Review
Pharmacology & Pharmacy
Clifford J. Bailey, Mike Gwilt
Summary: The clinical literature review shows that metformin treatment in Covid-19 patients with diabetes can improve clinical outcomes, reduce admission into intensive care, and decrease mortality. The pleiotropic actions of metformin, such as reducing insulin resistance and inflammation, may play a role in these effects. Modulation of the ACE2 protein via the AMP kinase pathway could also be involved. However, caution should be exercised in patients with severe Covid-19, as metformin withdrawal may be necessary to avoid acidosis and lactic acidosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Oncology
Ya-Hui Chen, Po-Hui Wang, Pei-Ni Chen, Shun-Fa Yang, Yi-Hsuan Hsiao
Summary: Metformin has potential anticancer effects in the treatment of cervical cancer, either alone or in combination with other agents, providing clinical benefits and improving treatment efficacy while reducing adverse reactions.
Review
Medicine, Research & Experimental
Sara S. Bashraheel, Hadeel Kheraldine, Sarah Khalaf, Ala-Eddin Al Moustafa
Summary: Due to the strong association between diabetes and cancer incidents, several anti-diabetic drugs, including metformin, have been examined for their anticancer activity. Metformin exhibits anticancer activity by impacting different molecular pathways and indirectly inhibiting IGF-1R signaling in breast malignancy. Breast cancer, especially the HER2-positive subtype, is highly aggressive with a high rate of lymph node metastasis. This review summarizes the association between diabetes and human cancer, focusing on metformin's anticancer activity and combination therapy strategies in HER2-positive breast cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Mirian Galliote Morale, Rodrigo Esaki Tamura, Ileana Gabriela Sanchez Rubio
Summary: Metformin is the most widely used drug for type 2 diabetes and has shown antitumor activity in various types of cancer cells. In vitro studies have demonstrated that metformin regulates almost all hallmarks of cancer and has the potential to synergize with other chemotherapeutic agents.
Review
Biochemistry & Molecular Biology
Santosh Kumar Singh, Tejumola Apata, Shriti Singh, Melayshia McFadden, Rajesh Singh
Summary: The association between diabetes mellitus and ovarian cancer has been supported by recent studies, with emerging evidence suggesting that metformin may have protective effects against ovarian cancer. Metformin exerts anti-cancer properties by activating the MAPK pathway, inhibiting the PI3K/AKT/mTOR pathway, and increasing tumor suppressor genes.
Review
Oncology
Guido Eibl, Enrique Rozengurt
Summary: Metformin has beneficial effects in pancreatic cancer, reducing the risk of developing the disease and improving survival in patients, mainly through its direct effects on transformed pancreatic epithelial cells and indirect effects on extra-pancreatic tissues.
CANCER AND METASTASIS REVIEWS
(2021)
Article
Oncology
Yong-Moon Mark Park, Dale P. Sandler
Summary: The relationship between type 2 diabetes, metformin, and breast cancer is intricate. While T2D may increase the risk, metformin as a primary treatment option for T2D could potentially decrease the risk of breast cancer. Research efforts are focused on untangling the effects of T2D and metformin use on breast cancer risk in a prospective study.
BRITISH JOURNAL OF CANCER
(2021)
Article
Chemistry, Multidisciplinary
Xiao Yang, Yuan Cheng, Jingyi Zhou, Lingpu Zhang, Xingchen Li, Zhiqi Wang, Shenyi Yin, LiRong Zhai, Ting Huang, Xiaotong Wu, Boqiang Shen, Yangyang Dong, Lijun Zhao, Yujing Chi, Yuanyuan Jia, Jiaqi Wang, Yijiao He, Xiying Dong, Haihua Xiao, Jianliu Wang
Summary: This study found that diabetes is closely related to endometrial cancer and there is currently no effective treatment for patients with both conditions. Through experiments, a new drug (JX06-NPs) that disrupts cancer metabolism was discovered to significantly inhibit the growth of endometrial cancer cells, with better results when combined with metformin. This study provides a new adjuvant therapy for patients with diabetes and endometrial cancer.
Article
Oncology
Y-M M. Park, D. B. Bookwalter, K. M. O'Brien, C. L. Jackson, C. R. Weinberg, D. P. Sandler
Summary: The study found that type 2 diabetes is associated with an increased risk of breast cancer, but the risk may be reduced with the use of metformin, particularly for estrogen receptor-positive breast cancer.
ANNALS OF ONCOLOGY
(2021)
Review
Endocrinology & Metabolism
Traci E. LaMoia, Gerald Shulman
Summary: Metformin is a commonly used first-line therapy for type 2 diabetes, mainly acting through inhibition of hepatic gluconeogenesis to lower blood glucose levels. Despite controversy over its mechanism of action, recent studies have supported a redox-dependent mechanism.
Review
Geriatrics & Gerontology
Die Hu, Fangfang Xie, Yongwei Xiao, Chen Lu, Jianing Zhong, Defa Huang, Jie Chen, Jifu Wei, Yu Jiang, Tianyu Zhong
Summary: Aging is a universal phenomenon characterized by a loss of reproductive capacity and declining fitness in all biological organisms. In humans, aging is associated with an increased incidence of diseases, making the aging population a primary public burden of the 21st century. The discovery of novel anti-aging drugs is crucial to delay the aging process and maintain the fitness of the aging population, with metformin gaining attention in recent years for its potential anti-aging effects.
Article
Biochemistry & Molecular Biology
Zhaoli Chu, Yao Tan, Chenxing Xu, Dongting Zhangsun, Xiaopeng Zhu
Summary: In this study, the molecular mechanisms of metformin in cervical cancer cells were evaluated using flow cytometry, western blotting, and RNA sequencing. The results showed that metformin inhibited cell viability, promoted apoptosis, and induced changes in gene expression associated with apoptosis signaling pathways, PI3K-AKT, mTOR, and AMPK signaling pathways.
Review
Cell Biology
Xiao-yu Wu, Wen-Wen Xu, Xiang-kun Huan, Guan-nan Wu, Gang Li, Yu-Hong Zhou, Masoud Najafi
Summary: Resistance of cancer cells to anti-tumour agents is a major challenge in cancer treatment. Metformin, an antidiabetic drug, can enhance cell death mechanisms and play a key role in inducing cell death, thereby increasing the therapeutic efficiency of anti-cancer therapy.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Tianli Hui, Chao Shang, Liu Yang, Meiqi Wang, Ruoyang Li, Zhenchuan Song
Summary: Early reports suggest that the drug metformin, used to treat T2DM, may have a positive impact on the prognosis of cancer. A study on Chinese breast cancer patients with T2DM found that those using metformin showed improved disease-free and overall survival compared to those not using the drug.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Fidelma Dunne, Christine Newman, Alberto Alvarez-Iglesias, John Ferguson, Andrew Smyth, Marie Browne, Paula O'Shea, Declan Devane, Paddy Gillespie, Delia Bogdanet, Oratile Kgosidialwa, Aoife Egan, Yvonne Finn, Geraldine Gaffney, Aftab Khattak, Derek O'Keeffe, Aaron Liew, Martin O'Donnell
Summary: Early initiation of metformin is not superior to placebo for the primary outcome of gestational diabetes. Further investigation of metformin in larger clinical trials is supported by the prespecified secondary outcome data.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Oncology
Fu-Ming Zi, Jing-Song He, Yi Li, Cai Wu, Li Yang, Yang Yang, Li-Juan Wang, Dong-Hua He, Yi Zhao, Wen-Jun Wu, Gao-Feng Zheng, Xiao-Yan Han, He Huang, Qing Yi, Zhen Cai
Review
Oncology
Fuming Zi, Jingsong He, Donghua He, Yi Li, Li Yang, Zhen Cai
MOLECULAR MEDICINE REPORTS
(2015)
Article
Oncology
Donghua He, Xing Guo, Enfan Zhang, Fuming Zi, Jing Chen, Qingxiao Chen, Xuanru Lin, Li Yang, Yi Li, Wenjun Wu, Yang Yang, Jingsong He, Zhen Cai
Article
Oncology
Jing Cheng, Jifu Zheng, Ninghong Guo, Fuming Zi
MOLECULAR MEDICINE REPORTS
(2017)
Article
Oncology
Xuanru Lin, Li Yang, Gang Wang, Fuming Zi, Haimeng Yan, Xing Guo, Jing Chen, Qingxiao Chen, Xi Huang, Yi Li, Enfan Zhang, Wenjun Wu, Yang Yang, Donghua He, Jingsong He, Zhen Cai
Review
Oncology
Haimeng Yan, Donghua He, Xi Huang, Enfan Zhang, Qingxiao Chen, Ruyi Xu, Xinling Liu, Fuming Zi, Zhen Cai
Article
Oncology
Fu-Ming Zi, Jing-Song He, Yi Li, Cai Wu, Wen-Jun Wu, Yang Yang, Li-Juan Wang, Dong-Hua He, Li Yang, Yi Zhao, Gao-Feng Zheng, Xiao-Yan Han, He Huang, Qing Yi, Zhen Cai
CANCER BIOLOGY & THERAPY
(2014)
Article
Biochemistry & Molecular Biology
Ning-Hong Guo, Ji-Fu Zheng, Fu-Ming Zi, Jing Cheng
BIOSCIENCE REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Ji-Fu Zheng, Ning-Hong Guo, Fu-Ming Zi, Jing Cheng
MOLECULAR AND CELLULAR BIOLOGY
(2020)
Review
Oncology
Fuming Zi, Li Yu, Qingzhi Shi, Aiping Tang, Jing Cheng
Article
Oncology
Shuchong Mei, Yuan Zhang, Li Yu, Guoan Chen, Fuming Zi
Summary: The study found that there were significant differences in FAP alpha expression between AML patients and healthy donors in BM samples, and BMMSCs can protect AML cells from apoptosis through activating the beta-catenin signaling pathway. FAP alpha plays an important role in the AML BM microenvironment and its increased expression may be a poor prognostic factor for AML patients.
Article
Multidisciplinary Sciences
Ruiqi Li, Shuchong Mei, Qiang Ding, Qingming Wang, Li Yu, Fuming Zi
Summary: HK2 is highly expressed in most tumors and related to the progression of some tumors. HK2 expression is associated with the infiltration of specific cell types in certain tumors.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Fu-Ming Zi, Zhong-Zheng Zheng, Ke-Ming Du, Lin An, Qing-Ming Wang
Summary: HLA-C*03:621 differs from HLA-C*03:04:01:01:01 by one nucleotide in exon 1.
Article
Endocrinology & Metabolism
Dongmei Hou, Qiang Ding, Ruiqi Li, Yuan Zhang, Fuming Zi
Summary: The aim of this study was to investigate the action and mechanism of metformin in acute myeloid leukemia (AML), in order to find cost-effective drugs for synergistic therapy to improve the survival rate of AML patients. The results showed that metformin inhibited AML cell proliferation, induced apoptosis, and arrested the cell cycle at the G0/G1 phase by inhibiting the PI3K/AKT/mTOR pathway.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)