly lower mechanical pain threshold, but no significant difference in thermal pain threshold. The serum levels of substance P, nitric oxide, and calcitonin gene-related peptide were significantly higher in the group receiving alcoholic drinks. This model can be used to investigate the mechanisms of hangover headaches.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2023)
Article
Endocrinology & Metabolism
Zhen Liang, Dong Sun, Shuaiyao Lu, Zhengjun Lei, Shusen Wang, Zhifeng Luo, Jinqin Zhan, Shuangshuang Wu, Yong Jiang, Zhi Lu, Shicheng Sun, Yingying Shi, Haiting Long, Yanling Wei, Wenhai Yu, Zhihui Wang, Liew Soon Yi, Yun Zhang, Wenyong Sun, Xiaofeng Fang, Yanyan Li, Sufang Lu, Jiayun Lv, Weiguo Sui, Zhongyang Shen, Xiaozhong Peng, Yuanyuan Du, Hongkui Deng
Summary: This study demonstrates the successful implantation of human pluripotent stem cell-derived islets in a new transplantation site in the abdomen, leading to improved glycemic control in diabetic primates. The results suggest the potential of using this transplantation site for human pluripotent stem cell-based therapies for diabetes.
